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  • enzyme
  • Many studies suggest that mammalian PAH shows behavior comparable to porphobilinogen synthase (PBGS), wherein a variety of factors such as pH and ligand binding are reported to affect enzyme activity and protein stability. (wikipedia.org)
  • inhibitor
  • Finally, mice were given the 5-HT precursor l -tryptophan (TRP) or the 5-HT synthesis inhibitor p -chlorophenylalanine (PCPA) ( Koe and Weissman, 1966 ) to assess how treatments that boost or lower 5-HT synthesis affect the citalopram response. (jneurosci.org)
  • Fenclonine, also known as para-chlorophenylalanine (PCPA), acts as a selective and irreversible inhibitor of tryptophan hydroxylase, which is a rate-limiting enzyme in the biosynthesis of serotonin. (wikipedia.org)
  • R)-Nepicastat HCl, the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors. (selleckchem.com)
  • homologous
  • The structure of the N-terminal regulatory domain has also been determined, and together with the solved structure of the homologous tyrosine hydroxylase C-terminal tetramerization domain, a structural model of tetrameric PAH has been proposed. (wikipedia.org)
  • enzyme
  • The activity of the enzyme was higher at mid-dark than mid-light in the two brain areas. (ac.ke)
  • The mechanisms of these pharmacological actions are not only poorly understood but are assumed to involve a wide spectrum of enzyme effects in addition to physiochemical effects on other parameters of drug activity such as membrane permeability, electrolyte activities, and so on. (springer.com)
  • Phenylalanine hydroxylase is the rate-limiting enzyme of the metabolic pathway that degrades excess phenylalanine. (wikipedia.org)
  • Many studies suggest that mammalian PAH shows behavior comparable to porphobilinogen synthase (PBGS), wherein a variety of factors such as pH and ligand binding are reported to affect enzyme activity and protein stability. (wikipedia.org)
  • synthesis
  • Because there were no strain differences in catecholamine synthesis, locomotor activity, and brain levels of citalopram at the end of the behavioral test, the results suggest that the failure of citalopram to reduce immobility time in DBA/2J and BALB/c mice is attributable to genotype-dependent impairment of 5-HT synthesis. (jneurosci.org)
  • Do tryptophan concentrations limit protein synthesis at specific sites in the brain? (springer.com)
  • genetically
  • Hence, our study shows, for the first time, evidence of a link between genetically controlled serotonergic modulation of amygdala activity and placebo-induced anxiety relief. (jneurosci.org)
  • amygdala
  • Results showed that placebo response was accompanied by reduced stress-related activity in the amygdala, a brain region crucial for emotional processing. (jneurosci.org)
  • Path analysis supported that the genetic effect on symptomatic improvement with placebo is mediated by its effect on amygdala activity. (jneurosci.org)
  • brain
  • Badawy, A. A., & Evans, M. The role of free serum tryptophan in the biphasic effect of acute ethanol administration on the concentrations of rat brain tryptophan, 5-hydroxytryptamine and 5-hydroxyindol-3-ylacetic acid. (springer.com)
  • Brain activity was assessed during a stressful public speaking task by means of positron emission tomography before and after an 8 week treatment period. (jneurosci.org)
  • Further investigation into the long-term effects of chloroamphetamines discovered that administration of 4-CMA caused a prolonged reduction in the levels of 5-HT and the activity of tryptophan hydroxylase in the brain one month after injection of a single dose of the drug. (wikipedia.org)
  • Scientific studies have found that numerous brain areas show altered activity in patients suffering from depression, and this has encouraged advocates of various theories that seek to identify a biochemical origin of the disease, as opposed to theories that emphasize psychological or situational causes. (wikipedia.org)
  • vivo
  • 5-HT2C receptors exhibit constitutive activity in vivo, and may retain the ability to influence neurotransmission in the absence of ligand occupancy. (wikipedia.org)
  • noradrenaline
  • FLA 136 does not stimulate the postsynaptic α-adrenoreceptors mediating the increase in flexor reflex activity but it probably decelerates the utilization of noradrenaline by a stimulation of another kind of α-adrenoreceptors sensitive to yohimbine. (springer.com)
  • reaction
  • This initial reaction catalyzed by tyrosine hydroxylase has been shown to be the rate limiting step in the production of catecholamines. (wikipedia.org)
  • Although initially an arene oxide or radical intermediate was proposed, analyses of the related tryptophan and tyrosine hydroxylases have suggested that the reaction instead proceeds through a cationic intermediate that requires Fe(IV)=O to be coordinated to a water ligand rather than a hydroxo group. (wikipedia.org)
  • enzymatic activity
  • Chronic administration of clomipramine increased the enzymatic activity at the two times of day to different levels of significance. (ac.ke)
  • The hydrophobic C-terminus acts as the mitochondrial anchoring domain and participates in enzymatic activity. (wikipedia.org)
  • serotonergic system
  • Research on the effects of light therapy on seasonal affective disorder suggests that light deprivation is related to decreased activity in the serotonergic system and to abnormalities in the sleep cycle, particularly insomnia. (wikipedia.org)
  • central
  • 5HT is causally involved in numerous central nervous activities, and it has several functions in peripheral tissues, including the maintenance of vascular tone and gut motility. (wikipedia.org)
  • enzyme
  • Many studies suggest that mammalian PAH shows behavior comparable to porphobilinogen synthase (PBGS), wherein a variety of factors such as pH and ligand binding are reported to affect enzyme activity and protein stability. (wikipedia.org)
  • genes
  • Here we describe the egg-laying phenotypes of eight levamisole resistance genes, which affect the activity of levamisole-sensitive nicotinic receptors in nematodes. (genetics.org)
  • These genes control the production of hydroxylase enzymes that are critical for producing and recycling THB. (wikipedia.org)
  • depression
  • Scientific studies have found that numerous brain areas show altered activity in patients suffering from depression, and this has encouraged advocates of various theories that seek to identify a biochemical origin of the disease, as opposed to theories that emphasize psychological or situational causes. (wikipedia.org)
  • regulatory
  • The relationship of history radiostrontium and radiocesium indicated which the regulatory assumption following the Fukushima incident of a optimum activity of 90Sr getting 10% from the particular 137Cs concentrations may shortly be in danger, as the 90Sr/137Cs proportion increases as time passes. (lecollege.org)
  • The original assumption that was shown in the regulatory limitations was predicated on the encounters from the Chernobyl incident as well as the fallout of the atmospheric nuclear explosions,17 presuming an activity correlation of 90Sr:106Ru:134Cs:137Cs = 5.2:4.3:25.9:64.6. (lecollege.org)
  • significantly
  • We discovered that myocardial high Bosutinib PDCD5 over-expression leads to dilated center and cardiomyopathy failing followed by significantly improved autophagy, which is connected with improved p53 activity. (researchreport-digital.com)
  • disorder
  • Research on the effects of light therapy on seasonal affective disorder suggests that light deprivation is related to decreased activity in the serotonergic system and to abnormalities in the sleep cycle, particularly insomnia. (wikipedia.org)
  • downstream
  • The enhanced autophagy in high over-expressing line was associated with significant increase in p53 activity and its downstream target damage-regulated autophagy modulator expression. (researchreport-digital.com)
  • meat
  • Figure 3 Radiocesium (134Cs + 137Cs) activity concentrations in meat/eggs from Fukushima prefecture sampled over the period Mar. 11, 2011 until Mar. 31, 2012. (lecollege.org)
  • brain
  • For example, long-term exposure to nicotine leads to long-lasting changes in both the abundance and functional activity of nicotinic receptors in brain neurons, processes thought to be critical for nicotine addiction ( D ani and H einemann 1996 ). (genetics.org)
  • responsible
  • It has been suggested that the resulting deficit in the CNS neurotransmitter activity is, at least in part, responsible for the neurologic manifestations and eventual death of these patients. (wikipedia.org)
  • Numerous
  • 5HT is causally involved in numerous central nervous activities, and it has several functions in peripheral tissues, including the maintenance of vascular tone and gut motility. (wikipedia.org)
  • effects
  • Kubo, I. Antifungal activity of alkanols against Zygosaccharomyces bailii and their effects on fungal plasma membrane. (emis.info)
  • addition
  • Also, it had been shown how the addition of 14 amino acidity residues or even more from the capsid proteins 1D towards the N-terminal of 2A escalates the activity of self-cleavage up to 99? (world-of-links.com)