Adhesion dna binding proteins. Medical search. Frequent questions

Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. (embl-heidelberg.de)
Using bioinformatics tools and biochemical experiments, we have identified the heparin-binding hemagglutinin (HbhA) protein of Mtb as a novel sequence-independent DNA-binding protein which has previously been characterized as an adhesion molecule required for extrapulmonary dissemination. (bvsalud.org)
The tensin family member cten (C-terminal tensin like) is an Src homology 2 (SH2) and phosphotyrosine binding domain-containing focal adhesion molecule that may function as a tumor suppressor. (rupress.org)
Differential regulation of endothelial cell adhesion molecule expression by nitric oxide donors and antioxidants. (uchicago.edu)
Mutations of the KAL1 gene, which encodes a putative neural cell adhesion molecule, have been described in several patients with X-linked Kallmann syndrome. (medscape.com)

The protein-protein interaction (PPI) of differentially expressed genes was drawn by the STRING website, and the results were imported into Cytoscape for visualization. (hindawi.com)
The results of GO analysis showed that the downregulated genes were significantly enriched in matrix adhesion and angiogenesis and upregulated differential genes were significantly enriched in cell adhesion and vascular development. (hindawi.com)
KEGG pathway analysis showed that the differential genes of LUAD were significantly enriched in viral carcinogenesis and adhesion spots. (hindawi.com)
Extensive evidence has revealed that the core clock machinery involves "clock genes" and "clock proteins" functioning as molecular cogs. (bioone.org)
Of the 31 genes, the 21 upregulated genes were primarily associated with cell paracrine and intracellular signaling, transcription regulation and cell adhesion and migration, and their transcriptional products included transforming growth factor-β2 (TGF-β2), insulin-like growth factor-binding protein 2 and transcriptional factor AP-2α/γ ( 11 ). (spandidos-publications.com)
By contrast, the 10 downregulated genes were primarily associated with epithelial membrane proteins ( 11 ). (spandidos-publications.com)
Genes mainly involved in coding adhesion molecules and growth factors have also been found to be upregulated in other types of CAFs, including colon ( 12 ) and pancreatic ( 13 ). (spandidos-publications.com)
Aiolos is a member of a class of proteins called transcription factors - proteins that control which genes are turned on or off by binding to DNA and other proteins. (rdworldonline.com)
Once bound to DNA, these proteins can promote or block the enzyme that controls the reading, or "transcription," of genes, making genes more or less active. (rdworldonline.com)
Epac 1 and Epac 2 are products of impartial genes: Epac 1 a protein comprising 881 amino acids (molecular mass 100 kDa), whereas Epac 2 is usually a protein comprising 1011 amino acids (molecular mass 110 kDa). (researchensemble.com)
functional ThyX protein rather than any undesired effect on the surrounding genes. (alk-inhibitors.com)

In TGF-beta-treated MCF10A mammary epithelial cells overexpressing HER2 and by chromatin immunoprecipitation, we identified novel Smad targets including protein tyrosine phosphatase receptor type kappa (PTPRK). (nih.gov)

The fusion gene is critical to the progression of cancer because it inhibits the androgen receptor expression and it binds and inhibits androgen receptors already present in the cell. (wikipedia.org)
Transcriptional activation of the orphan nuclear receptor Nurr1 by ligands targeting its heterodimer partner retinoid X receptor alpha (RXRα) occurs through a nonclassical pharmacological mechanism involving ligand-binding domain protein-protein interaction inhibition. (elifesciences.org)
The 1st identified mobile receptor because of this nuclear proteins was the receptor for advanced glycation end items (Trend), which mediates the relationships between advanced glycation end item (Age group)Cmodified proteins as well as the endothelium and additional cell types (7). (exposed-skin-care.net)
For death-receptor-induced necroptosis, the protein kinase receptor-interacting protein kinase 1, 3 (RIPK1, RIPK3) and mixed lineage kinase domain-like protein (MLKL) are the key components of the necroptosis machinery [ 1 , 2 , 3 ]. (biomedcentral.com)
In this study, the long binding helix of this ligand was downsized to an enzymatically stable cyclic peptide endowed with sub-nanomolar binding affinity toward the αvβ6 receptor and remarkable selectivity against other integrins. (cipsm.de)
Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. (cancerindex.org)
When GFLs bind with GFRα, they form complexes and associate with the RET receptor, subsequently activating downstream signaling. (medsci.org)
Using knock-out and B-cell-conditional knock-out murine models, we identify Carabin as a new negative regulator of B-cell function, whose deficiency in B cells speeds up early B-cell responses and makes the mice more susceptible to anti-dsDNA production and renal lupus flare after stimulation with a Toll-like Receptor 9 agonist, CpG-DNA. (cnrs.fr)
In one patient, isolated bioinactive luteinizing hormone (LH) was present as a result of a homozygous mutation in the LH beta subunit gene, which prevented binding of LH to its receptor. (medscape.com)
Homozygous mutations in GPR54, a gene encoding a G protein-coupled receptor, which binds kisspeptin 1, have been reported as a cause of hypogonadotropic hypogonadism. (medscape.com)
The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. (cancer-genetics.org)
The newly-generated sequences were genetically and phylogenetically compared to the WHO-recommendedvaccines and other Africa strains sampled since 1994.Uganda strain hemagglutinin (n=206), neuraminidase (n=207), and matrix protein (MP, n=213) sequences had 95.23-99.65%, 95.31-99.79%, and 95.46-100% amino acid similarity to the 2010-2020 season vaccines, respectively, with several mutated hemagglutinin antigenic, receptor binding, and N-linked glycosylation sites. (cdc.gov)

High mobility group (HMG) proteins are chromatin regulators with essential functions in development, cell differentiation and cell proliferation. (us.es)
In this work, we used chromatin immunoprecipitation (ChIP) with an anti-nitro-tyrosine antibody followed by mass spectrometry to identify nitrated DNA binding proteins in T. cruzi and to detect alterations in nitration levels induced upon parasite incubation with the ECM. (omicsdi.org)

We previously observed that the metabolic thiol antioxidant alpha-lipoic acid (LA) inhibits LPS-induced expression of cellular adhesion molecules and adherence of monocytes to human aortic endothelial cells. (oregonstate.edu)
E-selectin (SELE) is a part of a family of divalent cation-dependent carbohydrate-binding glycoproteins or adhesion molecules. (prospecbio.com)
One of the most significant current discussions in Cu biochemistry relates to the mechanisms of the positive and negative actions of Cu ions based on the generation of reactive oxygen species, including radicals that can interact with DNA molecules. (mdpi.com)
By manipulating and controlling molecules and cells on their natural length scales we develop novel tools to address urgent needs in biology and medicine for DNA analysis, cell fractionation and cell manipulation on the single-cell level. (lu.se)

Track B receptors are important proteins that work with BDNF factor to mediate synaptic development. (crunchtime-records.com)
We review here the recent developments on the structural and functional characterization of this evolutionary ancient and important family of proteins, which can function as cytokine receptors (Toll in Drosophila) or pattern recognition receptors (TLR4 in mammals) and activate similar, albeit non identical signal transduction pathways, in flies and mammals. (cnrs.fr)
1979. Transition and heavy metal inhibition of ligand binding to muscarinic acetylcholine receptors from rat brain. (cdc.gov)

This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. (cancer-genetics.org)

In MCF10A/HER2 cells, TGF-beta enhanced cell motility, FAK phosphorylation, F-actin assembly, and focal adhesion formation and inhibited RhoA activity. (nih.gov)
Mutations on DLC-1 perturb the interaction with cten and disrupt the focal adhesion localization of DLC-1. (rupress.org)
When these DLC-1 mutants were fused to a focal adhesion targeting sequence, their tumor suppression activities were significantly restored. (rupress.org)
These results provide a novel mechanism whereby the SH2 domain of cten-mediated focal adhesion localization of DLC-1 plays an essential role in its tumor suppression activity. (rupress.org)
Focal adhesions are integrin-mediated cell matrix junctions connecting the ECM to the actin cytoskeleton. (rupress.org)
Tensin is a gene family with four members (tensin1, tensin2, tensin3, and cten), and their encoding proteins are localized to the cytoplasmic side of focal adhesions. (rupress.org)

However, it has been shown that cAMP also exert its effects through a PKA-independent pathway activating a family of proteins known as Epac proteins [9], [10]. (researchensemble.com)

These complexes interact with 5'-AMP-activated protein kinase (AMPK) that is part of the mechanistic target of rapamycin (mTOR) pathway, which is involved in cellular energy, cytokinesis, cell motility, cellular adhesion, and nutrient sensing. (medscape.com)

The ERG gene encodes for a protein, also called ERG, that functions as a transcriptional regulator. (wikipedia.org)
Transcriptional regulator ERG is a nuclear protein that binds purine-rich sequences of DNA. (wikipedia.org)
Transcriptional regulator ERG is required for platelet adhesion to the subendothelium and regulates hematopoiesis. (wikipedia.org)
DNA binding protein ERG fuses with RNA binding proteins EWS and TLS/FUS in Ewing's sarcoma and acute myeloid leukemias respectively and function as transcriptional activators. (wikipedia.org)
A total of 7 possible genetic alterations and epigenetic changes in CAFs are discussed, including gene differential expression, karyotype analysis, gene copy number variation, loss of heterozygosis, allelic imbalance, microsatellite instability, post‑transcriptional control and DNA methylation. (spandidos-publications.com)
Epigenetic alterations, represented by post-transcriptional control and DNA methylation, have been the focus of recent studies. (spandidos-publications.com)
Rabbit polyclonal to ZNF624.Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, mostof which encompass some form of transcriptional activation or repression. (researchensemble.com)
May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. (lu.se)

Ubiquitination targets proteins for degradation and is a potent regulator of cellular protein function. (embl-heidelberg.de)
Analysis of virulence related gene expression and computational simulations of pivotal proteins involved in pathogenesis demonstrate that myricetin downregulates the saeR global regulator and interacts with sortase A and α-hemolysin. (nature.com)
The Smad7 protein is negative regulator of the TGF-β signaling pathway, which is upregulated in patients with breast cancer. (cancerindex.org)

used the z-Movi ® to resolve the adhesion forces and kinetics between CD4+ T lymphocytes (CD4) and fibronectin. (lumicks.com)

Administration of ADAMs pan inhibitor reduces the levels of soluble cell surface proteins in WT tumors/mice and leads to the dramatic decrease in metastasis. (biomedcentral.com)
The increase in adherence of S. pneumoniae could be inhibited by the DNA synthesis inhibitor cytosine arabinofuranoside, which is known to block the late phase of the adenovirus infection. (lu.se)
Kask L., Hillarp A., Ramesh B., Dahlbäck B., and Blom A. M. (2002) Structural requirements for the intra-cellular subunit polymerization of the complement inhibitor C4b-binding protein. (lu.se)

In 1994, through application of broad range molecular cell signal transduction and possibly eukaryotic transcrip- amplification and DNA sequencing, the causative agent tion. (cdc.gov)

This means that when the ERG gene was not actively transcribed and the ERG protein produced, a mouse's hematopoietic cells were unable to function properly. (wikipedia.org)
This means that the protein transcribes for with the gene could be produced in excess or under- produced resulting in unnatural activity in cells. (wikipedia.org)
DNA-binding proteins (DNA-BPs) and RNA-binding proteins (RNA-BPs) have critical roles in living cells in all kingdoms of life. (nature.com)
Proteins of interest (POI) are tagged with a GFP and transiently expressed in plant cells to serve as donor fluorophore. (nature.com)
OBJECTIVE High-mobility group package-1 (HMGB1) proteins is a nuclear DNA-binding proteins released from necrotic cells, inducing inflammatory reactions and promoting cells restoration and angiogenesis. (exposed-skin-care.net)
High-mobility group package-1 (HMGB1) is usually a nuclear proteins that functions as a cytokine when released in to the extracellular milieu by necrotic and inflammatory cells, and it is involved with inflammatory reactions and tissue restoration (4). (exposed-skin-care.net)
MLKL activation also leads to the protease, ADAMs-mediated ectodomain shedding of cell surface proteins of necroptotic cells. (biomedcentral.com)
Here, we report that the ectodomain shedding of cell surface proteins of necroptotic cells is critical for the promoting effect of tumor necroptosis in tumor metastasis through inhibiting the anti-tumor activity of T cells. (biomedcentral.com)
Cells differentiating into neuroectoderm undergo apoptosis in the absence of functional retinoblastoma family proteins. (mcmaster.ca)
As test cases to examine changes in protein presence associated with tumor growth inhibition, we applied SILAC-based proteomics on human colon carcinoma cells treated with galectin-4 (Gal-4). (uni-muenchen.de)
By tracing significant alterations of protein expression likely relevant for the observed phenotypic effects, the capacity of a galectin to affect the proteome of human colon cancer cells at multiple sites is revealed. (uni-muenchen.de)
We identify glucose-regulated protein 78 (Grp78) as a circulating antagonist of AdipoR function produced by fat cells in response to dietary sugar. (cnrs.fr)
However, how signals are transmitted within cells by this binding has not been clearly shown. (crunchtime-records.com)
Peripheral blood mononuclear cells from CTL-suspected patients were stimulated with HBHA, early secreted antigenic target 6 (ESAT-6), or purified protein derivative (PPD) for 24 h in the presence of IL-7. (bvsalud.org)
siRNA-mediated knockdown of either PHF14 or HMG20A in MDA-MB-231 cells causes similar defects in cell migration, invasion and homotypic cell-cell adhesion ability, but neither af- fects proliferation. (us.es)
The virus-infected cells were harvested at various times after infection and analyzed for the ability to bind strains of Haemophilus influenzae and Streptococcus pneumoniae. (lu.se)
Adenovirus (types 1, 2, 3, and 5) commonly causing respiratory tract infections increased the binding of adherent S. pneumoniae strains to the cells. (lu.se)
Adherence was not affected by pretreatment of the cells with virus particles or viral proteins. (lu.se)
UT Southwestern Medical Center cancer researchers have identified a protein critical to the spread of deadly cancer cells and determined how it works, paving the way for potential use in diagnosis and eventually possible therapeutic drugs to halt or slow the spread of cancer. (rdworldonline.com)
The protein, Aiolos, is produced by normal blood cells but commits a kind of "identity theft" of blood cells when expressed by cancer cells, allowing the latter to metastasize, or spread, to other parts of the body. (rdworldonline.com)
Aiolos decreases the production of cell adhesion proteins and disrupts critical cell adhesion processes, including processes that allow tissue cells to anchor to their physical environment, a necessary requirement for cells to survive and spread. (rdworldonline.com)
Metastatic cells don't need this adhesion, allowing them to proliferate instead. (rdworldonline.com)
Aiolos also represses another protein called p66Shc, which otherwise would suppress metastatic ability, which is the ability of the cancer cells to spread. (rdworldonline.com)
1 BL tumour cells usually express IgM, 13 - 15 B-cell markers such as CD19, CD20 and CD22 and markers of germinal centre (GC) centroblasts such as CD10, BCL6 4 and the human germinal centre-associated lymphoma (HGAL) protein. (bmj.com)
They identified three interaction states between the cells: unbound, binding, and bound. (lumicks.com)
Interaction strengths below 30 pN were defined for unbound cells, between 30 pN and 55 pN for transiently binding and crawling cells, and 55 pN and above for bound cells ( Figure 7) . (lumicks.com)
7 Cumulative probability distribution plot of the rupture forces shown for unbound, binding, and bound cells, IL7-activated and non-activated. (lumicks.com)
9 Fraction cells bound as a function of time, plotted for non-activated and IL-7-activated CD4 on glass functionalized or not with fibronectin. (lumicks.com)
X-ray crystallography studies of full-length Epac2, solved in the absence of cAMP, indicate the presence of autoinhibitory properties in the C-terminal region, which cease upon binding of cAMP [12] In somatic cells, the role of Epac has been extensively documented, as it is usually involved in a wide BMS-650032 manufacturer range of functions. (researchensemble.com)
Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells, which are added to human E-Seletin/CD62E coated plates 2ug/ml. (prospecbio.com)
Myelinating Schwann cells form a myelin sheath around a single axon and express high levels of myelin-related proteins and messenger RNA (mRNA). (medscape.com)
Trouw L., Nilsson S., Goncalvez I., Landberg G. and Blom A. M. (2005) C4b-binding protein binds to necrotic cells and DNA, which limits DNA release and inhibits complement activation. (lu.se)

Webb, J. H., Villoutreix, B. O., Dahlbäck, B. and Blom A. M. (2001) Localization of a hydrophobic binding site for protein S on the b-chain of C4BP. (lu.se)

The spacing of the cysteines in such a domain is C-x(2)-C-x(9 to 39)-C-x(1 to 3)-H-x(2 to 3)-C-x(2)-C-x(4 to 48)-C-x(2)-C. Metal ligand pairs one and three co-ordinate to bind one zinc ion, whilst pairs two and four bind the second. (embl-heidelberg.de)

To obtain structural information, we synthesized single and double zinc finger peptides from the yeast transcription activator ADR1, and assessed the metal-binding and DNA-binding properties of these peptides, as well as the solution structure of the metal-stabilized domains, with the use of a variety of spectroscopic techniques. (embl.de)
Copper ions bind to biomolecules (e.g., peptides and proteins) playing an essential role in many biological and physiological pathways in the human body. (mdpi.com)

The phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway was recently shown to negatively regulate LPS-induced acute inflammatory responses. (oregonstate.edu)
Sjöberg A., Önnerfjord, P., Mörgelin, M., Heinegård, D. and Blom A. M. (2005) Extracellular matrix and inflammation: fibromodulin activates the classical pathway of complement by directly binding C1q. (lu.se)

During protein synthesis, ribosomes become stalled on polyproline-containing sequences, unless they are rescued in archaea and eukaryotes by the initiation factor 5A (a/eIF-5A) and in bacteria by the homologous protein EF-P. While a structure of EF-P bound to the 70S ribosome exists, structural insight into eIF-5A on the 80S ribosome has been lacking. (cipsm.de)

This LA-dependent increase in Akt phosphorylation was accompanied by inhibition of LPS-induced NF-kappaB DNA binding activity and up-regulation of TNFalpha and monocyte chemoattractant protein 1. (oregonstate.edu)
Myricetin affects both surface proteins and secreted proteins which indicate that its action is unrelated to inhibition of the agr quorum sensing system. (nature.com)
disables inhibition of NF-kappa-B DNA-binding activity. (lu.se)
Mark L., Lee W. H., Villoutreix B. O., Proctor D., Blackbourn, D., Spiller B. O. and Blom A. M. (2004) KSHV complement control protein mimics human molecular mechanisms for inhibition of the complement system. (lu.se)

In the proposed "zinc finger" DNA-binding motif, each repeat unit binds a zinc metal ion through invariant Cys and His residues and this drives the folding of each 30-residue unit into an independent nucleic acid-binding domain. (embl.de)

The adaptor protein Grb2 is able to enhance the activity of the cytoplasmic tyrosine kinase Btk through a novel mechanism, revealing a new role for Grb2 in B-cell signaling. (elifesciences.org)
The role of cAMP in spermatic functions was classically thought to be mediated exclusively through the activation of Protein Kinase A (PKA). (researchensemble.com)
The activation of AC leads finally to an increase in the intracellular concentration of cAMP, which in turn activates protein kinase A (PKA), a serine/threonine kinase. (researchensemble.com)

Extra-macrochaetae sequesters these basic-region-helix-loop-helix transcription factors as heterodimers inefficient for binding to DNA. (biologists.com)

Histone H1, H2B, H2A and H3 were detected among the 9 most abundant nitrated DNA binding proteins using this proteomic approach. (omicsdi.org)
The majority ofzinc-finger proteins contain a Krppel-type DNA binding domain and a KRAB domain, which isthought to interact with KAP1, thereby recruiting histone modifying proteins. (researchensemble.com)

To illustrate our approach, we provide experimental procedures to detect the interaction between plant DNA and two proteins (the AeCRN13 effector from the oomycete Aphanomyces euteiches and the AtWRKY22 defensive transcription factor from Arabidopsis ). (nature.com)
The RING domain is a protein interaction domain that has been implicated in a range of diverse biological processes. (embl-heidelberg.de)
We report that cten binds to another tumor suppressor, deleted in liver cancer 1 (DLC-1), and the SH2 domain of cten is responsible for the interaction. (rupress.org)
Blom, A. M. , Rytkönen, A., Vasquez, P., Dahlbäck, B. and Johnsson, A-B. (2001) A novel interaction between type IV pili of Neisseria gonorrhoeae and complement regulatory protein - C4b-binding protein. (lu.se)

ERG and its fusion proteins EWS-ERG and TLS/FUS-ERG inhibit apoptosis. (wikipedia.org)
Figure 8: GFP lifetime distribution of GFP:AeCRN13 and GFP:AeCRN13 AAA fusion proteins in plant nuclei. (nature.com)

The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. (cancerindex.org)

The ECM proteins bind to the extracellular domains of integrin heterodimers, whereas the actin stress fibers link to integrin cytoplasmic tails via large molecular complexes. (rupress.org)

1D annotation analysis of the results indicated down-regulation of DNA replication-associated processes, while protein presence for secretory and transport functions appeared increased. (uni-muenchen.de)
The defects suggest faulty specification of different cell types and result in impairment of processes as diverse as cell proliferation and commitment, cell adhesion and cell recognition. (biologists.com)
If Extramacrochaetae par-ticipates in cell specification by dimerizing with basic-region-helix-loop-helix proteins, the variety of defects and tissues affected by the insufficiency of extramacrochaetae suggests that helix-loop-helix proteins are involved in many embryonic developmental processes. (biologists.com)
Nucleoid-associated proteins (NAPs) regulate multiple cellular processes such as gene expression, virulence, and dormancy throughout bacterial species. (bvsalud.org)
The z-Movi ® is a useful tool to obtain insights into cell adhesion processes. (lumicks.com)

Ploidy and MYCN amplification have been used as genetic markers for risk stratification and therapeutic decision making, and, more recently, gene expression profiling and genome-wide DNA copy number analysis have come into the picture as sensitive and specific tools for assessing prognosis. (biomedcentral.com)
These results are consistent with another study concerning the gene expression profiling of breast CAFs, which were detected using a complementary DNA microarray ( 15 ). (spandidos-publications.com)

Now a large and ever increasing number of genetic subtypes has been described, and major advances in molecular and cellular biology have clarified the understanding of the role of different proteins in the physiology of peripheral nerve conduction in health and in disease. (medscape.com)

A single zinc finger can exist as an independent structure sufficient for zinc-dependent DNA binding. (embl.de)

The five tested lines-LS 180, Vaco 432, Colo 205, CX 1, and HCT 116 responded with differentiation and reduced proliferation to Gal-4 binding. (uni-muenchen.de)

In acute myeloid leukemia, the t(16;21) translocation in myeloid leukemia fuses TLS/FUS to ERG which disrupts the natural TLS/FUS RNA binding domain, and instead inserting the ERG DNA binding domain. (wikipedia.org)

The αvβ6 integrin binds the RGD-containing peptide of the foot and mouth disease virus with high selectivity. (cipsm.de)

For viral infection-induced necroptosis, RIPK3 and MLKL, but not RIPK1, are required and another protein, Z-DNA-binding protein 1 (ZBP1), also known as DNA-dependent activator of IFN regulatory factors (DAI), functions upstream of RIPK3-MLKL to initiate the formation of the necrosome [ 16 ]. (biomedcentral.com)

Adhesion of T. cruzi trypomastigotes to components of the extracellular matrix (ECM) is an important step in mammalian host cell invasion. (omicsdi.org)

Hudson, W.H. & Ortlund, E.A. The structure, function and evolution of proteins that bind DNA and RNA. (nature.com)
HMGB1 function is usually modified in diabetes, as well as the signaling systems brought on by this proteins are not completely understood. (exposed-skin-care.net)
The Drosophila Extramacrochaetae protein antagonizes the proneural function of the Achaete and Scute proteins in the generation of the adult fly sensory organs. (biologists.com)
Various SlitTrack2 gene mutations related to schizophrenia and bipolar disorder have actually been reported previously, but how these mutations affect the function of the SlitTrack2 protein and cause brain disease has not been clearly known. (crunchtime-records.com)
This study detected various SlitTrack2 gene mutations that were not previously reported through exome sequencing in patients with brain, mental and developmental disorders and systematically analyzed how these mutations affect the structure and function of the SlitTrack2 protein. (crunchtime-records.com)
The N-terminal regulatory domain name bears a disheveled, Egl-10, pleckstrin (DEP) domain name implicated in membrane association and a high-affinity cAMP-binding domain name (cAMP-B). Epac2 additionally contains a second low-affinity cAMP-A domain name of uncertain biological function. (researchensemble.com)
Blom A. M. , Webb J., Villoutreix B. and *Dahlbäck B. (1999) A cluster of positively charged amino acids in the N-terminal modules of C4BP a-chain is crucial for the C4b binding and factor I cofactor function. (lu.se)

Meanwhile, synaptic adhesion proteins bind with each other physically and chemically and then transmit cellular signals in both directions. (crunchtime-records.com)
PSPN not only binds GFRα4 but also signals in neurons mediated by GFRα1 [ 5 ]. (medsci.org)

Blom A. M . , Berggård K., Webb J. H., Villoutreix B., Lindahl G. and Dahlbäck B. (2000) Human C4b-binding protein has overlapping but not identical binding sites for C4b and streptococcal M-proteins. (lu.se)

Anatomy18

Organisms16

Diseases1

Chemicals and Drugs118

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes77

Disciplines and Occupations1

Information Science3

Health Care2

Molecule5

Genes11

Epithelial1

Receptor12

Chromatin2

Molecules4

Receptors3

Homology1

Focal6

Family of proteins1

Cellular Adhesion1

Transcriptional8

Regulator3

Kinetics1

Inhibitor3

Signal transduction1

Cells32

Localization1

Ligand1

Peptides2

Pathway2

Sequences1

Inhibition4

Motif1

Kinase3

Transcription factors1

Histone2

Interaction4

Fusion proteins2

Nuclear1

Complexes1

Processes5

Gene expression2

Physiology1

Zinc finger1

Proliferation1

Disrupts1

Integrin1

Viral1

Extracellular1

Function7

Signals2

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