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  • methyltransferase
  • Vaccination with Salmonella enterica serovar Typhimurium lacking DNA adenine methyltransferase confers cross-protective immunity against multiple Salmonella serotypes. (mdpi.com)
  • To identify genes encoding proteins that may contribute to cross-protective immunity, we used a Salmonella Typhimurium DNA adenine methyltransferase mutant strain (UK-1 dam mutant) derived from the parental UK-1 strain, and assessed the transcriptional profile of the UK-1 dam mutant and UK-1 strain grown under conditions that simulate the intestinal or endosomal microenvironments encountered during the infective process. (mdpi.com)
  • DNA adenine methyltransferase (Dam) is widespread and conserved among the γ-proteobacteria. (osti.gov)
  • transport
  • Under conditions in which extensive metabolism of intracellular adenosine was present, [3H]adenosine accumulation by DDT1 MF-2 cells was almost completely inhibited by iodotubercidin and the adenosine deaminase inhibitor erythro-9-(2-hydroxy-3-nonyl)-adenine or by the nucleoside transport inhibitor nitrobenzylthioinosine. (aspetjournals.org)
  • Adenine nucleotide transport by wild-type AAC2 is inhibited by the sulfhydryl reagent 2-sulfonatoethyl-methanethiosulfonate (MTSES), whereas the activity of a mutant AAC2, devoid of cysteines, is unaffected. (cam.ac.uk)
  • guanine
  • adenine and guanine are constituents of all nucleic acids (see below) and, hence, are found in all plant and animal tissues. (dictionary.com)
  • On August 8, 2011, a report, based on NASA studies with meteorites found on Earth, was published suggesting building blocks of DNA and RNA (adenine, guanine and related organic molecules) may have been formed extraterrestrially in outer space. (wikipedia.org)
  • nucleic
  • A major goal of origin-of-life studies is to determine potential mechanisms for the prebiotic synthesis of nucleic acid bases, such as adenine. (acs.org)
  • Compounds
  • Adenine is also part of other biologically important compounds, such as ATP, NAD, and vitamin B-12, and occurs in tea. (dictionary.com)
  • Adenine forms several tautomers, compounds that can be rapidly interconverted and are often considered equivalent. (wikipedia.org)
  • protein
  • Adenosine methylation does not occur naturally in eukaryotes and therefore adenine methylation in any region can be concluded to have been caused by the fusion protein, implying the region is located near a binding site. (wikipedia.org)
  • Flavin adenine dinucleotide synthetase 1 is a protein that in humans is encoded by the FLAD1 gene. (wikipedia.org)
  • molecule
  • Both adenine-fed wild-type (WT) and Jα18KO mice exhibited renal dysfunction, but adenine-fed Jα18KO mice presented higher expression of kidney injury molecule-1 (KIM-1), tumor necrosis factor (TNF)-α and type I collagen. (springer.com)
  • The image on the right shows pure adenine, as an independent molecule. (wikipedia.org)
  • occurs
  • If adenine formation occurs throughout space, 'life everywhere might have started out pretty much the same way,' he adds. (acs.org)
  • chemical
  • This enzyme catalyses the following chemical reaction S-adenosyl-L-methionine + DNA adenine ⇌ {\displaystyle \rightleftharpoons } S-adenosyl-L-homocysteine + DNA 6-methylaminopurine This is a large group of enzymes. (wikipedia.org)
  • serum
  • Does anyone do these kind of assays, and do you typically remove the serum when you load the cells with hot adenine? (bio.net)
  • cells
  • The approach I am going to take is to metabolically label the cells with [3H]-adenine, and then measure the [3H]-cAMP that is produced from drug treatments in the assay several hours later. (bio.net)
  • To analyze the role of activated iNKT cells in our model, we administered αGalCer in WT mice during adenine ingestion. (springer.com)
  • Ectopic expression of Dam in eukaryotic cells leads to methylation of adenine in GATC sequences without any other noticeable side effect. (wikipedia.org)
  • found
  • However, in isolated conditions, i.e. in an inert gas matrix and in the gas phase, mainly the 9H-adenine tautomer is found. (wikipedia.org)