AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesNamed GroupsHealth Care
Bone TransplantationBone BanksBone and BonesLiver TransplantationTransplantation, HomologousBone Marrow TransplantationKidney TransplantationBone RemodelingHematopoietic Stem Cell TransplantationTransplantation, AutologousHeart TransplantationLung TransplantationBone DensityStem Cell TransplantationTransplantation ConditioningGraft SurvivalOrgan TransplantationBone MarrowBone ResorptionBone Marrow CellsGraft RejectionPancreas TransplantationTissue DonorsIslets of Langerhans TransplantationTransplantationTransplantation ImmunologyCell TransplantationTransplantation ChimeraBone NeoplasmsBone DevelopmentBone DiseasesGraft vs Host DiseaseImmunosuppressive AgentsTransplantation, IsogeneicTreatment OutcomeLiving DonorsTransplantation, HeterotopicCord Blood Stem Cell TransplantationBone RegenerationHeart-Lung TransplantationTime FactorsTissue and Organ ProcurementTransplantation ToleranceRetrospective StudiesBone MatrixPeripheral Blood Stem Cell TransplantationImmunosuppressionHistocompatibility TestingLiver FailureFetal Tissue TransplantationPostoperative ComplicationsSkin TransplantationMesenchymal Stem Cell TransplantationTransplantation, HeterologousRecurrenceWhole-Body IrradiationWaiting ListsBone Diseases, MetabolicHistocompatibility
RemissionHematopoietic stem cell transChemotherapyChronic myeloidMultiple MyelomaLymphoblasticAutologous bone marrow traHematology2023NeoplasmsWhite blood cells called myeloidLeukaemia and Bone Marrow TransplaRelapsePromyelocyticMyelodysplastic syndromesSymptoms of acute myeloidTreated with allogeneicTreatmentsClinicalStem cellsBlood and marrow transplantationDiagnosed with acute myeloidOutcomes2020Allogeneic Stem CellMalignantPeripheralMyelocytic leukemiaCancerMyelogenousTreatment2019Causes acuteRadiationMedical oncologyCell Transplantation
Remission12
  • For three years she underwent several rounds of chemotherapy as well as radiation therapy and bone-marrow transplantation, but the cancer did not stay in remission. (worldpressphoto.org)
  • Alexander Kiani Introduction: Treatment-free remission (TFR) is increasingly considered as treatment goal for patients with chronic myeloid leukemia (CML), but information. (karger.com)
  • Criteria for defining a complete remission in acute myeloid leukaemia revisited. (rug.nl)
  • HDC with transplant is now standard therapy in multiple myeloma, acute myeloid leukemia in first remission, and intermediate-grade non-Hodgkin's lymphoma. (bdbiosciences.com)
  • Non-low-risk patients are evaluated for stem cell transplantation in first remission. (medscape.com)
  • Recent advances in flow cytometric and molecular measurable residual disease detection have further enhanced modern risk-stratified approaches to chemotherapy and allocation to allogeneic hematopoietic stem cell transplantation (HSCT) in first complete remission (CR1) when indicated. (haematologica.org)
  • This initial treatment aims to clear as many leukemia cells as possible in the blood and bone marrow and to induce remission. (medicalnewstoday.com)
  • Acute myeloid leukemia (AML) patients often undergo allogeneic hematopoietic cell transplantation (alloHCT) in first complete remission (CR). (elsevierpure.com)
  • People in remission from AML may be candidates for allogeneic stem cell transplantation. (clevelandclinic.org)
  • The patient received induction chemotherapy with daunorubicin and cytarabine and achieved remission, was treated with allogeneic bone marrow transplantation, but died 7 months after initial diagnosis. (ajmc.com)
  • Treatment includes induction chemotherapy to achieve remission and postremission chemotherapy (with or without stem cell transplantation) to avoid relapse. (msdmanuals.com)
  • the ATO dosage is 0.15 mg/kg/day IV until bone marrow remission occurs (maximum induction, 60 doses). (medscape.com)
Hematopoietic stem cell trans6
Chemotherapy17
  • The increasing success of intensive consolidation chemotherapy (CCT) as an alternative to bone marrow transplant (BMT) in acute myeloid leukaemia (AML) necessitates comparison of the impact on quality of life (QoL) of these two treatment modalities. (ox.ac.uk)
  • It is also used to treat neutropenia induced by chemotherapy during the treatment of acute myeloid leukemia. (wikipedia.org)
  • Stem cell transplantation is performed after high-dose chemotherapy (HDC) to restore a cancer patient's blood and immune cell production capacity. (bdbiosciences.com)
  • 3 Following exogenous stimulation, such as chemotherapy or using growth factors such as granulocyte colony stimulating factor (G-CSF) and filgrastim, the number of HSCs in the peripheral blood increases, either becoming on par or even exceeding the number in the bone marrow. (bdbiosciences.com)
  • Saja received her initial chemotherapy in Rabat, before returning home to Gaza in February 2020 to continue her treatment and undergo bone marrow transplantation in the occupied Palestinian territory. (who.int)
  • Throughout efforts to refer Saja for bone marrow transplant, she has been receiving chemotherapy at Rantisi Hospital in Gaza City. (who.int)
  • The publication, "Marrow irradiation with high-dose 153 Samarium-EDTMP followed by chemotherapy and hematopoietic stem cell infusion for acute myelogenous leukemia" by Vilmarie Rodriguez, M.D., a Pediatric Oncologist at The Mayo Clinic in Rochester, Minnesota, appears in a recent issue of the peer-reviewed journal Leukemia & Lymphoma (Leuk Lymphoma. (salesandmarketingnetwork.com)
  • His main academic and clinical interests focus on prognostication of acute myeloid leukaemia (AML), bone marrow transplantation, late effects of chemotherapy/ bone marrow transplantation, fertility in recipients of chemotherapy and immunotherapy of haematological malignancies (i.e. monoclonal antibodies, CAR-T cells). (hcahealthcare.co.uk)
  • The procedure involves depleting diseased bone marrow with chemotherapy or radiation and then intravenously infusing healthy donor stem cells into the patient. (shebaonline.org)
  • Doctors can use stem cell transplants or bone marrow transplants to give people with AML higher doses of chemotherapy. (medicalnewstoday.com)
  • Before chemotherapy medicines suppress the immune system, hematopoietic stem cells-which produce blood cells-that are generated from a person's bone marrow or blood are collected or kept. (bonemarrowtransplantations.com)
  • Although the incidence of acute nonlymphocytic leukemia is increased in PV, the incidence of acute leukemia in patients not exposed to chemotherapy or radiation therapy is low. (basicmedicalkey.com)
  • Interestingly, chemotherapy, including hydroxyurea, has been associated with acute leukemia in JAK2 V617F-negative stem cells in some PV patients. (basicmedicalkey.com)
  • For example, people who have stem cell transplantation go through intensive chemotherapy before treatment. (clevelandclinic.org)
  • Approximately one-third of children with acute myeloid leukemia (AML) experience disease relapse despite risk-adapted intensive multiagent chemotherapy with or without hematopoietic cell transplantation (HCT) [ 1 ]. (biomedcentral.com)
  • AML (Acute Myeloid Leukemia) is a blood cancer (haematological malignancy), and the standard way of treating older AML patients is chemotherapy. (lu.se)
  • Acute urinary retention has not yet been undergo intensive chemotherapy, we preferred a therapeutic described in the literature as a side effect of decitabine. (bvsalud.org)
Chronic myeloid12
  • He has been awarded RO1 funding in the past for the use of autologous dendritic cell therapy for chronic myeloid leukemia. (mayoclinic.org)
  • Phenotypically diverse myeloid neoplasms that include patients that have been categorized as: chronic eosinophilic leukemia (CEL)/ atypical chronic myeloid leukemia with eosinophilia in 4 (Luciano et al. (atlasgeneticsoncology.org)
  • 2010), chronic myeloid leukemia (CML) in 1 (Hild & Fonatsch. (atlasgeneticsoncology.org)
  • Methods: We evaluated the IRF4 expression kinetics during tyrosine kinase inhibitor (TKI) treatment in a cohort of 116 chronic myeloid leukemia (CML) patients to elucidate its role in the disease course. (karger.com)
  • Pia Raanani Introduction: Data regarding the prevalence of paraproteinemia in patients with chronic myeloid leukemia (CML) are lacking. (karger.com)
  • Its occurrence is linked to leukemic diseases of the myeloid cell line, most commonly in acute myeloid leukemia (AML) and less commonly in chronic myeloid leukemia (CML), myelodysplastic syndrome (MDS) or other myeloproliferative disorders [ 4 ]. (biomedcentral.com)
  • A Retrospective Real-Life Analysis of Chronic Myeloid Leukemia Patients in Suboptimal Response to Imatinib. (unito.it)
  • Age influences initial dose and compliance to imatinib in chronic myeloid leukemia elderly patients but concomitant comorbidities appear to influence overall and event-free survival. (unito.it)
  • As the therapy is used, each leukemia subtype had its peculiarities regarding the treatment, especially the introduction of imatinib for chronic myeloid leukemia (CML) and prophylactic cranial irradiation for cases of ALL. (sld.cu)
  • Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukemia treated with nilotinib. (uib.no)
  • Cytogenetic and molecular genetic evolution of chronic myeloid leukemia. (lu.se)
  • Chronic myeloid leukemia (CML) is genetically characterized by the presence of the reciprocal translocation t(9;22)(q34;q11), resulting in a BCR/ABL gene fusion on the derivative chromosome 22 called the Philadelphia (Ph) chromosome. (lu.se)
Multiple Myeloma2
  • Oryzon's LSD1 advanced leads were efficacious in the treatment of Acute Lymphoblastic Leukemia (ALLs), which represents 25% of juvenile leukemia, and in certain types of multiple myeloma and Chronic Lymphocytic leukemia. (technologynetworks.com)
  • Dr. Aditya Murali has a special interest in Haemato Oncology, Acute Myeloid, Multiple Myeloma, Leukaemia and Bone Marrow Transplantation. (chieftourism.com)
Lymphoblastic5
  • Myeloproliferative disorders (MPD) with eosinophilia (or chronic eosinophilic leukemia (CEL) and sporadic cases with acute myeloid leukemia (AML), B-cell acute lymphoblastic leukemia (ALL) or lymphoma. (atlasgeneticsoncology.org)
  • q11)) is the hallmark of chronic myelogenous leukemia (CML) but is also present in 15-30% of adult B-cell acute lymphoblastic. (karger.com)
  • Clofarabine increases the eradication of minimal residual disease of primary B-precursor acute lymphoblastic leukemia compared to high-dose cytarabine without improvement of outcome. (uke.de)
  • It is concluded a prevalence of leukemia in pediatric patients, with a predominance of the subtype Acute Lymphoblastic Leukemia (ALL). (sld.cu)
  • In children poor prognosis or relapsed acute myeloid leukaemia, relapsed acute lymphoblastic leukaemia and conditioning before bone marrow transplantation. (medscape.co.uk)
Autologous bone marrow tra1
  • It was approved by the FDA in March 1991 under the trade name Leukine for acceleration of white blood cell recovery following autologous bone marrow transplantation in patients with non-Hodgkin's lymphoma, acute lymphocytic leukemia, or Hodgkin's disease. (wikipedia.org)
Hematology2
  • He was the Director of the Myeloid Disease Oriented Group in the Division of Hematology from 2002 to 2016. (mayoclinic.org)
  • A respected specialist in the field, Dr. Smith is a professor and chair of City of Hope's Department of Hematology & Hematopoietic Cell Transplantation . (cityofhope.org)
20232
  • Bone Marrow Transplant;58(7): 801-810, 2023 07. (bvsalud.org)
  • The American Cancer Society estimates that in the United States in 2023 there will be about 20,000 new cases of acute myeloid leukemia (AML) and about 11,300 deaths , almost all in adults. (msdmanuals.com)
Neoplasms2
  • Chromosomal translocations involving chromosome bands 5q31-33 that contain the gene encoding the platelet-derived growth factor beta receptor (PDGFRB) are associated with a significant minority of patients with BCR/ABL1-negative chronic myeloid neoplasms. (atlasgeneticsoncology.org)
  • Acute myeloid leukemia has a number of subtypes and precursor neoplasms that are distinguished from each other by morphology, immunophenotype, cytochemistry, and genetic abnormalities (see also The 2016 World Health Organization [WHO] Classification of myeloid neoplasms ) all of which have important implications for prognosis and treatment. (msdmanuals.com)
White blood cells called myeloid2
  • It affects a group of white blood cells called myeloid cells, which normally develop into various types of mature blood cells, such as red blood cells, white blood cells and platelets. (shebaonline.org)
  • In some cases, myelodysplastic syndromes can lead to acute myeloid leukaemia (AML, a cancer affecting white blood cells called myeloid cells). (europa.eu)
Leukaemia and Bone Marrow Transpla1
Relapse4
  • After multivariable adjustment , statistically significant associations between primary resistance, pre- transplantation measurable residual disease , DNMT3A mutation , or white blood cell count at diagnosis and early relapse were observed. (bvsalud.org)
  • Acute and chronic toxicities were primarily related to GVHD, infection and relapse rather than to TBI. (nature.com)
  • Although outcomes of children and adolescents with newly diagnosed acute myeloid leukemia (AML) have improved significantly over the past two decades, more than one-third of patients continue to relapse and experience suboptimal long-term outcomes. (haematologica.org)
  • The first evidence for the therapeutic effectiveness of natural killer (NK) cells in AML was established in a study of 57 adult patients, in which none of the 20 individuals who received haploidentical cell transplantation from a killer immunoglobulin-like receptor (KIR)-human leukocyte antigen (HLA)-mismatched donor experienced disease relapse [ 2 ]. (biomedcentral.com)
Promyelocytic2
  • Acute promyelocytic leukemia (APL) is a subtype of AML with recurrent genetic abnormalities. (msdmanuals.com)
  • Acute promyelocytic leukemia (APL) is a distinct variant of acute myeloid leukemia (AML). (medscape.com)
Myelodysplastic syndromes2
  • myelodysplastic syndromes, a group of conditions where too few blood cells are produced by the bone marrow. (europa.eu)
  • Clinical outcomes and characteristics of patients with TP53-mutated acute myeloid leukemia or myelodysplastic syndromes: a single center experience. (cdc.gov)
Symptoms of acute myeloid1
Treated with allogeneic1
Treatments8
Clinical4
  • His research interests include clinical trials for acute and chronic leukemia including blood and marrow transplantation and supportive care of blood and marrow transplant patients. (mayoclinic.org)
  • Tandem Autologous Hematopoietic Cell Transplantation for Patients with Primary Progressive or Recurrent Hodgkin Lymphoma: A SWOG and Blood and Marrow Transplant Clinical Trials Network Phase II Trial (SWOG S0410/BMT CTN 0703). (cityofhope.org)
  • Areas related to clinical and experimental transplantation are also of interest. (lidsen.com)
  • We examined the effect of depth of clinical response, including incomplete count recovery (CRi) and/or measurable residual disease (MRD), in patients from the Center for International Blood and Marrow Transplantation Research (CIBMTR) registry. (elsevierpure.com)
Stem cells9
Blood and marrow transplantation2
  • He just completed an 8 year term as chair of the Committee on Education for the American Society of Blood and Marrow Transplantation. (mayoclinic.org)
  • Recommendations of CDC, the Infectious Disease Society of America, and the American Society of Blood and Marrow Transplantation. (cdc.gov)
Diagnosed with acute myeloid1
  • Pamela was diagnosed with acute myeloid leukemia in January 2000, when she was aged 20. (worldpressphoto.org)
Outcomes3
  • Results of Bone marrow transplant in Max hospital are very successful, as the surgeons pay close attention to even the smallest details and choose the best course of care, resulting in the best outcomes. (bonemarrowtransplantations.com)
  • Acute myeloid leukemia is a complicated heterogenous hematological cancer with a poor prognosis, but novel targets may lead to improved treatment and outcomes going forward. (ajmc.com)
  • Predictors of outcomes in adults with acute myeloid leukemia and KMT2A rearrangements. (cdc.gov)
20203
  • 14 September 2020 - Saja is a 9-year-old girl who was diagnosed with acute myeloid leukaemia in May 2019. (who.int)
  • She needs a bone marrow transplant, not available in the Gaza Strip, and has not been able to access the treatment she needs since March 2020. (who.int)
  • An initial appointment was scheduled for 22 March 2020 at An-Najah Hospital in Nablus, in the West Bank, but the hospital only offers autologous transplantation (using the patient's own bone marrow), while Saja needed an allogeneic transplant (with bone marrow from a donor). (who.int)
Allogeneic Stem Cell10
Malignant5
  • Acute myeloid leukemia (AML) is a malignant disease of the bone marrow in which hematopoietic precursors are arrested in an early stage of development. (medscape.com)
  • Myeloid sarcoma (MS), also known as chloroma, is an extramedullary manifestation of malignant primitive myeloid cells. (biomedcentral.com)
  • Aplastic anemia due to the progressive failure of the bone marrow, malignant neoplasias such as acute myeloid leukemia, liver tumors and squamous cell carcinoma are some of the possible evolutions of Fanconi Anemia. (bvsalud.org)
  • An increased risk for the development of malignant neoplasias in individuals with Fanconi Anemia has been reported, and this is progressive after bone marrow transplantation. (bvsalud.org)
  • In acute myeloid leukemia (AML), malignant transformation and uncontrolled proliferation of an abnormally differentiated, long-lived myeloid progenitor cell results in high circulating numbers of immature blood cells and replacement of normal marrow by malignant cells. (msdmanuals.com)
Peripheral6
  • 2 HSCs are primarily found in bone marrow niches, but a small fraction of HSCs can also be found in the peripheral blood. (bdbiosciences.com)
  • This pharmacologically induced egress of HSCs into peripheral blood, called mobilization, is utilized as the preferred strategy for generating HSCs for transplantation. (bdbiosciences.com)
  • 3 Autologous stem cell transplantation almost exclusively uses peripheral blood, while for allogeneic SCT, T-lymphocytes in the peripheral blood could pose some danger. (bdbiosciences.com)
  • Leukemia is a group of clonal diseases derived from a single cell with a genetic alteration in bone marrow or peripheral lymphoid tissue, and each type is determined by the specificity of the source cell. (sld.cu)
  • Examination of peripheral blood smear and bone marrow is diagnostic. (msdmanuals.com)
  • 2. Presence of a FLT3 (ITD and/or TKD) or CBL mutation in a bone marrow or peripheral blood sample taken no more than 42-days prior to cycle 1 day 1 if treatment on this treatment arm. (who.int)
Myelocytic leukemia1
  • According to the American Cancer Society, acute myeloid leukemia (AML), also known as acute myelocytic leukemia or acute myelogenous leukemia, is a cancer that begins in cells that normally develop into blood cells. (salesandmarketingnetwork.com)
Cancer4
  • An immune cell in the tumor microenvironment that may be important for inhibiting the immune response against bladder cancer is the myeloid derived suppressor cell (MDSC). (iospress.com)
  • The predominant pattern of treatment failure in AML involves incomplete elimination of the disease from the bone marrow," said Dr. Peter Anderson, a Pediatric Oncologist at The University of Texas MD Anderson Cancer Center, an investigator in the study and co-author of the publication. (salesandmarketingnetwork.com)
  • Acute myeloid leukemia (AML) is a cancer of the blood and bone marrow. (shebaonline.org)
  • Acute myeloid leukemia (AML) is a type of cancer in which the bone marrow makes too many immature white blood cells called myeloblasts. (medicalnewstoday.com)
Myelogenous2
  • Role of signal transduction inhibition in treatment of acute myelogenous leukemia/myelodysplasia. (rochester.edu)
  • This is a multicenter, open-label, Phase 1/2a dose escalation and expansion study of orally administered emavusertib (CA-4948) monotherapy in adult patients with Acute Myelogenous Leukemia (AML) or high risk Myelodysplastic Syndrome (MDS). (rochester.edu)
Treatment7
  • Treatment protocols for acute myeloid leukemia (AML) are provided below, including a general treatment approach and treatment recommendations for relapsed or refractory disease. (medscape.com)
  • Independently, Oryzon´s compounds were shown to be efficient in the treatment of acute myeloid leukemia (AML), which represents 40% of all leukemia in humans, and especially in mixed lineage leukemia (MLL), an aggressive form of acute myeloid leukemia. (technologynetworks.com)
  • When necessary, bone marrow transplants can be performed as part of acute myeloid leukemia treatment. (shebaonline.org)
  • Past patients of Max Healthcare are well impressed by the treatment results of Bone marrow transplants. (bonemarrowtransplantations.com)
  • Intending to enhance the quality of life for patients and their families, the Center provides top-notch treatment facilities utilizing cutting-edge technology and cutting-edge medicines to treat the majority of complicated illnesses requiring allogeneic transplantation. (bonemarrowtransplantations.com)
  • Treatment of patients with B-cell chronic lymphocytic leukaemia (CLL) with sufficient bone marrow reserves. (medscape.co.uk)
  • For example, +8 is more common after busulfan than hydroxyurea therapy, and the secondary changes seen after interferon-alpha treatment or bone marrow transplantation are often unusual, seemingly random, and occasionally transient. (lu.se)
20192
  • Saja's mother is from Morocco, and she was diagnosed with acute myeloid leukaemia during a family visit to Rabat, Morocco, in May 2019. (who.int)
  • The radiology databases of 4 German university hospitals (University of Leipzig, Martin-Luther University of Halle (Saale), University Medicine of Göttingen, Ulm University Medical Center) were retrospectively screened for myeloid sarcoma in the time period between 01/2001 and 06/2019. (biomedcentral.com)
Causes acute2
  • What causes acute myeloid leukemia (AML)? (medlineplus.gov)
  • An uncommon but potential y lized to act as an alkylating agent, Infection with HIV-1 is the cause of dangerous side effect of immuno- causes acute myeloid leukaemia and the acquired immune deficiency syn- suppression to support organ trans- carcinoma of the urinary bladder in drome (AIDS). (who.int)
Radiation2
  • Additionally, it is used as a medical countermeasure for treating people who have been exposed to sufficient radiation to suppress bone marrow myelogenesis. (wikipedia.org)
  • In March 2018 the label was extended to use as a countermeasure for acute radiation syndrome. (wikipedia.org)
Medical oncology1
Cell Transplantation3