• Future trials should evaluate whether node-negative colon cancer patients with BMM benefit from adjuvant chemotherapy. (nih.gov)
  • Since then, the field of adjuvant therapy has greatly expanded to include a wide range of adjuvant therapies to include chemotherapy, immunotherapy, hormone therapy, and radiation. (wikipedia.org)
  • citation needed] Hyperthermia therapy or heat therapy is also a kind of adjuvant therapy that is sometimes given in combination with radiotherapy or chemotherapy to boost the effects of these conventional treatments in treating advanced cancers. (wikipedia.org)
  • But adjuvant treatments with cryotherapy, topical chemotherapy, and radiation therapy have shown increased success. (duke.edu)
  • She subsequently underwent adjuvant chemotherapy with docetaxel anhydrous, cyclophosphamide, and pegfilgrastim and postchemotherapy reexcision of her margins, with all new margins reported as negative. (medscape.com)
  • Treatment is usually neo-adjuvant chemotherapy and limb salvage surgical resection, followed by adjuvant chemotherapy +/- radiation. (orthobullets.com)
  • Various modalities including immunological therapy, chemotherapy and radiation therapy have been tested in the adjuvant setting over the past three decades. (amegroups.org)
  • Neoadjuvant chemoradiation therapy (CRT), radical resection based on total mesorectal excision (TME), and adjuvant chemotherapy have improved the survival and recurrence rates of locally advanced rectal cancer [ 2 , 3 ]. (pfmjournal.org)
  • The current trial, BNIT-BR-003, will evaluate the safety and biological activity of a fixed dose of MVA-BN®-HER2 following adjuvant chemotherapy in patients with HER-2-positive breast cancer. (stanford.edu)
  • PURPOSE: Randomized phase III trial to determine the effectiveness of adjuvant chemotherapy in treating women who have undergone resection for local and/or regional relapsed breast cancer. (stanford.edu)
  • Clinical trials performed during the 1980's have shown that treatment of localized osteosarcoma with adjuvant chemotherapy improves a patient's chance of survival and decreases the risk of cancer recurrence compared to surgery alone. (radiationoncologyassociates.co)
  • Is 6 Months the Optimal Duration of Adjuvant Chemotherapy for Pancreatic Cancer? (cancerdiagnosisprognosis.org)
  • The results indicated that the adjuvant therapy given after the initial radical mastectomy "significantly decreased recurrence rate in pre-menopausal women with four or more positive axillary lymph nodes. (wikipedia.org)
  • For high-risk melanoma, adjuvant therapy aims at eradicating melanoma micrometastases in those patients that carry an unacceptable risk of mortality from melanoma recurrence. (amegroups.org)
  • For high-risk melanoma, adjuvant therapy focuses on clinically invisible disease that may lead to future mortality from melanoma recurrence and presents an opportunity at curing this disease. (amegroups.org)
  • The presence of micrometastases may cause osteosarcoma recurrence following local treatment with surgery alone. (radiationoncologyassociates.co)
  • One of the reasons for recurrence in pathologically node-negative patients could be missed micrometastasis and occult tumor cells on routine histopathological examination or inadequate lymph node harvesting leading to understaging ( 4 ). (turkjsurg.com)
  • No adjuvant therapy was given because the size of tumour was small, there was no residual tumor in mastectomy specimen and she had no distant metastasis. (bvsalud.org)
  • Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms . (lookformedical.com)
  • COMBI-AD is a randomized, large, phase 3, well-powered adjuvant trial which tested the targeted therapies dabrafenib and trametinib versus placebo in high-risk resected stage IIIA, IIIB, and IIIC melanoma (per American Joint Committee on Cancer 7th edition criteria). (medscape.com)
  • This study certainly suggests longer-term benefit with the targeted therapies dabrafenib and trametinib for adjuvant therapy of resected high-risk stage III melanoma. (medscape.com)
  • Advances in our understanding of melanoma molecular biology and host immunology have given ways to novel targets and therapeutic agents that have demonstrated unprecedented results in the management of metastatic disease and currently are being tested in the adjuvant stetting where recent data support a significant clinical impact of adjuvant ipilimumab. (amegroups.org)
  • Here, we review the standard of care melanoma adjuvant therapy along with the main completed, current and planned clinical trials. (amegroups.org)
  • Pembrolizumab has been approved for the adjuvant treatment of adults and pediatric patients with stage IIB or IIC melanoma who have underwent complete resection. (oncnursingnews.com)
  • After 6 months of additional follow-up, patients with resected high-risk stage II melanoma continued to experience improved relapse-free survival following treatment with adjuvant pembrolizumab. (oncnursingnews.com)
  • There is also an adenoma/adenocarcinoma sequence where benign tumors, such as intraductal papillary mucinous neoplasm and mucinous cystic neoplasm…, can transform into what looks exactly like the disease process of the other pathway. (jnccn.org)
  • Tumors affecting the orbit include benign and malignant neoplasms arising from the various structures in the orbit including the blood vessels, nerves, bones, orbital fat and other soft tissues. (cybersight.org)
  • For example, radiotherapy or systemic therapy is commonly given as adjuvant treatment after surgery for breast cancer. (wikipedia.org)
  • Adjuvant systemic therapy and radiotherapy are often given following surgery for many types of cancer, including colon cancer, lung cancer, pancreatic cancer, breast cancer, prostate cancer, and some gynaecological cancers. (wikipedia.org)
  • Thus, systemic therapy is often needed to treat undetectable micrometastases. (radiationoncologyassociates.co)
  • Historically, systemic therapy was administered as an adjuvant, or after surgery. (radiationoncologyassociates.co)
  • thus, tumors with a high cell turnover are most susceptible (certain leukemias and lymphomas, small proliferating tumors, "recruited" tumor cells, and micrometastases). (doctorlib.info)
  • Several systemic therapies, such as oxaliplatin + irinotecan/fluorouracil/leucovorin (FOLFIRINOX) and gemcitabine + nab-paclitaxel, have shown activity in the adjuvant and neoadjuvant settings. (jnccn.org)
  • Preclinical success has led to a profusion of clinical trials on LB100 adjuvant therapies, including a phase I trial in extensive-stage small-cell lung cancer, a phase I/II trial in myelodysplastic syndrome, a phase II trial in recurrent glioblastoma, and a completed phase I trial assessing the safety of LB100 and docetaxel in various relapsed solid tumors. (cancerbiomed.org)
  • The aim of adjuvant treatment is to improve disease-specific symptoms and overall survival. (wikipedia.org)
  • A forest plot for RFS for dabrafenib and trametinib versus placebo looking at virtually every prognostic factor (eg, gender, age, macrometastases, micrometastases, ulceration, tumor burden, substage) found that the HRs did not overlap 1, and they were all in favor of dabrafenib and trametinib. (medscape.com)
  • Adjuvant therapy, also known as adjunct therapy, adjuvant care, or augmentation therapy, is a therapy that is given in addition to the primary or initial therapy to maximize its effectiveness. (wikipedia.org)
  • The surgeries and complex treatment regimens used in cancer therapy have led the term to be used mainly to describe adjuvant cancer treatments. (wikipedia.org)
  • An example of such adjuvant therapy is the additional treatment usually given after surgery where all detectable disease has been removed, but where there remains a statistical risk of relapse due to the presence of undetected disease. (wikipedia.org)
  • The term "adjuvant therapy," derived from the Latin term adjuvāre, meaning "to help," was first coined by Paul Carbone and his team at the National Cancer Institute in 1963. (wikipedia.org)
  • Despite the initial pushback from the breast cancer surgeons who believed that their radical mastectomies were sufficient in removing all traces of cancer, the success of Bonadonna's and Fisher's trials brought adjuvant therapy to the mainstream in oncology. (wikipedia.org)
  • Neoadjuvant therapy, in contrast to adjuvant therapy, is given before the main treatment. (wikipedia.org)
  • Oncologists use statistical evidence to assess the risk of disease relapse before deciding on the specific adjuvant therapy. (wikipedia.org)
  • Because the treatment is essentially for a risk, rather than for provable disease, it is accepted that a proportion of patients who receive adjuvant therapy will already have been cured by their primary surgery. (wikipedia.org)
  • Some forms of cancer fail to benefit from adjuvant therapy, however. (wikipedia.org)
  • The ultimate goal of adjuvant therapy is to provide a potential cure before progression into advanced inoperable stages. (amegroups.org)
  • Of particular interest are adjuvant therapy, treatment of metastatic disease, methods for treatment of locally advanced breast cancer and inflammatory breast cancer. (stanford.edu)
  • Negative regulation of protein phosphatase 2A (PP2A) as an adjuvant therapy has demonstrated such chemo- and radio-sensitizing effects 4 . (cancerbiomed.org)
  • We studied 5 consecutive cases of GCT involving the distal radius operated by en-bloc resection of tumor followed by reconstruction with ipsilateral non-vascularized fibular graft with a minimum 1 year follow-up. (jbstjournal.com)
  • Patients with a micrometastasis in a lymph node were later allowed with a study amendment. (johnshopkins.edu)
  • Patients received adjuvant paclitaxel for 12 weeks with trastuzumab, and trastuzumab was continued for 1 year. (johnshopkins.edu)
  • The purpose of our study was to develop modern epidemiological data for adult patients completing an appendectomy for UA secondary to an appendiceal neoplasm (AN). (cancerindex.org)
  • Inguinofemoral radiotherapy may be a safe alternative for patients with vulvar cancer and sentinel node micrometastases who might otherwise face the morbidity of a lymphadenectomy. (oncnursingnews.com)
  • Most patients diagnosed with localized osteosarcoma actually have micrometastases that are undetectable by current procedures. (radiationoncologyassociates.co)
  • Most of the pancreatic cancers develop through a pancreatic intraepithelial neoplasm mechanism, which is basically dysplasia that increases over time until you have a full-blown pancreatic ductal adenocarcinoma," Dr. Tempero stated. (jnccn.org)
  • Adjuvant Cisplatin Plus Gemcitabine in Operable Cholangiocellular Carcinoma. (cancercentrum.se)
  • Nevertheless, there is an established way through which to increase the immunogenicity of immunotherapy-by the use of adjuvants. (mdpi.com)
  • Sentinel lymph node (SLN) biopsy technique has been described in colon cancer to detect micrometastasis (MM) ( 6 ). (turkjsurg.com)
  • Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system. (lookformedical.com)
  • The goals of pharmacotherapy are to reduce morbidity and to eradicate the neoplasm. (medscape.com)
  • Sentinel nodes revealed evidence of one node with 0.1-mm micrometastasis and three negative nodes. (medscape.com)
  • Neoplasms containing cyst-like formations or producing mucin or serum. (lookformedical.com)
  • If known disease is left behind following surgery, then further treatment is not technically adjuvant. (wikipedia.org)
  • The patient opted for breast conservation with postoperative radiation and adjuvant systemic treatment. (medscape.com)
  • The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause. (lookformedical.com)
  • In 1968, the National Surgical Adjuvant Breast and Bowel Project (NSABP) published its B-01 trial results for the first randomized trial that evaluated the effect of an adjuvant alkylating agent in breast cancer. (wikipedia.org)
  • Breast cancer refers to several types of neoplasm arising from breast tissue, the most common being adenocarcinoma of the cells lining the terminal duct lobular unit. (capsulehealth.one)
  • Micrometastases are cancer cells that have spread beyond the area of the original cancer. (radiationoncologyassociates.co)
  • Ability of neoplasms to infiltrate and actively destroy surrounding tissue. (lookformedical.com)
  • Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. (lookformedical.com)
  • Methods which attempt to express in replicable terms the extent of the neoplasm in the patient. (lookformedical.com)
  • An adjuvant used on its own specifically refers to an agent that improves the effect of a vaccine. (wikipedia.org)
  • Nasopharyngeal carcinoma (NPC) is a rare head and neck neoplasm worldwide. (intechopen.com)