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  • adcy9
  • There are ten known isoforms of adenylyl cyclases in mammals: ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 ADCY10 These are also sometimes called simply AC1, AC2, etc., and, somewhat confusingly, sometimes Roman numerals are used for these isoforms that all belong to the overall AC class III. (wikipedia.org)
  • PACAP
  • The activation of pituitary adenylate cyclase-activating peptide (PACAP) systems in the BNST mediates many consequences of chronic stressor exposure that may engage in part downstream corticotropin-releasing hormone (CRH) signaling. (springer.com)
  • receptors
  • The ±-isoprenaline subsensitivity of cardiac adenylate cyclase can, thus, be attributed to a defective enzymatic system and not to a reduction in the number of beta-adrenoceptors implying that the internal components of the system were more sensitive to acute ischemia than the outward oriented hormone receptors. (springer.com)
  • Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase. (wikipedia.org)
  • Adenylyl cyclases are often activated or inhibited by G proteins, which are coupled to membrane receptors and thus can respond to hormonal or other stimuli. (wikipedia.org)
  • secretin
  • Chatelain P, Robberecht P, Waelbroeck M, De Neef P, Camus JC, Nguyen Huu A, Roba J, Christophe J (1983) Topographical distribution of the secretin- and VIP-stimulated adenylate cyclase system in the heart of five animal species. (springer.com)
  • myocardial
  • We evaluated the effects of ischemic injury on the myocardial adenylate cyclase system, 5 h after ligation of the left anterior descending coronary in 5 anesthetized dogs. (springer.com)
  • human
  • Perturbations in adenylyl cyclase activity have been implicated in alcohol and opioid addiction and is associated with human diseases, including thyroid adenoma, Anthrax, precocious puberty in males and chondrodysplasia punctata diseases. (wikipedia.org)
  • These adenylyl cyclases are the most familiar based on extensive study due to their important roles in human health. (wikipedia.org)
  • stimulation
  • Adenylate cyclase activities in the basal state and under stimulation with NaF, forskolin, Gpp(NH)p, ±-isoprenaline and VIP were all markedly and similarly reduced, being only about 30% of comparable activities in membranes from control areas. (springer.com)