• OSMR is widely expressed across non-haematopoietic, hepatocytes, mesothelial cells, glial cells and epithelial cell types across various organs and mammary glands. (wikipedia.org)
  • The reason that causes hypoparathyroidism is neck operation that injury the parathyroid glands or removes the parathyroid glands. (ncl.edu.tw)
  • Therefore, in clinical treatment, allotransplantation of parathyroid glands is used but restricted to immunologic rejection. (ncl.edu.tw)
  • Parathyroid hormone (PTH) is an endocrine peptide found exclusively in the parathyroid glands, whereas parathyroid hormone-related protein (PTHrP) is expressed in a wide range of tissues and organs and exerts endocrine, paracrine, and autocrine actions. (bvsalud.org)
  • The endocrine system plays a vital role in biological functions, including endocrine glands and hormones. (sciencetec.in)
  • It constitutes the glands located throughout our body, and receptors of various organs and tissues to reorganize and respond to hormones. (sciencetec.in)
  • Hormones are secreted from endocrine glands in the body. (sciencetec.in)
  • Glands are being ductless, hormones are directly secreted into the bloodstream. (sciencetec.in)
  • But of the above glands and organs, other tissues and organs also secrete hormones. (sciencetec.in)
  • It produces a number of hormones and regulates most of the functions of other glands. (sciencetec.in)
  • Adrenal glands produce adrenaline hormones in times of fear, tension, or anger, affecting the heartbeat and energy level in muscles. (sciencetec.in)
  • The endocrine system coordinates functioning between different organs through hormones, which are chemicals released into the bloodstream from specific types of cells within endocrine (ductless) glands. (msdmanuals.com)
  • Огляд функції паращитовидної залози There are typically four parathyroid glands. (msdmanuals.com)
  • by the parathyroid glands, primarily in response to blood calcium levels), whereas many (eg, secretion of thyroid or gonadal hormones) are controlled to a great extent. (msdmanuals.com)
  • In response, the pituitary releases various hormones that stimulate certain endocrine glands throughout the body. (msdmanuals.com)
  • Changes in circulating levels of hormones produced by these endocrine glands are detected by the hypothalamus, which then increases or decreases its stimulation of the pituitary to maintain homeostasis. (msdmanuals.com)
  • These anterior pituitary hormones regulate peripheral endocrine glands (the thyroid, adrenals, and gonads) as well as growth and lactation. (msdmanuals.com)
  • Collectively, our data demonstrated parathyroid tissues and cells loaded in gelatin scaffolds and prepared as double-layered microbeads through alginate hydrogel encapsulation, possessing optimal cell proliferation rate and calcium-responsive PTH secretion capability. (ncl.edu.tw)
  • Some hormones produced by the pituitary directly alter the behavior of specific cells in tissues to generate physiological changes, whereas other pituitary hormones trigger cells in other organs to release hormones which change cell behavior. (tomsk.ru)
  • Hormones are chemical substances produced by the body, coordinate different functions, and carry messages through blood streams to different organs, skin, muscles, and other tissues. (sciencetec.in)
  • Cachexia is a wasting disorder of adipose and skeletal muscle tissues that leads to profound weight loss and frailty. (phoenixpeptide.com)
  • This compound promotes absorption of calcium and phosphate from the gut, contributes to extracellular calcium and phosphate homeostasis directly and through an interaction with parathyroid hormone (PTH), facilitates mineralisation of the skeleton, and is important for muscle function.4 In addition, almost every nucleated cell expresses the vitamin D receptor, and many extrarenal tissues have the capacity to make 1,25-(OH)2D. (vitamindwiki.com)
  • Glucose is converted into glycerol in adipose tissues and thus insulin promotes deposition of fat. (howmed.net)
  • Once in circulation, hormones affect function of the target tissues, which may be another endocrine gland or an end organ. (msdmanuals.com)
  • Additionally, estrogen receptors have been observed in numerous tissues including fat tissue, skeletal muscle and the liver - suggesting estrogen's importance in managing metabolism. (testosteronejunkie.com)
  • Through binding to PTH1R and activation of cyclic adenosine monophosphate (cAMP)-dependent protein kinase A in white adipose tissue, PTH and PTHrP can stimulate the expression of thermogenic genes causing adipose tissue browning. (bvsalud.org)
  • OSM signaling via the OSMR is believed to play an important role in bone turnover as Mice lacking the OSMR receptor have osteopetrotic phenotypes. (wikipedia.org)
  • Insulin signaling through the insulin receptor increases linear growth through effects on bone and the GH-IGF-1 axis. (medscape.com)
  • A randomized, double blind placebo controlled clinical trial to assess the efficacy and safety of sitagliptin on bone measures in women affected by type 2 diabetes. (uniroma1.it)
  • Growth Hormone (GH) - stimulates cells to produce insulin-like growth factor 1 (IGF-1) which stimulate growth of muscle and bone. (tomsk.ru)
  • Sclerostin is produced in osteocytes, which are a type of bone cell. (enlightenedstates.com)
  • Homozygotes for a targeted null mutation exhibit high levels of serum calcium and parathyroid hormone, parathyroid hyperplasia, bone defects, reduced growth, and early death. (jax.org)
  • Bone as a mineralized and dynamic tissue supports and protects the rest of body [ 1 , 2 ]. (biomedcentral.com)
  • Rad GTPase is essential for the regulation of bone density and bone marrow adipose tissue in mice. (iu.edu)
  • Local factors, including transcription factors such as SRY-box 9 protein (SOX9), Runt-related transcription factor 2 (RUNX2), and bone morphogenetic proteins (BMPs), along with signaling pathways such as the Wnt pathway, play critical roles in chondrocyte proliferation and differentiation. (pfmjournal.org)
  • Parathyroid hormone-related protein (PTHrP) is a critical regulator of bone resorption and augments osteolysis in skeletal malignancies. (phoenixpeptide.com)
  • We recently identified a unique peptide fragment of parathyroid hormone-related protein (PTHrP), PTHrP(12-48), as a validated serum biomarker in breast cancer patients that correlates with and predicts the presence of bone metastases. (phoenixpeptide.com)
  • J Bone Min Res 2020;35(2):269-276. (bouxseinlab.org)
  • Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodeling. (bouxseinlab.org)
  • Somatotrophs produce growth hormone and make up about 50% of the anterior pituitary. (tomsk.ru)
  • Growth hormone (GH), sex hormone, thyroid hormone, as well as glucocorticoids affect chondrocyte proliferation and hypertrophy. (pfmjournal.org)
  • Receptors on the cell surface bind with hormones that regulate enzyme activity or affect ion channels (eg, growth hormone, thyrotropin-releasing hormone). (msdmanuals.com)
  • Oncostatin-M specific receptor subunit beta also known as the Oncostatin M receptor (OSMR) , is one of the receptor proteins for oncostatin M, that in humans is encoded by the OSMR gene. (wikipedia.org)
  • Small Indels in the Androgen Receptor Gene: Phenotype Implications and Mechanisms of Mutagenesis. (medscape.com)
  • CaSR and PTHrP87-139 were modulated through treating the isolated superficial zone cells with activator/SiRNA and via deleting CaSR or parathyroid hormone-related peptide (PTHrP) gene in mice with the promoter gene of proteoglycan 4 (Prg4-CreERT2 ) in the tamoxifen-inducible pattern with or without additional injection of Cinacalcet, the CaSR agonist, or PTHrP87-139 peptide. (bvsalud.org)
  • Hormone receptors in the endocrine system often trigger changes in gene expression to alter the activities of key biochemical or physiological pathways. (tomsk.ru)
  • Combinatorial signalling and gene transcription in neuroendocrine cells: does PACAP potentiate hormone-dependent gene transcription? (endocrine-abstracts.org)
  • Heritable disorders associated with low 1,25(OH)2 D levels include vitamin D-dependent rickets type 1 (inactivating mutation in the 1-hydroxylase gene),[5] autosomal-dominant hypophosphatemic rickets (mutation of the gene coding for FGF-23, which prevents its breakdown),[6] and X-linked hypophosphatemic rickets (mutations that elevate levels of FGF-23). (medscape.com)
  • Receptors inside cells interact with hormones that regulate gene function (eg, corticosteroids, vitamin D, thyroid hormone). (msdmanuals.com)
  • This protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. (wikipedia.org)
  • Besides analytical problems (hydrophobicity, low circulating concentrations, ability to bind to lipids, albumins and vitamin D binding protein, presence of multiple vitamin D metabolites and variable ratios of 25(OH)D 2 and 25(OH)D 3 in the blood), vitamin D shows great preanalytical variability, since its concentration is drastically influenced by seasonal changes, exposure to sun, type of clothes or sun block creams. (biochemia-medica.com)
  • Parathyroid hormone-related protein (PTHrP) is a pleiotropic hormone essential for morphogenesis, tissue differentiation, as well as cell regulation and function. (bvsalud.org)
  • Leptin (from Greek λεπτός leptos , 'thin' or 'light' or 'small') is a protein hormone predominantly made by adipose cells and its primary role is likely to regulate long-term energy balance . (cloudfront.net)
  • Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia. (phoenixpeptide.com)
  • Adrenal hormones help in regulating many bodily functions including metabolism, blood pressure, immune system. (sciencetec.in)
  • Depending on the hormone imbalance, congenital adrenal hyperplasia can be classified as salt-wasting, hypertensive, virilizing, or feminizing. (lookformedical.com)
  • The hypothalamus is a component of the central nervous system and regulates the release of hormones from cells in the pituitary. (tomsk.ru)
  • These include cell receptors in the arcuate and ventromedial nuclei , as well as other parts of the hypothalamus and dopaminergic neurons of the ventral tegmental area , consequently mediating feeding . (cloudfront.net)
  • The central location of action ( effect ) of the fat cell-specific hormone leptin is the hypothalamus , a part of the brain , which is a part of the central nervous system. (cloudfront.net)
  • The primary function of the hormone leptin is the regulation of adipose tissue mass through central hypothalamus mediated effects on hunger , food energy use, physical exercise and energy balance . (cloudfront.net)
  • The posterior pituitary ( neurohypophysis): -an extension of the hypothalamus -stores and secretes two hormones from the hypothalamus. (optimalhealth.in)
  • Secretion of pituitary hormones is controlled by the hypothalamus. (msdmanuals.com)
  • Identification of a dopamine- and 3'5'-cyclic adenosine monophosphate-regulated phosphoprotein of 32 kD (DARPP-32) in parathyroid hormone-producing cells of the human parathyroid gland. (cornell.edu)
  • Without the pituitary gland hormone, human growth and development shall be affected beyond recovery. (sciencetec.in)
  • It is a very important hormone-producing gland. (sciencetec.in)
  • Iodine is absorbed into our bloodstream from food, from where it is carried to the thyroid gland to produce thyroid hormones. (sciencetec.in)
  • The t hyroid gland present in the anterior neck is responsible for the synthesis and secretion of thyroid hormones: thyroxine (T4) and triiodothyronine (T3). (myendoconsult.com)
  • Firstly, T4 is the predominant thyroid hormone secreted by the thyroid gland, accounting for approximately 90% of endogenous total thyroid hormone production[1]. (myendoconsult.com)
  • Thyroid hormone synthesis is a highly regulated process that occurs in the thyroid gland, specifically within the thyroid follicular cells. (myendoconsult.com)
  • The addition of exogenous reduced glutathione (GSH) to the gland suspension reactivated dose dependently the acid secretion which had been inhibited by 2 microM E3810 or omeprazole as a function of the incubation time. (shengsci.com)
  • There are two main types of epithelium in the mammary gland: luminal and basal. (biologists.com)
  • GLP-1R activation results in feeding suppression, while GCGR activation stimulates increased energy expenditure, adipose tissue browning, mobilization and metabolism of fat, leading to substantial body weight loss and clearance of liver fat in animal models 12 - 17 . (researchsquare.com)
  • Whole blood-based transcriptional risk score for nonobese type 2 diabetes predicts dynamic changes in glucose metabolism. (medscape.com)
  • Hormones may be the answer to many questions, starting from metabolism, growth factors, sexual drive, and sleep cycles to reproductions and so on. (sciencetec.in)
  • Thyroid hormones regulate many of the body functions including metabolism, growth, and development, regulating body temperature and brain development, etc. (sciencetec.in)
  • Growth, metabolism, and differentiation of chondrocytes, which are the key cellular players in this process, are regulated by systemic hormones, local factors, and cellular signaling pathways. (pfmjournal.org)
  • Parafollicular C cells, larger separate groups of epithelial cells situated between the thyroid follicles, are responsible for the secretion of the peptide hormone calcitonin, which plays a role in the regulation of calcium metabolism. (myendoconsult.com)
  • Thyroid hormones are important regulators of various physiological processes, such as cellular growth and metabolism. (myendoconsult.com)
  • Insulin is a hormone secreted by the beta cells of pancreas , and is important in the regulation of carbohydrate and fat metabolism in the body. (howmed.net)
  • Scientists continue to gain more insights into estrogens' effect on REE, making it evident that these hormones possess vast potential to advance our knowledge about metabolism and body functioning. (testosteronejunkie.com)
  • The pharmacodynamics of ALT-801, a GLP-1/glucagon receptor dual agonist optimized for NASH and weight loss, were compared to semaglutide (GLP-1 receptor agonist) and elafibranor (peroxisome proliferator-activated receptor, PPAR-α/δ, agonist) in a biopsy-confirmed, diet-induced obese (DIO) mouse model of NASH (DIO-NASH). (researchsquare.com)
  • Beyond the GLP-1 receptor (GLP-1R) agonists, unimolecular peptide dual agonists activating both GLP-1R and the glucagon receptor (GCGR) have been developed with the aim to achieve superior therapeutic benefits versus single agonist peptides 12 , 13 . (researchsquare.com)
  • Glucagon-like peptide 1 Analogues as Adjunctive Therapy for Patients with Type 1 Diabetes: an Updated Systematic Review and Meta-analysis. (medscape.com)
  • Hereditary vitamin D-resistant rickets is a very rare autosomal recessive disorder in which mutations of vitamin D receptor (VDR) coding genes cause failure or abnormal binding of vitamin D to VDRs. (medscape.com)
  • OSMR is a member of the type I cytokine receptor family. (wikipedia.org)
  • It is a single-transmembrane-domain type I cytokine receptor , [20] a special class of cytokine receptors . (cloudfront.net)
  • Information in the endocrine system is transmitted through several small molecules, peptides and proteins that function as hormones. (tomsk.ru)
  • The production of hormones in the endocrine system can be regulated by the concentration of certain molecules or ions (e.g. glucose, calcium) or by the nervous system which allows for integration of external stimuli or input from higher parts of the brain. (tomsk.ru)
  • The anterior pituitary or adenohypophysis is a collection of cells that secrete hormones to control the activities of cells in other endocrine organs. (tomsk.ru)
  • Some of these hormones control the production of hormones in other organs while others have direct effects on basic biological properties. (tomsk.ru)
  • It releases human growth hormones (HGH or GH), thyroid-stimulating hormones (TSH), adrenocorticotrophin hormone (ATCH), follicle-stimulating hormone (FSH), and many more. (sciencetec.in)
  • Most processed food contains highly refined carbohydrates that alter insulin physiology and promote adipose tissue deposition [17,18] . (diabeets.com)
  • These hormones are released by cells in one part of the body, enter the circulatory system to distribute throughout the body and bind specific receptors in other cells. (tomsk.ru)
  • At their best, they usually rely on some mysterious things called ionic pumps, that perform active transport, powered by little motors, under instructions from molecules that act on their specific receptors. (raypeat.com)
  • Lack of OSMRβ activity has also been linked to adipose tissue inflammation and insulin resistance preceding obesity. (wikipedia.org)
  • Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) have long been considered liver manifestations of the metabolic syndrome, and their connection to obesity is well-recognized 1 , 2 . (researchsquare.com)
  • The expanding worldwide obesity epidemic 3 and its comorbidities 4 (cardiovascular disease, type 2 diabetes mellitus, extra-hepatic malignancies, NAFLD/NASH) have increased the importance of finding effective treatments for this obesity-associated spectrum of disease. (researchsquare.com)
  • In obesity , a decreased sensitivity to leptin occurs (similar to insulin resistance in type 2 diabetes ), resulting in an inability to detect satiety despite high energy stores and high levels of leptin. (cloudfront.net)
  • Studies showed that monosodium glutamate (MSG) induces raised echelons of oxidative stress, and excessive hepatic lipogenesis is concomitant to obesity and type 2 diabetes mellitus (T2DM). (diabeets.com)
  • Current studies regarding the consumption of ready-prepared foods and their consequences reliably reported a significant correlation between obesity, several noninfectious illnesses (noncommunicable diseases (NCDs)), cardiovascular diseases, hypertension, several types of malignancies, and many more [1-5] . (diabeets.com)
  • Genetic and environmental influences also can have an effect on this process, including diet, obesity, high insulin levels, medications (e.g. hormone replacement therapy), or overexposure to estrogen-producing chemicals in the environment. (testosteronejunkie.com)
  • Some regulate the biochemical and physiological activity of other cells while others stimulate cells in other parts of the body to release their own hormones. (tomsk.ru)
  • Peripheral endocrine organ functions are controlled to varying degrees by pituitary hormones. (msdmanuals.com)
  • The present purpose was to delineate the relation of calcium-sensing receptor (CaSR) and parathyroid hormone-related peptide nuclear localization sequence (PTHrP87-139 ), and their role in the proliferation behaviors of the superficial zone cells. (bvsalud.org)
  • Plasma 1,25-dihydroxyvitamin D (1,25(OH)2 D) is tightly controlled by plasma parathyroid hormone (PTH), serum calcium, serum phosphate, and fibroblast-like growth factor 23 (FGF-23). (medscape.com)
  • Anti-apoptotic strategies include inhibition of caspase, poly [ADP-ribose] polymerase (PARP), and Bcl-2 proteins as well as induction of the PKB/Akt pathway and inhibitors of apoptosis (IAP) family of proteins. (biomedcentral.com)
  • Thymus also produces several hormones including thymopoietin,(polypeptide hormone consisting of 49 amino acids) thymosin & thymulin, which stimulate other parts of the immune system. (sciencetec.in)
  • Insulin is made up of 2 polypeptide chains linked by disulphide linkages. (howmed.net)
  • Insulin resistance is associated with the capillary permeability of thigh muscles in patients with type 2 diabetes. (medscape.com)
  • Insulin resistance was proven in numerous studies to be the onset of many metabolic disorders in humans, especially diabetes mellitus [ 1 ] [ 2 ] . (encyclopedia.pub)
  • Insulin resistance indicates the inability or inefficiency of the body to respond well to hormone insulin [ 9 ] . (encyclopedia.pub)
  • Adipose tissue inflammation appears to be a risk factor for the progression of chronic kidney disease (CKD), but the effect of CKD on adipose tissue inflammation is poorly understood. (mdpi.com)
  • The purpose of this study was to clarify the involvement of uremic toxins (indoxyl sulfate (IS), 3-indoleacetic acid, p-cresyl sulfate and kynurenic acid) on CKD-induced adipose tissue inflammation. (mdpi.com)
  • PTH and PTHrP have a similar homology, sharing the initial 13 amino acid residues at the N-terminus and binding to the same type 1 PTH receptor (PTH1R), which regulates calcium homeostasis. (bvsalud.org)
  • Thereafter, detailed structure alignment and molecular docking simulations predicted a lack of interaction between PTHrP(12-48) and the cognate PTH1 receptor (PTHR1). (phoenixpeptide.com)
  • Conventional and microwave-assisted SPPS approach: a comparative synthesis of PTHrP(1-34)NH(2). (phoenixpeptide.com)
  • Attracted by the possibility to optimize time and yield of the synthesis of difficult peptide sequences by MW irradiation, we compared Fmoc/tBu MW-assisted SPPS of 1-34 N-terminal fragment of parathyroid hormone-related peptide (PTHrP) with its conventional SPPS carried out at RT. (phoenixpeptide.com)
  • Predominantly, the 'energy expenditure hormone' leptin is made by adipose cells , and is thus labeled fat cell-specific . (cloudfront.net)
  • Mariano García Arranz has the following conflict of interest: MGA is inventor on 2 patents entitled "Identification and isolation of multipotent cells from non-osteochondral mesenchymal tissue" (10157355957US) and "Use of adipose tissue-derived stromal stem cells in treating fistula" (US11/167061). (wjgnet.com)
  • Intracellular cell signalling occurs as a consequence of extracellular binding of the ligand OSM to OSMR complexes, formed from dimerization with receptor subunits such as gp130. (wikipedia.org)
  • Activation of the OSMR-gp130 complex by OSM triggers Janus Kinase 1 (JAK1) and Jak2 cross phosphorylation of tyrosine residues on the intracellular receptor domain. (wikipedia.org)
  • Free T3 exerts its effects by binding to its cognate intracellular thyroid hormone receptors (TRs)[3]. (myendoconsult.com)
  • The amount of circulating leptin correlates with the amount of energy reserves, mainly triglycerides stored in adipose tissue. (cloudfront.net)
  • Leptin receptors are expressed by a variety of brain and peripheral cell types. (cloudfront.net)
  • Although regulation of fat stores is deemed to be the primary function of leptin, it also plays a role in other physiological processes, as evidenced by its many sites of synthesis other than fat cells, and the many cell types beyond hypothalamic cells that have leptin receptors . (cloudfront.net)
  • Leptin acts directly on leptin receptors in the cell membrane of different types of cells in the human body in particular, and in vertebrates in general. (cloudfront.net)
  • The leptin receptor is found on a wide range of cell types. (cloudfront.net)
  • Immunohistochemical evidence for the existence of a dopamine- and cyclic AMP-regulated phosphoprotein (DARPP-32) in brown adipose tissue of pigs. (cornell.edu)
  • It produces hormones like Triiodothyronine or T3, Tetraiodothyronine/ thyroxine or T4, and both are made in epithelial cells of the thyroid. (sciencetec.in)
  • In tumor-induced osteomalacia, tumor-secreted FGF-23 inhibits enzyme 1α-hydroxylase and subsequently results in decreased 1,25(OH)2 D synthesis. (medscape.com)
  • HIV protease inhibitors have been reported to markedly suppress the activities of 25- and 1α-hydroxylase and thus affect 1,25(OH)2 D synthesis. (medscape.com)
  • The insulin signaling pathway begins with the binding of the peptide hormone insulin to its corresponding receptor, the insulin receptor. (encyclopedia.pub)
  • Peptide hormone insulin is secreted by β-cells of the islet, which function as messengers that instruct designated peripheral insulin-sensitive cells in the body to take up glucose. (encyclopedia.pub)
  • OSM in-vivo regulation of hematopoiesis, through stimulation of stromal cells & hematopoietic progenitors - megakaryocytic and erythrocytic progenitors, is carried out by the OSMRβ receptor. (wikipedia.org)
  • Effects of bariatric surgery on blood and vascular large extracellular vesicles according to type 2 diabetes status. (medscape.com)
  • Approach to the Patient with Youth-Onset Type 2 Diabetes. (medscape.com)
  • Metabolites as Risk Factors for Diabetic Retinopathy in Patients with Type 2 Diabetes: a 12-year Follow-up Study. (medscape.com)
  • Serum MicroRNA-191-5p Levels in Vascular Complications of Type 1 Diabetes: the EURODIAB Prospective Complications Study. (medscape.com)
  • The explosion of vitamin D utilization is a result of many promising observational studies that have associated vitamin D concentration with health benefits in cardiovascular diseases, cancer, diabetes, fertility, and many others ( 2 ). (biochemia-medica.com)
  • Mitchell DM, Caksa S, Joseph T, Bouxsein ML, Misra M. Elevated HbA1c is associated with altered cortical and trabecular microarchitecture in girls with type 1 diabetes. (bouxseinlab.org)
  • An Inverse Agonist Ligand of the PTH Receptor Partially Rescues Skeletal Defects in a Mouse Model of Jansen's Metaphyseal Chondrodysplasia. (bouxseinlab.org)
  • In a study by Levin et al (2007), 13% of patients with an estimated glomerular filtration rate (eGFR) greater than 80 mL/min and more than 60% of patients with an eGFR of less than 30 mL/min had low serum levels of 1,25(OH)2 D.[3] Impaired production of the enzyme 1α-hydroxylase in kidney failure was thought to be the main mechanism. (medscape.com)
  • 3. Activation of lipoprotein lipase which splits triglycerides into fatty acids, which are transported into adipose cells and stored. (howmed.net)
  • OSM receptor is abundantly expressed on endothelial and stromal/fibroblast cells in the lung of mice. (wikipedia.org)
  • Therefore, we aim to develop a cell transplantation platform that protects the transplanted cells, impedes the immunological attack, and releases the parathyroid hormone. (ncl.edu.tw)
  • In this study, we developed alginate microbeads for the delivery of parathyroid cells, compared the microbeads crosslinked with calcium or barium ions, and also pre-loaded cells in a gelatin scaffold to manufacture the microbeads with double-layered structure. (ncl.edu.tw)
  • Data revealed that the microbeads prepared with double-layered structure possess optimal cells proliferation rate and parathyroid hormone (PTH) secretion capability, which shows no significant difference compared with a control group. (ncl.edu.tw)
  • Cells in the pituitary produce many different hormones. (tomsk.ru)
  • The pancreatic islet of Langerhans consists of three types of cells, i.e., alpha cells, beta cells, and delta cells. (encyclopedia.pub)
  • Induction of functional beta-adrenergic receptors in rat aortic smooth muscle cells by sodium butyrate. (shengsci.com)
  • The polyhydroxyethylmethacrylate (poly-HEMA)- and type-I collagen-coated culture plate models were adapted to harvest the TB-induced differentiated cells by agitati. (shengsci.com)
  • Some hormones exert an effect on cells of the organ from which they were released (paracrine effect), some even on the same cell type (autocrine effect). (msdmanuals.com)
  • Hormones bind selectively to receptors located inside or on the surface of target cells. (msdmanuals.com)
  • Each type has its own configuration or number of atoms that enable it to interact with receptors throughout its body and activate specific cells as needed. (testosteronejunkie.com)
  • 2. Highly potent and selective pyrazolylpyrimidines as Syk kinase inhibitors . (biomedfrontiers.org)
  • The insulin receptor is a receptor tyrosine kinase (RTK) that conformationally consists of two alpha and two beta subunit tetramers. (encyclopedia.pub)
  • The insulin receptor exhibiting kinase activity is responsible for its autophosphorylation at the tyrosine residue site upon insulin binding. (encyclopedia.pub)
  • Study endpoints included body and liver weight, liver and plasma total cholesterol and triglycerides, plasma aminotransferases, histological analysis of liver steatosis, inflammation (galectin-3) and fibrosis (collagen type 1 alpha 1), and evaluation of individual animal changes in composite Non-alcoholic Fatty Liver Disease Activity Score (NAS) and fibrosis stage. (researchsquare.com)