• relapse
  • In this review, we aim to summarize the current literature reporting on the use of Aza and DAC to prevent or to treat relapse of myeloid malignancies after allo-SCT. (springer.com)
  • blood
  • RH genotyping of single erythropoietic burst-forming units, combined with microsatellite analysis of blood, different tissues, sorted blood cell subsets, and erythropoietic burst-forming units, indicated myeloid lineage-restricted loss of heterozygosity (LOH) of variable chromosome 1 stretches encompassing the RHD / RHCE gene loci. (bloodjournal.org)
  • The Rh blood group antigens are exposed on the RhD (CD240D) and RhCcEe (CD240CE) polypeptides encoded by the closely linked RHD and RHCE genes, respectively, on the short arm of chromosome 1 (1p36.2-p34). (bloodjournal.org)
  • genes
  • Genome-wide bisulfite sequencing in several cell types has established that the promoters of the most highly expressed genes show the lowest levels of CpG methylation and, conversely, that dense CpG methylation of promoters is associated with low gene expression ( 2 , 5 , 6 ). (frontiersin.org)
  • patients
  • Data from The Cancer Genome Atlas (TCGA) was utilized to correlate miR-378 expression with progression-free survival (PFS) among patients treated with anti-angiogenic therapy by using Kaplan-Meier and Cox proportional hazards. (cancerindex.org)
  • implies
  • Whether this association implies causality, and if so in which direction, is unclear: there is considerable evidence that DNA methylation follows rather than "instructs" gene expression ( 3 , 4 , 7 ) as further discussed below. (frontiersin.org)
  • cell
  • Similar problems are encountered in the diagnosis of lymphoproliferative disorders, although certain disorders such as hairy cell leukemia (HCL) can be quite distinctive morphologically. (thefreelibrary.com)
  • Several new subtypes of B-ALL have been recently described that exhibit distinct leukemic cell gene expression profiles, but diverse, often cytogenetically cryptic founding alterations (Figure 2). (medworm.com)
  • treatment
  • PPARγ is an important mediator of the differentiation of preadipocytes to adipocytes and is a target in the treatment of diabetes, where receptor activation increases sensitivity to endogenous insulin. (aacrjournals.org)
  • Cancer
  • This manuscript was supported in part by the MD Anderson Cancer Centre Leukaemia Support Grant (CCSG) CA016672 and the MD Anderson Cancer Center Leukemia SPORE CA100632. (medworm.com)
  • potential
  • The importance of TAM is its potential to transform into an acute leukaemia, known as myeloid leukaemia of Down syndrome (ML‐DS), which is estimated to occur in ~20-30% of babies with TAM, although the exact frequency is not known. (pubmedcentralcanada.ca)
  • therapy
  • Ideally, such a therapy mediates direct antileukemic effects and strengthens the graft-versus-leukemia (GvL) reaction, while on the other hand is not associated with an extensive risk for severe graft-versus-host disease (GvHD) and offers an acceptable toxicity profile. (springer.com)