• inhibition
  • Pretreatment with tryptophan raised 5-HTP accumulation and reinstated the antidepressant-like effect of citalopram in DBA/2J and BALB/c mice, whereas pharmacological inhibition of 5-HT synthesis prevented the effect of citalopram in C57BL/6J and 129/Sv mice. (jneurosci.org)
  • homologous
  • The structure of the N-terminal regulatory domain has also been determined, and together with the solved structure of the homologous tyrosine hydroxylase C-terminal tetramerization domain, a structural model of tetrameric PAH has been proposed. (wikipedia.org)
  • synthesis
  • Because there were no strain differences in catecholamine synthesis, locomotor activity, and brain levels of citalopram at the end of the behavioral test, the results suggest that the failure of citalopram to reduce immobility time in DBA/2J and BALB/c mice is attributable to genotype-dependent impairment of 5-HT synthesis. (jneurosci.org)
  • metabolism
  • Rather, we found that live C. albicans shifts tryptophan metabolism by inhibiting IDO expression away from kynurenines and toward 5-hydroxytryptophan metabolites. (jimmunol.org)
  • In conclusion, live C. albicans inhibits host Th17 responses by modulatory effects on tryptophan metabolism. (jimmunol.org)
  • In this study, we demonstrate that this is indeed the case, with live C. albicans exerting inhibitory effects on IL-17 production through the modulation of tryptophan metabolism. (jimmunol.org)
  • It participates in tryptophan metabolism through the kynurenine catabolic pathway. (wikipedia.org)
  • receptors
  • 5-HT2C receptors exhibit constitutive activity in vivo, and may retain the ability to influence neurotransmission in the absence of ligand occupancy. (wikipedia.org)
  • protein
  • Many studies suggest that mammalian PAH shows behavior comparable to porphobilinogen synthase (PBGS), wherein a variety of factors such as pH and ligand binding are reported to affect enzyme activity and protein stability. (wikipedia.org)
  • noradrenaline
  • FLA 136 does not stimulate the postsynaptic α-adrenoreceptors mediating the increase in flexor reflex activity but it probably decelerates the utilization of noradrenaline by a stimulation of another kind of α-adrenoreceptors sensitive to yohimbine. (springer.com)
  • depression
  • Scientific studies have found that numerous brain areas show altered activity in patients suffering from depression, and this has encouraged advocates of various theories that seek to identify a biochemical origin of the disease, as opposed to theories that emphasize psychological or situational causes. (wikipedia.org)
  • reaction
  • This initial reaction catalyzed by tyrosine hydroxylase has been shown to be the rate limiting step in the production of catecholamines. (wikipedia.org)
  • Although initially an arene oxide or radical intermediate was proposed, analyses of the related tryptophan and tyrosine hydroxylases have suggested that the reaction instead proceeds through a cationic intermediate that requires Fe(IV)=O to be coordinated to a water ligand rather than a hydroxo group. (wikipedia.org)
  • enzymatic activity
  • Chronic administration of clomipramine increased the enzymatic activity at the two times of day to different levels of significance. (ac.ke)
  • The hydrophobic C-terminus acts as the mitochondrial anchoring domain and participates in enzymatic activity. (wikipedia.org)
  • reduction
  • Further investigation into the long-term effects of chloroamphetamines discovered that administration of 4-CMA caused a prolonged reduction in the levels of 5-HT and the activity of tryptophan hydroxylase in the brain one month after injection of a single dose of the drug. (wikipedia.org)
  • central
  • 5HT is causally involved in numerous central nervous activities, and it has several functions in peripheral tissues, including the maintenance of vascular tone and gut motility. (wikipedia.org)
  • effects
  • Research on the effects of light therapy on seasonal affective disorder suggests that light deprivation is related to decreased activity in the serotonergic system and to abnormalities in the sleep cycle, particularly insomnia. (wikipedia.org)
  • release
  • IL-17A, the major cytokine secreted by Th17 cells, possesses multiple proinflammatory functions, such as recruiting neutrophils ( 4 , 5 ), activating neutrophil/macrophage phagocytosis activity, and inducing β-defensin release ( 6 ). (jimmunol.org)