• Jembrana
  • Multiple epitopes were recognized in a region corresponding to the major homology region of the human immunodeficiency virus, a region with significant sequence similarity to other lentiviruses including simian immunodeficiency virus, puma lentivirus, feline immunodeficiency virus, Jembrana disease virus, visna virus, and caprine arthritis encephalitis virus. (pubmedcentralcanada.ca)
  • Jembrana disease was reported initially in Bali cattle (Bos javanicus) on Bali island in 1964 and the causative agent was subsequently identified as a bovine lentivirus and designated Jembrana disease virus (JDV). (edu.au)
  • Changes in lymphocyte subsets during the course of Jembrana disease were investigated and analysis of the results showed that lymphopenia, a characteristic of the acute febrile phase of Jembrana disease, was at least partly due to a significant decrease in CD4+ and CD8+ T-cells and CD21+ B-cells. (edu.au)
  • lentivirus
  • Inactivated whole-virus preparations are useful against some diseases, but these vaccines generally do not generate a potent major histocompatibility complex (MHC) class I-restricted cytotoxic T-lymphocyte (CTL) response necessary to clear lentiviral-infected cells and are not effective against lentivirus variants ( 15 , 29 ). (pubmedcentralcanada.ca)
  • This atypical lentivirus causes an acutely pathogenic disease that is associated with clinical signs and pathological lesions attributable to a disease primarily affecting the lymphoid system. (edu.au)
  • clinical
  • The development of immune responses capable of recognizing conserved epitopes expressed on virus and viral-infected cells is critical to the control of virus replication and therefore clinical disease. (pubmedcentralcanada.ca)