Adhesion activation receptors lymphocyte homing. Medical search. Frequent questions

Lymphocyte homing receptors are cell adhesion molecules expressed on lymphocyte cell membranes that recognize addressins on target tissues. (wikipedia.org)
These diverse tissue-specific adhesion molecules on lymphocytes (homing receptors) and on endothelial cells (vascular addressins) contribute to the development of specialized immune responses. (wikipedia.org)
High endothelial venules (HEVs) are cells found in secondary lymphoid organs that express large quantities of cell adhesion molecules, enabling undifferentiated lymphocytes to bind. (wikipedia.org)
HEVs develop from cytokine production after exposure to antigen and express adhesion molecules from the selectin family, mucin-like family, and the Ig superfamily. (wikipedia.org)
Molecules on the surface of lymphocytes called homing receptors interact specifically with HEV and play a central role in the migration. (wdv.com)
In the present study we demonstrate that Tpo can stimulate the adhesion of the Mo7e progenitor cell line to fibronectin (Fn) as well as vascular cell adhesion molecule-1 through activation of very late antigen (VLA)-4 and VLA-5, adhesion molecules previously demonstrated to be involved in regulation of steady state hemopoiesis. (ox.ac.uk)
Thus, Tpo might play an important role in early hemopoiesis, at least in part through its ability to promote adhesion through activation of adhesion molecules on hemopoietic progenitor cells. (ox.ac.uk)
A number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathogenic organisms. (reactome.org)
The presence of these molecules on somatic cells is picked up by C-lectin NK immune receptors. (reactome.org)
For example, lymphoid cells may fine tune the presence and concentration of adhesion molecules belonging to the IgSF, Selectin and Integrin class that interact with a number of vascular markers of inflammation. (reactome.org)
Circulating memory T cells can be divided into tissue-specific subsets, which traffic through distinct tissue compartments during physiologic immune surveillance, based on their expression of adhesion molecules and chemokine receptors. (biomedcentral.com)
It also induces vascular adhesion molecule-1 (VCAM-1), L-selectin, lymphocyte function-associated antigen-1 (LFA-1), and additional TCS ERK 11e (VX-11e) molecules that can result in the homing of immune cells to the glands12. (isct-eu2018.com)
Lymphocyte function-associated antigen 1 (LFA-1), a member of the integrin family of adhesion molecules, is expressed mainly on αß T cells. (bvsalud.org)
LECs can modulate dendritic cell function, present antigens to T cells on MHC class I and MHC class II molecules, and express immunomodulatory cytokines and receptors, which suggests that their roles in adaptive immunity are far more extensive than previously realized. (jci.org)
Cell migration is mainly governed by adhesion of cells to substrates (other cells or connective tissue) and by extracellular signalling molecules acting as motogenic stimuli or directional guidance cues 2 . (nature.com)
Rabbit vascular endothelial adhesion molecules: ELAM-1 is most elevated in acute inflammation, whereas VCAM-1 and ICAM-1 predominate in chronic inflammation. (cdc.gov)

L-selectin is able to mediate vessel adhesion whereas α4 integrins, α4β1 or α4β7, can perform primary or secondary adhesion through a stronger tethering and even contribute to transendothelial migration of lymphocytes. (wikipedia.org)

α4β7 is an α4 integrin class homing receptor that targets lymphocytes in the gut expressing mucosal adhesion molecule-1(MAdCAM-1), mostly expressed in Peyer's patches. (wikipedia.org)
associated with skin-homing) as well as the expression of integrin α4β7 and CCR9 (associated with gut-homing) was analyzed on CD4+ memory T cells in CSF from individuals with non-inflammatory neurological diseases using flow cytometry. (biomedcentral.com)
For instance, studies in mice have demonstrated that CD4+ T cells activated in cutaneous lymph nodes upregulate trafficking determinants specific for the skin, such as P-selectin ligand, while T cells responding to antigen in intestinal lymph nodes express high levels the gut-associated adhesion molecule integrin α4β7 and acquire responsiveness to the intestinal CC-chemokine ligand CCL25 [ 2 ]. (biomedcentral.com)
Cytoplasmic actin-binding proteins such as talin kindlin and filamin (FLN) bind directly to integrin tails and positively or negatively regulate integrin function: the currently available evidence shows that talin and kindlin promote integrin activation whereas FLN is definitely a negative regulator of integrin functions such as cell adhesion and migration8 9 FLN also serves as a scaffolding protein for Rho or Ras family members10. (hiv-proteases.com)
Integrin αLß2 (CD11a/CD18, CD11a) is a critical leukocyte adhesion molecule in leukocyte arrest and immunological synapse formation. (bvsalud.org)

This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. (antibodies-online.com)
Here we report that when mice lacking the RelA subunit of NF-κB are brought to term by breeding onto a tumor necrosis factor receptor (TNFR)1-deficient background, the mice that are born lack lymph nodes, Peyer's patches, and an organized splenic microarchitecture, and have a profound defect in T cell-dependent antigen responses. (rupress.org)
Tumor-infiltrating lymphocyte (TIL) therapy is a type of adoptive cellular therapy by harvesting infiltrated lymphocytes from tumors, culturing and amplifying them in vitro and then infusing back to treat patients. (biomedcentral.com)
Its diverse TCR clonality, superior tumor-homing ability, and low off-target toxicity endow TIL therapy unique advantages in treating solid tumors compared with other adoptive cellular therapies. (biomedcentral.com)
Currently, the most widely-used TIL production method is to isolate infiltrating lymphocytes from tumor tissues and then culture and expand these cells in vitro. (biomedcentral.com)
Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)
The prevention of immune cell access into the tumor, the accumulation of inhibitory FoxP3 + regulatory T cells (Treg) and/or myeloid-derived suppressor cells (MDSCs), the activation of negative immunoregulatory pathways, and the dysregulation of effector T cells are all mechanisms by which tumors evade the host immune system. (biomedcentral.com)
It has been proposed that four different types of tumor microenvironment exist based on the presence or absence of tumor-infiltrating lymphocytes and programmed death-ligand 1 (PD-L1) expression. (aacrjournals.org)
Modification with chimeric antigen receptors (CARs) endows T cells with tumor specific cytotoxicity and thus induce anti-tumor immunity against malignancies. (ijbs.com)
Advances in our understanding on the interaction between the immune system and tumor cells have contributed to the rapid development of novel therapeutic strategies based on chimeric antigen receptor (CAR) or T cell receptor (TCR) modified T cells. (ijbs.com)
Adhesion with HA plays an important role in cell migration, tumor growth and progression. (novoprolabs.com)
Lastly, we show that tumor necrosis factor a stimulates both DC adhesion and transmigration of dermal LEC monolayers in vitro and that the process is efficiently inhibited by ICAM-1 and VCAM-1 adhesion-blocking monoclonal antibodies. (birmingham.ac.uk)

B lymphocytes migrate better to mucosa-associated lymphoid tissue (Peyer's patches), and T lymphocytes preferentially to the peripheral lymph nodes. (wikipedia.org)
Naive lymphocytes are able to circulate into secondary lymphoid tissues, Peyer's patches, lymph nodes, and the spleen. (wikipedia.org)
When rolling lymphocytes are exposed to chemokines present within the HEV chemokine signalling coupled with Gi proteins activates leukocyte function-associated-1 (LFA-1) a major receptor that mediates homing to peripheral lymph nodes. (hiv-proteases.com)
Intro Chronic lymphocytic leukemia (CLL) probably the most common type of adult leukemia in Traditional western countries is seen as a the progressive build up of phenotypically adult monoclonal LY2784544 (Gandotinib) B lymphocytes in the peripheral bloodstream lymph nodes and bone tissue marrow. (cell-signaling-pathways.com)
CD62L is important in lymphocyte homing to high endothelial venules (HEV) in peripheral lymph nodes and leukocyte "rolling" on activated endothelium. (biolegend.com)

We show that inflammatory cytokines trigger activation of dermal lymphatic endothelial cells (LECs), leading to expression of the key leukocyte adhesion receptors intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin, as well as a discrete panel of chemokines and other potential regulators of leukocyte transmigration. (birmingham.ac.uk)

Functionally, CD44 is involved in lymphocyte recirculation, adhesion, activation, lymph node homing, and to a larger extent in other tissue types, cell- cell and cell-matrix interactions. (roche.com)
CD44 is also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. (novoprolabs.com)

Flow cytometric analysis of CD44 on human peripheral blood lymphocytes. (bdbiosciences.com)
and (iii) the dramatic reductions to lymphocyte numbers and function 1-2 h after exercise reflects a transient and time-dependent redistribution of immune cells to peripheral tissues, resulting in a heightened state of immune surveillance and immune regulation, as opposed to immune suppression. (frontiersin.org)
The differentiation of naïve T cells into an activated memory phenotype is characterized by an extensive change in the expression of trafficking determinants, resulting in the acquisition of homing receptors that enable the cells to migrate from the circulation into peripheral tissues. (biomedcentral.com)
Lymphocytes recirculate continuously between the peripheral lymphoid cells via the blood and lymphatic systems1 2 Lymphocytes enter across the high endothelial venule (HEV) into lymphoid cells via a specialized connection with venule. (hiv-proteases.com)
Naive lymphocytes (TN) are 1st captured and then they undergo rolling because of poor binding between L-selectin and sulfated sialyl Lex-related O-glycans indicated on HEVs collectively called peripheral lymph node addressin (PNAd). (hiv-proteases.com)
18 Studies on B cell receptor gene usage of these infiltrating IgG positive lymphocytes demonstrate that they are of peripheral and not mucosal origin in UC versus controls. (bmj.com)

CD44 is an 80-95 kDa type I transmembrane glycoprotein, also known as Phagocytic glycoprotein-1 (Pgp-1), or Extracellular matrix receptor type III (ECMR-III). (bdbiosciences.com)
CD44 is the receptor for hyaluronic acid. (bdbiosciences.com)
CD44 has functional roles in cell migration, lymphocyte homing and adhesion during hematopoiesis and lymphocyte activation. (bdbiosciences.com)
CD44 is a cell-surface glycoprotein that plays a role in cell-cell interactions, cell adhesion and migration. (whispermovie.com)
CD44 is an integral cell membrane glycoprotein with a postulated role in matrix adhesion lymphocyte activation and lymph node homing. (wdv.com)
1990) demonstrated that CD44 is the main cell surface receptor for hyaluronate. (wdv.com)
Interestingly, high levels of the adhesion molecule CD44 on leukemic cells are essential to generate leukemia. (bioxcell.com)
Language": "en", "Country": "XG", "Code": "Storage Conditions (Product)" }, { "Name": "Content", "Value": "Anti-CD44 (SP37) Rabbit Monoclonal Primary Antibody contains sufficient reagent for 50 tests. (roche.com)
Language": "en", "Country": "XG", "Code": "Content" }, { "Name": "Intended Use", "Value": "L'anticorps Anti-CD44 (SP37) Rabbit Monoclonal Primary Antibody est dirigé contre la protéine CD44. (roche.com)
Le CD44 est une protéine du récepteur transme\u0002mbranaire de type I exprimée dans plusieurs types de cellules, notamment les lymphocytes T et B, les monocytes,les granulocytes, les érythrocytes, les fibroblastes, les cellules épithéliales et les mastocytes. (roche.com)
Cet anticorps est conçu pour être utilisé en diagnostic in vitro (DIV)", "Language": "fr", "Country": "XG", "Code": "Intended Use" }, { "Name": "Background Information", "Value": "Anti-CD44 (SP37) is a rabbit monoclonal antibody produced against a conserved region of the CD44 protein. (roche.com)
1,2,3,4 CD44 is one of two major hyaluronan (HA) binding proteins required for activation of hyaluronan. (roche.com)
1. Aruffo A, Stamenkovic I, et al.CD44 is the principal cell surface receptor for hyaluronate. (roche.com)
5. Bartolazzi A., Nocks A., et al.Glycosylation of CD44 is implicated in CD44-mediated cell adhesion to hyaluronan. (roche.com)

The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. (antibodies-online.com)
1989) refined the assignment of the lymphocyte homing receptor gene to 11pter-p13 by study of Chinese hamster-human cell hybrids in which the human parent cells had various deletions of human chromosome 11. (wdv.com)
Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
Several studies have suggested that short-acting beta2-agonists such as albuterol may produce adverse outcomes (eg, decreased peak flow or increased risk of exacerbations) in patients homozygous for arginine (Arg/Arg) at the 16th amino acid position of beta-adrenergic receptor gene compared with patients homozygous for glycine (Gly-Gly). (medscape.com)

Lymphocyte homing refers to adhesion of the circulating lymphocytes in blood to specialized endothelial cells within lymphoid organs. (wikipedia.org)

Upon exposure to antigens, lymphocytes lack homing ability during a period of sessile differentiation and cell division, and antigen specific lymphocytes are stored in the spleen for 1-3 days. (wikipedia.org)
The microarchitecture of secondary lymphoid organs plays an important role in facilitating the activation and maturation of antigen-specific lymphocytes and ultimately the mounting of an adaptive immune response ( 1 ). (rupress.org)

VP79s showed selective cytotoxicity in patient derived MM cells compared to normal donor lymphocytes and reduced the viability of MM patient samples in a dose-responsive manner suggesting its potential as an anti-MM therapeutic. (confex.com)
Examine pre and post cell surface expression analysis using scleroderma fibroblasts in the presence of normal donor lymphocytes and immune modulatory therapy. (immune3d.com)

Furthermore, lymphocytes can alter cell adhesion molecule "activatability" to increase binding ability. (wikipedia.org)
Additionally, α4β1 with the ligand vascular adhesion molecule-1(VCAM-1) function in lymphocyte trafficking and inflammation. (wikipedia.org)
Thrombopoietin promotes adhesion of primitive human hemopoietic cells to fibronectin and vascular cell adhesion molecule-1: role of activation of very late antigen (VLA)-4 and VLA-5. (ox.ac.uk)
This may be presented directly to a specific T-cell receptor in the context of an MHC molecule. (reactome.org)
We reasoned that a bias (either enrichment or depletion) of CSF T cell expression of known organ-specific trafficking determinants might suggest that homing of T cells to the subarachnoid space could be governed by a CNS-specific adhesion molecule or chemokine receptor. (biomedcentral.com)
In this study, TRAIL receptor-Death receptor 4 (DR4), DR5, and LFA-1 ligand-intercellular adhesion molecule-1 (ICAM-1) were upregulated in IL-1ß-stimulated HFLS-RA. (bvsalud.org)
Immunoadhesin structure The majority of immunoadhesins combine the hinge and Fc regions of an IgGl heavy chain with the extracellular domain (ECU) of a type I transmembrane protein, usually a receptor or an adhesion molecule (Fig. 1). (coek.info)

In addition, immunotherapeutic strategies such as adoptive cell therapy and chimeric antigen receptors can be extremely expensive. (immune3d.com)

In addition to α4 integrins, LFA-1 and Mac-1 mediate the prevention of lymphocyte transendothelial migration into target tissues. (wikipedia.org)
CD9 antigen modulates cell adhesion, migration and platelet activation. (techblessing.com)
Genome-wide microarray analyses of the lungs identified a range of differentially expressed genes that potentially function in the acute-to-chronic transition through pathways involving immune and inflammatory regulation, responses to stress and extracellular stimuli, and cell migration and adhesion. (cdc.gov)
It may be achieved, at least partially, by more extensive basic studies investigating the spatiotemporal dynamics of T cell activation by CARs and unraveling the connection between T cell migration in solid tumors and the effectiveness in eradication of solid tumors and metastases [ 5 ]. (ijbs.com)
IMMUNE 3D ® aims to elucidate the role of lymphocyte migration and infiltration in regulating the fibrotic diseases. (immune3d.com)
Likewise, lysophosphatidic acid receptor 1 (LPA 1 ) is implicated in cancer cell proliferation and migration. (biomedcentral.com)
To elucidate the distinctive molecular characteristics and functional implications of the CXCR4-LPA 1 heteromer, we performed various assays, including cAMP, BRET for G protein activation, β-arrestin recruitment, ligand binding, and transwell migration assays. (biomedcentral.com)

The 515 monoclonal antibody can reportedly block cellular adhesion to hyaluronic acid. (bdbiosciences.com)
It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). (antibodies-online.com)
By mimicking hyaluronic acid-rich niche in the mesenchyme of embryonic submandibular glands (eSMGs) with NiCHE coating on substrates including polycarbonate membrane, stiff agarose hydrogel, and polycaprolactone scaffold, we observed significantly enhanced cell adhesion, vascular endothelial and progenitor cell proliferation, and branching of in vitro -cultured eSMGs. (bioxcell.com)

Mediated by lymphocyte receptors and vascular ligand interactions, "tethering" is a reversible linkage that leads to either rolling along the vessel wall or transient immediate arrest. (wikipedia.org)
The most common example of this type of fusion protein combines the hinge and Fc regions of an immunoglobulin (Ig) with domains of a cell-surface receptor that recognizes a specific ligand (Box 1). (coek.info)
CXC chemokine receptor 4 (CXCR4) and its ligand CXCL12, both of which are overexpressed in many cancers, play a pivotal role in metastasis. (biomedcentral.com)
Ligand binding induces conformational changes in GPCRs followed by intracellular signaling through activation of heterotrimeric G proteins and recruitment of β-arrestins. (biomedcentral.com)

The process of lymphocyte homing is deliberate, mediated by lymphocyte-endothelial recognition mechanisms that enable antigen-specific immune responses. (wikipedia.org)
Lymphocyte homing receptor control of organ-specific lymphocyte trafficking is thought to prevent autoreactivity in immune responses during B and T cell differentiation. (wikipedia.org)
Mature lymphocytes are constantly recirculating in the blood and can traffic to secondary lymphoid tissue as well as target tissue including mucosal tissues of the lamina propria, inflammation, and other extralymphoid immune effector sites. (wikipedia.org)
While trafficking of T cells to the skin and gut is well characterized, less is known about the mechanisms governing homing of T cells across the choroid plexus into the CSF during immune surveillance of the healthy brain [ 11 ]. (biomedcentral.com)
In vivo activation of a T helper 2-driven innate immune response in lung fibrosis induced by multi-walled carbon nanotube s. (cdc.gov)
Our study uncovers activation of a Th2-driven immune/inflammatory response during pulmonary fibrosis development induced by MWCNT. (cdc.gov)
because it combines 'immune and 'adhesion' functions. (coek.info)
it is only effective in 30-40% of patients and nonspecific immunologic activation can lead to immune-related adverse events, including muscle weakness, joint pain, inflammatory arthritis, and myositis. (immune3d.com)
The exit of antigen-presenting cells and lymphocytes from inflamed skin to afferent lymph is vital for the initiation and maintenance of dermal immune responses. (birmingham.ac.uk)
they have receptors for the crystallizable fragment (Fc) region of immunoglobulin (Ig) G and for complement, which enable them to bind with immune complexes and present the complex to B cells in germinal centers of secondary lymphoid organs. (msdmanuals.com)

Naive lymphocyte extravasation into Peyer's patches is often mediated by L-selectin and limited expression of α4 integrins and other homing receptors prevents these lymphocytes from accessing mucosal effector tissue. (wikipedia.org)

Activation of integrins is definitely regulated by relationships with numerous intracellular adaptor proteins7. (hiv-proteases.com)

CD62L is rapidly shed from lymphocytes and neutrophils upon cellular activation and the expression levels of CD62L (in conjunction with other markers) have been used to distinguish naïve, effector, and memory T cells. (biolegend.com)

Cutaneous infiltration by neoplastic lymphocytes may be seen in acute myeloid leukemia , acute lymphocytic leukemia , chronic myeloid leukemia , chronic lymphoid leukemia , hairy cell leukemia, prolymphocytic leukemia, chronic myelomonocytic leukemia, and myelodysplastic syndromes . (medscape.com)

1989) demonstrated that the lymphocyte homing receptor is identical to the human leukocyte surface glycoprotein called CDw44, on the basis of studies at the Third International Workshop on Human Leukocyte Differentiation Antigens. (wdv.com)

Unlike the ability of these cytokines to synergistically enhance growth of Mo7e as well as normal progenitor cells, no synergy was observed with regard to their ability to enhance adhesion. (ox.ac.uk)
Induction of Th2 cytokines took place in CD4+ T lymphocytes indicating activation of Th2 cells. (cdc.gov)

Once in the lymph node, the cells experience a second chemokine, (C-C motif) ligand19 (CCL19), which interacts with the same receptor (C-C chemokine receptor 7, CCR7) but interacts only weakly with sugars. (nature.com)

Lymphoid cells are able to regulate their location and movement in accordance to their state of activation, and home in on tissues expressing the appropriate complementary ligands. (reactome.org)

Cutaneous T-cell lymphoma (CTCL) (see the image below) is a heterogeneous group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin, with no evidence of extracutaneous disease at the time of diagnosis. (medscape.com)
Cutaneous T-cell lymphomas (CTCLs) are malignancies of skin-homing lymphoid cells, that have up to now not been investigated thoroughly for common oncogenic mutations. (techblessing.com)
Intro Cutaneous T-cell lymphomas (CTCLs) are uncommon malignancies of skin-homing T lymphocytes. (techblessing.com)

Beyond chemokines our approach is broadly applicable to alternative systems of chemo- and haptotaxis such as cells migrating along gradients of adhesion receptor ligands vs. any soluble cue. (nature.com)

The mouse monoclonal antibody Hermes-3 recognizes the 85-95 kD human lymphocyte homing receptor. (wdv.com)

Rheumatoid arthritis (RA) is characterized by synovial proliferation and lymphocyte accumulation leading to progressive damage of the periarticular bone and the articular cartilage. (bvsalud.org)

CXCL12 activation rapidly reduced the kinase activity of LOK to one-third which was consistent with the kinetics of reduction of the phosphorylation of ERM proteins. (hiv-proteases.com)
These data suggest that OCLN Rap1-GDP is required for LOK activation and takes on an important part in the phosphorylation of ERM proteins in resting cells. (hiv-proteases.com)
Activation of RAS causes RAF recruitment and activation by phosphorylation. (techblessing.com)
Furthermore, induction involved activation of a Th2 cell-specific signaling pathway through phosphorylation of STAT6 and up-regulation of GATA-3 to mediate the transcription of Th2 target genes. (cdc.gov)
Examination of upstream mediators of STAT3 signalling suggested a mechanism for VP79s inhibition of STAT3 activation via inhibition of JAK2 phosphorylation and downregulation of the IL-6 receptors, CD126 and CD130. (confex.com)

the lymphocyte homing receptor' 'also appears to be identical'' to the Pgp-1 glycoprotein of Omary et al. (wdv.com)

This combination of effector cells requires a crosslinking antigen to evoke an antibody driven PMN inflammatory response via their Fc receptors. (bmj.com)

Free lymphocytes constantly recirculate in blood after their re-entry from lymphoid tissue, via lymphatic and thoracic ducts. (wikipedia.org)

While attached to the vessel, lymphocytes test target tissue for chemokines and pro-adhesive factors that then prompt "arrest. (wikipedia.org)

The identification of cognate antigen sets off activation, cytokine secretion, and proliferation25. (isct-eu2018.com)
Activated γδ T cells exhibit strong cytotoxic activity and cytokine secretion functions and are effective antitumor lymphocytes with simple and direct recognition modes and rapid responses. (explorationpub.com)

solid course="kwd-title" Keywords: plasmacytoma, nasal area, sinusitis Launch Plasma cells are older B lymphocytes typically within high or low volume in various tissue and organs and in inflammatory foci generally. (siamtech.net)
Moreover, our findings propose a therapeutic potential in combined CXCR4 and LPA 1 inhibitors for cancer and inflammatory diseases associated with these receptors, simultaneously raising concerns about the use of LPA 1 antagonists alone for such conditions. (biomedcentral.com)

Furthermore, second messenger inhibitors implicated essential and complimentary roles of phosphatidylinositol-3-kinase and protein kinase C in mediating Tpo-induced adhesion. (ox.ac.uk)
An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. (lookformedical.com)
EB-virus latent membrane protein 1 potentiates the stemness of nasopharyngeal carcinoma via preferential activation of PI3K/AKT pathway by a positive feedback loop. (novoprolabs.com)
G protein-coupled receptor heteromerization is believed to exert dynamic regulatory impact on signal transduction. (biomedcentral.com)
G protein-coupled receptors (GPCRs) are the largest family of plasma membrane receptors that orchestrate intracellular signaling in response to diverse extracellular stimuli [ 1 , 2 ]. (biomedcentral.com)

Finally, it retrospectively analyze the activation strategies and clinical relevance of existing γδ T cell adoptive immunotherapies. (explorationpub.com)

Coexpression of LPA 1 with CXCR4 reduced CXCL12-mediated cAMP inhibition, ERK activation, Gα i/o activation, and β-arrestin recruitment, while CXCL12 binding to CXCR4 remained unaffected. (biomedcentral.com)

other lymphocyte subsets. (123dok.net)

Prolonged use may be associated with tachyphylaxis due to beta2-receptor downregulation and receptor hyposensitivity. (medscape.com)

Organ-specific lymphocyte homing is important for antigen-specificity and in avoiding autoimmune cross-reactions. (wikipedia.org)

L-selectin, for example, is also able to be cleaved by an enzyme, ensuring proper binding of lymphocytes and allowing release of non-target cells. (wikipedia.org)

VP79s was shown to overcome adhesion mediated drug resistance in MM cells in a co-culture model system with bone marrow stromal cells which induces MM cell resistance to treatment with the proteasome inhibitor bortezomib. (confex.com)

Additional reported applications (for the relevant formats) include: immunoprecipitation 1-3 , complement-dependent cytotoxicity 4 , in vivo and in vitro blocking of adhesion 1-3,5 , and immunohistochemical staining of acetone-fixed frozen sections and zinc-fixed paraffin-embedded sections 6 . (biolegend.com)

Using mouse-human T-lymphocyte hybrids and hybrids of Chinese hamster ovary cells with human amniotic fibroblasts, Ala-Kapee et al. (wdv.com)

Antigen-antibody complexes may anchor to the cell via a small number of lymphoid-specific Fc receptors that may, in turn, influence cell function further. (reactome.org)

Tpo-induced adhesion was concentration dependent, reached a maximum following 30 min, and appeared to be dependent on adenylate cyclase, and tyrosine kinase activity. (ox.ac.uk)
In Spa-1-expressing cells the basal kinase activity increased to 1.8 times and hardly decreased after CXCL12 p-Coumaric acid activation indicating that the conversion to Rap1-GTP is important for reduction of LOK kinase activity by chemokine (Fig. 5g). (hiv-proteases.com)

Anatomy53

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Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Psychiatry and Psychology1

Phenomena and Processes45

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Information Science4

Molecules16

Transendothelial migration of lymphocytes1

Integrin5

Tumor12

Lymph nodes5

Leukocyte adhesion1

Recirculation2

Peripheral6

CD4414

Gene4

Endothelial cells1

Antigen specific lymphocytes2

Normal donor lymphocytes2

Molecule7

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Migration7

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Ligand4

Immune10

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Infiltration1

Antigens1

Cytokines2

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