• lipolysis
  • The invention provides methods for determining the ability of compounds to regulate lipogenesis and lipolysis by acting as a sulfonylurea-1 (SUR 1) potassium channel activator, an adipocyte potassium channel activator, an SUR 1 antagonist, and an adipocyte specific SUR 1 antagonist. (google.com)
  • The present invention recognizes the presence of the sulfonylurea receptor in adipocytes and its utility in identifying compounds and in regulating lipogenesis and lipolysis. (google.com)
  • In adipocytes, aquaglyceroporins mediate glycerol uptake and release across the plasma membrane, which are two key steps for triacylglycerols (TAGs) synthesis (lipogenesis) and hydrolysis (lipolysis). (mdpi.com)
  • 11 Although triglyceride lipolysis in adipocytes was unaffected, triglyceride synthesis was decreased, and this was accompanied by decreased expression of the active (cleaved) form of SREBP-1c (sterol regulatory element binding protein-1c). (ahajournals.org)
  • Insulin counter-regulates this increase in lipolysis when it binds to insulin receptors on the adipocyte cell membrane. (wikipedia.org)
  • Marrow
  • MAT, by its "specific marrow location, and its adipocyte origin from at least LepR+ marrow MSC is separated from non-bone fat storage by larger expression of bone transcription factors", and likely indicates a different fat phenotype. (wikipedia.org)
  • Histologic sections demonstrating Marrow Adipocytes Representative distal femur histologic section of a 16-week old healthy C57BL/6 mouse demonstrating a typical quantity of marrow adipocytes. (wikipedia.org)
  • Marrow adipocytes are difficult to isolate and quantify because they are interspersed with bony and hematopoietic elements. (wikipedia.org)
  • proliferation
  • Lipoma in patients with the multiple endocrine neoplasia type 1 (MEN1) syndrome is a type of benign fat-cell tumor that has biallelic inactivation of MEN1 that encodes menin and could serve as a model to investigate normal and pathologic fat-cell (adipocyte) proliferation and function. (hindawi.com)
  • receptor
  • Toll-like receptor ligands cause proinflammatory and prodiabetic activation of adipocytes via phosphorylation of extracellular signal-regulated kinase and c-Jun N-terminal kinase but not interferon regulatory factor-3," Endocrinology , vol. 151, pp. 1097-1108, 2010. (hindawi.com)
  • mRNA
  • Hcy (300-1000 μmol/l) also increased mRNA expression of resistin in primary rat adipocytes in a time- and concentration-dependent manner, with maximal induction at 24 h of approximately fourfold with 1,000 μmol/l. (diabetesjournals.org)
  • Adipocytes from females have higher mRNA/protein levels of several genes involved in glucose and lipid metabolism. (diabetesjournals.org)
  • resistin
  • On the other hand, angiotensin II and resistin are vasoconstrictors released by adipocytes. (ugent.be)
  • RESEARCH DESIGN AND METHODS- The effect of Hcy on the expression and secretion of resistin and insulin resistance was investigated using primary rat adipocytes and mice with hyperhomocysteinemia (HHcy). (diabetesjournals.org)
  • CONCLUSIONS- HHcy may promote insulin resistance through the induction of resistin expression and secretion from adipocytes via the activation of the ROS-PKC-NF-κB pathway. (diabetesjournals.org)
  • mice
  • Differentiated hMSC-Tert were stably transduced with or without siRNA targeting APOE while murine adipocytes were isolated from wild type and Apoe knockout mice. (osti.gov)
  • knockdown
  • Adipocytes derived from Men1-KO mESCs or after menin knockdown in 3T3-L1 cells showed a 1.5-1.7-fold increase in fat-cell size. (hindawi.com)
  • Human APOE knockdown hMSC-Tert adipocytes accumulated markedly less triglycerides compared to control cells. (osti.gov)
  • accumulates
  • B , When ABCA1 is absent in adipocytes, free cholesterol accumulates, particularly in the plasma membrane, and presumably also in the endoplasmic reticulum (ER). (ahajournals.org)
  • incubation
  • Incubation of cells for 24 h with 100 μ mol/L alliin prevented the increase in the expression of proinflammatory genes, IL-6, MCP-1, and Egr-1 in 3T3-L1 adipocytes exposed to 100 ng/mL LPS for 1 h. (hindawi.com)
  • lipopolysaccharide
  • The aim of this study was to assess both glycerol permeability and metabolism in undifferentiated 3T3-L1 cells (UDCs) as well as in untreated (CTL-DCs) versus lipopolysaccharide (LPS-DCs)-treated differentiated 3T3-L1 adipocytes. (mdpi.com)
  • We examined the effects of alliin in lipopolysaccharide- (LPS-) stimulated 3T3-L1 adipocytes by RT-PCR, Western blot, and microarrays analysis of 22,000 genes. (hindawi.com)
  • cells
  • False-colour scanning electron micrograph of human fat cells, or adipocytes, in human skin. (sciencephoto.com)
  • Approximately 10% of fat cells are renewed annually at all adult ages and levels of body mass index without a significant increase in the overall number of adipocytes in adulthood. (wikipedia.org)
  • Nevertheless, histological techniques and fixation make possible visualization of MAT, quantification of adipocyte size, and MAT's association with the surrounding endosteum, milieu of cells, and secreted factors. (wikipedia.org)
  • Both adipocytes and brown adipocyte may be derived from pericytes, the cells which surround the blood vessels that run through white fat tissue. (wikipedia.org)
  • cell
  • In contrast to the upper body fat cell response, the number of lower-body adipocytes did significantly increase during the course of experiment. (wikipedia.org)
  • This condition cannot be effectively corrected through diet and exercise alone, as the panniculus consists of adipocytes and other supporting cell types shrunken to their minimum volume and diameter. (wikipedia.org)
  • size
  • Reintroduction of an ordinary chow diet to such animals precipitated a period of weight loss during which only mean adipocyte size returned to normal. (wikipedia.org)
  • Notably, there was no change in the size of the lower-body adipocytes. (wikipedia.org)
  • intake
  • Adipocytes stay in a dynamic state, they start expanding when the energy intake is higher than the expenditure and undergo mobilization when the energy expenditure exceeds the intake. (wikipedia.org)