Loading...
  • treatment
  • The study population is the patients administered with only the oral opioid analgesic for cancer pain treatment, and administered with the immediate opioid analgesic for breakthrough pain more than twice a day on average for the three days prior to the 2nd visit. (bioportfolio.com)
  • If you are randomly (by chance) selected to receive placebo, you will receive this medication throughout the treatment period of the study. (bioportfolio.com)
  • Data from this study will provide essential information for choosing the doses of ralfinamide to be used in the treatment of this type of pain and potentially other types of pain. (bioportfolio.com)
  • In this sub-population, statistically significant improvements in severity of pain, as measured on the VAS and 11-point Likert scales, as well as a greater proportion of patients meeting "responder" criteria, compared to the placebo group, were noted with ralfinamide treatment. (bioportfolio.com)
  • Individuals who have been vocal about pain levels and received negative responses may feel angry, refusing treatment as an expression of emotional pain. (caregiver.com)
  • Has demonstrated effectiveness in treatment of chronic pain. (medscape.com)
  • Your doctor may prescribe additional pain relievers that act more quickly for treatment of acute or 'breakthrough' pain. (pharmasave.com)
  • Pain may occur as a result of cancer, cancer treatment, or both. (nyhq.org)
  • Dr. James Gorman, CEO and Chief Medical Officer for BDC commented, "The Cephalon commitment to develop CEP 37247 for non-operative treatment of sciatic pain is encouraging news for the patients, physicians and payors urgently seeking a more effective non-operative treatment for this prevalent, debilitating condition. (bio-medicine.org)
  • Most chronic (long-lasting) pain is caused by the illness and most acute (short-term) pain is caused by treatment or diagnostic procedures. (wikipedia.org)
  • and treats distressing symptoms such as pain to relieve suffering during treatment and healing. (wikipedia.org)
  • When a painful injury or pathology is resistant to treatment and persists, when pain persists after the injury or pathology has healed, and when medical science cannot identify the cause of pain, the task of medicine is to relieve suffering. (wikipedia.org)
  • There is a continuing risk in many types of pain management for the patient to take treatment which is less effective than needed or which causes other difficulty and side effects. (wikipedia.org)
  • A goal of pain management for the patient and their health care provider to identify the amount of treatment which addresses the pain but which is not too much treatment. (wikipedia.org)
  • Sometimes pain management covers a problem, and the patient might be less aware that they need treatment for a deeper problem. (wikipedia.org)
  • The area of intranasal medication delivery provides a huge opportunity for research - both for specifically developed pharmaceutical drugs designed for intranasal treatment, as well as for investigating off label uses of commonly available generic medications. (wikipedia.org)
  • brand name Duragesic, made by Alza Corp.) through an FTC consent agreement derailing the possibility of a monopoly in the treatment of breakthrough chronic pain by Alza Corp. In some cases, physicians instruct patients to apply more than one patch at a time, giving a much wider range of possible dosages. (wikipedia.org)
  • As with any medical treatment, medications used in the management of MS may have several adverse effects, and many possible therapies are still under investigation. (wikipedia.org)
  • Placebo
  • Preemptive Analgesia Decreases Pain Following Anorectal Surgery: A Prospective, Randomized, Double-Blinded, Placebo-Controlled Trial. (bioportfolio.com)
  • For example, it is possible through psychosurgery and some drug treatments, or by suggestion (as in hypnosis and placebo), to reduce or eliminate the unpleasantness of pain without affecting its intensity. (wikipedia.org)
  • The researchers found that TENS therapy given twice a day for 3 days resulted in significant pain reduction and was found to be more effective than NSAID or placebo. (wikipedia.org)
  • opiate
  • The U.S. Food and Drug Administration (FDA) is warning patients and healthcare providers to examine any bottles of opiate pain medications made by Endo Pharmaceuticals to ensure all of the tablets are the same. (drugs.com)
  • dose
  • The dose of study drug is flexible and will increase or decrease based on the frequency of immediate-release opioid analgesic doses needed to manage pain. (bioportfolio.com)
  • The purpose of this repeated dose study is to develop recommended dosing information for initiation of therapy with OROS Hydromorphone in patients with chronic non-malignant pain convertin. (bioportfolio.com)
  • When pain resurfaces before the next scheduled dose of medication and isn't associated with a voluntary or involuntary action, the physician can be notified to examine the timing and amount of around the clock medication. (caregiver.com)
  • Tolerance occurs when a dose that used to provide acceptable pain relief is no longer effective, and higher doses are required to achieve the same level of pain relief. (pharmasave.com)
  • If you plan on stopping the medication, your doctor may want you to reduce the dose gradually to reduce the severity of withdrawal effects. (pharmasave.com)
  • Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. (pharmasave.com)
  • If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor. (pharmasave.com)
  • Do not stop taking this medication without talking to your doctor first, and do not increase the dose of this medication without consulting your doctor. (pharmasave.com)
  • rescue
  • Doctors James Elam, Peter Safar and Archer S. Gordon set to educating the world about rescue breathing, preventive measures and trying to discover a way to treat acute cardiac arrest. (wikipedia.org)
  • nociceptive pain
  • Woolf suggests three classes of pain: nociceptive pain, inflammatory pain which is associated with tissue damage and the infiltration of immune cells, and pathological pain which is a disease state caused by damage to the nervous system or by its abnormal function (e.g. fibromyalgia, peripheral neuropathy, tension type headache, etc. (wikipedia.org)
  • Nociceptive pain is caused by stimulation of sensory nerve fibers that respond to stimuli approaching or exceeding harmful intensity (nociceptors), and may be classified according to the mode of noxious stimulation. (wikipedia.org)
  • Nociceptive pain may also be divided into "visceral", "deep somatic" and "superficial somatic" pain. (wikipedia.org)
  • doses
  • There are also some discrepancies between guidelines, which recommend the use of lower doses of opioids in older patients, and the findings in the literature which suggest that pain is often undertreated in this age group. (frontiersin.org)
  • Do not take this medication in higher doses or for a longer period of time than prescribed by your doctor. (pharmasave.com)
  • If you miss several doses in a row, contact your doctor before restarting the medication. (pharmasave.com)
  • Administration of high doses of intravenous corticosteroids, such as methylprednisolone, is the routine therapy for acute relapses. (wikipedia.org)
  • commonly
  • Though prescriptions can be for different amounts and delivery methods, such as the lozenge, patch or pills, the data visualized below is for the most commonly prescribed size and dosage of each medication. (10news.com)
  • the two most commonly used markers being 3 months and 6 months since the onset of pain, though some theorists and researchers have placed the transition from acute to chronic pain at 12 months. (wikipedia.org)
  • The most commonly abused medications that the company produces are MS Contin and OxyContin. (wikipedia.org)
  • Steroids, antiasthma medications such as salbutamol, ipratropium, montelukast and a large number of inhalational anaesthetic agents are being used commonly. (wikipedia.org)
  • resolves
  • Most pain resolves once the noxious stimulus is removed and the body has healed, but it may persist despite removal of the stimulus and apparent healing of the body. (wikipedia.org)
  • Pain that lasts a long time is called chronic or persistent, and pain that resolves quickly is called acute. (wikipedia.org)
  • prescribe
  • Under a marketing strategy that Arthur Sackler had pioneered decades earlier, the company aggressively pressed doctors to prescribe the drug, wooing them with free trips to pain-management seminars and paid speaking engagements. (wikipedia.org)
  • flares
  • Chronic pain may be continuous with occasional sharp rises in intensity (flares), or intermittent: periods of painlessness interspersed with periods of pain. (wikipedia.org)
  • peripheral
  • Both central and peripheral pain receptor sensitization are thought to contri. (bioportfolio.com)
  • Pain is usually transitory, lasting only until the noxious stimulus is removed or the underlying damage or pathology has healed, but some painful conditions, such as rheumatoid arthritis, peripheral neuropathy, cancer and idiopathic pain, may persist for years. (wikipedia.org)
  • He completed his Anesthesiology residency at Yale University, with specialty training in chronic pain management, obstetric and peripheral vascular anesthesia. (wikipedia.org)
  • unpleasant sensory
  • Pain is an unpleasant sensory or emotional experience. (nyhq.org)
  • The International Association for the Study of Pain's widely used definition defines pain as "an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage", however, due to it being a complex, subjective phenomenon, defining pain has been a challenge. (wikipedia.org)
  • intense
  • Pain that causes intense mental or physical distress, that may feel "knife-like. (nyhq.org)
  • Pain is a distressing feeling often caused by intense or damaging stimuli. (wikipedia.org)
  • To define the pain problem, a health care provider will likely ask questions such as these: How intense is the pain? (wikipedia.org)
  • People experiencing pain may have difficulty recognizing or describing what they feel and how intense it is. (wikipedia.org)
  • patients
  • Efficacy and safety evaluation phase: Potential patients determined for participation in the study during the 1st visit and administered with oral strong opioid analgesic ┬┐(not the study drug┬┐) until the 2nd visit and with immediate-release opioid analgesic whenever breakthrough pain is present. (bioportfolio.com)
  • The current study will evaluate the safety, tolerability and analgesic efficacy of ralfinamide in patients with chronic neuropathic low back pain due to nerve compression, i.e., compression radiculopathy or post-traumatic/post-surgical lumbar radiculopathy. (bioportfolio.com)
  • In earlier work, the Sponsor developed a computer image processing system for analysis of pain diagrams from patients with chronic pain. (bioportfolio.com)
  • The purpose of this study is to evaluate the effect of an algorithm, where ICU patients pain are assessed systematically with valid pain assessment tools and where pain is treated after pa. (bioportfolio.com)
  • The purpose of this study is to describe the use of pain treatments in Taiwan, the demographics, clinical characteristics of patients requiring pain treatments, current treatments, outcome. (bioportfolio.com)
  • pain in patients undergoing laminectomy. (bioportfolio.com)
  • In both acute and chronic health conditions, pain is top on the list of concerns for patients, caregivers and physicians. (caregiver.com)
  • Healthcare practitioners and patients have a closer relationship in deciding pain management routes, incorporating "natural" and prescribed medications and "alternative" methods of pain relief. (caregiver.com)
  • Patients who take it are usually already on other medications, thus increasing the risk of drug interactions. (10news.com)
  • As part of the acquisition, Cephalon will gain rights to the BDC intellectual property estate covering the use of cytokine inhibitors, including TNF inhibitors, for sciatic pain in patients with intervertebral disk herniation, as well as other spinal disorders. (bio-medicine.org)
  • All 116 patients were pre-treated with opioids according to WHO III standards for symptomatic pain control. (ons.org)
  • Some patients, however, may be unable to give verbal feedback about their pain. (wikipedia.org)
  • Health care providers and patients may have difficulty communicating with each other about how pain responds to treatments. (wikipedia.org)
  • Different therapies are used for patients experiencing acute attacks, for patients who have the relapsing-remitting subtype, for patients who have the progressive subtypes, for patients without a diagnosis of MS who have a demyelinating event, and for managing the various consequences of MS. The primary aims of therapy are returning function after an attack, preventing new attacks, and preventing disability. (wikipedia.org)
  • Preoperative
  • Pain Management and Safety Profiles after Preoperative versus Postoperative Thoracic Epidural Insertion for Bilateral Lung Transplantation. (bioportfolio.com)
  • patient's
  • Over time, medications are adjusted to account for changes in the pain cycle, including a patient's tolerance to a given dosage. (caregiver.com)
  • Healthcare professionals have an ethical obligation to ensure that, whenever possible, the patient or patient's guardian is well-informed about the risks and benefits associated with their pain management options. (wikipedia.org)
  • Healthcare
  • Fortunately, pain control centers, physicians and other healthcare personnel have become more aware over the years. (caregiver.com)
  • physicians
  • Physicians have a specific protocol, or pathway, to follow when managing pain for adults and children. (caregiver.com)
  • Drug-seeking tactics that addicts undergo to obtain the medication include "doctor shopping", which is visiting a number of different physicians to obtain additional prescriptions and refusal to follow up with appropriate examinations. (wikipedia.org)
  • Opioids
  • Oxymorphone extended-release tablets are indicated for the management of chronic pain and only for people already on a regular schedule of strong opioids for a prolonged period. (wikipedia.org)
  • Experts are divided regarding use for non-cancer-related chronic pain, as most opioids have great potential for dependence and have also been alleged to create paradoxical pain sensitivity. (wikipedia.org)
  • Tricyclic
  • Cimetidine can also interact with a number of psychoactive medications, including tricyclic antidepressants and selective serotonin reuptake inhibitors, causing increased blood levels of these drugs and the potential of subsequent toxicity. (wikipedia.org)
  • relief
  • Noticing the time of pain onset and keeping a record can help the doctor make a decision about keeping pain relief consistent. (caregiver.com)
  • Medication for this type of pain is generally around the clock to provide continuity of relief. (caregiver.com)
  • Today's viewpoint incorporates consistent pain relief with keeping the patient alert and functioning. (caregiver.com)
  • Tablets or capsules are to be taken every 12 or 24 hours on a regular schedule in order to achieve and maintain pain relief. (pharmasave.com)
  • Addiction is defined as a psychological need to use the medication for reasons other than pain relief. (pharmasave.com)
  • According to the National Cancer Institute, the answers you give to the following questions can help your doctor locate the cause of the pain and develop a plan to provide you with as much relief as possible. (nyhq.org)
  • The muscles contract to withdraw from the source of pain and the brain releases inhibitory chemicals to decrease the transmission and provide analgesic relief. (wikipedia.org)
  • Pain relief after injection begins after about 5-10 minutes and 15-30 minutes after rectal administration, and lasts about 3-4 hours for immediate-release tablets and 12 hours for extended-release tablets. (wikipedia.org)
  • characteristics
  • The major identifying characteristics include alterations of visual perception, psychotherapeutic breakthrough experiences leading to personal growth, experiences of religious epiphany/mystical transcendence, and 'bad trips' - negative/unpleasant panic-attack control-loss experiences (note: these three characteristics of psychedelic tripping are not mutually exclusive, there is a wide overlap between them). (wikipedia.org)
  • Tablets
  • Novartis Consumer Health Inc. is voluntarily recalling all lots of Excedrin , Bufferin , Gas-X Prevention, and NoDoz due to reports of chipped or broken tablets and gelcaps, and inaccurate packaging resulting in bottles that may contain the incorrect medication. (drugs.com)
  • To preserve the long-acting activity of the medication, the tablets or capsules must not be chewed or crushed. (pharmasave.com)
  • Immediate-release oxymorphone tablets are recommended for breakthrough pain for people on the extended-release version. (wikipedia.org)
  • oxycodone
  • Oxycodone is available as single-ingredient medication in immediate release and controlled release. (wikipedia.org)
  • Serious side effects of oxycodone include reduced sensitivity to pain (beyond the pain the drug is taken to reduce), euphoria, anxiolysis, feelings of relaxation, and respiratory depression. (wikipedia.org)
  • Warrants
  • Based on the information in the nerve impulses, the brain is able to identify the location and intensity of the pain and what kind of reaction it warrants. (wikipedia.org)
  • therapeutic
  • Founded in 1987, Cephalon, Inc. is an international biopharmaceutical company dedicated to the discovery, development and commercialization of many unique products in four core therapeutic areas: central nervous system, inflammatory diseases, pain and oncology. (bio-medicine.org)
  • Physical medicine and rehabilitation employs diverse physical techniques such as thermal agents and electrotherapy, as well as therapeutic exercise and behavioral therapy, alone or in tandem with interventional techniques and conventional pharmacotherapy to treat pain, usually as part of an interdisciplinary or multidisciplinary program. (wikipedia.org)
  • Acupuncture involves the insertion and manipulation of needles into specific points on the body to relieve pain or for therapeutic purposes. (wikipedia.org)
  • Cimetidine inhibits ALA synthase activity and hence may have some therapeutic value in preventing and treating acute porphyria attacks. (wikipedia.org)
  • sensory
  • Although there has not been adequate evidence based research on acute sensory TENS, chronic conditions are efficacious in relieving pain. (wikipedia.org)
  • Essentially, the gate control theory states that sensory fibers carry their signal faster than pain fibers, and thus make their way to the dorsal root ganglion of the spine (the gate) much faster. (wikipedia.org)
  • This in turn causes the pain signal to be blocked by the sensory TENS signal. (wikipedia.org)
  • treat
  • It is important to assess the pain, treat, and evaluate it. (frontiersin.org)
  • Sustained-release pain relievers should only be used when chronic pain control is necessary and should not be used to treat acute, or short-term pain. (pharmasave.com)
  • The Company's lead initiative focuses on the development of a TNF inhibitor therapy to treat the underlying cause of pain in sciatica. (bio-medicine.org)
  • Intranasal Calcitonin, calcitonin-salmon is used to treat Hypercalcaemia arising out of malignancy, Paget's disease of bone, post menopausal and steroid induced osteoporosis, Phantom limb pain and other metabolic bone abnormalities, available as Rockbone, Fortical and Miacalcin Nasal Spray. (wikipedia.org)
  • stimuli
  • Visceral structures are highly sensitive to stretch, ischemia and inflammation, but relatively insensitive to other stimuli that normally evoke pain in other structures, such as burning and cutting. (wikipedia.org)
  • Transduction is when the thermal, mechanical, or chemical energy from the pain-causing stimuli is converted into electrical energy so it can be transmitted through the nervous system. (wikipedia.org)
  • visceral
  • Nociceptive pain may also be divided into "visceral", "deep somatic" and "superficial somatic" pain. (wikipedia.org)
  • Visceral structures are highly sensitive to stretch, ischemia and inflammation, but relatively insensitive to other stimuli that normally evoke pain in other structures, such as burning and cutting. (wikipedia.org)
  • Visceral pain is diffuse, difficult to locate and often referred to a distant, usually superficial, structure. (wikipedia.org)
  • include
  • Serious side effects of oxycodone include reduced sensitivity to pain (beyond the pain the drug is taken to reduce), euphoria, anxiolysis, feelings of relaxation, and respiratory depression. (wikipedia.org)
  • Drug-seeking tactics that addicts undergo to obtain the medication include "doctor shopping", which is visiting a number of different physicians to obtain additional prescriptions and refusal to follow up with appropriate examinations. (wikipedia.org)
  • Examples of injuries that produce superficial somatic pain include minor wounds and minor (first degree) burns. (wikipedia.org)
  • The major identifying characteristics include alterations of visual perception, psychotherapeutic breakthrough experiences leading to personal growth, experiences of religious epiphany/mystical transcendence, and 'bad trips' - negative/unpleasant panic-attack control-loss experiences (note: these three characteristics of psychedelic tripping are not mutually exclusive, there is a wide overlap between them). (wikipedia.org)
  • Management
  • Under a marketing strategy that Arthur Sackler had pioneered decades earlier, the company aggressively pressed doctors to prescribe the drug, wooing them with free trips to pain-management seminars and paid speaking engagements. (wikipedia.org)
  • Abnormalities
  • exposure during pregnancy is associated with about three times as many major abnormalities as usual, mainly spina bifida with the risks being related to the strength of medication used and use of more than one drug. (wikipedia.org)
  • Intranasal Calcitonin, calcitonin-salmon is used to treat Hypercalcaemia arising out of malignancy, Paget's disease of bone, post menopausal and steroid induced osteoporosis, Phantom limb pain and other metabolic bone abnormalities, available as Rockbone, Fortical and Miacalcin Nasal Spray. (wikipedia.org)
  • bipolar
  • Unlike depressive disorders, the treatment of bipolar disorders almost always includes ongoing medication pdf . (eatdrinkitaly.org)
  • Valproate (VPA), and its valproic acid, sodium valproate, and valproate semisodium forms, are medications primarily used to treat epilepsy and bipolar disorder and to prevent migraine headaches. (wikipedia.org)
  • risks
  • Because this medication can be potentially harmful to the fetus, valproate should be considered for women of childbearing potential only after the risks have been discussed. (wikipedia.org)
  • Withdrawal
  • The term breakthrough bleeding or breakthrough spotting is usually used for women using hormonal contraceptives, such as IUDs or oral contraceptives, in which it refers to bleeding or spotting between any expected withdrawal bleedings, or bleeding or spotting at any time if none is expected. (wikipedia.org)
  • emergency
  • In adults who go to the emergency department with an unclear cause of pain, about 30% have pain due to coronary artery disease. (wikipedia.org)
  • experience
  • The International Association for the Study of Pain's widely used definition defines pain as "an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage", however, due to it being a complex, subjective phenomenon, defining pain has been a challenge. (wikipedia.org)
  • After some years, many of the people who have this subtype begin to experience neurologic decline without acute relapses. (wikipedia.org)
  • skin
  • Superficial pain is initiated by activation of nociceptors in the skin or other superficial tissue, and is sharp, well-defined and clearly located. (wikipedia.org)
  • people
  • In some arguments put forth in physician-assisted suicide or euthanasia debates, pain has been used as an argument to permit people who are terminally ill to end their lives. (wikipedia.org)