Acute cyclosporine. Medical search. Frequent questions

Immunosuppressive regimens typically include a combination of a calcineurin inhibitor (tacrolimus or cyclosporine), an antiproliferative agent (mycophenolate mofetil, mycophenolate sodium, or azathioprine), and corticosteroids. (nih.gov)
Determine the safety and efficacy of sirolimus when administered with tacrolimus and methotrexate for the prevention of acute graft-versus-host disease (GVHD) in patients with hematological malignancies undergoing hematopoietic stem cell transplantation from unrelated donors. (knowcancer.com)
The trial evaluated abatacept when added to a standard-of-care regimen (methotrexate plus a calcineurin inhibitor, either cyclosporine or tacrolimus) for prophylaxis of acute GVHD. (dana-farber.org)
or tacrolimus dosing may also lead to biliary symptoms and acute pancreatitis. (stat-signal.com)

This study demonstrates an early colon survival advantage for patients treated with infliximab compared to those receiving i.v. cyclosporine for acute severe colitis requiring hospitalization at our institution. (medscape.com)
A retrospective study, performed by the Royal Brisbane group [ 24 ] (in abstract only at present) compared infliximab and cyclosporine as salvage therapy in acute severe UC and also reported similar findings. (medscape.com)
This analyzed 72 patients and compared colectomy rates at 12 months, which were 68% and 44% for cyclosporine and infliximab, respectively ( P = 0.049). (medscape.com)
However not all studies analyzing effectiveness of cyclosporine or infliximab have utilized the Oxford criteria. (medscape.com)
[ 17 ] comparing outcomes of a cohort given cyclosporine to another given infliximab, apart from the 17 cases previously included in the Jarnerot study. (medscape.com)
however, approximately 30%-40% of patients progress to second-line (salvage) therapy with infliximab or ciclosporin. (bmj.com)
Infliximab as rescue therapy after cyclosporin in an acute ulcerative colitis flare]. (bvsalud.org)
Infliximab como rescate a ciclosporina en un brote grave de colitis ulcerosa. (bvsalud.org)
The first stage of treatment is corticosteroids and if this fails, it is followed by a second line of medical therapy such as Remicade (infliximab) or Cyclosporine. (eu.com)

It is recommended that patients taking cyclosporine capsules, (NON-MODIFIED) over a period of time be monitored at repeated intervals for cyclosporine blood concentrations and subsequent dose adjustments be made in order to avoid toxicity due to high concentrations and possible organ rejection due to low absorption of cyclosporine. (nih.gov)
Cyclosporine has been demonstrated to suppress some humoral immunity and to a greater extent, cell-mediated reactions such as allograft rejection, delayed hypersensitivity, experimental allergic encephalomyelitis, Freund's adjuvant arthritis, and graft vs. host disease in many animal species for a variety of organs. (nih.gov)
Furthermore, acute cellular rejection is common after transplantation and will occur in up to 90% of patients and episodes are most likely to occur in the first post-operative year. (wikipedia.org)
Consequently, the application of ciclosporin by oral and IV administration has led to efforts to treat acute and acute refractory rejection by direct aerosol administration first in animal models and soon thereafter in transplant patients. (wikipedia.org)
A randomized, placebo-controlled trial of aerosolized ciclosporin that was published in the New England Journal of Medicine demonstrated a marked improvement in survival and reduction of chronic rejection incidence, but not in the primary endpoint of acute rejection. (wikipedia.org)
Chronic rejection of the lungs differs significantly from acute rejection. (wikipedia.org)
Whereas acute rejection exhibits perivascular infiltration of mononuclear cells and attendant inflammation of the surrounding tissue chronic rejection appears to have significant epithelial involvement and is essentially a fibro-proliferative disorder of the small airways. (wikipedia.org)
In fact, despite improvements in outcome associated with acute rejection, virtually no improvement in survival has been noted in chronic rejection over the last 20 years. (wikipedia.org)
The objective of this study is to conduct prospective clinical studies to investigate the impact of generic immunosuppressants on short term acute rejection and long term patient graft survival. (nih.gov)
The patient's medication protocol is discussed within this article, including the use of inhaled cyclosporine to treat acute cellular rejection, one of the major complications associated with lung transplantation. (ijpc.com)
NFATC1 genotypes affect acute rejection and long-term graft function in cyclosporine-treated renal transplant recipients. (cdc.gov)
Biopsy-confirmed acute rejection incidents showed a trend in favor of Group B (10%) vs. Group A (26%) and Group C (20%) combined (P=0.07). (northwestern.edu)
This three-year (interim) analysis has indicated a trend towards better graft function, fewer endocrine disorders, and fewer acute rejection episodes comparing adjunctive MMF and Tacro vs. Siro and Tacro or Siro and CsA, in the dosages used. (northwestern.edu)

Effectiveness of maintenance azathioprine therapy without oral cyclosporine after severe attacks of ulcerative colitis refractory to endovenous steroids]. (bvsalud.org)

The American College of Rheumatology (ACR) published guidelines on the treatment and prophylaxis of acute gouty arthritis and the management of hyperuricemia. (medscape.com)

The aim of the present study was to evaluate the immunosuppressive activity of mycophenolate mofetil (MMF), sirolimus, and their combination in an experimental model of hepatocyte allotransplantation in rats with acute liver failure. (nih.gov)

A 19-year-old man presented with acute severe ulcerative colitis. (bmj.com)
Up to a quarter of patients with ulcerative colitis (UC) will develop acute severe colitis (ASC) during their disease course, a potentially life-threatening condition. (bmj.com)
P227 Timing of acute severe colitis in the course of an inflammatory bowel disease: is it a prognostic factor? (ecco-ibd.eu)
In this study, we aimed to compare outcomes of patients with a severe acute colitis (SAC) inaugurating their inflammatory bowel disease (IBD) with SAC occurring in those with Known diagnosis of IBD. (ecco-ibd.eu)
We conducted a retrospective chart review of patients who were admitted to our unit for severe acute colitis over 7 years. (ecco-ibd.eu)
Patients with severe acute colitis inaugurating their IBD seemed to have more severe clinical presentation than in those followed for IBD and complicated by SAC. (ecco-ibd.eu)
Q: One thing that really struck me about the wide spectrum of the different models for colitis, from the chemical induced in the rapid acute models versus the chronic and spontaneous - it actually parallels a field that I'm familiar with, which is Parkinson's disease. (taconic.com)
Can you speak to the fact that in the colitis research publications, chemically-induced acute models may have a larger footprint, but do you think that that necessarily translates there better utility or wider adoption? (taconic.com)
Colitis ulcerosa en paciente con inmunodeficiencia común variable: ¿difiere el tratamiento del habitual? (bvsalud.org)
Ahead of the first ESCP/ECCO regional masterclass in Moscow, Professor Yves Panis (Professor of Digestive Surgery at the Université Paris VII and Head of the Department of Colorectal Surgery at Beaujon Hospital, Clichy, France) discusses the surgical treatment of acute severe colitis. (eu.com)
Although there are no established national registries or surveys on the exact numbers regarding the prevalence of acute severe colitis, the current evidence suggests that around 10-15% of all the patients with ulcerative colitis will at some point develop acute severe colitis. (eu.com)
The surgical benefits for treating acute severe colitis have been known for many years," explained Professor Panis. (eu.com)
Just after the Second World War, St Marks Hospital in London, UK, reported a mortality rate of over 50% for patients with acute severe colitis because they were treated with steroids without surgery. (eu.com)
This is usually the case in 70% of patients who have acute non-complicated colitis. (eu.com)
However, in patients who present with acute complicated colitis such as perforation or a large dilatation of the colon, then surgery is recommended before medical treatment. (eu.com)
For example, if the patient has acute colitis on the left colon and the transverse colon but the right colon is OK, then it is best to perform a subtotal colectomy with ileostomy with sigmoid-ostomy without any anastomosis in the abdomen. (eu.com)

Acute Kidney Injury (AKI) Acute kidney injury is a rapid decrease in renal function over days to weeks, causing an accumulation of nitrogenous products in the blood (azotemia) with or without reduction in amount of urine. (msdmanuals.com)
Etiology references Acute tubular necrosis (ATN) is kidney injury characterized by acute tubular cell injury and dysfunction. (msdmanuals.com)

Cyclosporin A therapy in steroid-refractory patients with chronic inflammatory bowel diseases]. (nih.gov)
About a quarter of the patients that develop acute GVHD may not respond to steroid and have steroid refractory GVHD (SR-aGVHD). (clinicaltrialsgps.com)

The U.S. Food and Drug Administration (FDA) today approved a treatment to prevent acute graft-versus-host disease (GVHD) in patients 2 years of age or older receiving a hematopoietic stem cell transplant from a matched or single-HLA-mismatched unrelated donor. (dana-farber.org)
With abatacept's approval as a preventive option for acute GVHD, we hope hematopoietic stem cell transplant becomes a more accessible option for more patients, particularly those of diverse ethnicities who have lower likelihoods of finding matched donors," said Steven Devine, MD, Chief Medical Officer of NMDP/Be The Match, and Associate Scientific Director of CIBMTR. (dana-farber.org)
Corticosteroids are the standard initial therapy for Acute GvHD (aGVHD) after HSCT (hematopoietic stem cell transplant aka BMT) and 25-41% patients will respond to prednisone (or methylprednisolone) at a dose of 2mg/kg/day. (clinicaltrialsgps.com)

The 12-month colectomy rate of 68% (13/19) for cyclosporine observed in this study is higher than the colectomy rate of 36% (5/14) reported in the study by D'Haens et al . (medscape.com)
There was no difference between both of the groups with regard to use of cyclosporine, colectomy, and recurrence of SAC. (ecco-ibd.eu)

Cyclosporine, the active principle in cyclosporine capsules, USP (NON-MODIFIED) is a cyclic polypeptide immunosuppressant agent consisting of 11 amino acids. (nih.gov)
Ciclosporin is a cyclic polypeptide that has been used widely as an orally-available immunosuppressant. (wikipedia.org)

Ciclosporin has been touted as a therapeutic option in moderate to severe asthmatic patients as a corticosteroid sparing agent. (wikipedia.org)
or (4) invite selected subjects patients to participate in limited pilot studies of novel combinations of standard therapeutic agents, such as rituximab and cyclosporine. (nih.gov)
To my knowledge, the only therapeutic that works consistently as a positive treatment control in DSS is something like cyclosporine A. A lot of the biologics don't work. (taconic.com)
This study aims to determine if two therapeutic treatments- cyclosporine and etanercept- are effective in improving the short-term outcomes of SJS/TEN compared to the typical standard of care. (sjsupport.org)

Inhaled ciclosporin has also shown promise in several other lung conditions. (wikipedia.org)
A multicentre retrospective study was undertaken to examine patients with interstitial lung disease (ILD) with the initial clinical manifestation of an anti-synthetase syndrome (anti-Jo-1 antibodies), and to analyse the characteristics and long-term outcome of these patients according to their clinical presentation (acute or gradual onset), treatment and adverse events related to treatment. (bmj.com)
The current review highlights the latest research findings in apoptosis after acute lung ischaemia-reperfusion injury. (ersjournals.com)
Overexpression of the multidrug resistance proteins P-glycoprotein (Pgp), multidrug resistance protein (MRP-1), breast cancer resistance protein (BCRP), and lung resistance protein (LRP) is associated with treatment failure in acute myeloid leukemia (AML) and other malignancies. (aacrjournals.org)

Acute GVHD is a potentially life-threatening complication in which T cells in the transplanted donor bone marrow attack the recipient's healthy cells and tissues, causing major damage to the skin, liver, and GI tract. (dana-farber.org)
When the donor is unrelated, as many as 70 percent of transplant recipients develop acute GVHD, particularly when donor and recipient are not fully matched on immune factors known as human leukocyte antigens (HLA). (dana-farber.org)
Acute GVHD happens when the donor cells attack and damage your tissues and organs after transplant. (clinicaltrialsgps.com)

Typical light microscopic changes included myofiber necrosis with interstitial edema and inflammatory infiltration in areas of acute injury. (aspetjournals.org)
characterized by acute tubular cell injury and dysfunction. (msdmanuals.com)

Treatment continues in the absence of acute graft-vs-host disease or unacceptable toxicity. (knowcancer.com)
Acute Graft Versus Host Disease (GVHD) is a serious medical condition that is a common development after Bone Marrow Transplant (BMT). (clinicaltrialsgps.com)

In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of ACE-inhibitors with drugs that affect RAAS may increase the risk of renal impairment (including acute renal failure) and cause loss of antihypertensive effect. (medscape.com)

Cyclosporin was the probable cause in our case as other causes of acute hepatitis were ruled out and withdrawal led to cure. (nih.gov)

Spondyloarthropathies (SpA) encompass a group of chronic inflammatory diseases sharing common genetic and clinical features, including the association with HLA-B27 antigen, the involvement of both the axial and the peripheral skeleton, the presence of dactylitis, enthesitis, and typical extra-articular manifestations such as psoriasis, inflammatory bowel disease, and acute anterior uveitis (AAU). (hindawi.com)
A study was undertaken to evaluate a large number of patients with anti-Jo-1 antibodies who presented with ILD as the initial clinical manifestation, with or without extrarespiratory symptoms suggestive of connective tissue disease, and to describe the characteristics and long-term outcome of these patients according to their clinical presentation (acute or gradual onset), treatment and adverse events related to treatment. (bmj.com)
The Pgp modulator cyclosporin A has shown clinical efficacy in AML, whereas its analogue PSC-833 has not. (aacrjournals.org)
Cyclosporin A is known to also modulate MRP-1, and we hypothesized that broad-spectrum multidrug resistance modulation might contribute to its clinical efficacy. (aacrjournals.org)
Cyclosporin A modulates Pgp, MRP-1, BCRP, and LRP, and this broad-spectrum activity may contribute to its clinical efficacy. (aacrjournals.org)
NATIENS is a clinical trial for Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis patients in the acute stage. (sjsupport.org)
Some species of fungi, including some molds, are known to be capable of producing secondary metabolites, or mycotoxins, some of which find a valuable clinical use, e.g., penicillin and cyclosporine. (aecb.net)

Patients receiving abatacept demonstrated reductions in severe acute GvHD, and improved survival in transplants involving both 8/8 matched and 7/8 mismatched unrelated donors," said Kean. (dana-farber.org)

Twenty-four male Wistar rats with portacaval anastomosis were randomised into four groups receiving ciclosporin or vehicle and ammonia or saline infusion. (wjgnet.com)

Steroids are the first line of treatment for acute GVHD. (clinicaltrialsgps.com)

Although the incidence of drug-induced skeletal muscle toxicity is very low (0.1-0.2%) with monotherapy, it may increase following concomitant drug therapy with the immunosuppressant, cyclosporine A (CsA), and possibly with certain other hypolipidemic agents. (aspetjournals.org)

Cyclosporin is used for the treatment of corticosteroid-resistant inflammatory bowel disease. (nih.gov)
Regular liver tests would thus be required for patients given cyclosporin for chronic inflammatory bowel disease. (nih.gov)
These efforts probed the anti-inflammatory and immunosuppressive properties of ciclosporin after regional deposition of drug in the lungs. (wikipedia.org)
The disease course is usually complicated by extra-articular manifestations (EAMs), such as psoriasis, inflammatory bowel disease (IBD), and acute anterior uveitis (AAU) [ 2 ]. (hindawi.com)

HMG-CoA reductase inhibitor-induced myopathy in the rat: cyclosporine A interaction and mechanism studies. (aspetjournals.org)
Cases of myopathy and rhabdomyolysis with acute renal failure secondary to myoglobinuria have been reported. (nih.gov)

Only physicians experienced in immunosuppressive therapy and management of organ transplant patients should prescribe cyclosporine capsules, (NON-MODIFIED). (nih.gov)
Cyclosporine capsules, (NON-MODIFIED) should be administered with adrenal corticosteroids but not with other immunosuppressive agents. (nih.gov)

For the induction of acute liver failure the recipients were injected with N-dimethyl-nitrosamine 24 hr before transplantation. (nih.gov)

To investigate the neuroprotective potential of ciclosporin during acute liver failure. (wjgnet.com)
Acute liver failure and hyperammonaemia can lead to severe brain oedema. (wjgnet.com)

Acute hepatitis with predominant major transaminase elevation occurred in a patient treated with cyclosporin for corticosteroid-resistant Crohnś disease. (nih.gov)
Six months earlier, acute B cell-type lymphoblastic leukemia was diagnosed in the patient for which he received bone marrow transplantation (BMT). (psychiatrictimes.com)

Ciclosporin was brought to market in 1983 but the first non human aerosol studies were not published until the late 1980s. (wikipedia.org)
The formulation for the cyclosporine for aerosol that was prepared by a compounding pharmacist is included with this article. (ijpc.com)

In agricultural settings, inhalation exposure to high concentrations of mixed organic dusts - which include bacteria, fungi, endotoxins, glucans, and mycotoxins - is associated with organic dust toxic syndrome, an acute febrile illness. (aecb.net)

Since allergy is an immune-mediated condition, cyclosporine was investigated as an alternative to corticosteroids and found effective for most patients. (marvistavet.com)

Experimental evidence suggests that the effectiveness of cyclosporine is due to specific and reversible inhibition of immunocompetent lymphocytes in the G 0 - or G 1 -phase of the cell cycle. (nih.gov)

A good 4-8 weeks are needed to see a good response to cyclosporine which makes it fairly useless for acute flare ups. (marvistavet.com)

32 patients, 15 (47%) presenting with acute onset and associated respiratory insufficiency (group A) and 17 (53%) with gradual onset (group G) were examined. (bmj.com)
The antihistamine is effective for acute onset and reduces pruritus, while the decongestant reduces chemosis, eyelid edema, and redness via vasoconstriction. (uspharmacist.com)

Preserving mitochondrial function by treatment with ciclosporin has shown potential in in vitro studies. (wjgnet.com)
Cyclosporin treatment of anal and perianal lesions associated with Crohn's disease. (nih.gov)

Other subjects may be treated with either conventional or approved agents, or (with separate consent) with a novel combination of conventional therapies (rituximab and cyclosporine) as part of pilot studies that would involve long-term follow-up care at the NIH. (nih.gov)

Numerous assays are being developed to measure blood concentrations of cyclosporine. (nih.gov)

Gabay C., Gigley J. , Sipe J., Arend W.P., Fantuzzi G. (2001) Production of IL-1 receptor antagonist by hepatocytes is regulated as an acute-phase protein in vivo. (uwyo.edu)

Anatomy2

Organisms3

Diseases11

Chemicals and Drugs22

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes10

Named Groups1

Health Care6

Tacrolimus4

Infliximab9

Rejection13

Azathioprine1

Prophylaxis of acute1

Sirolimus1

Colitis16

Kidney injury2

Refractory2

Hematopoietic stem cell3

Colectomy2

Cyclic polypeptide2

Therapeutic4

Lung4

Donor3

Injury2

Graft2

Renal impairment1

Causes of acute1

Clinical7

Severe acute1

Male Wistar rats1

GVHD1

Immunosuppressant1

Inflammatory4

Myopathy2

Immunosuppressive2

Recipients1

Liver failure2

Patient2

Aerosol2

Syndrome1

Corticosteroids1

Effectiveness1

Flare1

Onset2

Treatment2

Combination1

Concentrations1

Hepatocytes1