• The data reflect the subjects whose test results were considered positive or negative for neutralizing activity to BOTOX Cosmetic in a mouse protection assay. (aaaai.org)
  • The results of these tests are highly dependent on the sensitivity and specificity of the assay. (aaaai.org)
  • Most importantly, we demonstrate that many compounds previously failed in human clinical trials, showed no stress reducing activity in the zebrafish assay. (whiterose.ac.uk)
  • citation needed] Sensitivity (Se), specificity (Sp), predictive value of positive values results (PV(+)) and negative values results (PV(-)) are presented in the grid below:[citation needed] Comparison of SATRO-ECG results - SPECT (exercise) for particular parts of the cardiac muscle is presented in the grid below: where: IS - interventricular septum, AW - anterior wall, IW - inferior wall, LW - lateral wall. (wikipedia.org)
  • However, due to th e limited sensitivities and predictive values of RIDTs, negative results of RIDTs do not exclude influenza virus infection in patients with signs and symptoms suggestive of influenza. (cdc.gov)
  • It facilitates the evaluation of electrical activity of myocardium, and therefore, early detection of ischemic changes in the heart. (wikipedia.org)
  • Also, we sought to improve the sensitivity of obesogen detection/validation methods to establish a framework for post-toxicological chemical assessment. (nist.gov)
  • Unfortunately, the available biomarkers for SKM injury do not fully meet the needs for satisfactory detection of drug-induced damage, both in clinical and research settings, mainly due to their low sensitivity and specificity. (degruyter.com)
  • OCT-Angiography was observed to have high sensitivity and specificity for the detection of choroidal neovasculariasation in myopic eyes. (bmj.com)
  • Decreases in serum iron and TIBC were associated with the clinical activity of CD. (nature.com)
  • Naringin appears to have sufficient safety, specificity, and sensitivity to be a clinical OATP1A2 inhibitor probe. (nih.gov)
  • The availability of these definitions in RA has provided an additional outcome measure in clinical trials, allowing identification of patients who achieve a desired state rather than just a reduction in disease activity that may still represent a considerable burden of disease. (bmj.com)
  • The availability of these cut-off points for disease activity has also meant that they can be used in clinical trials to guide treatment. (bmj.com)
  • The dosage is then tapered according to disease activity as assessed using a combination of clinical symptoms and ESR and/or CRP. (bmj.com)
  • e influenza activity has been documented in the community or geographic area, a clinical diagnosis of influenza can be made for outpatients with signs and symptoms consistent with suspected influenza, especially during periods of peak influenza activity in the community. (cdc.gov)
  • Analytical techniques in clinical chemistry for the estimation of polypeptide hormone concentrations in biological fluids are changing from limited reagent, radioimmunoassay methods to excess reagent immunoradiometric methods, with a consequential improvement in sensitivity, precision and speed. (ucl.ac.uk)
  • A very high Sensitivity and specificity in detecting this disease were obtained. (wikipedia.org)
  • High specificity is ensured due to HotStarTaq Plus DNA Polymerase. (qiagen.com)
  • In particular, there are no definitions of high or low disease activity states available in PsA. (bmj.com)
  • In rheumatoid arthritis (RA) there are continuous composite outcome measures such as the Disease Activity Score (DAS), for which different cut-off points identify disease activity states ranging from high to remission. (bmj.com)
  • All developed count-to-activity thresholds demonstrated high levels of sensitivity and specificity. (humankinetics.com)
  • When cross-validated in an independent group ( N = 20), high levels of sensitivity and specificity generally remained (≥73.1%, intensity and monitor dependent). (humankinetics.com)
  • The screen shows optimal quality control, maintaining a high sensitivity and specificity withoutcompromising throughput. (whiterose.ac.uk)
  • RESULTS: In both plans, current caries activity alone had relatively low sensitivity and high specificity in identifying patients who would experience subsequent caries. (healthpartners.com)
  • D-dimer has a high capacity for positive screening, and US has a high sensitivity. (nxtbook.com)
  • It should be optimised to inactivate enzyme activity until heat is applied and the PCR cycle is triggered. (ibtimes.com)
  • Thus, even with the greater than 99% sensitivity of the current tests for HBsAg, including both RIA and enzyme immunoassay (EIA), not all HBV carriers are detected by screening for HBsAg, and a small number of transfusion recipients still develop hepatitis B (14-16). (cdc.gov)
  • This difference in substrate sensitivity may be due to the lower enzyme specificity of phenyl acetate. (cdc.gov)
  • The Committee also considered a report from a WHO informal consultation on low levels of reverse transcriptase enzyme (RTase) activity found in some viral vaccines derived from chicken cells, notably measles, mumps, combined measles-mumps-rubella and yellow fever vaccines. (who.int)
  • Due to differing methodological approaches, results are not comparable when developing thresholds for the determination of moderate- to vigorous-intensity physical activity. (humankinetics.com)
  • This study aimed to develop and validate count-to-activity thresholds for 1.5, 3, and 6 metabolic equivalents of task in five of the most commonly used activity monitors in adolescent research. (humankinetics.com)
  • Receiver-operating-characteristic analysis was used to examine the area under the curve and to define count-to-activity thresholds for the vertical axis (all monitors) and the sum of the vector magnitude (ActiGraph wGT3X-BT and activPAL3 micro) for 15 s (all monitors) and 60 s (ActiGraph monitors) epochs. (humankinetics.com)
  • Both studies show that LRR equipment has an important diagnostic ability and that the control of sensitivity and specificity can be achieved with methods that control thresholds [40]. (nxtbook.com)
  • However, RIDTs have limited sensitivity to detect influenza virus infection and negative test results should be interpreted with caution given the potential for false negative results. (cdc.gov)
  • Our results indicate that the contrast sensitivity rhythm is modulated by D4Rs via a signaling pathway that involves NPAS2-mediated circadian regulation of Adcy1 . (jneurosci.org)
  • control/patient) Sensitivity (%) Specificity (%) Study 131 (61/70) 84 69 (45/24) 83-96 71-89 82.9 81.6 35-56 59-90 44-85 Discussion and Conclusion This article discussed the approach for conventional DVT diagnostic management and highlighted the potential of POCT equipment in DVT diagnosis. (nxtbook.com)
  • Nous avons élaboré une version en langue arabe de ce questionnaire et avons testé sa fiabilité et sa validité concurrente et discriminante en tant qu'outil diagnostic d'un trouble dépressif majeur. (who.int)
  • CWAF and specifically COREXIT were found to have significant dose-dependent obesogenic activities. (nist.gov)
  • These vignettes were submitted to 163 GPs, who were asked to assess disease activity using a visual analogue scale (VASph), this being the only physician-dependent component of the PMR-AS. (bmj.com)
  • NIOSH sampling and analytical methods are intended to promote accuracy, sensitivity, and specificity in industrial hygiene analyses and related applications. (cdc.gov)
  • In the United States (U.S.), influenza activity has increased significantly over recent weeks with influenza A(H3N2) viruses predominating so far this season. (cdc.gov)
  • To avoid these disadvantages in the present investigation, we used resting-state fMRI in order to reveal potential links between whole brain activity and insulin and glucose levels in different metabolic states. (frontiersin.org)
  • To evaluate the validity and reliability of the polymyalgia rheumatica (PMR) activity score (PMR-AS) for relapse diagnosis by general practitioners (GPs) who manage a large proportion of patients with PMR. (bmj.com)
  • The use of International Reference Materials for designating the activity or identity of biological preparations used in prophylaxis, therapy or diagnosis, ensures comparability of the activities of these substances worldwide. (who.int)
  • Activity Spectra for Substances), which is based on a revised Na?ve Bayes algorithm, was applied since it had been shown to be powerful and to provide good predictions of many biological activities based on just the structural formula of a compound even if the information in the training set is definitely incomplete. (exposed-skin-care.net)
  • CONCLUSION: FLIP elicited increased SNS activity and modulation in this bi-ethnic cohort. (bvsalud.org)
  • It has been shown that PON1 levels appear to be lower in older populations, but no known study has measured serum PON1 activity levels in the same individuals over time. (cdc.gov)
  • The biological activities of these different forms were determined using a sensitive and specific in-vitro bioassay developed in the course of this study. (ucl.ac.uk)
  • Current sleep study evidence suggests that even before first tooth contact a series of physiological events occur which include activation of the autonomic cardiac system at minus 4 minutes, brain activity at minus four seconds, a rise in jaw opener muscle tone with 2 big breaths, and an increase in heart rate at minus one second. (medscape.com)
  • Our study demonstrates a circadian rhythm of contrast sensitivity that peaks during the daytime, and that its regulation involves interactions of D4Rs, the clock gene Npas2 , and the clock-controlled gene adenylyl cyclase 1 ( Adcy1 ) in a subset of retinal ganglion cells (RGCs). (jneurosci.org)
  • We evaluated whether dobutamine gated blood pool scintigraphy (DOB-GBP) can predict improvement in cardiac sympathetic nerve activity and cardiac function after beta-blocker therapy in patients with dilated cardiomyopathy (DCM). (nih.gov)
  • DOB-GBP can be used to predict improved cardiac sympathetic nerve activity, cardiac function, and symptoms after treatment in patients with DCM. (nih.gov)
  • Patients were divided into three groups according to the CDAI(Crohn's disease activity index)scores. (nature.com)
  • 2 The recognition of the severity of this disease and the recent availability of highly effective therapies has resulted in the need for accurate assessment of patients' overall disease activity and their response to treatment. (bmj.com)
  • In an experiment that happened in 1991, 77 patients were lying in bed at 120º hip and knee angles to perform 10 ankle dorsiflexion activities over 15 s. (nxtbook.com)
  • With the examination of 82 patients, the sensitivity could reach 69.7% and the specificity 81.6% compared with venography, which had a significant ability to exclude DVT [9]. (nxtbook.com)
  • Physicians supervised on their surveillance activities had significantly better surveillance practices than non-supervised physicians, whereas physicians who received training and feedback on their surveillance activities did not perform any better than those who did not. (who.int)
  • 1 Treatment with disease-modifying drugs can significantly improve disease activity. (bmj.com)
  • The absence or presence of neovascular activity was significantly associated with specific OCT-A features of neovascularization. (bmj.com)
  • OBJECTIVE: To examine the relative contribution of current caries activity, past caries experience, and dentists' subjective assessment of caries risk classifications. (healthpartners.com)
  • Strikingly, differences in plasma insulin levels between hunger and satiety states after glucose administration at the time of the scan were negatively related to brain activity in the posterior insula and superior frontal gyrus (SFG), while plasma glucose levels were positively associated with activity changes in the fusiform gyrus. (frontiersin.org)
  • Npas2 −/− and Adcy1 −/− mice show strikingly similar reductions in the contrast sensitivity rhythm to that in mice lacking D4Rs. (jneurosci.org)
  • Results: Serum-free conditions greatly enhanced sensitivity without reducing specificity in ligand binding assays. (nist.gov)
  • Lowest serum cholinesterase activity (nadir) stratified by outcome. (ajtmh.org)
  • Receiver-operating characteristic curve for ability of association of serum cholinesterase activity with mortality. (ajtmh.org)
  • Lowest serum cholinesterase activity (nadir) stratified by the development of the nosocomial infection. (ajtmh.org)
  • Individual variation in paraoxonase 1 activity in human serum over time. (cdc.gov)
  • Low PON1 activity levels have been associated with increased risk for atherosclerosis and other disorders. (cdc.gov)
  • Human activities are estimated to have caused approximately 1.0°C of global warming above pre-industrial levels (SR15). (ipcc.ch)
  • The WarmStart technology helps establish flexibility, while maintaining robustness in specificity and sensitivity," said Hornblower. (neb.com)
  • Los Alamos National Laboratory, s. 1-43, 2006, arXiv:physics/0602162v2 [physics.med-ph] Janicki JS, Leoński W, Jagielski J. Partial potentials of selected cardiac muscle regions and heart activity model based on single fibres. (wikipedia.org)
  • Increased SNS activity may precede volume-loading hypertension, contribute to increases in cardiac troponin T (cTnT), endothelial dysfunction and small vessel disease. (bvsalud.org)
  • The whole procedure takes 20min by using an optimal combination of nuclide activities, collimators, and imaging matrix. (lu.se)
  • The Luna kits are well-suited for those who are concerned about non-specific amplification during reaction setup, or a reduction in RT activity at elevated temperatures. (neb.com)
  • Treatment with botulinum toxins may result in the formation of neutralizing antibodies that may reduce the effectiveness of subsequent treatments by inactivating biological activity of the toxin. (aaaai.org)
  • The optimised bioassay has been demonstrated to result in increased specificity and sensitivity. (ucl.ac.uk)
  • BACKGROUND AND AIMS: Decreased heart-rate-variability (HRV) indicates increased sympathetic nervous system (SNS) activity and modulation with a shift in the sympatho-vagal balance towards SNS predominance. (bvsalud.org)
  • However, negative RIDT results do not exclude influenza virus infection as a cause of a respiratory outbreak because of the limited sensitivity of these tests. (cdc.gov)
  • We recommend training activities for physicians and health care workers involved in the measles control as well a system of feedback to health care workers. (who.int)
  • Further improvement in sensitivity accrued when dentists' subjective assessment was included, but performance was different in the two plans in terms of false-positives. (healthpartners.com)
  • To create minimal disease activity (MDA) criteria for psoriatic arthritis (PsA). (bmj.com)
  • The sensitivity and specificity of the Amsel criteria are 37%-70% and 94%-99%, respectively, compared with the Nugent score ( 1002 ). (cdc.gov)
  • METHODS: Administrative data from two dental plans were analyzed to determine dentists' risk classification, as well as current caries activity and previous caries experience at the time of the classification. (healthpartners.com)
  • A main goal of ongoing NIOSH methods development activities is to ensure that NIOSH methods are harmonized with relevant international voluntary consensus standards. (cdc.gov)
  • 2 In particular, the newer biological therapies have been shown to reduce disease activity in many areas including enthesitis, dactylitis and axial disease, previously treatment challenges, and have been shown to reduce progression of joint damage. (bmj.com)
  • It defines a satisfactory state of disease activity rather than a change, and encompasses all aspects of the disease. (bmj.com)
  • Performance in all forms of motor activity related to sport performance improves progressively during the course of the childhood years as a consequence of normal growth and development. (humankinetics.com)
  • The Osom BV Blue test (Sekisui Diagnostics) detects vaginal sialidase activity ( 1003 , 1004 ). (cdc.gov)
  • Thus, depending on the availability of data for a particular biological activity, one may choose the 1st or the second approach for creating ligand-based computational tools to achieve the Tlr2 best possible results in virtual testing. (exposed-skin-care.net)
  • task-based designs focus on a small fraction of the brain's overall activity only. (frontiersin.org)
  • Sensitivity improved, but at the cost of specificity when previous caries experience was included in the models. (healthpartners.com)
  • Fig. 1: Rapid reorganization of CA3SC activity during sensory experience. (nature.com)
  • Our Reports provide a complete overview of the Organisation and its mission: science, research, training activities, and more. (icgeb.org)
  • Sensitivities and specificities of FMS predicting claims at various FMS score cut points, ranging from 10 to 20 were tested. (cdc.gov)