White adiposAccumulationLiverAdipocytesSkeletalBrown adiposAdiposityMacrophagesMetabolismTriglyceridesCompared adipose tissue macrophageExpression in adipose tissueInfiltrationPparHepaticInflammation and insulin resistanceLoss of adiposeRegulatesSubcutaneousLipidsTriglycerideObese miceHomeostasisDepositionVarious tissuesAdipocyte-specificSoleus muscleWhole-body insulin resistanceAssociated with insulin resistancePathwaysLipodystrophyFattyMetabolicallyExcessInflammatoryBlood glucoseMale miceLipogenicType 2 diabetC57BLProteinSystemicEnergy expenditureHypertriglyceridemiaOverexpressionHigh-fatReductionDysfunction
White adipos8
- Namely, CDK4 promotes the insulin signaling pathway in white adipose tissue (7) , while directly repressing the AMPK signaling pathway (6) . (unil.ch)
- The mRNA expression levels of peroxisome proliferator-activated receptor (PPAR)-γ and lipocalin-2 in white adipose tissue were, respectively, down- and up-regulated. (biomedcentral.com)
- Reduction of PPAR-γ expression and generation of a pro-inflammatory environment by increased lipocalin-2 expression in white adipose tissue may contribute to stress-induced glucose intolerance. (biomedcentral.com)
- This study aims to unveil biological markers that establish the molecular basis of stress-induced glucose intolerance, with a special emphasis on the visceral white adipose tissue (vWAT). (biomedcentral.com)
- Along with adipocyte hypertrophy, macrophage infiltration of white adipose tissue (WAT) is associated with the pathophysiology of obesity, AD and IR, albeit the underlying molecular mechanisms are uncharacterized. (hhs.gov)
- Adipose tissue, especially white adipose tissue (WAT), has been recognized as an essential endocrine and inflammation organ in addition to its energy storage function. (inventbiotech.com)
- Reconstitution of UCP1 using CRISPR/Cas9 in the white adipose tissue of pigs decreases fat deposition and improves thermogenic capacity. (inventbiotech.com)
- The favorable metabolic phenotype resulted from activation of energy expenditure, in part via BAT activation and beiging of white adipose tissue. (elifesciences.org)
Accumulation13
- The present article discusses how accumulation of triacylglycerol in adipocytes can lead to deterioration of the responsiveness of glucose metabolism in other tissues. (cambridge.org)
- Accumulation of triacylglycerol in skeletal muscles and in liver is associated with insulin resistance. (cambridge.org)
- Adipocyte Senp2 deciency resulted in less adipose lipid storage accompanied by an ectopic fat accumulation and insulin resistance under high-fat diet feed- ing. (deepdyve.com)
- In adipocyte Senp2-deciency mice, accumulation of the SUMOylated Setdb1 suppressed the expression of Pparg and Cebpa genes as well as lipid metabolism-related target genes, which would decrease the ability of lipid storage in adipocytes. (deepdyve.com)
- adqcKO Mechanistically, adipocyte Senp2 deciency caused the downregula- Senp2 mice exhibit an ectopic lipid accumulation and tion of Pparg and Cebpa as well as their downstream target genes insulin resistance related to lipid storage. (deepdyve.com)
- In diet-induced obese mice, HILPDA deficiency in macrophages markedly reduced lipid accumulation in macrophages yet it did not alter any measured inflammatory or metabolic parameters. (wur.nl)
- This research questions the contribution of lipid droplet accumulation in adipose tissue macrophages in obesityinduced inflammation and metabolic disfunction. (wur.nl)
- Similarly, in diet-induced NASH mice, HILPDA hepatocyte deficiency modestly yet significantly reduced liver triglyceride accumulation and plasma ALT levels. (wur.nl)
- At 30 weeks of age, male, but not female, Akr1d1-/- mice were more insulin tolerant and had reduced lipid accumulation in the liver and adipose tissue yet had hypertriglyceridemia and increased intramuscular triacylglycerol. (ox.ac.uk)
- We found that the lipid accumulation in the adipose tissue of DKO was further aggravated compared to AKO, while the insulin resistance and hepatic steatosis were abolished in DKO, compared to LKO. (tus.ac.jp)
- Moreover, we hypothesized that these mice would have accumulation of TGs in other tissues, such as the liver or skeletal muscle, resulting in lipotoxicity and metabolic derangements, such as insulin resistance or fatty liver disease. (elifesciences.org)
- Moreover, in the heart of SCD4-/- mice fed HFD, decreased lipid accumulation was accompanied by higher rate of lipolysis, increased mitochondria quality control, lower activity of NADH dehydrogenase and level of reactive oxygen species. (edu.pl)
- In mice, adipocyte MHCII increased within 2 weeks on HFD, paralleling increases in proinflammatory ART markers and decreases in anti-inflammatory ART markers, and preceding adipose tissue macrophage (ATM) accumulation and proinflammatory M1 polarization. (nih.gov)
Liver25
- Cortisol is known to cause resistance to the action of insulin in multiple target tissues including liver, muscle, and adipose tissue. (genengnews.com)
- In contrast, 11beta-HSD-1 knockout mice resist visceral obesity and diabetes through improved function of insulin in liver and adipose tissues. (genengnews.com)
- Data indicates that elevated levels of adipose and liver 11beta-HSD-1 are detrimental to metabolic control. (genengnews.com)
- In wild-type mice, AS160 expression is relatively high in adipose tissue and soleus muscle, low in EDL (extensor digitorum longus) muscle and detectable in liver only after enrichment. (dundee.ac.uk)
- Despite having lower blood glucose levels under both fasted and random-fed conditions, the AS160-knockout mice exhibited insulin resistance in both muscle and liver in a euglycaemic clamp study. (dundee.ac.uk)
- The liver also contributes to the AS160-knockout phenotype via hepatic insulin resistance, elevated hepatic expression of phosphoenolpyruvate carboxykinase isoforms and pyruvate intolerance, which are indicative of increased gluconeogenesis. (dundee.ac.uk)
- Overall, as well as its catalytic function, AS160 influences expression of other proteins, and its loss deregulates basal and insulin-regulated glucose homoeostasis, not only in tissues that normally express AS160, but also by influencing liver function. (dundee.ac.uk)
- The two functions of sulforaphane newly uncovered by the current study are expected to contribute to improvement of inflammation of the liver or adipose tissues and insulin resistance as well as to prevention of lifestyle diseases. (medicalxpress.com)
- Fatty acid synthesis (de novo lipogenesis, DNL) is elevated in liver in obesity and type 2 diabetes and is usually associated with insulin resistance. (grantome.com)
- However, knocking down the elevated ChREBP expression in liver of obese mice improves insulin sensitivity and metabolic syndrome. (grantome.com)
- The research contained in this thesis first sought to improve our current knowledge on the transcriptional regulation by peroxisome proliferator-activated receptors (PPAR)-α activation on human liver in vivo using a novel humanized-liver mouse model. (wur.nl)
- The role of PPARα in gene regulation in mouse liver is well characterized. (wur.nl)
- Model systems to study PPARα in human liver vary from hepatoma cell lines, human primary hepatocytes, human precision cut liver slices, and mice expressing human PPARα. (wur.nl)
- A novel model to study in vivo PPARα activation in human liver is a chimeric mouse carrying human liver cells. (wur.nl)
- Our results support the major role of PPARα in regulating hepatic lipid metabolism, highlight the more modest effect of PPARα activation on gene regulation in human liver compared to mouse liver, and indicate that PPARα may have a suppressive effect on DNA synthesis in human liver. (wur.nl)
- These results demonstrate that Lkb1 plays an important role in maintaining body weight, liver and adipose tissue function, blood glucose homeostasis and survival in adult mice. (omicsdi.org)
- Type 2 diabetes is typified by insulin-resistance in adipose tissue, skeletal muscle, and liver, leading to chronic hyperglycemia. (arizona.edu)
- The levels of insulin receptor were generally higher in insulin-responsive tissues (especially the liver) from female MARCH1 KO mice compared to males, with the potential to account in part for the differences between male and female MARCH1 KO mice. (arizona.edu)
- The inter-organ crosstalk between the critical organs of lipid metabolism (e.g., liver and adipose tissue) is crucial to maintain the lipid homeostasis. (tus.ac.jp)
- Growth hormone (GH) plays important roles in maintaining metabolic equilibrium via GH receptor (GHR), illustrated previously by our GHR tissue specific knockout mouse models in either the liver (LKO) or adipose tissue (AKO). (tus.ac.jp)
- To understand the reciprocal inter-organ regulatory routes, we reported the construction of liver/adipose double GHR knockout mouse model (DKO). (tus.ac.jp)
- Our data indicate that GHR regulates the crosstalk between adipose tissue and liver through fatty acid desaturation. (tus.ac.jp)
- Exceeding the capacity to store TG in adipocytes occurs in obesity and is often accompanied by deposition of TG in other tissues and metabolic diseases, such as diabetes mellitus or non-alcoholic fatty liver disease. (elifesciences.org)
- In the present study, we test the hypothesis that reactivation of glucocorticoids, in peripheral tissues by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), is a major determinant of exogenous Cushing s syndrome.WT, global 11β-HSD1 knockout (GKO), liver-specific 11β-HSD. (endocrine-abstracts.org)
- Patients suffering from lipodystrophies experience reduced body fat, severe insulin resistance, hypertriglyceridemia, and hypoleptinemia, and nonalcoholic fatty liver disease. (medscape.com)
Adipocytes15
- 2003). Selective Cellular uptake of fatty acids and following storage in the form of disruption of Pparγ2 or adipocyte-specic Pparγ knockout leads TGs in adipocytes are key steps in lipid storage. (deepdyve.com)
- To develop our research, we use tissue-specific knockout mice, as well as cellular models of adipocytes. (unil.ch)
- Adipocytes are the main constituent cells of adipose tissue. (frontiersin.org)
- Consistent with this paradoxical phenotype, basal glucose uptake was higher in AS160-knockout primary adipocytes and normal in isolated soleus muscle, but their insulin-stimulated glucose uptake and overall GLUT4 levels were markedly decreased. (dundee.ac.uk)
- Here, we examined the pleiotropic role of caspase 8 in adipocytes and obesity-associated insulin resistance. (bvsalud.org)
- Caspase 8 expression was increased in adipocytes from mice and humans with obesity and insulin resistance. (bvsalud.org)
- We will create mice that overexpress or lack ChREBP selectively in adipocytes. (grantome.com)
- Aim 2 is to determine whether absence of ChREBP selectively in adipocytes causes systemic insulin resistance. (grantome.com)
- Molecular, cell biological, biochemical and quantitative microscopy methods will be used to determine the mechanisms for regulation of ChREBP nuclear-cytoplasmic shuttling and activation in adipocytes, and the potential role of insulin signaling in regulation of adipose-ChREBP activity. (grantome.com)
- Because reduced ChREBP expression in adipose tissue of obese humans correlates highly with insulin resistance, understanding the mechanisms that regulate ChREBP in adipocytes could lead to novel therapeutic approaches to prevent and treat type 2 diabetes. (grantome.com)
- Alpha-synuclein (SNCA) as the presynaptic protein is expressed in different tissues and prevents insulin-resistance (IR) through increasing glucose-uptake by adipocytes and muscles. (biomedcentral.com)
- We hypothesized that mice lacking TG storage in adipocytes would result in excess TG storage in cell types other than adipocytes and severe lipotoxicity accompanied by metabolic disease. (elifesciences.org)
- To test this hypothesis, we selectively deleted both TG-synthesis enzymes, DGAT1 and DGAT2, in adipocytes (ADGAT DKO mice). (elifesciences.org)
- We generated mice lacking both known TG synthesis enzymes, DGAT1 and DGAT2 1 , 2 , in adipocytes. (elifesciences.org)
- Mouse 3T3-L1 and primary adipocytes activated T cells in an antigen-specific, contact-dependent manner, indicating that adipocyte MHCII is functional. (nih.gov)
Skeletal4
- 2010). Senp2 also regulates fatty acid metabolism in skeletal Downloaded from https://academic.oup.com/jmcb/article-abstract/10/3/258/4763638 by Ed 'DeepDyve' Gillespie user on 26 June 2018 Senp2 regulates adipose lipid storage by de-SUMOylation of Setdb1 j 259 muscle (Koo et al. (deepdyve.com)
- In present study we assessed the probable effect of insulin resistance on SNCA expression in muscle C2C12 cells and also skeletal muscle tissues of type 2 diabetic mice. (biomedcentral.com)
- Insulin resistance (IR) as the main hyperglycemic process in non-insulin dependent diabetes mellitus (NIDDM) is observed in many tissues such as adipose and skeletal muscle [ 2 ]. (biomedcentral.com)
- Because thermogenesis in skeletal muscle and fat burning in adipose tissue are two effects of ADRB3 that have been well studied, there is a significant amount of scientific interest in determining whether or not Fragment 176-191 may give comparable properties in research models. (asianage.com)
Brown adipos4
- We were first to show the presence of P311 in WAT, brown adipose tissue (BAT) and beige adipose tissue. (hhs.gov)
- Avian species do not have brown adipose tissue (BAT), and lack Uncoupling Protein 1 ( UCP1 ) [ 12 ]. (biomedcentral.com)
- However, isolation of WAT and brown adipose tissue (BAT) is technically challenging due to their high lipid and low protein contents. (inventbiotech.com)
- The primary function of brown adipose tissue (BAT) is to use lipids to generate heat through uncoupling of oxidative phosphorylation in mitochondria. (endocrine-abstracts.org)
Adiposity10
- Knockout mice also gained less weight on HFD, with decreased adiposity, adipocyte size and hepatic steatosis. (bvsalud.org)
- Ablation of IGF1 receptors from myeloid cells reduced phagocytosis, increased macrophages in adipose tissue, elevated adiposity, lowered energy expenditure, and led to insulin resistance in mice fed a high-fat diet. (umn.edu)
- KO) female mice exhibit excessive weight gain and excessive visceral adiposity when reared on standard chow diet, without increased inflammatory cell infiltration of adipose tissue. (arizona.edu)
- By contrast, male MARCH1 KO mice had similar weight gain and visceral adiposity to wildtype (WT) male mice. (arizona.edu)
- Our results showed that under HFD condition, SCD4-/- mice had lower adiposity, improved insulin resistance index and preserved heart structure compared to control mice. (edu.pl)
- Here we investigated the roles of ghrelin in HFCS- and SUC-induced adiposity and insulin resistance. (tamu.edu)
- Interestingly, we also found that ghrelin deletion exacerbates HFCS-induced adiposity and inflammation in adipose tissues, as well as whole-body insulin resistance. (tamu.edu)
- HFD-fed MHCII(-/-) mice developed less adipose inflammation and insulin resistance than did wild-type mice, despite developing similar adiposity. (nih.gov)
- Obesity is characterized by increased body adiposity and leads to insulin resistance. (medscape.com)
- The resemblance between the metabolic abnormalities of these extreme states of adiposity underscores the importance of fat tissue in energy homeostasis. (medscape.com)
Macrophages7
- The WAT of P311 knockout (KO) mice has fewer resident macrophages and decreased cellular dynamics, including decreased autophagy and apoptosis. (hhs.gov)
- As studies are limited, resident macrophages could alter adipocyte function early in adipose tissue development, a novel mechanism requiring exploration. (hhs.gov)
- Adipose tissue cell densities of activated (cfms + ) and total (CD68 + ) macrophages were determined. (silverchair.com)
- We studied the function of HILDPA in adipose tissue macrophages (ATM) in the context of obesity-induced inflammation and in hepatocytes during non-alcoholic steatohepatitis (NASH). (wur.nl)
- To this end we used a HILPDA tissue-specific knockout mice model in macrophages and hepatocytes generated by using LysM-Cre and Alb-Cre transgenic mice, respectively. (wur.nl)
- Surprisingly, cold challenge did not trigger an overt M2-like state and failed to induce tyrosine hydroxylase expression in adipose tissue macrophages of control or MIKO mice. (umn.edu)
- Macrophages, the most predominant inflammatory cells in adipose tissue, play an important role in obesity-related inflammation [ 4 ]. (biomedcentral.com)
Metabolism9
- Importantly, the alternative splicing of the LMNA gene was highly sensitive to the levels of specific Serine-Arginine rich (SR) proteins (5) , and produced several splicing isoforms that affect adipose tissue metabolism and aging in opposite manners, with Lamin A and Progerin promoting energy expenditure and aging, while Lamin C favors slower metabolism and moderately slows the aging process in mice (4) . (unil.ch)
- Her contributions place as a key molecular hub, that regulates key signaling pathways to coordinate cell metabolism and cellular function and overall promote anabolism in the context of cycling cells and in differentiated tissues (6-8) . (unil.ch)
- Our research focuses on the roles of two particular RNA binding proteins of the SR protein family, SRSF1 and SRSF2, in metabolism and adipose tissue biology. (unil.ch)
- When activated, PPAR-γ up-regulates the transcription of genes mainly involved in fatty acid metabolism and triglyceride storage, promoting adipogenesis and lipids uptake to the adipose tissue [ 17 , 18 ] improving whole body insulin sensitivity. (biomedcentral.com)
- Moreover, decreased insulinaemia in B-Atgl-KO mice was associated with increased energy expenditure, and lipid metabolism in brown (BAT) and white (WAT) adipose tissues, leading to reduced fat mass and body weight. (omicsdi.org)
- In the healthy state effective anti-hyperglycemic, anti-inflammatory, and anti-oxidative defense lines keep circle activities below a pathogenetically relevant threshold, safeguarding the physiological role of glucose, cytokines and reactive oxygen species in signal transduction, energy metabolism, and tissue functions. (profil.com)
- Type 2 diabetes mellitus (T2DM) is a progressive metabolic disease characterized by pancreatic β-cell dysfunction and peripheral insulin resistance, leading to defects in glucose metabolism and chronic low-grade inflammation. (frontiersin.org)
- This study will be of high interest to those in the adipose tissue biology and metabolism fields. (elifesciences.org)
- Our findings suggest that HFCS and SUC have differential effects on lipid metabolism: while sucrose promotes obesogenesis, HFCS primarily enhances inflammation and insulin resistance, and ghrelin confers protective effects for these metabolic dysfunctions. (tamu.edu)
Triglycerides1
- Because energy sources are not always available from the environment, many metazoan organisms have evolved the ability to store large amounts of metabolic energy as triglycerides (TG) in adipose tissue. (elifesciences.org)
Compared adipose tissue macrophage1
- We compared adipose tissue macrophage infiltration and release of pro-inflammatory adipokines in PE and healthy pregnancy. (silverchair.com)
Expression in adipose tissue1
- Furthermore, in humans, increased lipogenic enzyme expression in adipose tissue is associated with enhanced insulin sensitivity. (grantome.com)
Infiltration1
- Obesity elicits immune cell infiltration of adipose tissue provoking chronic low-grade inflammation. (diabetesjournals.org)
Ppar3
- Under physiological conditions, the main- PPARγ mutation has been shown to link to familial partial lipody- tenance of normal adipose tissue mass is mainly the result of a strophy, a clinical disorder characterized by the loss of adipose balance of lipid storage and lipolysis (Bouchard et al. (deepdyve.com)
- Gene expression studies performed on PPARα null mice have shed light into a variety of genes regulated by PPARα. (wur.nl)
- Quantitative PCR indicated that induction of PPARα targets by fenofibrate was less pronounced in the human hepatocytes than in the residual mouse hepatocytes. (wur.nl)
Hepatic2
- The researchers found that the mice fed with sulforaphane exhibited weight gain rate 15 percent lower than the mice fed without sulforaphane, 20 percent visceral fat reduction, and reduction of augmentation of their hepatic steatosis and blood glucose level . (medicalxpress.com)
- Hydroxytyrosol ameliorates insulin resistance by modulating endoplasmic reticulum stress and prevents hepatic steatosis in diet-induced obesity mice. (inventbiotech.com)
Inflammation and insulin resistance2
- The new functions of sulforaphane are expected to contribute to improvement of inflammation and insulin resistance so as to prevent lifestyle diseases. (medicalxpress.com)
- Through future clinical studies, sulforaphane could be recommended as a supplementary diet product for ameliorating bacterial flora in the gut, after evaluation of its obesity prevention effects, its effectiveness for inflammation and insulin resistance , as well as its safety. (medicalxpress.com)
Loss of adipose1
- The aggravated IR phenotype was associated with loss of adipose functionality, switch from adipocyte hyperplasia to hypertrophy and hepatosteatosis. (elsevierpure.com)
Regulates3
- Meijer's studies of cryptochrome-deficient mice (a photoreceptor which regulates entrainment by light) revealed that they show no neuronal activity in the SCN because the circadian rhythm is generated from a transcription-translation feedback loop, which includes both positive and negative feedback via certain circadian clock genes. (wikipedia.org)
- Little information is available about how post-transcriptional RNA processing regulates metabolic adaptation in adipose tissue depots. (unil.ch)
- This proposal addresses this critical interface through studies in adipose tissue of a glucose-controlled protein, ChREBP, that regulates lipid synthesis. (grantome.com)
Subcutaneous2
- Right: CT images revealed that HF+SFN mice had less visceral fat than HF mice upon examination of visceral fat and subcutaneous fat. (medicalxpress.com)
- Subcutaneous and visceral adipose tissue biopsies were collected from healthy ( n =13) and PE ( n =13) mothers. (silverchair.com)
Lipids1
Triglyceride2
- To directly assess the role of beta cell lipolysis in insulin secretion and whole-body energy homeostasis, inducible beta cell-specific adipose triglyceride lipase (ATGL)-deficient (B-Atgl-KO) mice were studied under normal diet (ND) and high-fat diet (HFD) conditions. (omicsdi.org)
- This study introduces a valuable paradigm in the field of adipose tissue biology: blocking triglyceride storage in adipose tissue does not lead to lipodystrophy and impaired glucose homeostasis but instead improves metabolic health. (elifesciences.org)
Obese mice4
- Saponins from Boussingaultia gracilis prevent obesity and related metabolic impairments in diet-induced obese mice. (inventbiotech.com)
- AOD 9604 was speculated to exhibit a potentially significant fat-burning impact when given to obese mice and beta(3)-AR knock-out mice for an extended period in a research published in 2001. (asianage.com)
- After 14 days of presentation, the compound AOD 9604 was suggested to lower both the weight and the amount of body fat in the obese mice. (asianage.com)
- It was determined that the alleged capacity of AOD 9604 to raise the synthesis of beta-3 adrenergic receptors (also known as ADRB3 in obese mice) may have been responsible for this finding. (asianage.com)
Homeostasis6
- Excess or insufcient lipid storage in generation of the intermediate species of diacylglycerol (DAG) adipose tissues would impair nutrient homeostasis, which is and monoacylglycerol (MAG) (Young and Zechner, 2013). (deepdyve.com)
- Our recent paper demonstrates that adipose tissue ChREBP is a key determinant of systemic insulin sensitivity and glucose homeostasis in humans and rodents. (grantome.com)
- Our recently published work demonstrates that ChREBP in fat tissue has an essential role in regulation of insulin-sensitivity and glucose homeostasis. (grantome.com)
- A beta cell ATGL-lipolysis/adipose tissue axis controls energy homeostasis and body weight via insulin secretion in mice. (omicsdi.org)
- The results support the concept that fuel excess can drive obesity and diabetes via hyperinsulinaemia, and that an islet beta cell ATGL-lipolysis/adipose tissue axis controls energy homeostasis and body weight via insulin secretion. (omicsdi.org)
- We also examined the role of DOC2b on systemic homeostasis using DOC2b knockout (KO) mice. (tokushima-u.ac.jp)
Deposition1
- This situation leads to fat deposition in other tissues. (cambridge.org)
Various tissues4
- The body weight reduction was due to reduced weight of various tissues but the brown and white adipose tissues underwent much more pronounced weight reduction relative to the overall body weight reduction. (omicsdi.org)
- IR and compensatory hyperinsulinaemia have differing pathogeneses in various tissues, and IR varies among different PCOS phenotypes. (biomedcentral.com)
- We searched PubMed, Google Scholar, Elsevier, and UpToDate databases in this review, and focused on the pathogenesis of IR in women with PCOS and the pathophysiology of IR in various tissues. (biomedcentral.com)
- This paper aims to summarize recent findings on the involvement of IR in the occurrence and development of PCOS and the mechanism of IR in various tissues. (biomedcentral.com)
Adipocyte-specific2
- We will develop adipocyte-specific P311 KO conditional mice using novel CRISPR technology to evaluate the adipocyte-specific P311 roles. (hhs.gov)
- Adipocyte-specific activation of Ikbkb or housing mice at thermoneutrality attenuated improvements in glucose tolerance. (bvsalud.org)
Soleus muscle2
- Insulin-stimulated glucose uptake was also measured using isolated soleus muscle and epididymal adipose tissue. (tokushima-u.ac.jp)
- Insulin-stimulated glucose uptake was impaired in isolated soleus muscle and epididymal adipose tissues from DOC2b KO mice. (tokushima-u.ac.jp)
Whole-body insulin resistance1
- AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues. (dundee.ac.uk)
Associated with insulin resistance3
- Obesity is associated with insulin resistance. (cambridge.org)
- Lipodystrophy, lack of adipose tissue, is also associated with insulin resistance. (cambridge.org)
- It has reported that decreased levels of plasma alpha-synuclein were associated with insulin resistance. (biomedcentral.com)
Pathways4
- In addition to physiological and metabolic characterization, in both aims we will perform genomic and lipidomic analyses of adipose tissue and serum to identify pathways associated with insulin sensitivity and insulin resistance. (grantome.com)
- In conclusion, our study demonstrates dysregulation of inflammatory pathways predominantly in visceral adipose tissue in PE. (silverchair.com)
- In contrast, pathways connected to DNA synthesis were downregulated by fenofibrate in chimeric mice with hepatocyte humanized livers yet upregulated by fenofibrate in normal mouse livers. (wur.nl)
- At the proliferation stage, proliferation related pathways and basic cellular and metabolic processes were inhibited, while regulatory factors that initiate differentiation enter the ready-to-activate state, which provides a precondition for initiating adipose differentiation. (biomedcentral.com)
Lipodystrophy5
- In lipodystrophy there is insufficient adipose tissue to absorb the postprandial influx of fatty acids, so these fatty acids will again be directed to other tissues. (cambridge.org)
- These processes to severe lipodystrophy and induces insulin resistance in mice (He et al. (deepdyve.com)
- Senp2 knockout mice exhibited a lipodystrophy-like phenotype. (deepdyve.com)
- We expected to generate a mouse model similar to those of classic lipodystrophy due to defects of TG storage in adipose tissue. (elifesciences.org)
- Lipodystrophy, the abnormal distribution of fat, encompasses lipoatrophy, the loss of fat, and other abnormalities of adipose tissue. (medscape.com)
Fatty2
- Björntorp , P ( 1994 ) Fatty acids, hyperinsulinemia, and insulin resistance: which comes first? (cambridge.org)
- Emerging evidence has demonstrated that saturated fatty acids prime pro-IL-1β production and inflammasome-mediated IL-1β activation is critical in obesity-associated insulin resistance (IR). (elsevierpure.com)
Metabolically3
- We use modern molecular biology, cellular biology and RNA sequencing approaches, in addition of metabolically phenotyping our conditional knockout models. (unil.ch)
- In contrast, our new data indicate DNL in adipose tissue is metabolically beneficial since it promotes insulin sensitivity an protects against high fat diet-induced insulin resistance. (grantome.com)
- However, ADGAT DKO mice were unexpectedly otherwise metabolically healthy and did not accumulate TGs ectopically or develop associated metabolic perturbations, even when fed a high-fat diet. (elifesciences.org)
Excess3
- Any plausible explanation for the link between excess adipose tissue and insulin resistance needs to be able to account for this observation. (cambridge.org)
- Thus, in the postprandial period especially, there is an excess flux of circulating lipid metabolites that would normally have been 'absorbed' by adipose tissue. (cambridge.org)
- Remarkably, the knockout mice were also protected from excess weight gain when they were co-housed with control mice, hinting that "good" bacteria from the control mice were getting into them and helping to protect them. (integrativepractitioner.com)
Inflammatory7
- The overactivation of the sympathetic system and the promotion of a pro-inflammatory state in the adipose tissue [ 8 ] are common features of insulin resistance [ 9 - 12 ]. (biomedcentral.com)
- However, expression of macrophage/inflammatory markers and fibrosis were not different between HILPDA knockout and floxed mice. (wur.nl)
- Anti-inflammatory Activity of Isomaltodextrin in a C57BL/6NCrl Mouse Model with Lipopolysaccharide-induced Low-grade Chronic Inflammation (Doctoral dissertation). (inventbiotech.com)
- In that case hyperglycemia, (pro)inflammatory states and oxidative stress may trigger progressively irreversible processes eventually accounting for beta-cell dysfunction and death, the development of insulin resistance, and other manifestations of diabetes and its comorbid conditions. (profil.com)
- Scientists from the University of North Carolina School of Medicine discovered that the anti-inflammatory protein NLRP12 normally helps protect mice against obesity and insulin resistance when they are fed a high-fat diet. (integrativepractitioner.com)
- The study , published in Cell Host & Microbe , showed that NLRP12's anti-inflammatory effect promotes the growth of a "good" family of gut-dwelling bacteria, called Lachnospiraceae , that produce small molecules butyrate and propionate, which in turn promote gut health and protect mice against obesity and insulin resistance. (integrativepractitioner.com)
- Adipose-resident T cells (ARTs) regulate metabolic and inflammatory responses in obesity, but ART activation signals are poorly understood. (nih.gov)
Blood glucose1
- Accordingly, the Rosa-Lkb1 mice had increased blood glucose levels and were intolerant to glucose challenge. (omicsdi.org)
Male mice1
- B-Atgl-KO male mice fed an HFD showed reduced insulinaemia, glycaemia in the fasted and fed states and after glucose challenge, as well as enhanced insulin sensitivity. (omicsdi.org)
Lipogenic1
- Expression levels of adipogenic and lipogenic genes in adipose tissues were also dramatically reduced by Lkb1 deletion. (omicsdi.org)
Type 2 diabet7
- Insulin resistance underlies a constellation of adverse metabolic and physiological changes (the insulin resistance syndrome) which is a strong risk factor for development of type 2 diabetes and CHD. (cambridge.org)
- Insufcient adipose lipid storage is asso- ciated with many pathological conditions including hyperlipidemia, insulin resistance, and type 2 diabetes. (deepdyve.com)
- This program addresses several features of the metabolic syndrome, a combination of disorders including abdominal obesity, high blood pressure, and insulin resistance or glucose intolerance, all of which contribute to an increased risk of coronary heart disease, stroke, and type 2 diabetes. (genengnews.com)
- Major gaps exist in our knowledge of the molecular mechanisms underlying insulin resistance and type 2 diabetes. (grantome.com)
- We are in the midst of a growing epidemic of obesity, insulin resistance and type 2 diabetes. (grantome.com)
- Major gaps exist in our knowledge of the molecular mechanisms underlying insulin resistance and type 2 diabetes, limiting our ability to develop highly effective and safe therapies. (grantome.com)
- Type 2 diabetes due to insulin-resistance can decrease SNCA gene expression in muscles. (biomedcentral.com)
C57BL3
- Sixteen male C57BL/6 mice were divided into two experimental groups, including control and type 2 diabetic mice with IR (induced by high-fat diet + low-dose streptozotocin). (biomedcentral.com)
- This study was conducted on a total of 16 male C57BL/6 mice (Pasteur Institute, Iran) with 8 weeks of age and approximately 20-25 g. (biomedcentral.com)
- Akr1d1-/- mice were generated on a C57BL/6 background. (ox.ac.uk)
Protein6
- We found that SET domain bifurcated 1 Since no difference in food intake was observed between adqcKO f/f (Setdb1) was a SUMOylated protein and that Senp2 de-SUMOylated Senp2 and Senp2 mice fedeitherwithNCD or HFD and regulated Setdb1 action in trimethylation at histone 3 lysine 9 (Supplementary Figure S2A). (deepdyve.com)
- Tissue-specific and SRSF1-dependent splicing of fibronectin, a matrix protein that controls host cell invasion. (unil.ch)
- Alpha-synuclein (SNCA, α-Syn) as one of the members of synuclein protein family is mainly expressed in brain tissue. (biomedcentral.com)
- All the mice were fed with a normal pellet diet (NPD) containing 5% fat, 50% carbohydrate, 25% protein and total calorific value 25 kJ/kg (Royan Institute, Iran) and free water 1 week before the initiation of the experiment and allowed to acclimatize to the laboratory environment. (biomedcentral.com)
- A. SDS-PAGE (10%) profiles of total protein extracted from different adipose tissues. (inventbiotech.com)
- High Efficiency Protein Extraction from Adipose Tissues. (inventbiotech.com)
Systemic1
- While mature-onset obesity is evident in LFD-IL-1RI(-/-) mice, the additional metabolic insult of HFD was required to drive adipose inflammation and systemic IR. (elsevierpure.com)
Energy expenditure2
- Finally, the Rosa-Lkb1 mice had much reduced oxygen consumption, carbon dioxide production, and energy expenditure. (omicsdi.org)
- Thus, the ADGAT DKO mice provide a fascinating new model to study the coupling of metabolic energy storage to energy expenditure. (elifesciences.org)
Hypertriglyceridemia1
- Overexpression of 11beta-HSD-1 in mouse adipose tissue leads to a metabolic syndrome-like phenotype including increased central obesity, hypertension, impaired glucose tolerance, and hypertriglyceridemia. (genengnews.com)
Overexpression1
- In this study, we observed the overexpression of SUMO-specic protease 2 (Senp2) in adipose tissues during obesity. (deepdyve.com)
High-fat10
- Although less fat stor- adqcKO pose lipid storage in adipocyte-specic Senp2 knockout mice fed age was shown in Senp2 adipose tissues, the increased with high-fat diets (HFD). (deepdyve.com)
- 1) ameliorating obesity by adipose tissue browning to augment energy consumption and 2) improving 'high-fat' gut bacterial flora and metabolic endotoxemia. (medicalxpress.com)
- In the current study, the researchers of Kanazawa University in collaboration with the researchers of Kagome Co., Ltd. compared the body weight of mice fed with high-fat food supplemented with sulforaphane and others with high-fat food but without sulforaphane. (medicalxpress.com)
- Left: Mice fed with high fat food + sulforaphane (HF+SFN) showed reduced body weight gain in comparison with mice fed with high fat food only (HF). (medicalxpress.com)
- On the other hand, since Nrf2-knockout mice fed with high-fat food supplemented with sulforaphane did not show reduced body weight increase or fat burning through adipose tissue browning, the importance of Nrf2 is now clearly shown as the target molecule of sulforaphane for ameliorating obesity. (medicalxpress.com)
- All the mice were divided into two groups with eight animals for each experimental groups as given below: group (1) healthy mice as controls fed with normal chow, group (2) the mice with diebetes induced by high-fat diet + STZ (HFD + STZ). (biomedcentral.com)
- Male Akr1d1-/- mice were challenged with a high fat diet (60% kcal from fat) for 20 weeks. (ox.ac.uk)
- With this apparent contradiction, the present study evaluated whether IL-1RI(-/-) mice were protected against long-term (6 mo) high-fat diet (HFD)-induced IR. (elsevierpure.com)
- The scientists fed mice that lacked the NLRP12 gene and ordinary mice a high-fat diet for several months. (integrativepractitioner.com)
- To address this issue, we used SCD4 knock-out (SCD4-/-) mice fed a high-fat diet (HFD) to induce obesity. (edu.pl)
Reduction5
- Thus, in tumor-bearing mice, 60% tumor reduction was observed, while in metastatic mice, the number of nodules decreased by 25% compared to the control group. (researchgate.net)
- Naoto Nagata et al, Glucoraphanin Ameliorates Obesity and Insulin Resistance Through Adipose Tissue Browning and Reduction of Metabolic Endotoxemia in Mice, Diabetes (2017). (medicalxpress.com)
- Deletion of Lkb1 in adult mice results in body weight reduction and lethality. (omicsdi.org)
- The Rosa-Lkb1 mice exhibited body weight reduction and died within 6 weeks after tamoxifen induction. (omicsdi.org)
- The investigation of adipose macrophage phenotype in obese myeloid IGF1R knockout (MIKO) mice revealed a reduction in transcripts associated with M2-like macrophage activation. (umn.edu)
Dysfunction2
- Adipocyte dysfunction (AD) is cardinal feature of metabolic dysregulation and increases the risk for developing insulin resistance (IR), DM, and hypertension. (hhs.gov)
- We will also explore key adipocyte cellular processes of apoptosis and autophagy/lipophagy, which may affect adipocyte turnover in the WAT of P311 KO mice, leading to adipocyte hypertrophy and dysfunction, and thus metabolic deregulation. (hhs.gov)