• subset
  • A subset of chromosomal translocations in acute leukemias results in the fusion of the trithorax‐related protein HRX with a variety of heterologous proteins. (embopress.org)
  • A subset of acute leukemias carries translocations of chromosome band 11q23 with reciprocal partners located at 30 or more cytogenetically diverse loci (for a review, see Waring and Cleary, 1997 ). (embopress.org)
  • Myelodysplastic syndrome (MDS) is a set of disorders characterized by marrow failure with peripheral blood cytopenias, a peculiar set of morphologic abnormalities in hematopoietic cells, increased marrow blasts in some cases, frequent characteristic cytogenetic abnormalities, and frequent progression to a subset of acute myeloid leukemia (AML). (medscape.com)
  • Nevertheless, a significant subset of pediatric myeloid disease (estimated at 10-15%) consists of MDS and MDR-AML. (medscape.com)
  • relapse
  • In this review, we aim to summarize the current literature reporting on the use of Aza and DAC to prevent or to treat relapse of myeloid malignancies after allo-SCT. (springer.com)
  • chromosome
  • The Rh blood group antigens are exposed on the RhD (CD240D) and RhCcEe (CD240CE) polypeptides encoded by the closely linked RHD and RHCE genes, respectively, on the short arm of chromosome 1 (1p36.2-p34). (bloodjournal.org)
  • cells
  • The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. (cancerindex.org)
  • Expression of miR-378 was analyzed in ovarian cancer cell lines and human tumors vs. normal ovarian epithelial cells by qRT-PCR. (cancerindex.org)
  • Schenk M, Bouchon A, Birrer S, Colonna M, Mueller C: Macrophages expressing triggering receptor expressed on myeloid cells-1 are underrepresented in the human intestine. (exbio.cz)
  • In this study, we compared the activity of several PPARγ ligands including BRL49653 (rosiglitazone), 15-deoxy-Δ12,14-prostaglandin J 2 , and the novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid on leukemia cells. (aacrjournals.org)
  • The infected cells had a dramatically enhanced potential to generate myeloid colonies with primitive morphology in vitro . (embopress.org)
  • Immortalized cells or enriched primary hematopoietic stem cells transduced with HRX-ENL induced myeloid leukemias in syngeneic and SCID recipients. (embopress.org)
  • Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation," The Journal of Immunology , vol. 182, no. 1, pp. 259-273, 2009. (hindawi.com)
  • genes
  • Genome-wide bisulfite sequencing in several cell types has established that the promoters of the most highly expressed genes show the lowest levels of CpG methylation and, conversely, that dense CpG methylation of promoters is associated with low gene expression ( 2 , 5 , 6 ). (frontiersin.org)
  • implies
  • Whether this association implies causality, and if so in which direction, is unclear: there is considerable evidence that DNA methylation follows rather than "instructs" gene expression ( 3 , 4 , 7 ) as further discussed below. (frontiersin.org)
  • treatment
  • PPARγ is an important mediator of the differentiation of preadipocytes to adipocytes and is a target in the treatment of diabetes, where receptor activation increases sensitivity to endogenous insulin. (aacrjournals.org)
  • potential
  • The importance of TAM is its potential to transform into an acute leukaemia, known as myeloid leukaemia of Down syndrome (ML‐DS), which is estimated to occur in ~20-30% of babies with TAM, although the exact frequency is not known. (pubmedcentralcanada.ca)
  • diagnosis
  • Similar problems are encountered in the diagnosis of lymphoproliferative disorders, although certain disorders such as hairy cell leukemia (HCL) can be quite distinctive morphologically. (thefreelibrary.com)
  • cell lines
  • Primary colonies could be replated for at least three generations in vitro and established primitive myelomonocytic cell lines upon transfer into suspension cultures supplemented with interleukin‐3 and stem cell factor. (embopress.org)
  • disease
  • Ideally, such a therapy mediates direct antileukemic effects and strengthens the graft-versus-leukemia (GvL) reaction, while on the other hand is not associated with an extensive risk for severe graft-versus-host disease (GvHD) and offers an acceptable toxicity profile. (springer.com)