• We describe 3 culture-proven cases of adenovirus serotype 14 infection in New Brunswick, Canada, during the summer of 2011. (cdc.gov)
  • In contrast to the respiratory serotype Ad5, the preferential ocular tropism of Ad19 and subsequent productive infection likely depends both on its control of some host differentiation/development genes and on the different host defense /inflammatory responses it elicits. (arvojournals.org)
  • Latent infection with adenovirus and respiratory syncytial virus (RSV) is associated with chronic obstructive pulmonary disease (COPD). (spandidos-publications.com)
  • According to previous studies, adenovirus and RSV may result in chronic infection in the lungs ( 2 , 6 - 10 ). (spandidos-publications.com)
  • However, chronic adenovirus and RSV infection data are currently unclear and, to the best of our knowledge, few longitudinal studies have been conducted on the association between chronic infection and COPD. (spandidos-publications.com)
  • 2021. The fiber knob protein of human adenovirus type 49 mediates highly efficient and promiscuous infection of cancer cell lines using a novel cell entry mechanism . (cardiff.ac.uk)
  • Human adenovirus (Adv) infection is responsible for most community-acquired pneumonia in infants and children, which results in significant morbidity and mortality in children every year. (hindawi.com)
  • Knowing the miRNA expression profile will help understand the role of miRNAs in modulating the host response to adenovirus infection and possibly improve the diagnosis of adenovirus-infected pneumonia. (hindawi.com)
  • Human adenovirus (Adv) infection is responsible for most community-acquired pneumonia in infants and children [ 1 , 2 ]. (hindawi.com)
  • Immunological studies with blood samples from severe cases of adenovirus infection is necessary to understand the pathogenesis of the hybrid variant among children. (telegraphindia.com)
  • The index case and a further individual were diagnosed with an adenovirus serotype 4 co-infection. (biomedcentral.com)
  • The relevance of the adenovirus co-infection remains unclear and merits further investigation. (biomedcentral.com)
  • Viral conjunctivitis is a highly contagious acute conjunctival infection usually caused by an adenovirus. (msdmanuals.com)
  • Adenovirus Infections Infection with one of the many adenoviruses may be asymptomatic or result in specific syndromes, including mild respiratory infections, keratoconjunctivitis, gastroenteritis, cystitis, and primary. (msdmanuals.com)
  • four (8%) did not test positive for adenovirus. (cdc.gov)
  • Of patients tested, 268 were positive for adenovirus. (wikipedia.org)
  • The results showed that three sputum samples were positive for adenovirus in patients experiencing an exacerbation, while one was positive among the patients in a stable condition. (spandidos-publications.com)
  • Adenovirus serotype 14 (Ad14) is a serovar of adenovirus which, unlike other adenovirus serovars, is known to cause potentially fatal adenovirus infections. (wikipedia.org)
  • Human adenovirus, a DNA virus, is associated with respiratory infections and smoking-induced lung function impairment ( 2 , 3 ). (spandidos-publications.com)
  • Objective -To detect bovine adenovirus serotype 7 (BAV-7) infections in calves by use of viral isolation and serologic testing. (avma.org)
  • Dr. Potter] Adenoviruses are respiratory DNA viruses that primarily cause respiratory infections, but they can also cause gastrointestinal infections and conjunctivitis. (cdc.gov)
  • Other countries have documented problems with adenovirus infections in their military populations. (cdc.gov)
  • Usually, adenovirus is known to cause mild infections. (telegraphindia.com)
  • Adv infects the host cells through binding to different cellular receptors such as coxsackievirus and adenovirus receptor (CAR) [ 12 ]. (hindawi.com)
  • The coxsackievirus and adenovirus receptor (CAR) has been identified as the cellular receptor for group B coxsackieviruses, including serotype 3 (CVB3). (rcsb.org)
  • The vaccine - developed through a collaboration between Beth Israel Deaconess Medical Center (BIDMC) and J&J - uses a common cold virus, called adenovirus serotype 26 (Ad26), to deliver the SARS-CoV-2 spike protein into host cells, where it stimulates the body to raise immune responses against the coronavirus. (savedelete.com)
  • Janssen's Ad26.Mos4.HIV is a tetravalent vaccine candidate containing recombinant adenovirus serotype 26 (Ad26) vectors with mosaic inserts. (precisionvaccinations.com)
  • Jcovden Janssen COVID-19 Vaccine (Ad26.COV2.S) Johnson & Johnson is an adenovirus serotype 26 (Ad26) vector-based vaccine. (precisionvaccinations.com)
  • Recombinant adenovirus type 5 (rAd) has been used as a vaccine platform against many infectious diseases and has been shown to be an effective vaccine vector. (mdpi.com)
  • In a phase II/III clinical trial intraperitoneal (i.p.) administration of a group C adenovirus vector (Ad5) caused bowel adhesion formation, perforation and obstruction. (ox.ac.uk)
  • Intro Adenovirus vectors are believed a respected viral vector system for vaccines for their powerful immunogenicity and making feasibility. (synanet2020.com)
  • A simian adenoviral vector termed adenovirus C68 (AdC68) was generated as a molecular clone to express the glycoprotein of rabies virus. (wistar.org)
  • We characterized two immunodominant CD8 T cell populations generated in response to immunization of BALB/c mice with a replication-deficient adenovirus serotype 5 vector expressing the HIV-derived Gag and Pol proteins at equivalent levels. (nih.gov)
  • The strongest adenovirus vectors for make use of as vaccines derive from adenovirus serotype 5 (Advertisement5) (1C6). (synanet2020.com)
  • Adenovirus-based vectors can handle generating powerful and protecting T cell and antibody reactions in animal versions (7C17), and medical data conclusively display that Advertisement5 vectors can induce powerful Compact disc8+ and Compact disc4+ T cell and antibody reactions in vaccinated volunteers (18C25). (synanet2020.com)
  • They support the development of E1/E4-removed vectors predicated on Advertisement5 aswell as choice adenovirus serotypes (43C46). (synanet2020.com)
  • Adenovirus (Ad) vectors are among the most commonly used viral vectors in gene therapy clinical trials because they have the following advantages. (hindawi.com)
  • On the other hand, Ad vectors also have a number of disadvantages, including their low transduction efficiency in cells lacking coxsackievirus-adenovirus receptor (CAR) and their induction of innate immune responses. (hindawi.com)
  • Adenovirus serotype 5 vaccine vectors trigger IL-27-dependent inhibitory CD4 + T cell responses that impair CD8 + T cell function. (bvsalud.org)
  • Isolates from 50 (74%) of these patients were available for further adenovirus typing at either CDC or OSPHL. (cdc.gov)
  • Eighty-eight adenovirus (Ad) isolates and associated clinical data were collected from walk-in patients with influenza-like illness in Egypt during routine influenza surveillance from 1999 through 2002. (utmb.edu)
  • The isolates included common species B1 serotypes (Ad3 and Ad7), common species C serotypes (Ad1, Ad2, and Ad5), the less common species B2 serotype Ad11, and three isolates of the rare species B1 serotype Ad16. (utmb.edu)
  • The deduced amino acid sequences of the outer capsid protein, VP7, of serotype G1 rotavirus clinical isolates collected over a 6 year period (1990-1995) in Melbourne, Australia, were examined. (microbiologyresearch.org)
  • Antigenic characterization using a panel of serotype G1-specific neutralizing monoclonal antibodies classified lineage II isolates (1990-1993) as monotype G1a while lineage I isolates were classified as monotype G1b (1993-1995). (microbiologyresearch.org)
  • Our results indicated that temporal genetic variation of the VP7 of serotype G1 rotaviruses was associated with changes in the antigenicity of these isolates. (microbiologyresearch.org)
  • Millipore) for adenovirus showed few epithelial cells which had cytoplasmic granular and nuclear positivity. (cdc.gov)
  • Molecular epidemiology analysis of fowl adenovirus detected from apparently healthy birds in eastern China. (cabi.org)
  • Fowl adenovirus is of major concern to the poultry industry worldwidely. (cabi.org)
  • In order to monitor the prevalent status of Fowl adenovirus in China, a total of 1920 clinical samples from apparently healthy birds in the 25 sites of poultry flocks, Slaughterhouse and living bird markets from 8. (cabi.org)
  • 2018. Ad5NULL-A20 - a tropism-modified, αvβ6 integrin-selective oncolytic adenovirus for epithelial ovarian cancer therapies . (cardiff.ac.uk)
  • These peptides were then tested in our previously described oncolytic cancer vaccine platform PeptiCRAd, a vaccine platform that combines an immunogenic oncolytic adenovirus (OAd) coated with tumor antigen peptides. (elifesciences.org)
  • This NIH -funded research aimed to test adenoviral recombinants based on simian serotypes for induction of immune responses to gag/pol/rev/env of HIV -1 or SIV -1 in mouse and primate models. (wistar.org)
  • One simian adenovirus species, SAdV-A, has been recognized by the International Committee on Taxonomy of Viruses ( 2 ). (cdc.gov)
  • In addition, at least 25 simian adenovirus types have been identified ( 3 ). (cdc.gov)
  • We previously reported the detection of several new simian adenovirus strains in fecal specimens from captive monkeys in China ( 3 ). (cdc.gov)
  • Consequently, we further characterized 10 of these novel simian adenovirus strains by sequencing the entire open-reading frames of the hexon genes. (cdc.gov)
  • We performed alignment analysis of the complete nucleotide hexon sequences of the 10 novel strains and of reference human and simian adenoviruses by using the MUSCLE program within the MEGA5 software package ( 6 ). (cdc.gov)
  • Hexon genes of the 10 simian adenovirus strains ranged in length from 2,739 to 2,820 nt and from 913 to 940 aa. (cdc.gov)
  • Comparison of the hexon gene sequences of simian adenovirus types identified in this study with human and simian adenovirus sequences from GenBank revealed 9 previously reported hypervariable regions (HVRs): HVR1-HVR9 ( 5 , 7 ). (cdc.gov)
  • The simian adenovirus types within the same cluster were closely related in all 9 HVRs (data not shown). (cdc.gov)
  • Phylogenetic analysis of complete hexon gene nucleotide sequences from human and simian adenoviruses. (cdc.gov)
  • The AAV1- CAG-GCaMP6f is a pre-packaged rAAV in serotype 1 (with capsid from AAV serotype 1 and 2xITR from AAV serotype 2) which over-expresses genetically encoded calcium indicator GCaMP6f under CAG promoter (also known as CBA promoter). (signagen.com)
  • Lali K. Medina-Kauwe (2013) Development of adenovirus capsid proteins in targeting gene and drug delivery, Therapeutic Delivery , 4(2):267-77. (cedars-sinai.edu)
  • Hexon is the most abundant protein in the icosahedral capsid, and the hexon gene is commonly analyzed to characterize and determine adenovirus types ( 5 ). (cdc.gov)
  • Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR. (expasy.org)
  • 2019. Diversity within the adenovirus fiber knob hypervariable loops influences primary receptor interactions . (cardiff.ac.uk)
  • Adenovirus serotype 14 (Ad14) is a rarely reported but emerging serotype of adenovirus that can cause severe and sometimes fatal respiratory illness in patients of all ages, including healthy young adults. (cdc.gov)
  • Adenovirus also was isolated by culture, confirmed by immunofluorescence assay (IFA), and typed as Ad14 by antibody neutralization assay. (cdc.gov)
  • In comparison with the Ad14 patients, among the 12 adenovirus non-type 14 patients (i.e., all but three) whose medical charts were reviewed, nine (75%) were male. (cdc.gov)
  • Of 118 serotyped patients, 106 (90%) were identified as Ad14. (wikipedia.org)
  • BACKGROUND: In 2007, a US Air Force training facility reported a cluster of severe respiratory illnesses associated with a rare human adenovirus (Ad) serotype, Ad14. (itg.be)
  • CONCLUSIONS: Emergence of Ad14, a rare Ad serotype, caused a protracted outbreak of respiratory illness among military recruits. (itg.be)
  • Sequence homology between human and animal rotavirus serotype-specific glycoproteins. (microbiologyresearch.org)
  • La présente étude réalisée en Jordanie en 2007-2008 a permis d'identifier l'incidence et les caractéristiques cliniques de la gastro-entérite à rotavirus chez les enfants de moins de cinq ans hospitalisés pour une diarrhée. (who.int)
  • Adenovirus antigens can be detected by enzyme immunoassay. (medscape.com)
  • Application of the method allowed an inclusive determination of the serotypes found in the Egyptian respiratory sample set and demonstrated that coinfections are common and may play a previously unrecognized role in adenovirus pathogenesis, evolution, and epidemiology. (utmb.edu)
  • These highly upregulated microRNAs may have crucial roles in Adv pathogenesis and are potential biomarkers for adenovirus-infected pneumonia. (hindawi.com)
  • Originally discovered in 1955, human adenovirus serotype 14 (HAdV-14) had rarely been reported in medical literature for over 30 years. (cdc.gov)
  • 2022. Development of a low seroprevalence, αvβ6 integrin selective virotherapy based on human adenovirus type 10 . (cardiff.ac.uk)
  • Derivation of neutralizing monoclonal antibodies to human rotaviruses and evidence that an immunodominant neutralization site is shared between serotypes 1 and 3. (microbiologyresearch.org)
  • Simple and specific enzyme immunoassay using monoclonal antibodies for serotyping of human rotaviruses. (microbiologyresearch.org)
  • Human Advs are divided into seven subgroups including 53 serotypes based on immunologic and biological characteristics. (hindawi.com)
  • Human adenoviruses (HAdVs) can cause a variety of human illnesses, with associated temporal and geographic changes in disease incidence. (annals.edu.sg)
  • Human adenoviruses (HAdVs) are well known pathogens that cause a variety of human illnesses. (annals.edu.sg)
  • The therapeutic efficacy of Human adenovirus e serotype 4 strain cl-68578 antigen can be decreased when used in combination with Sorivudine. (drugbank.com)
  • Adenovirus serotype 11 causes less long-term intraperitoneal inflammation than serotype 5: implications for ovarian cancer therapy. (ox.ac.uk)
  • The lab is applying its adenovirus vaccine expertise against SARS-CoV-2, utilizing a modified chimpanzee virus as a vaccine delivery vehicle to induce an immune response. (wistar.org)
  • Respiratory Ad distributions are geographically variable, and serotype prevalence has not been previously characterized in this region. (utmb.edu)
  • The present study aimed to investigate the prevalence of adenovirus and RSV serotypes A and B in individuals with acute exacerbations of COPD (COPD‑AE) and stable COPD. (spandidos-publications.com)
  • The aim of the present study was to investigate the prevalence of adenovirus and RSV A and B among patients with COPD-AE and those in a stable condition. (spandidos-publications.com)
  • Adenoviruses commonly infect vertebrates, including humans and nonhuman primates ( 1 ). (cdc.gov)
  • AAV6-ChIEF-tdTOMATO the serotype 8 rAAV which expresses a hybrid of Channelrhodopsin-1/2 under CAG promoter fusion with reporter tdTOMATO. (signagen.com)
  • 488.00 : SignaGen Laboratories, A Gene Delivery Company Providing Custom AAV Adenovirus Lentivirus Production Services & Manufacturing DNA/siRNA Transfection Reagents. (signagen.com)
  • Adenovirus (Ad) is the major cause of viral conjunctivitis worldwide, with serotypes Ad8, Ad19 and Ad37 predominantly infecting the eye. (arvojournals.org)
  • Earlier, during the pre-Covid times, only 3 to 4 per cent of the total samples tested for respiratory viral diseases would have the hybrid of adenovirus type 3 and 7, she said. (telegraphindia.com)
  • Epidemic keratoconjunctivitis is a severe form of viral conjunctivitis that is usually caused by adenovirus serotypes Ad 5, 8, 11, 13, 19, and 37. (msdmanuals.com)
  • According to ICMR-National Institute of Cholera and Enteric Diseases, of the 1,708 samples tested between January 1 and March 9, 650 were positive for the adenovirus. (telegraphindia.com)
  • Strains isolated from severely ill patients were closely related to strains of a genomic variant, adenovirus 14p1, circulating in the United States and Ireland. (cdc.gov)
  • There are dozens of different strains of this virus, called serotypes. (cdc.gov)
  • Since 2011, several novel adenoviruses have been isolated from nonhuman primates, including a group of new strains, designated SAdV-B, from asymptomatic rhesus macaques housed at 5 different primate facilities located across the United States ( 2 , 4 ). (cdc.gov)
  • In this review article, we outline key characteristics of major gene therapy viruses-adenovirus, adeno-associated virus (AAV), and lentivirus-and summarize the mechanisms regulating important steps in the virus journey from binding at peripheral nerve terminals to nuclear delivery. (frontiersin.org)
  • Hematoxylin and eosin-stained lung tissue (original magnification ×10) from a patient in New Brunswick, Canada, with a fatal case of pneumonia caused by adenovirus 14. (cdc.gov)
  • In our study, total RNA extracted from whole blood of adenovirus-infected pneumonia children and healthy controls were analyzed by small RNA deep sequencing. (hindawi.com)
  • But serotype 7 of the virus is one of the types associated with severe diseases like pneumonia," said Chandramouli Bhattacharya, an infectious disease expert. (telegraphindia.com)
  • However, we had found that i.p. group B, in contrast to group C adenoviruses, did not cause adhesions in nude BALB/c ovarian cancer models, prompting further investigation. (ox.ac.uk)
  • Dr. Gaydos] In the 1950s, the adenoviruses were shown to be the most important cause of acute, febrile respiratory disease in military trainees, and almost all of this morbidity was caused by two types: Adenovirus Type 4 and Adenovirus Type 7. (cdc.gov)
  • More than 50 distinct serotypes have been identified since the early 1950s. (annals.edu.sg)
  • We while others have shown that it's possible to displace the nine hypervariable parts of the Advertisement5 hexon with those produced from group C (31) or group D (34, 35) serotypes. (synanet2020.com)
  • A hybrid of adenovirus type 3 and 7 has been detected in the majority of the swab samples that tested positive for the virus since January. (telegraphindia.com)
  • The therapeutic efficacy of Adenovirus type 7 vaccine live can be decreased when used in combination with Sorivudine. (drugbank.com)
  • At least three more children suffering from respiratory diseases died at Kolkata's hospitals on Friday and health experts said an immunological study of a hybrid of two types of adenovirus, detected in a large number of swab samples of sick children, was required to understand what was causing the severity and so many deaths. (telegraphindia.com)
  • Through retrospective examination of laboratory reports from the three clinical laboratories in the state that have virology capacity and the Oregon State Public Health Laboratory (OSPHL), OPHD identified 68 persons who tested positive (by culture, PCR, or IFA) for adenovirus during November 1, 2006--April 30, 2007. (cdc.gov)
  • Serotype identity is clinically relevant because it predicts vaccine efficacy and correlates strongly with both clinical presentation and epidemiological pattern. (utmb.edu)
  • Adenoviruses have been isolated from both clinically healthy and diseased birds worldwide. (scialert.net)
  • The laboratory developed an adenovirus-based vaccine against rabies virus that can provide rapid immunity following a single administration. (wistar.org)
  • A community outbreak of adenovirus was reported in Taiwan in 2011, using a vigilant surveillance system comprising 12 contract virological laboratories across the country. (annals.edu.sg)
  • Perhaps because many considered adenovirus-associated disease in the military a problem of the past, this notification and the possible loss of these critical vaccines was not widely appreciated. (cdc.gov)
  • 2006) Novel fiber-dependent entry mechanism for adenovirus serotype 5 in lacrimal acini. (cedars-sinai.edu)
  • Postmortem tracheal and gastric swabs from the infant were sent to the Wadsworth Center laboratory of the New York State Department of Health, where adenovirus was detected by polymerase chain reaction (PCR). (cdc.gov)
  • Species and serotype identities were determined using several well-validated multiplex PCR protocols culled from the literature and supplemented with a few novel primer sets designed to identify rare types. (utmb.edu)