• lipolysis
  • The invention provides methods for determining the ability of compounds to regulate lipogenesis and lipolysis by acting as a sulfonylurea-1 (SUR 1) potassium channel activator, an adipocyte potassium channel activator, an SUR 1 antagonist, and an adipocyte specific SUR 1 antagonist. (google.com)
  • The present invention recognizes the presence of the sulfonylurea receptor in adipocytes and its utility in identifying compounds and in regulating lipogenesis and lipolysis. (google.com)
  • In adipocytes, aquaglyceroporins mediate glycerol uptake and release across the plasma membrane, which are two key steps for triacylglycerols (TAGs) synthesis (lipogenesis) and hydrolysis (lipolysis). (mdpi.com)
  • Insulin counter-regulates this increase in lipolysis when it binds to insulin receptors on the adipocyte cell membrane. (wikipedia.org)
  • Vivo
  • This mouse uses an inducible, adipose specific LacZ transgene, where one can label all the currently existing adipocytes as LacZ positive (blue stained) and evaluate the new (white, unlabelled) adipocytes in vivo. (wikipedia.org)
  • Marrow
  • MAT, by its "specific marrow location, and its adipocyte origin from at least LepR+ marrow MSC is separated from non-bone fat storage by larger expression of bone transcription factors", and likely indicates a different fat phenotype. (wikipedia.org)
  • Histologic sections demonstrating Marrow Adipocytes Representative distal femur histologic section of a 16-week old healthy C57BL/6 mouse demonstrating a typical quantity of marrow adipocytes. (wikipedia.org)
  • Marrow adipocytes are difficult to isolate and quantify because they are interspersed with bony and hematopoietic elements. (wikipedia.org)
  • vascular
  • In this study, we hypothesized that pre-exposure of the stromal vascular (SV) fraction of primary human adipogenic precursor cells ( h ASC) to BMP7 would convert metabolically active brown adipocytes. (springer.com)
  • knockdown
  • Adipocytes derived from Men1-KO mESCs or after menin knockdown in 3T3-L1 cells showed a 1.5-1.7-fold increase in fat-cell size. (hindawi.com)
  • Human APOE knockdown hMSC-Tert adipocytes accumulated markedly less triglycerides compared to control cells. (osti.gov)
  • cellular
  • However, controversy still surrounds the cellular identity in BMP7-mediated transition of white to brown adipocytes. (springer.com)
  • Dedifferentiation is associated with downregulation of transcripts encoding proteins involved in mature adipocyte functions and upregulation of genes involved in matrix remodeling, cellular development, and cell cycle. (hindawi.com)
  • cells
  • Caffeic Acid Phenethyl Ester Regulates PPAR's Levels in Stem Cells-Derived Adipocytes," PPAR Research , vol. 2016, Article ID 7359521, 13 pages, 2016. (hindawi.com)
  • With this review we will provide a working model indicating a close interaction in between bacterial translocation, activation of the adipocytes, and subsequent direction of the infiltrating immune cells. (frontiersin.org)
  • The size of adipocytes varies according to their lipid content and is linked to the function of the cells, with larger adipocytes usually being more active with regard to their metabolic activity and adipokine production ( 2 ). (frontiersin.org)
  • The aim of this study was to assess both glycerol permeability and metabolism in undifferentiated 3T3-L1 cells (UDCs) as well as in untreated (CTL-DCs) versus lipopolysaccharide (LPS-DCs)-treated differentiated 3T3-L1 adipocytes. (mdpi.com)
  • Approximately 10% of fat cells are renewed annually at all adult ages and levels of body mass index without a significant increase in the overall number of adipocytes in adulthood. (wikipedia.org)
  • Nevertheless, histological techniques and fixation make possible visualization of MAT, quantification of adipocyte size, and MAT's association with the surrounding endosteum, milieu of cells, and secreted factors. (wikipedia.org)
  • Both adipocytes and brown adipocyte may be derived from pericytes, the cells which surround the blood vessels that run through white fat tissue. (wikipedia.org)
  • mice
  • Differentiated hMSC-Tert were stably transduced with or without siRNA targeting APOE while murine adipocytes were isolated from wild type and Apoe knockout mice. (osti.gov)
  • white
  • CD137 and TMEM26), (3) glucose and fatty acid uptake, and (4) basal and cAMP-stimulated oxygen consumption rate compared to white adipocyte control. (springer.com)
  • The second develops from white adipocytes that are stimulated by the sympathetic nervous system. (wikipedia.org)
  • size
  • Reintroduction of an ordinary chow diet to such animals precipitated a period of weight loss during which only mean adipocyte size returned to normal. (wikipedia.org)
  • Notably, there was no change in the size of the lower-body adipocytes. (wikipedia.org)
  • cell types
  • This condition cannot be effectively corrected through diet and exercise alone, as the panniculus consists of adipocytes and other supporting cell types shrunken to their minimum volume and diameter. (wikipedia.org)
  • control
  • No such studies have been performed perhaps due to the limitation of procuring normal adipocytes that can serve as a matched control for the abnormal adipocytes in the lipoma. (hindawi.com)
  • rather
  • Interestingly, individuals who become obese as adults, rather than as adolescents, have no more adipocytes than they had before. (wikipedia.org)
  • model
  • Lipoma in patients with the multiple endocrine neoplasia type 1 (MEN1) syndrome is a type of benign fat-cell tumor that has biallelic inactivation of MEN1 that encodes menin and could serve as a model to investigate normal and pathologic fat-cell (adipocyte) proliferation and function. (hindawi.com)