Adenovirus adenoviridae infections. Medical search. Frequent questions

Brincidofovir (BCV, CMX001) is an orally bioavailable lipid conjugate of cidofovir that has in vitro activity against adenoviruses and other double-stranded DNA viruses. (nih.gov)
Enteric viruses such as adenovirus-F and -G (Adenoviridae), norovirus and sapovirus (Caliciviridae), astrovirus (Astroviridae), and rotavirus (Reoviridae) are spread by fecal-oral transmission resulting in localized intestinal infections characterized by tissue inflammation, disruption of the epithelial barrier, malabsorption, diarrhea, and vomiting. (nih.gov)
The family Adenoviridae includes non-enveloped viruses with linear dsDNA genomes of 25-48 kb and medium-sized icosahedral capsids. (bvsalud.org)
INTRODUCTION - Adenoviruses are a family of viruses that are an important cause of febrile illnesses in young children. (medilib.ir)
The most important host defense against many viruses, including adenoviruses, is cell-mediated immunity. (medilib.ir)
These viruses cause infections ranging from mild syndromes to severe, life-threatening disease. (cdc.gov)
Adenoviruses are DNA viruses classified according to 3 major capsid antigens (hexon, penton, and fiber). (msdmanuals.com)
Adenoviruses are double-stranded DNA viruses infecting vertebrate hosts, such as reptiles and amphibians. (huveta.hu)
The different adenovirus types possess quite narrow host spectra, that are each animal species may have its own adenovirus, therefore these viruses are perfectly suitable for investigating co-evolution. (huveta.hu)
The highest rates of viral infections were reported for RSV (45.2%), PIV (11.6%), and adenovirus (9.8%), with a relatively low rate (7.2%) for influenza viruses. (datexis.com)
Antibiotics have no effect on viruses, but antiviral drugs have been developed to treat life-threatening infections. (wikidoc.org)

This property is often used to isolate adenoviruses from clinical specimens in diagnostic virology laboratories. (medilib.ir)

Astroviruses were detected in 7% of the stools compared with 20% infected with rotaviruses and only 3% infected with enteric adenoviruses. (smu.ac.za)

Coagulation factor X activates innate immunity to human species C adenovirus. (nih.gov)
We modeled the interface of human species C adenovirus (HAdv) interaction with coagulation factor X (FX) and introduced a mutation that abrogated formation of the HAdv-FX complex. (nih.gov)
The genome of this promiscuous pathogen is embedded with evidence of unprecedented multiple, multidirectional, stable, and reciprocal cross-species infections of hosts from three species (human, chimpanzee, and bonobo). (bvsalud.org)
The fiber protein from most adenoviruses, except species B, binds to the cellular receptor CAR (coxsackie-adenovirus receptor), which also binds coxsackie B virus [ 2 ]. (medilib.ir)
The 51 recognized serotypes of human adenoviruses have been placed in 7 human adenovirus species, A-G ( 1 ). (cdc.gov)
There are 7 human adenovirus species (A to G) and 57 serotypes. (msdmanuals.com)
Serotypes (named with Arabic numbers) have been grouped into species designated Human adenovirus A-G. (nih.gov)
Human adenovirus comprises 6 species (A through F) consisting of serotypes 1 - 51, and associated with a variety of clinical illnesses. (publichealthlab.ca)
The subgroup C human adenoviruses induce selective export of newly synthesized vital mRNA from the nucleus to the cytoplasm, with concomitant inhibition of export of the majority of cellular mRNA species. (princeton.edu)
These transcripts, which contain no vital sequences, therefore reproduce the behavior of exceptional cellular mRNA species observed when transcription of their genes is activated during the late phase of infection (U.-C. Yang, W. Huang, and S. J. Flint, J. Virol. (princeton.edu)
Because these observations implied that translational of viral mRNA species was defective in mutant virus-infected cells, the association of viral late mRNAs with polyribosomes was examined during the late phase of infection at a nonpermissive temperature. (princeton.edu)
During the late phase of infection, neither the polyribosome association nor the translation of most viral early mRNA species was affected by the H5ts1 mutation. (princeton.edu)
We therefore conclude that the Ad5 L4 100-kDa protein is necessary for efficient initiation of translation of viral late mRNA species during the late phase of infection. (princeton.edu)

This NOSI encourages studies focusing on rotavirus, caliciviruses, astroviruses, and adenoviruses ( Human mastadenovirus F and G). (nih.gov)
Human adenoviruses (HAdVs) consist of nonenveloped, double-stranded DNA and belong to the family Adenoviridae , genus Mastadenovirus . (cdc.gov)

In immunocompetent hosts, most adenovirus infections are asymptomatic. (msdmanuals.com)
Infections are mostly asymptomatic, but can be associated with diseases of the respiratory, ocular, and gastrointestinal systems. (nih.gov)
Clinical correlation is necessary to determine the significance of this finding as asymptomatic, persistent, or recurrent adenovirus infections can occur. (publichealthlab.ca)
Taking into account asymptomatic infections and underreporting, it was estimated that 25,000 new cases of hepatitis A occurred that year. (abdominalkey.com)

Human adenovirus (HAdV) and norovirus (HuNoV) are estimated to cause an added 100,000 annual deaths. (nih.gov)
These gaps highlight the need for vaccines to prevent infections from RV, HAdV, HuNoV, HAstV, and HuSaV, which together account for most acute and chronic infections in people of all ages. (nih.gov)
Genomics analysis of a historically intriguing and predicted emergent human adenovirus (HAdV) pathogen, which caused pneumonia and death, provides insight into a novel molecular evolution pathway involving "ping-pong" zoonosis and anthroponosis. (bvsalud.org)
On the basis of this finding, partial hexon genes of adenovirus were amplified from all 31 samples by using PCR with HAdV-specific primers ( 8 ). (cdc.gov)

Astroviruses have been shown to be important aetiological agents associated with gastroenteritis in children, as have rotaviruses and the enteric adenoviruses. (smu.ac.za)
These were examined for the presence of astroviruses using a monoclonal antibody-based ELISA, and for rotaviruses and enteric adenoviruses using commercially available kits. (smu.ac.za)
whereas serotypes 40 and 41 is associated with enteric disease (enteric adenovirus) particularly in children - these enteric adenoviruses will not be detected with the assay described here. (publichealthlab.ca)

Of patients tested, 268 were positive for adenovirus. (wikipedia.org)
The results ( Table ) indicated that 53% (10/19) of the samples tested were positive for adenovirus. (cdc.gov)
An antemortem tracheal aspirate sample, received from the first case-patient who died, was positive for adenovirus. (cdc.gov)
Subsequently, postmortem lung and spleen tissue samples tested by PCR were also positive for adenovirus. (cdc.gov)

Group-reactive antigenic determinants are present on the hexon proteins from all human adenoviruses. (medilib.ir)
Recovery from adenovirus infection is associated with the development of serotype-specific neutralizing antibodies directed mainly at the major capsid protein hexon. (medilib.ir)

abstract = "The ability of adenovirus early region proteins, E1B-55K and E4orf6, to usurp control of cellular ubiquitin ligases and target proteins for proteasome-dependent degradation during infection is well established. (birmingham.ac.uk)
abstract = "Background and Methods: The high burden of respiratory infections in military populations is well documented throughout history. (usuhs.edu)

Most adenoviruses readily infect human epithelial cell lines, exhibiting a characteristic cytopathic effect. (medilib.ir)

The use of a number of different adenovirus early region mutants identified the specific and sole requirement for E4orf3 in mediating TIF1 gamma degradation. (birmingham.ac.uk)

PBMC from donors were stimulated twice with autologous DC transduced with an adenovirus vector expressing LMP2a. (nih.gov)
Co-administration of an adjuvanted protein and an adenovirus vector showed an acceptable safety and reactogenicity profile and resulted in strong, multifunctional and complementary HIV-specific immune responses. (emmes.com)
A murine stem cell virus (MSCV)-based retroviral vector (MSCV-hIL12.B7) utilized distinct IRES sequences from the encephalomyocarditis virus (EMCV) and the foot-and-mouth disease virus (FMCV), whereas Ad5-based adenovirus vectors contained transcriptional units with two EMCV IRES sequences under the control of murine (AdMh12.B7) or human (AdHh12.B7) cytomegalovirus promoters. (mcmaster.ca)
To evaluate the concept that in vivo transfer of the Escherichia coli cytosine deaminase gene will confer sensitivity of a solid tumor to the prodrug 5-fluorocytosine (5FC), we constructed an adenovirus vector (AdCMV.CD) carrying the cytosine deaminase gene driven by the cytomegalovirus (CMV) promoter, infected HT29 colon carcinoma cells in vitro and in vivo, and evaluated cell growth over time. (uky.edu)

Symptoms include: Cold symptoms, such as coughing, sore throat, sneezing, and a runny nose Pharyngitis Bronchitis Diarrhea Pneumonia Conjunctivitis Fever Cystitis (bladder inflammation) Rash illness The viral infection presents with symptoms similar to those of other common bacterial and viral infections, such as influenza. (wikipedia.org)
Streptococcal pharyngitis Streptococci are gram-positive aerobic organisms that cause many disorders, including pharyngitis, pneumonia, wound and skin infections, sepsis, and endocarditis. (msdmanuals.com)
Overview of Pneumonia Pneumonia is acute inflammation of the lungs caused by infection. (msdmanuals.com)
Respiratory syncytial virus (RSV) is the most frequent cause of lower respiratory tract infection in infants and children and the second most common viral cause of pneumonia in adults. (medscape.com)
Influenza pneumonia: Amantadine hydrochloride and rimantadine hydrochloride are approved for the prevention and treatment of influenza A virus infection. (medscape.com)

Purifi ed supernatant of Since the recent discoveries of Ebola virus, Henipavi- these cell cultures was subjected to negative-staining elec- rus, and severe acute respiratory syndrome-associated tron microscopy, which showed numerous adenovirus-like coronavirus infections, interest in the role of bats as hosts particles (Figure 1, panel A). The family Adenoviridae was for pathogens has markedly increased ( 1 ). (cdc.gov)
Regulatory T Cells in Arterivirus and Coronavirus Infections: Do They Protect Against Disease or Enhance it? (mdpi.com)

Adenovirus serotype 14 (Ad14) is a serovar of adenovirus which, unlike other adenovirus serovars, is known to cause potentially fatal adenovirus infections. (wikipedia.org)
Serotype differences - Over 60 human adenovirus serotypes have been described, based upon antigenic determinants detected by viral neutralization assay (51 serotypes) and other new "types" identified by molecular analyses [ 6 ]. (medilib.ir)
Neutralizing antibodies protect against infection with the same serotype of the virus but not against other serotypes. (medilib.ir)
Human adenovirus serotype 5 (HAdV5) has been used in human studies for gene delivery, but has limited infection in DCs, which lack the proper receptors. (wustl.edu)

The spe- cies of bat involved was determined by amplifi cation and We tested 55 deceased vespertilionid bats of 12 spe- sequencing of the cytochrome B ( cytB ) gene, a standard cies from southern Germany for virus infections. (cdc.gov)

Adenovirus infections of the eye may lead to pharyngo-conjunctival fever, follicular conjunctivitis or epidemic keratoconjunctivitis. (publichealthlab.ca)

Here we show that the E4 gene product, E4orf3 can, independently of E1B-55K and E4orf6, target the transcriptional corepressor transcriptional intermediary factor 1 gamma (TIF1 gamma) for proteasome-mediated degradation during infection. (birmingham.ac.uk)
Further studies suggested that TIF1 gamma possesses antiviral activity and limits adenovirus early and late gene product expression during infection. (birmingham.ac.uk)
We have investigated the humoral immune response to E1-deleted adenovirus vectors encoding the lacZ gene introduced into the brains of mice. (ox.ac.uk)
Apparent antibody production to beta-galactosidase, the product of the lacZ gene, was detected later than anti-adenovirus antibody. (ox.ac.uk)
This study demonstrates that E1-deleted adenovirus vectors injected into the brain trigger humoral immune responses to the adenovirus and its gene products, but they are not sufficient to block the infection of cells by adenovirus upon repeat injection. (ox.ac.uk)
When transcription of the MA gene was induced during the late phase of infection, newly synthesized MA RNA entered the cytoplasm. (princeton.edu)
Infection with AdCMV.CD, when as few as 10% of cells expressed the cytosine deaminase gene, was associated with a bystander effect when combined with 5FC in cell mixing studies. (uky.edu)
These observations suggest that adenovirus-mediated gene transfer of the E. coli cytosine deaminase gene and concomitant administration of 5FC may have potential as a strategy for local control of the growth of tumor cells susceptible to 5FU. (uky.edu)
When screening a number of adenovirus type 5 (Ad5) temperature-sensitive mutants for defects in viral gene expression, we observed that H5ts1-infected 293 cells accumulated reduced levels of newly synthesized viral late proteins. (princeton.edu)

Risks and outcomes of adenovirus disease in pediatric hematopoietic stem cell transplant recipients-Comparison of current antiviral treatment options. (uams.edu)
The majority of incidence of adenoviruses occurs in individuals who have undergone hematopoietic stem cell transplant and solid organ transplant recipients. (publichealthlab.ca)

The commercial assays for adenovirus antibodies, such as complement fixation and enzyme immunoassay, detect other adenovirus-specific antibodies that cross-react with all serotypes. (medilib.ir)
Due to a lack of effective antiviral treatment, several vaccines have been put forth to curb SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection and to reduce the mortality and morbidity rate by eliciting a protective immune response, primarily through virus-neutralizing antibodies specific for SARS-CoV-2 spike protein. (aboutscience.eu)

Do nonhuman primate or bat adenoviruses pose a risk for human health? (medscape.com)
Further analyses revealed that TIF1 gamma is targeted for degradation by a number of divergent human adenoviruses, suggesting that the ability of E4orf3 to regulate TIF1 gamma expression is evolutionarily conserved. (birmingham.ac.uk)
Human adenovirus type 7 was identified as the etiologic agent. (cdc.gov)
PCR product of postmortem samples RP381/11 on 3% agarose gel in study of human adenovirus type 7 outbreak in a police training center, Malaysia, 2011. (cdc.gov)
Human adenovirus, of the Adenoviridae family, is a nonenveloped icosahedral particle containing a single linear dsDNA genome. (publichealthlab.ca)
Respiratory and conjunctival infections caused by 33 identified serotypes of human adenoviruses. (nih.gov)
With a view to human clinical application, tricistronic retroviral and adenovirus vectors co-expressing IL-12 (IL-12p40 plus IL-12p35) and CD80 were constructed by utilizing two internal ribosome entry site (IRES) sequences to link the three cDNAs. (mcmaster.ca)
AdMh12.B7 was found to consistently direct higher levels of IL-12 and CD80 expression than AdHh12.B7 following infection of a number of human tumor cell lines. (mcmaster.ca)
To facilitate the investigation of parameters that govern selective export in adenovirus- infected cells, we constructed a marked human β-actin minigene under the control of the glucocorticoid-inducible enhancer-promoter of mouse mammary tumor virus and introduced it into the left end of the adenovirus type 5 (Ad5) genome. (princeton.edu)
Viral infections in human and animal hosts usually result in an immune response and disease . (wikidoc.org)
Our data show that adenovirus can be successfully used to efficiently deliver transgenes to primary human macrophages and RA joint tissue. (ox.ac.uk)

Virus diseases caused by the ADENOVIRIDAE . (bvsalud.org)
Most adenoviral diseases are self-limiting, although fatal infections can occur in immunocompromised hosts and occasionally in healthy children and adults. (medilib.ir)

In February 2007, an outbreak of acute respiratory infections with fever was reported among trainees at Lackland Air Force Base (LAFB) in San Antonio. (wikipedia.org)
They have been recognized for decades as the primary causes of acute respiratory disease (ARD), gastrointestinal infection, and fever ( 2 ). (cdc.gov)
Adenovirus types 3 and 7 cause a distinct syndrome of conjunctivitis, pharyngitis, and fever (pharyngoconjunctival fever). (msdmanuals.com)

Adenovirus infection in immunocompromised patients contributes to significant morbidity and mortality, especially after allogeneic hematopoietic cell transplantation (HCT). (nih.gov)
The primary pathogen responsible for morbidity among US recruits in training was shown to be adenovirus. (usuhs.edu)
Restoration of an effective adenovirus vaccine effort within the military is anticipated by 2008, potentially reducing the adenovirus morbidity suffered in this vulnerable population. (usuhs.edu)

and 3) develop and advance new vaccine candidates to prevent infection or severe gastrointestinal disease. (nih.gov)
A Phase I Double Blind, Placebo-Controlled, Randomized Study of the Safety and Immunogenicity of an Adjuvanted HIV-1 Gag-Pol-Nef Fusion Protein and Adenovirus 35 Gag-RT-Int-Nef Vaccine in Healthy HIV-Uninfected African Adults. (emmes.com)
Sequential prime-boost or co-administration of HIV vaccine candidates based on an adjuvanted clade B p24, RT, Nef, p17 fusion protein (F4/AS01) plus a non-replicating adenovirus 35 expressing clade A Gag, RT, Int and Nef (Ad35-GRIN) may lead to a unique immune profile, inducing both strong T-cell and antibody responses. (emmes.com)

With the advent of recommendations for vaccination of high-risk individuals and children residing in states with a high prevalence of HAV infection, followed by the more recent recommendation of routine vaccination of all children 1 year of age, the incidence of hepatitis A infections in the United States has decreased significantly. (abdominalkey.com)
2 In 2007, the reported incidence of hepatitis A infection was 1 case per 100,000 persons in the United States. (abdominalkey.com)
Global distribution of chronic Hepatitis B infection. (abdominalkey.com)
Nonsexual transmission may occur in settings of extended interpersonal contact such as those in households of individuals with chronic hepatitis B infection. (abdominalkey.com)

Furthermore, hPIV is a significant etiology of LRTI in children, second only to RSV, and adenoviruses are the second most common viral pathogen in children under two years of age. (datexis.com)

The virus shows symptoms typical of adenoviral infections. (wikipedia.org)
Adenoviral infections are being increasingly recognized as causes of severe respiratory and other clinical disease in immunocompromised adults. (msdmanuals.com)

Certain serotypes are associated with distinct clinical manifestations, reflecting preferential infection of the respiratory, gastrointestinal, and urinary tracts and conjunctiva ( table 1 ). (medilib.ir)

Initial mass spectrometric studies identified TIF1 family members-TIF1 alpha, TIF1 beta, and TIF1 gamma-as E1B-55K-binding proteins in both transformed and infected cells, but analyses revealed that, akin to TIF1 alpha, TIF1 gamma is reorganized in an E4orf3-dependent manner to promyelocytic leukemia protein-containing nuclear tracks during infection. (birmingham.ac.uk)
Taken together, these studies have identified novel adenovirus targets and have established a new role for the E4orf3 protein during infection. (birmingham.ac.uk)
Group B adenoviruses have been shown to bind to CD46, a complement-related protein [ 3,4 ]. (medilib.ir)

Adenovirus (AdV) capsid organization is considerably complex, not only because of its large size (~950 Å) and triangulation number ( pseudo T = 25), but also because it contains four types of minor proteins in specialized locations modulating the quasi-equivalent icosahedral interactions. (mdpi.com)

As an aid in diagnosing respiratory adenovirus infections and systemic adenovirus reactivation in immunocompromised, particularly bone marrow transplant, recipients. (publichealthlab.ca)
Injection of these non-replicating vectors into the brain induced systemic antibody production to adenovirus vectors in dose dependent manner. (ox.ac.uk)

Outbreaks of adenoviruses associated with respiratory disease have been reported worldwide ( 3 , 4 ) and commonly occur among the military trainees ( 5 , 6 ). (cdc.gov)
Case clusters of severe respiratory disease, caused by specific adenoviruses (particularly types 7, 14, and 55), have occurred in healthy adults. (msdmanuals.com)
Approximately 5% of acute respiratory disease in children and 10% of febrile illnesses and childhood pneumonias have been associated with adenovirus infection. (publichealthlab.ca)

2 Department of Infectious Disease, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas. (nih.gov)
The outcome of infection may vary from subclinical to lethal disease. (bvsalud.org)
When infections are symptomatic, a broad spectrum of clinical manifestations is possible because most adenoviruses that cause mild disease have affinity for a variety of tissues. (msdmanuals.com)
Because the majority of HAV infections in children result in subclinical disease, children play a major role in the transmission of the virus within communities. (abdominalkey.com)

Although these infections are common in humans, they are rarely fatal. (wikipedia.org)
Adenoviruses have been discovered in vertebrates from fish to humans. (bvsalud.org)
INTRODUCTION: Several viral infections cause life-threatening consequences in humans, making them the most serious public health concerns. (bvsalud.org)

The epidemiology, pathogenesis, and clinical manifestations of adenovirus infections will be reviewed here. (medilib.ir)

Bacterial vs. Viral Infections: How Do They Differ? (nih.gov)

There are antiviral medicines to treat some viral infections. (nih.gov)
Despite the fact that several antiviral medicines are available on the market, there is no full treatment for many important viral infections. (bvsalud.org)

In the control group, one specimen each had astrovirus or adenovirus and two shed rotaviruses. (smu.ac.za)
Rotavirus and astrovirus infections were more prevalent in the autumn and early winter than in other seasons. (smu.ac.za)
Astrovirus and rotavirus infections predominated in children between 3 and 22 months of age. (smu.ac.za)

Addition of the porcine fiber knob (PK) from porcine adenovirus type 4 to HAdV5 allows the virus to deliver genetic material via binding to glycosylated surface proteins and bypasses the coxsackie-and-adenovirus receptor required by wild-type HAdV5. (wustl.edu)

Although respiratory infections can be classified by the causative virus (eg, influenza), they are generally classified. (msdmanuals.com)
Patients with influenza virus tended to have significantly different rates of admission to the ICU (p=0.045), and mechanical ventilation (p=0.001), in comparison to those with non-influenza infections. (datexis.com)
twelve were positive for RSV, four for influenza virus, two for adenovirus, one for hMPV, one for PIV and four for mixed viral infections, respectively. (datexis.com)
Among individual viral pathogens, SARI patients with RSV and influenza had significant deaths (p= 0.045 and 0.006), in comparison to those with non-RSV and non-influenza viral infections. (datexis.com)

Anatomy3

Organisms9

Diseases5

Chemicals and Drugs13

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes8

Information Science2

Viruses11

Virology1

Infected with enteric1

Species13

Mastadenovirus2

Asymptomatic4

HAdv4

Enteric3

Positive for adenovirus4

Hexon2

Abstract2

Infect human1

Different adenovirus1

Vector4

Pneumonia5

Coronavirus infections2

Serotype4

Virus infections1

Pharyngo-conjunctival fever1

Gene9

Hematopoietic stem cell2

Antibodies2

Human11

DISEASES2

Fever3

Morbidity3

Vaccine3

Hepatitis4

Second most common viral1

Adenoviral2

Serotypes are associated1

Protein3

Icosahedral1

Systemic2

Respiratory disease3

Disease4

Humans3

Clinical manifestations1

Bacterial1

Antiviral medicines2

Astrovirus3

Receptor1

Influenza4