• catalytic
  • To establish whether TG2 transamidating activity is causally related to neurodegeneration, structurally diverse inhibitors have been developed that inhibit the cysteine catalytic site. (jneurosci.org)
  • Its catalytic activity is tightly regulated in response to a wide spectrum of biological cues ( 1 , 2 ). (pubmedcentralcanada.ca)
  • Three-dimensional modeling of TG5 showed that G113C lies close to the catalytic domain, and, furthermore, that this glycine residue is conserved in all known transglutaminases, which is consistent with pathogenicity. (wikipedia.org)
  • The cellular form is a dimer of two identical subunits, FXIII-A, each consisting of an activation peptide that is cleaved upon activation, a β-sandwich domain, a catalytic transglutaminase domain and two β-barrel domains. (wikipedia.org)
  • The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. (wikipedia.org)
  • vitro
  • An established, in vitro, biochemical cross-linking assay revealed that, although T109M is not pathogenic, G113C completely abolishes TG5 activity. (wikipedia.org)
  • Activation
  • As part of its activity in the coagulation cascade, thrombin also promotes platelet activation and aggregation via activation of protease-activated receptors on the cell membrane of the platelet. (wikipedia.org)
  • induces
  • Transglutaminase 2 overexpression induces depressive-like behavior and impaired TrkB signaling in mice. (abcam.com)
  • Cathepsin D enzymatic activity induces hydrolytic modification of apolipoprotein B-100-containing lipoproteins, including LDL, which means it may be involved in atherosclerosis as well. (wikipedia.org)
  • oxidative
  • 5. It has previously been suggested that changes in the crystallins that occur during aging and with cataract may be due to oxidative reactions and to transglutaminase activity. (biochemj.org)
  • and second, to understand whether a common putative mediator of death, oxidative stress, could induce TG message levels and activity as part of a death cascade. (jneurosci.org)
  • findings
  • In addition to explaining how TG2 can be activated by dietary gluten in the small intestinal mucosa of celiac sprue patients, our findings reveal a new strategy for inhibiting the undesirable consequences of TG2 activity in this widespread, lifelong disease. (pubmedcentralcanada.ca)
  • found
  • The compounds, sarcovagine-D, alkaloid-C, and holaphylline isolated from Sarcococca saligna were found to possess immunosuppressive activities. (frontiersin.org)