• Mechanical stretch decreased the expression of sarcoplasmic reticulum adenosine triphosphatase 2, and thus slower calcium reuptake kinetics, which was responsible for the susceptibility to alternans. (tmu.edu.tw)
  • Overexpression of sarcoplasmic reticulum adenosine triphosphatase 2 reversed all the effects of stretch on susceptibility to alternans. (tmu.edu.tw)
  • Exposure of epithelial type II cells to halothane reduced the activity of sodium, potassium-adenosine triphosphatase, and amiloride-sensitive Na channels, whereas Na cotransporters were unchanged. (asahq.org)
  • The decrease in sodium, potassium-adenosine triphosphatase activity was maximal for 30 min of exposure and reached 50, 42, and 56% for halothane concentrations of 1, 2, and 4%, respectively, and did not change for longer exposure times. (asahq.org)
  • Sodium, potassium-adenosine triphosphatase, and amiloride-sensitive Na channel activities are impaired by halothane in alveolar type II cells in vitro. (asahq.org)
  • 2007. Nitrosative stress and myocardial sarcoplasmic endoreticular calcium adenosine triphosphatase subtype 2a activity after lung resection in swine. . (cornell.edu)
  • The present study was aimed to evaluate the oxidants, enzymatic and nonenzymatic antioxidants, glycoproteins and membrane adenosine triphosphatases (ATPases). (scialert.net)
  • The conformation of H,K-ATPase determines the nucleoside triphosphate (NTP) selectivity for active proton transport. (jefferson.edu)
  • This protein is an adenosine triphosphate (ATP)-powered calcium pump, which uses energy from ATP molecules to pump charged calcium atoms (calcium ions) across cell membranes. (medlineplus.gov)
  • Magnesium is integral to the function of adenosine triphosphate and plays a role in a host of enzymatic reactions and transport processes, and in the synthesis of proteins, DNA and RNA. (irjs.info)
  • Ca 2+ -ATPase activity was measured after incubation with 45 Ca 2+ and adenosine triphosphate in the presence of specific Ca 2+ -ATPase inhibitors. (psu.edu)
  • APC improved adenosine triphosphate recovery in young rats but not in aged rats. (asahq.org)
  • 6,7 The mechanism of volatile anesthetic preconditioning (APC), although not fully understood, is believed to share similarities with IPC by activation of adenosine triphosphate (ATP)-sensitive potassium (K ATP ) channels, particularly in the mitochondria. (asahq.org)
  • affinity acid mechanism in base pollutants transduces with the complex of the many granule( protein) during the active M Calcium and increases in the core cleavage of the other enzyme internalization, a expression solely used triphosphate bike tumor polypeptide. (erik-mill.de)
  • Function of endoplasmic reticulum calcium ATPase in innate immunity-mediated programmed cell death. (jefferson.edu)
  • Bursts of neural activity induced in Drosophila comatosets and CaP60A Kumts mutants, with conditional defects in N-ethylmaleimide-sensitive fusion factor 1 and sarco-endoplasmic reticulum Ca2+ ATPase, respectively, result in persistent (>4 hr) activation of neuronal extracellular signal-regulated kinase (ERK). (colorado.edu)
  • Plasma membrane (PM) and endoplasmic reticulum (ER) Ca 2+ -adenosinetriphosphatases (ATPases) are the primary transporters that maintain [Ca 2+ ] i homeostasis in the liver. (psu.edu)
  • In this study it is shown that GroEL alone substantially reduces the inactivation of purified Ca(++)-ATPase from rabbit skeletal muscle sarcoplasmic reticulum. (birmingham.ac.uk)
  • This exacerbates the potential for cardiac arrythmias because the low levels of potassium reduces the amount of K+ at the ATPase pump and increase calcium levels too much which leads to these arrythmias. (wikipedia.org)
  • If arrhythmias prove troublesome, or malignant hyperkalemia occurs (inexorably rising potassium level due to paralysis of the cell membrane-bound, ATPase-dependent Na/K pumps), the specific antidote is antidigoxin (antibody fragments against digoxin, trade names Digibind and Digifab). (wikipedia.org)
  • A very common ATPase driven ion pump found universally in all animal cells is the sodium-potassium pump, which helps in the maintenance of membrane potential of the cells. (aakash.ac.in)
  • Magnesium and potassium are mainly intracellular ions, sodium and calcium are mainly extracellular ions. (raypeat.com)
  • When cells are excited, stressed, or de-energized, they lose magnesium and potassium, and take up sodium and calcium. (raypeat.com)
  • He and an associate drew attention to the close interrelationship of magnesium, calcium and intracellular potassium. (irjs.info)
  • The other cations have done pretty well, sodium in terms of volume regulation, potassium in terms of Nernst-Equation problems (like sudden cardiac loss of life) and calcium with regards to bone disease. (irjs.info)
  • Sodium-Potassium-Exchanging ATPase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
  • An enzyme that catalyzes the active transport system of sodium and potassium ions across the cell wall. (childrensmercy.org)
  • Sodium and potassium ions are closely coupled with membrane ATPase which undergoes phosphorylation and dephosphorylation, thereby providing energy for transport of these ions against concentration gradients. (childrensmercy.org)
  • This graph shows the total number of publications written about "Sodium-Potassium-Exchanging ATPase" by people in this website by year, and whether "Sodium-Potassium-Exchanging ATPase" was a major or minor topic of these publications. (childrensmercy.org)
  • Below are the most recent publications written about "Sodium-Potassium-Exchanging ATPase" by people in Profiles. (childrensmercy.org)
  • A Cl - /K + -co-transporter and a Na + /K + -ATPase pump transport Na + , K + and Cl - ions further over the basal membrane into the peritubular fluid. (trc-p.nl)
  • The Na + /K + -ATPase pump also brings K + back into the cell. (trc-p.nl)
  • Specifically, the hSPCA1 protein transports calcium ions into a cell structure called the Golgi apparatus, where they are stored until needed. (medlineplus.gov)
  • The hSPCA1 protein also transports manganese ions into the Golgi apparatus. (medlineplus.gov)
  • Mutations in this gene reduce the amount of functional hSPCA1 protein, which impairs the storage of calcium ions in the Golgi apparatus. (medlineplus.gov)
  • Na transport was then evaluated by direct measurement of radiolabeled ions uptake. (asahq.org)
  • Active transport helps in the accumulation of high concentrations of ions and molecules that the cell needs. (aakash.ac.in)
  • Mineral ions are absorbed from the soil by the root hair cells, against their concentration gradient, by the process of active transport and utilisation of energy. (aakash.ac.in)
  • Absorption of glucose from the intestinal lumen in humans, absorption of amino acids across the lining of intestines, outward movement of calcium ions from cardiac muscle cells are some of the other examples of active transport in living beings. (aakash.ac.in)
  • Active transport helps in moving metal ions, such as Na + , K + , Mg 2+ , and Ca 2+ across the cell membrane with the help of ion pumps or ion channels. (aakash.ac.in)
  • This movement of ions can be called active transport, without invoking the mysterious machinery of membrane pumps. (raypeat.com)
  • Normally, activation of the CB 1 receptor regulates renal vascular hemodynamics and stimulates the transport of ions and proteins in different nephron compartments. (degruyter.com)
  • Whereas the growth-promoting and antiapoptotic properties of Akt activation are well established, little is known about the effects of Akt on myocardial contractility, intracellular calcium (Ca2+) handling, oxygen consumption, and β-adrenergic pathway. (cnr.it)
  • The accumulation of intracellular calcium ([Ca 2+ ] i ) caused by ischemia-reperfusion during liver transplantation has been implicated as a factor leading to primary graft nonfunction. (psu.edu)
  • Both AEA and 2-AG are generated "on demand" from membrane phospholipid precursors in response to elevated intracellular calcium or metabotropic receptor activation [ 20 ]. (degruyter.com)
  • Calcium during the daytime and often fix carbon into calcium car- transport inhibitors and Ca2ϩ concentrations below 0.5 mM bonate and biomass at similar rates. (medpdfarticles.com)
  • The transport of substances across the cell membrane can either be active or passive. (aakash.ac.in)
  • The cellular energy used in active transport helps to move the molecules against any sort of resistance as is posed by a negative concentration gradient or the polar repulsion between the hydrophobic lipid bilayer of the cell membrane and hydrophilic substances to be transported across it. (aakash.ac.in)
  • In addition to synthesizing surfactant, alveolar type II cells actively transport sodium (Na) from the alveolar space to the interstitium. (asahq.org)
  • Cation-transporting proteins that utilize the energy of ATP hydrolysis for the transport of CALCIUM. (jefferson.edu)
  • This process uses transmembrane ATPases for the hydrolysis of ATP to generate energy. (aakash.ac.in)
  • We studied the spatial distribution, mobility, and trafficking of plasma membrane Ca2+ATPase-2 (PMCA2), a protein enriched in the hair cell apical membrane and essential for hair cell function. (elsevierpure.com)
  • Protein deficiency is an important cause of deranged calcium metabolism. (raypeat.com)
  • Porcine PM and ER Ca 2+ -ATPase activities were 0.47 ± 0.03 and 1.57 ± 0.10 nmol of Ca 2+ /mg of protein/min, respectively. (psu.edu)
  • calcium binding protein 39 [Source. (gsea-msigdb.org)
  • This methylation is formed below with: an phosphorylation acetyl-CoA with an calcium maltose, a level with a setting a004614, a consistent domain with an alpha, and a process with A, water and actomyosin dynamics to occur these three melanocytes of loop. (evakoch.com)
  • Rapid turnover of stereocilia membrane proteins: evidence from the trafficking and mobility of plasma membrane Ca(2+)-ATPase 2. (elsevierpure.com)
  • Dive into the research topics of 'Rapid turnover of stereocilia membrane proteins: evidence from the trafficking and mobility of plasma membrane Ca(2+)-ATPase 2. (elsevierpure.com)
  • It is the mode of transport which involves the expenditure of cellular energy and is often carried out against a concentration gradient (from lower to higher concentration) with the help of special membrane or carrier proteins. (aakash.ac.in)
  • They differ from CALCIUM CHANNELS which allow calcium to pass through a membrane without the use of energy. (jefferson.edu)
  • [1,2] Recently, however, halothane was shown to inhibit Na/calcium (Ca) exchanger and Ca channels in heart cells [3] and to decrease ion transport in canine tracheal epithelium, an effect that may contribute to decreased mucous clearance in the perioperative period. (asahq.org)
  • The type of active transport that uses chemical energy in the form of ATP for transporting molecules across a membrane is known as primary or direct active transport. (aakash.ac.in)
  • At their best, they usually rely on some mysterious things called ionic pumps, that perform active transport, powered by little motors, under instructions from molecules that act on their specific receptors. (raypeat.com)
  • Calcium is the most studied of all regulatory molecules, so it isnt surprising that there is more than one calcium paradox. (raypeat.com)
  • We hypothesized that the porcine liver is better than the rat liver as a model for the study of human liver Ca 2+ -ATPase activity. (psu.edu)
  • We also hypothesized that cold preservation would depress Ca 2+ -ATPase activity in the porcine liver. (psu.edu)
  • We conclude that the Ca 2+ -ATPase activity in the pig liver is equivalent to that of human liver, and thus, the pig liver is a better model than the rat liver. (psu.edu)
  • Cold preservation studies showed a significant decrease in porcine hepatic PM Ca 2+ -ATPase activity after 4 hours of storage and near-total inhibition after 12 hours. (psu.edu)
  • Porcine hepatic ER Ca 2+ -ATPase activity showed a 45% decrease in activity by 12 hours and a 69% decrease by 18 hours. (psu.edu)
  • We conclude that cold ischemia at clinically relevant times depresses PM Ca 2+ -ATPase more than ER Ca 2+ -ATPase activity in pig liver homogenates. (psu.edu)
  • This Hϩ flux ap- CO ϭ concentrations and the CaCO saturation state of the pears to be coupled to Ca2ϩ fluxes through Ca2ϩ/2Hϩ ex- change catalyzed by the enzyme Ca2ϩ adenosine triphospha- thereby stimulate photosynthesis? (medpdfarticles.com)
  • In biology and biochemistry, calcium is the substance most often studied, so it is significant that researchers still speak of a calcium paradox. (raypeat.com)
  • Active transport requires the expenditure of energy while passive transport does not require energy and is driven by concentration gradient. (aakash.ac.in)
  • Because the descending limb is permeable to water, but not to solutes and the ascending limb is impermeable to water but active in transport of solutes, a highly efficient concentration gradient is built (see figure above). (trc-p.nl)
  • The increased levels of oxidants and decreased levels of enzymatic, nonenzymatic antioxidants, glycoproteins and ATPases were observed in erythrocytes of aged rats. (scialert.net)
  • For unknown reasons, this abnormal calcium storage affects keratinocytes more than other types of cells. (medlineplus.gov)
  • In addition, abnormal calcium regulation disrupts the barrier function of the skin, making it more susceptible to infections. (medlineplus.gov)
  • Although ATP2C1 gene mutations probably also affect the transport of manganese within cells, abnormal manganese regulation is not thought to contribute to the signs and symptoms of Hailey-Hailey disease. (medlineplus.gov)
  • Influence of inhaled nitric oxide and hyperoxia on Na,K-ATPase expression and lung edema in newborn piglets. (childrensmercy.org)
  • In addition to proliferation and adhesion, calcium regulation in these cells appears to play an important role in maintaining the skin's barrier function, helping to keep foreign invaders such as bacteria out of the body. (medlineplus.gov)
  • Problems with calcium regulation impair many cell functions, including cell adhesion. (medlineplus.gov)
  • But there are ways of looking at the organism, focusing on energy metabolism, that dont involve the ad hoc theory of calcium pumps, and that make it easy to keep things in context. (raypeat.com)
  • In addition, the effects of halothane were assessed in the absence of extracellular calcium (Ca) with or without 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid, an intracellular Ca chelating agent. (asahq.org)
  • Metabolism - Dyslipoproteinemia (increased blood triglycerides and cholesterol), decreased glucose tolerance, insulin resistance, increased risk of metabolic syndrome, disturbances of bone and vitamin D metabolism, resistance to PTH, low circulating levels of PTH, resistance to vitamin D, low circulating levels of 25(OH)D, recurrence of calcium oxalate calculi. (illnesshacker.com)
  • functionally, unrelated suppressor transports found to the one-particle accumulation. (evakoch.com)
  • Objectives: The purpose of this study was to investigate the effect of stretch (the major risk factor for atrial fibrillation [AF]) on spatial and temporal alternations of action potential duration (APD-ALT) and calcium transient in cultured atrial myocyte monolayer. (tmu.edu.tw)
  • Results: High-rate pacing induced APD-ALT and calcium transient in atrial myocyte monolayer. (tmu.edu.tw)
  • Its final common pathway may be a disturbance in myocyte calcium homeostasis. (medscape.com)
  • PCP called much wiped in Drosophila, where it is the secretion of transport vectors and bodies in the gene( comprised in Maung and Jenny, 2011). (erik-mill.de)
  • Inflammation leads to excessive uptake of calcium by cells, and is a factor in obesity, depression, and the degenerative diseases. (raypeat.com)
  • Magnesium deficiency and calcium deficiency have some similar symptoms (such as cramping), but magnesium is antagonistic to calcium in many systems. (raypeat.com)
  • Actually they can never improve until their calcium and magnesium intakes are adequate. (raypeat.com)
  • Calcium supplements (or high calcium to magnesium diet). (illnesshacker.com)
  • This inhibition could reduce transepithelial Na transport. (asahq.org)
  • HALOTHANE and the volatile anesthetic agents can modulate ion channel function or ion transport in different tissues. (asahq.org)
  • Primary active transport can also use energy obtained from redox reactions and photons (light) for carrying out transport. (aakash.ac.in)
  • Vitamins K, E, and A are important in regulating calcium metabolism, and preventing osteoporosis. (raypeat.com)
  • Expression of the sarco/endoplasmic Ca(2+)-ATPase, SERCA1a, in fibroblasts induces the formation of organelle membrane arrays. (jefferson.edu)
  • The most common indications for digoxin are atrial fibrillation and atrial flutter with rapid ventricular response, especially in older or less active patients, though beta blockers and/or calcium channel blockers may be preferred in some patients, such as younger more active ones, or those without heart failure or hemodynamic instability. (wikipedia.org)
  • What are active transport? (aakash.ac.in)
  • The price paid is in terms of cellular energy and such a mode of transport is known as active transport. (aakash.ac.in)
  • In this article we will learn more about active transport. (aakash.ac.in)
  • Let us try to understand the process of active transport in detail. (aakash.ac.in)
  • Here, the process of active transport comes into the picture. (aakash.ac.in)
  • A distinctive feature of type II pRTA is that it is nonprogressing, and when the serum bicarbonate is reduced to approximately 15 mEq/L, a new transport maximum for bicarbonate is established and the proximal tubule is able to reabsorb all of the filtered bicarbonate. (medscape.com)
  • The mitochondria can bind a certain amount of calcium during stress, but accumulating calcium can reach a point at which it inactivates the mitochondria, forcing cells to increase their inefficient glycolytic energy production, producing an excess of lactic acid. (raypeat.com)
  • When cells are stressed or dying, they take up calcium, which tends to excite the cells at the same time that it inhibits their energy production, intensifying their stress. (raypeat.com)
  • The appropriate storage and release of calcium is essential for many cell activities, including cell growth and division (proliferation), cell movement (migration), and attachment of cells to one another (cell adhesion). (medlineplus.gov)
  • Interorganelle Tethering to Endocytic Organelles Determines Directional Cytokine Transport in CD4+ T Cells. (leica-microsystems.com)
  • if an organ such as the heart is deprived of calcium for a short time, its cells lose their ability to respond normally to calcium, and instead they take up a large, toxic amount of calcium. (raypeat.com)