Acute phase transcription chemotactic factors. Medical search. Frequent questions

SAA protein is an acute phase reactant, like C-reactive protein (CRP), and is synthesized by hepatocytes under the transcriptional regulation of cytokines, including interleukin (IL)-1, IL-6 and tumor necrosis factor (TNF). (medscape.com)
Expression and secretion of chemotactic cytokines IL-8 and MCP-1 by human endothelial cells after Rickettsia rickettsii infection: regulation by nuclear transcription factor NF-kappaB. (nih.gov)
Adipose tissue is an active endocrine organ that secretes various humoral factors (adipokines), and its shift to production of proinflammatory cytokines in obesity likely contributes to the low-level systemic inflammation that may be present in metabolic syndrome-associated chronic pathologies such as atherosclerosis. (hindawi.com)
The inflammatory process in asthma involves the increased expression of various pro-inflammatory chemokines, cytokines, growth factors, lipid mediators, adhesion molecules, enzymes, and receptors for the same inflammatory mediators 21 . (ersjournals.com)
At infection sites, activated T cells secrete cytokines (eg, interferon-gamma [IFN-gamma]) that induce production of macrophage migration inhibitory factor, preventing macrophages from leaving. (msdmanuals.com)
Activated macrophages kill intracellular organisms and secrete cytokines (eg, tumor necrosis factor-alpha [TNF-alpha], IL-10). (msdmanuals.com)
Inflammaging: Age and Systemic, Cellular, and Nuclear Inflammatory Biology in Older Adults https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777092/ "STAT signal transducer and activator of transcription … Within a community-dwelling sample of older adults, older age is associated with increases in STAT activation, along with increases of systemic inflammatory cytokines. (boaim2.se)
These neuroimmune factors include various cytokines, Toll-like receptors (TLRs), and high-mobility group protein box 1 (HMGB1). (nih.gov)

Infection of endothelial cells (EC) with Rickettsia rickettsii results in Rocky Mountain spotted fever, an acute illness characterized by systemic inflammation. (nih.gov)
Later, it was demonstrated to be a multifunctional cytokine that regulates numerous biological processes including the organ development, acute-phase responses, inflammation, and immune responses ( 2 ). (frontiersin.org)
The chemokine family contains many regulators of inflammation, cellular function and cellular migration-all critical factors in understanding the potential potency of a novel cellular therapeutic. (biomedcentral.com)
Identification of cytokine patterns associated with inflammation in acute SAH will provide insights into underlying biological processes of DCI and poor outcomes that may be amenable to interventions. (biomedcentral.com)
TGFβ1 was initially identified as a potent chemotactic cytokine to initiate inflammation, but the autoimmune phenotype seen in TGFβ1 knockout mice reversed the dogma of TGFβ1 being a pro-inflammatory cytokine to predominantly an immune suppressor. (ijbs.com)
Ligation of PRRs induces downstream-signaling pathways modifying the activity of transcription factors that regulates the expression of genes linked to inflammation. (intechopen.com)
This chronic low-grade inflammation occurring in the absence of overt infection has been defined as "inflammaging" and represents a significant risk factor for morbidity and mortality in the elderly. (boaim2.se)
The skin responds to injury with a series of dynamic processes that can be summarized into three phases: 1) coagulation/inflammation, 2) tissue formation and 3) remodeling. (scirp.org)

7. MEK/ERK and signal transducer and activator of transcription signaling pathways modulate oncostatin M-stimulated CCL2 expression in human osteoblasts through a common transcription factor. (nih.gov)

The protein has also been shown to be chemotactic for neutrophils, and it stimulates degranulation, phagocytosis, and cytokine release in these cells. (medscape.com)
Indeed, inflammatory process is regulated by the dynamics of cell populations that migrate to the lung, such as neutrophils and on the other hand, the role of the modulation of transcription factors and reactive oxygen species (ROS) sources, such as nuclear factor kappaB and NADPH oxidase. (openrespiratorymedicinejournal.com)
classification of E. coli mastitis, lifespan of neutrophils, host factors that influence severity, tissue damage and production loss. (123dok.net)

In both MS and EAE, VEGF acts as a pro-inflammatory factor in the early phase but its reduced responsivity in the late phase can disrupt neuroregenerative attempts, since VEGF naturally enhances neuron resistance to injury and regulates neural progenitor proliferation, migration, differentiation and oligodendrocyte precursor cell (OPC) survival and migration to demyelinated lesions. (biomedcentral.com)
It regulates the release of CYTOCHROME C and APOPTOSIS INDUCING FACTOR from the MITOCHONDRIA . (lookformedical.com)
Ethanol exposure activates signaling pathways featuring high-mobility group box 1 and Toll-like receptor 4 (TLR4), resulting in induction of the transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells, which regulates expression of several cytokine genes involved in innate immunity, and its target genes. (nih.gov)

Chronic or acute, recurrent, substantial elevations of SAA are necessary but not sufficient for the development of amyloidosis. (medscape.com)
Additionally, we summarize the roles of IL-6 in several renal diseases, such as IgA nephropathy, lupus nephritis, diabetic nephropathy, acute kidney injury, and chronic kidney disease. (frontiersin.org)
Acute forms of ocular allergy involve transient symptoms of itching, tearing, and swelling, while chronic allergies are sight-threatening and exhibit symptoms such as severe pain and visual disturbances ( Leonardi, 1999 ). (frontiersin.org)
Our results show that CXCL17 production increases in the lung of M. tuberculosis -infected mice during acute and chronic stages of infection. (aai.org)
ABL-001 (asciminib), a potent and selective allosteric tyrosine-protein kinase ABL1 inhibitor that is undergoing clinical development testing in patients with Chronic myeloid leukemia (CML) and Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia. (ncats.io)

Monocytes migrate into tissues, where over about 8 hours, they develop into macrophages under the influence of macrophage colony-stimulating factor (M-CSF), secreted by various cell types (eg, endothelial cells, fibroblasts). (msdmanuals.com)
Innate immune genes are associated with rapid first-line responses to infections that involve primarily immune cells called monocytes (e.g., the acute- phase response). (nih.gov)

[ 5 , 6 ] Under the influence of the inflammatory cytokine IL-6, hepatic transcription of the messenger ribonucleic acid (mRNA) for SAA may increase 1000-fold when exposed to an inflammatory stimulus. (medscape.com)
After an acute stroke, sensors of the innate immune system such as Toll-like receptors (TLRs) and innate immune cells, are activated by brain ischemia, leading to amplification of the inflammatory cascade. (en-journal.org)
These factors initiate the recruitment phase of inflammatory cells into the conjunctival mucosa, which leads to the late phase reaction. (frontiersin.org)
Here, the circulating phagocytic hemocytes were chemically depleted by injecting the snails with clodronate liposomes, and the effects on the cephalic tentacle regeneration onset and on Pc-Hemocyanin, Pc-transglutaminase (Pc-TG) and Pc-Allograft Inflammatory Factor-1 (Pc-AIF-1) gene expressions were investigated. (unimore.it)
Tuberculosis has been reported in patients treated for arthritis, inflammatory bowel disease, and other conditions with tumor necrosis factor (TNF)-alpha blockers/antagonists. (medscape.com)

16. Modulation of hepatic acute phase gene expression by epidermal growth factor and Src protein tyrosine kinases in murine and human hepatic cells. (nih.gov)

13. Regulation of vascular endothelial growth factor expression by EMMPRIN via the PI3K-Akt signaling pathway. (nih.gov)

Platelet-rich plasma (PRP) that harbors platelet-derived growth factor (PDGF) is another means of treating tendon injury, although the effect is limited, possibly because of a low concentration of PDGF in the preparation [ 5 ]. (biomedcentral.com)
Growth factors such as transforming growth factor β (TGF-β), epidermal growth factor (EGF), fibroblast growth factor (FGF) and platelet-derived growth factor (PDGF) are involved in the excessive deposition of collagen in the dermis and subcutaneous tissues often resulting in keloid and hypertrophic scars [2]. (scirp.org)

[ 1 ] It is characterized by extracellular tissue deposition of fibrils that are composed of fragments of serum amyloid A (SAA) protein, a major acute-phase reactant protein, produced predominantly by hepatocytes. (medscape.com)
The presence of peptide-aldehyde compound MG132 to inhibit proteasome-mediated degradation of the inhibitory protein IkappaBalpha and synthetic peptide SN-50 to inhibit the nuclear translocation of nuclear factor-kappa B (NF-kappaB) resulted in significant inhibition of the chemokine response. (nih.gov)
Some of their functions are overlapping such as both IL-6 and IL-11 participate in promoting the synthesis of acute-phase protein in hepatocytes ( 7 - 9 ), and IL-11, IL-6, OSM as well as CT-1 are all involved in the bone metabolism by stimulating osteoclast formation ( 10 , 11 ). (frontiersin.org)
Propolis and these components exhibited immunomodulatory effects on a wide spectrum of immune cells, including cells of lymphoid or monocytic lineages, mediated by the extracellular signal-regulated kinase 2 and mitogen-activated protein-kinase signalling pathway and by eukaryotic transcription factors: nuclear factor of activated T cells and nuclear factor κB. (ijpsonline.com)
These were, beta-catenin, neural cell adhesion molecule (NRCAM), matrix metalloproteinase-2 (MMP-2), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), hepatocyte growth factor-alpha (HGF-alpha), monocyte chemottractant protein-1 (MCP-1) and and Tie-2 as well as c-kit. (biomedcentral.com)
Together, these changes amplify expression of a large number of genes through kinase signaling pathways that converge on two transcription factors called nuclear factor kappa-light-chain-enhancer of activated B cells (NF- κ B) and activator protein-1 (AP-1). (nih.gov)

4. C5a differentially stimulates the ERK1/2 and p38 MAPK phosphorylation through independent signaling pathways to induced chemotactic migration in RAW264.7 macrophages. (nih.gov)

Transforming growth factor β (TGFβ) is a multipotent cytokine consisting of TGFβ1, 2, and 3, with TGFβ1 being the most abundant isoform in most tissues, including the skin. (ijbs.com)

3. Phosphatidylinositol 3-kinase/Akt pathway is involved in transforming growth factor-beta1-induced phenotypic modulation of 10T1/2 cells to smooth muscle cells. (nih.gov)

Thus, angiogenesis, that supplies several trophic factors, should be promoted in therapeutic neuroregeneration efforts to combat the progressive, degenerative phase of MS. (biomedcentral.com)

11. Activation of extracellular signal-regulated kinase signaling by epidermal growth factor mediates c-Jun activation and p300 recruitment in keratin 16 gene expression. (nih.gov)
17. Epidermal growth factor-induced matrix metalloproteinase-1 expression is negatively regulated by p38 MAPK in human skin fibroblasts. (nih.gov)
Wound healing gene expressions include Ap1, Fos and Jun genes, and the krox zinc finger transcription factors that appear to activate the upregulation of hundreds of genes involved in cellular proliferation and epidermal migration between the scab and the healthy wound granulation tissue. (scirp.org)

RT qPCR gene expression evaluation Expression of selected genes, for microarray validation and to more examine biological processes of curiosity, was studied by reverse transcription quantitative real time PCR , with target qPCR primer sequences offered in Extra file 2. (cgrpreceptor.com)

These models show in animals pathophysiological events for acute respiratory distress syndrome (ARDS), such as neutrophil activation, reactive oxygen species burst, pulmonary vascular hypertension, exudative edema, and other events associated with organ dysfunction. (openrespiratorymedicinejournal.com)
Angiogenesis, the formation of new vessels, is found in Multiple Sclerosis (MS) demyelinating lesions following Vascular Endothelial Growth Factor (VEGF) release and the production of several other angiogenic molecules. (biomedcentral.com)
An angiogenic response has also been documented in an experimental model of MS, experimental allergic encephalomyelitis (EAE), where blood-brain barrier disruption and vascular remodelling appeared in a pre-symptomatic disease phase. (biomedcentral.com)
Antihistamines with multiple mechanisms of action can be effective during the early and late phases of allergic conjunctivitis by blocking the interaction between β 1 integrins and vascular cell adhesion molecule (VCAM)-1. (frontiersin.org)

2. Virulence factors of E. coli mastitis strains. (123dok.net)
P. gingivalis expresses a broad range of virulence factors, of these cysteine proteases (gingipains) are of special importance both for the bacterial survival/proliferation and for the pathological outcome. (intechopen.com)
The mechanisms by which P. gingivalis and its virulence factors interact with host immune cells and contribute to the pathogenesis of periodontitis and CVD are far from completely understood. (intechopen.com)
The number of bacilli in the inoculum and the relative virulence of the organism are the major factors determining transmission of the disease. (medscape.com)

8. TGF-beta-induced expression of tissue inhibitor of metalloproteinases-3 gene in chondrocytes is mediated by extracellular signal-regulated kinase pathway and Sp1 transcription factor. (nih.gov)

Angiogenesis correlates with patient survival following acute ischaemic stroke, and survival of neurons is greatest in tissue undergoing angiogenesis. (biomedcentral.com)

The microcurrent and ultra-low energy studies demonstrate significant healing where age is not a factor with no reoccurrence of diabetic wounds and other skin lesions. (scirp.org)

Risk factors for the acquisition of tuberculosis (TB) are usually exogenous to the patient. (medscape.com)

Patients with acute SAH admitted to the Neuroscience Intensive Care Unit at the Memorial Herman Hospital-Texas Medical Center, Houston, TX, between July 2013 and March 2015 were enrolled in a prospective observational study. (biomedcentral.com)
This phase II trial studies how well pembrolizumab and interferon gamma-1b work in treating patients with stage IB-IVB mycosis fungoides and Sezary syndrome that has come back (relapsed) or has not responded to previous treatment (refractory). (stanford.edu)
This phase 1-2 trial studies the side effects and best dose of ipilimumab in combination with toll-like receptor 9 (TLR9) agonist SD-101 and radiation therapy in treating patients with recurrent low-grade B-cell lymphoma. (stanford.edu)
FA patients also develop clonal chromosomal abnormalities in the bone marrow progenitor cells (i.e., chromosome 1 or 2 abnormalities or monosomy 7), which may evolve into myelodysplasia (MDS) or acute myeloblastic leukemia (AML). (ashpublications.org)
This is a Phase 2a, multi-center, open-label, two-arm study of approximately 25 patients with active IgG4-related disease (IgG4-RD). The two arms include (1) Experimental: rilzabrutinib with glucocorticoids and (2) Active Comparator: glucocorticoids only. (stanford.edu)

magadii contained three genes en coding putative enzymes from the later on phases from the fol ate biosynthesis pathway. (cgrpreceptor.com)

Furthermore, the injection of bsc1qdc iRNA in the vasculature results in decreased transcription of the gene and a significant impairment of phagocytosis and degranulation, suggesting the involvement of this molecule in immune responses. (unimore.it)
The differences in immune responses between the sexes and the reproductive phases in women are accompanied by variations in sex hormones. (brainimmune.com)
In the brain, both neurons and supporting glial cells (both astrocytes and microglia) contribute to the release of and responses to these neuroimmune factors. (nih.gov)

key factor in the cows' defense against intramammary infection with E. coli. (123dok.net)
Environmental factors also contribute to the likelihood of acquiring the infection. (medscape.com)
In fact, infection with human immunodeficiency virus (HIV) is one of the most significant risk factors for TB infection. (medscape.com)

This suggests the role of stem cell-released signaling molecules and factors on tissue regeneration. (biomedcentral.com)

Connective tissue growth factor (CTGF) can promote tendon wound healing by stimulating proliferation of a TSPC population marked by CD146. (biomedcentral.com)

ABL001 is being tested in clinical trials for treatment of CML and Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia alone and in combination with niotinib, imatinib or dasatinib. (ncats.io)

The anatomical analysis of TSPC populations in the wound healing process supports the hypothesis that substantial expansion of resident TSPC by exogenous growth factor is beneficial for tendon healing. (biomedcentral.com)

Therapy, genetic factors, and environmental factors have all been proposed as possible contributors to the response of the primary disease. (medscape.com)
Aging is a complex process that results from a combination of environmental, genetic, and epigenetic factors. (boaim2.se)
Asthma is a heterogeneous disease caused by genetic and environmental factors. (biomedcentral.com)

Exogenous growth factors that activate TSPC proliferation have emerged as a promising approach for treatment. (biomedcentral.com)

It is well known that bacterial, cow and environmental factors are interdependent and influence mastitis susceptibility. (123dok.net)

F. Reverse transcription polymerase chain reaction(RT-PCR) ···5 G. 림프절 분리, 단백질 추출 및 western blot ···6 H. 면역조직화학 염색 ···7 I. FACS analysis ···8 III. (123dok.co)

Just seven years later, type III interferons were applied clinically for the first time when type III interferon drugs developed by two companies, BMS and Zymo Genetics, had entered phase three clinical trial. (heighpubs.org)

In addition, it has been reported that in vivo monitoring of transplanted MSCs in an acute myocardial infarction tracked only 4.4% of MSCs in the transplanted site after 1 week, which indicated the poor survival rate of transplanted MSCs. (biomedcentral.com)

Growth factors injected into and around the injured site to stimulate tendon stem/progenitor cells (TSPC) proliferation may offer an alternative option for promoting tendon repair. (biomedcentral.com)
Skin gamma delta T cells (γδT) appear to emit signal warnings about keratinocyte damage and release key growth factors [1]. (scirp.org)

The study suggests that synthetic 29-mer peptide may be an innovative therapy for acute tendon rupture. (biomedcentral.com)
This is an open label, non-randomized, single site Phase I study to test the manufacturing feasibility and safety of locoregional (LR) administration of B7-H3CART into the central nervous system of adult subjects with recurrent IDH wild-type GBM using a standard 3+3 dose escalation design. (stanford.edu)

Interleukin-6 (IL-6) was discovered in 1986 as a B cell stimulatory factor initiating IgG production ( 1 ). (frontiersin.org)
Other BBB permeability promoting factors such as interferon-γ (IFN-γ), tumour necrosis factor-α (TNF-α) and interleukin-1 (IL-1) have been described in MS [reviewed in 7] (Table 1 ). (biomedcentral.com)

These experimental animal models reproduce key components of the injury and resolution phases of human ALI/ARDS and provide a methodology to explore mechanisms and potential new therapies. (openrespiratorymedicinejournal.com)
29-mer) for treating acute tendon injury and to determine the timing and anatomical features of CD146- and necleostemin-positive TSPC in the tendon healing process. (biomedcentral.com)

Acute respiratory distress syndrome (ARDS) is defined as an acute-onset, progressive, hypoxic condition with radiographic bilateral lung infiltration, which develops after several diseases or injuries, and is not derived from hydrostatic pulmonary edema. (openrespiratorymedicinejournal.com)

Anatomy22

Organisms8

Diseases10

Chemicals and Drugs128

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes63

Disciplines and Occupations2

Information Science3

Health Care1

Cytokines8

Inflammation8

Signal transducer and activator of transcription1

Neutrophils3

Regulates3

Chronic5

Monocytes2

Inflammatory5

Hepatic1

Signaling pathway1

Platelet-derive2

Protein6

Macrophages1

Cytokine1

Modulation1

Trophic factors1

Epidermal3

Biological processes1

Vascular4

Virulence4

Expression1

Stroke1

Diabetic1

Tuberculosis1

Patients5

Enzymes1

Responses3

Infection3

Molecules1

Tissue1

Leukemia1

Substantial1

Genetic3

Exogenous1

Susceptibility1

Reverse1

Clinical1

Survival1

Growth factors2

Study2

Interleukin2

Injury2

Progressive1