• vaccines
  • Significant barriers exist to the development of effective vaccines that induce protection against the lentiviruses that cause severe disease in both humans and animals. (pubmedcentralcanada.ca)
  • Modified live vaccines are efficacious against numerous viral diseases, but concern over reversion to a virulent phenotype or recombination with endogenous or exogenous viruses have limited their use against lentiviruses ( 8 ). (pubmedcentralcanada.ca)
  • Synthetic peptide vaccines have numerous advantages including the inclusion of only defined epitopes to generate relevant immune responses rather than a broad response that may exacerbate infectivity and disease ( 4 , 23 , 29 , 48 ). (pubmedcentralcanada.ca)