Activity radicals lipid peroxidation. Medical search. Frequent questions

The aim of this work was to study the protective activity of a honey of multifloral origin, standardized for total antioxidant power and analytically profiled (HPLC-MS) in antioxidants, in a cultured endothelial cell line (EA.hy926) subjected to oxidative stress. (researchgate.net)
These data suggest that MDMA-induced toxicity of dopamine neurones in mice results from free radical formation which in turn induces an oxidative stress process. (erowid.org)
Although many factors have been implicated, cataract formation is primarily associated with oxidative stress produced by free radicals. (molvis.org)
Oxidative stress generates dangerous free radicals, which affect human health and exposing them to disease by altering the naturally structured cellular lining of human body subsequently causing lipid peroxidation and effects on enzyme activity as well as producing carcinogenesis. (ijpsonline.com)
The in vivo activity was investigated by measuring some oxidative stress markers. (hindawi.com)
It is present in the internal and external cell membranes and plays an important role in reducing oxidative stress and free radicals. (tratamientodelvitiligo.es)
Oxidative stress occurs when the intracellular concentration of free radicals increases over the physiologic value. (bvsalud.org)
To counteract the oxidative stress mammalian cells have antioxidant system which includes enzymatic activities such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx), and non enzymatic antioxidants including vitamins A, E, C, melatonin, uric acid (UA) and glutathione 6,10 . (bvsalud.org)
The supplementation of Trans-resveratrol attenuated the cardiac oxidative stress and increased the activity of catalase. (bvsalud.org)
TCDD for every step of the mechanism described for 2,3,7,8-TCDD carcinogenesis in humans including receptor binding, gene expression, protein activity changes, cellular replication, oxidative stress, promotion in initiation-promotion studies and complete carcinogenesis in laboratory animals. (who.int)

Native honey (1% w/v pH 7.4, 10(6) cells) showed strong quenching activity against lipophilic cumoxyl and cumoperoxyl radicals, with significant suppression/prevention of cell damage, complete inhibition of cell membrane oxidation, of intracellular ROS production and recovery of intracellular GSH. (researchgate.net)
Free radical-scavenging, inhibition power of lipid peroxidation and reducing power were also determined. (ishs.org)
Free radical-scavenging inhibition percentage at 50% was about 0.50, 0.268, 4.17 and 21.50 in sweet potatoes steamed with cloves, Guinea pepper, nutmeg and turmeric respectively. (ishs.org)
The antioxidant properties of methanolic leaf extracts were assessed under in vitro conditions using different antioxidant tests, including DPPH, nitric oxide, hydrogen peroxide, hydroxyl radical scavenging assay, reducing power, ferrous ion chelating, and lipid peroxidation inhibition assay. (unboundmedicine.com)
The EOs Mc_Lf_06 and Mc_Lf_10 showed the best antiproliferative activity but only achieving 20 % inhibition after 96 h of incubation for all concentrations tested. (2siglas.pt)
Extracts were fractionated using column chromatography, and antibacterial activities were assayed by the analyses of inhibition zones and bioautography, as well as by broth microdilution techniques. (innovareacademics.in)

As indicators of cytotoxicity, cell viability, release of alveolar enzymes activities (lactate dehydrogenase, N-acetyl glucosaminidase), production of reactive oxygen species (ROS), such as H2O2 and hydroxyl radical (OH), and lipid peroxidation were monitored after exposure of cells to grape- and citrus- farm dusts or inorganic components of these dusts. (cdc.gov)
[9] Research into how vitamin E prevents the process of lipid peroxidation led to the identification of antioxidants as reducing agents that prevent oxidative reactions, often by scavenging reactive oxygen species before they can damage cells. (wikipedia.org)
Antioxidants such as vitamin E, and vitamin C neutralize the activity of free radicals and protect the sperm from reactive oxygen species. (bvsalud.org)

Experiments with endothelial cells fortified with the isolated fraction from native honey enriched in antioxidants, exposed to peroxyl radicals from 1,1-diphenyl-2-picrylhydrazyl (AAPH, 10 mM) and to hydrogen peroxide (H2O2, 50-100 microM), indicated that phenolic acids and flavonoids were the main causes of the protective effect. (researchgate.net)
These results provide unequivocal evidence that, through the synergistic action of its antioxidants, honey by reducing and removing ROS, may lower the risks and effects of acute and chronic free radical induced pathologies in vivo. (researchgate.net)
Antioxidants provide protection to living organisms from damage caused by uncontrolled production of ROS and concomitant lipid peroxidation, protein damage and DNA stand breaking. (intechopen.com)
In this study, we aimed at proving a high peroxidative activity in BCC skin lesions which predicts the probable response of the tumor to local or systemic antioxidants in at-risk patients. (scirp.org)
Antioxidants benefit human body by neutralizing and removing free radicals in the blood stream. (ijpsonline.com)
Antioxidants are compounds that inhibit oxidation (usually occurring as autoxidation ), a chemical reaction that can produce free radicals . (wikipedia.org)
[7] [8] The possible mechanisms of action of antioxidants were first explored when it was recognized that a substance with anti-oxidative activity is likely to be one that is itself readily oxidized. (wikipedia.org)
These molecules undergo free radical chain reactions, but antioxidants inhibit them by preventing the oxidation processes. (wikipedia.org)

After sacriﬁce, extricated pup lenses were analyzed for mean activities of catalase, superoxide dismutase, glutathione peroxidase, glutathione S-transferase, and glutathione reductase. (molvis.org)
Changes in the activities of glutathione peroxidase (GSH-Px): glutathione reductase (GSH-R), and catalase, and in the content of reduced glutathione (GSH) in blood samples were determined by means of biochemical methods. (nih.gov)
Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx) activities and uric acid (UA) levels were measured in plasma and saliva. (bvsalud.org)

The juice (GFJ) was centrifuged at 3000 rpm for 5 min and used for determination of total phenolic content, 1,1?diphenyl?2?picrylhydrazyl (DPPH) radical scavenging activity and antimicrobial activity. (ijpsonline.com)
The leaf extract of M. piperita showed strong radical scavenging activity in both the 1, 1 diphenyl-2-picryl hydrazyl radical (DPPH*) and 2, 2 azinobis (3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS*+) assays. (unboundmedicine.com)
The antioxidant capability of the resulting plant extracts against a stable radical DPPH was evaluated and the most of plant extracts showed high efficiency in the DPPH test. (europa.eu)
The antioxidant activities were examined by DPPH and FRAP methods. (scirp.org)
The DPPH scavenging activity in Bellary and CO 3 onion varieties ranged from 6.5% - 11.8% whereas FRAP values ranged from 0.9 - 3.3 μM/100 μg FW. (scirp.org)
Antioxidant activities were evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. (innovareacademics.in)
SOR), hydrogen peroxide, and 2, 2-Diphenyl-2-picrylhydrazyl (DPPH) radical activity by a model (most biological y active) of the anticancer plant was also evaluated. (who.int)

Extracts from Forsythia suspensa, Helichrysum italicum, Scrophularia auriculata, Inula viscosa, Coptis chinensis, Poria cocos and Scutellaria baicalensis had previously shown anti-inflammatory activity in different experimental models. (nih.gov)
Most of the extracts were weak scavengers of the hydroxyl radical and C. chinensis and P. cocos exhibited the highest scavenging activity. (nih.gov)
The results of the present work suggest that the anti-inflammatory activities of the same extracts could be explained, at least in part, by their antioxidant properties. (nih.gov)
All extracts showed concentration-dependent increase in the antioxidant activity. (ijpsonline.com)
In this study, 21 diatoms, 7 dinoflagellates, and 4 flagellate species were grown in three different culturing conditions and the corresponding extracts were tested for possible antioxidant, anti-inflammatory, anticancer, anti-diabetes, antibacterial, and anti-biofilm activities. (frontiersin.org)
The present study was carried out to evaluate the radical scavenging and antibacterial activity of methanolic leaf extracts of mangrove plants. (unboundmedicine.com)
Methanolic extracts of R. mucronata were also found to be effective in protecting plasmid DNA against the strand breakage induced by hydroxyl radicals in a Fenton's reaction mixture. (unboundmedicine.com)
Methanolic leaf extracts of mangrove plants exhibited no antibacterial activity against seven food-borne pathogens studied. (unboundmedicine.com)
A number of formulation approaches have been employed to increase the solubility and oral absorption of some herbal extracts and products and subsequently to enhance their bioavailability and therapeutic activity. (europa.eu)
The results indicated that the both the methanolic extracts exhibited radical scavenging activity. (scirp.org)
2007). The screening of crude plant extracts for antimutagenic and anticarcinogenic activity has led to the identification of a variety of compounds (Wall et al . (scialert.net)
Total phenolic and flavonoid contents, free radical scavenging activity and ferric reducing activity of the extracts were also assessed. (ijpsonline.com)
A research team recently evaluated the antioxidant, anti-inflammatory and anticancer activities of extracts and compounds from black pepper. (doctorshealthpress.com)

I. viscosa and F. suspensa protected against enzymatic and non-enzymatic lipid peroxidation in model membranes and also showed scavenging property on the superoxide radical. (nih.gov)
By using pro-inflammatory transcription factor NF-kappaB, COX-1 and -2 enzymes (responsible for producing substances that fight inflammation), human tumor cell proliferation and "lipid peroxidation" (the process in which free radicals "steal" electrons from lipids in our cell membranes, causing cell damage and increased production of free radicals), the researchers were able to determine the health-boosting properties of pepper. (doctorshealthpress.com)
New water-soluble analogues of 1,3,7-trimethyluric acid with N-1 methyl replaced by various groups were prepared and evaluated for their ability to scavenge hydroxyl radicals as well as their protective potential against lipid peroxidation in erythrocyte membranes. (iisc.ac.in)
With the exception of 1-pentyl- and 1-(2'-oxopropyl)-3,7-dimethyluric acids, all other analogues tested are effective inhibitors of tert-butylhydroperoxide-induced lipid peroxidation in human erythrocyte membranes. (iisc.ac.in)

The deoxyribose degradation method indicates that all the analogues tested effectively scavenge hydroxyl radicals and some of them show better activity than uric acid and methyluric acids. (iisc.ac.in)
Zinc do not directly scavenge free radicals. (gvado.com)

The degree of lipid peroxidation was measured via thiobarbituric acid assays. (nih.gov)
The sample Mc_Lf_06 was the single one that presented higher antioxidant activity across the four assays (prevention of lipid peroxidation, ability for scavenging the ABTS, NO and hydroxyl radicals). (2siglas.pt)

It is impossible to measure free radicals directly in vivo, and it is necessary to rely on the quantification of their reaction products such as protein carbonyls, modified DNA, and lipid peroxidation products. (bmj.com)
Subcutaneous injection of sodium selenite led to severe oxidative damage in the lenticular tissues, shown by increased formation of formazan crystals, elevated generation of superoxide, hydroxyl, and nitric oxide radicals, and elevated inducible nitric oxide synthase gene and protein expression that possibly contributed to the opacification of the lens and thus cataract formation. (molvis.org)
When rat pups were treated with intraperitoneal administration of the extract of C. maritima , the generation of free radicals as well as the messenger ribonucleic acid and protein expression of inducible nitric oxide synthase were maintained at near normal levels. (molvis.org)
The blood glucose level, liver function enzymes, total protein, lipid, and cholesterol levels were significantly normalized by extract treatment. (hindawi.com)
Free reactive oxygen radicals cause damage of mammalian cells by oxidizing fatty acids, protein and DNA. (bvsalud.org)

Objective: To see whether there was a link between blood transfusion and lipid peroxidation as measured by urinary malondialdehyde (MDA) concentration in preterm infants. (bmj.com)
Malondialdehyde (MDA) is the most widely used index of lipid peroxidation 13 and is easily measured by the thiobarbituric acid reaction. (bmj.com)
Peroxidation is an oxidative process of unsaturated fatty acids (UFAs), resulting in creation of free radicals and carcinogenic metabolites such as malondialdehyde (MDA). (scirp.org)

Oxidation is a process which produces free radicals from cellular structures. (scirp.org)
Q10-Guard Plus contains high strength of CoQ10 to produce energy in supporting cellular activities. (gvado.com)
In the context, 1,25D3 (the active form of VD3) significantly reduced cellular free Fe2+, lipid peroxidation and lactic dehydrogenase (LDH) release induced by A. hydrophila in the splenic macrophages, indicating the protective effects of VD3 on A. hydrophila-led to ferroptosis-related injuries. (bvsalud.org)

Activity of superoxide dismutase (SOD), catalase (CAT), and glutathione reductase (GR), as well as levels of thiobarbituric acid reactive substances (TBARS) were assessed. (nel.edu)
Highly elevated contents of thiobarbituric acid reactive substances reflected extensive lipid peroxidation processes throughout the experiment. (nih.gov)

These changes indicate that ethanol toxicity induces profound changes in explorative behavior, mediated, at least partly, by changes in the free radical metabolism. (nih.gov)

The lipid peroxidation (TBARS) and the enzymatic activity of catalase (CAT) were measured in the cardiac muscle. (bvsalud.org)

All the analogues tested are susceptible to peroxidation in the presence of hemoprotein and hydrogen peroxide. (iisc.ac.in)

Since the metalloprotein superoxide dismutase, SOD, is the key enzyme involved in the detoxification of superoxide radicals, it may play a vital role in interindividual variation in superoxide radical turnover. (nature.com)

Spectral changes observed during the microsomal oxidation of aminopyrine by cumene hydroperoxide have demonstrated the formation of the aminopyrine radical prior to, and concomitant with, the formation of antipyrine red. (aspetjournals.org)
Thus, efficient trapping by nitrosobenzene of reactive organic radicals derived from cumene hydroperoxide inhibits their subsequent reactions, i.e., substrate oxidation and initiation of lipid peroxidation. (aspetjournals.org)

It has antiradical and anti-inflammatory activity and inhibits lipid peroxidation. (tratamientodelvitiligo.es)

M. Ashwini, J. Balaganesh, S. Balamurugan, S. Murugan and R. Sathishkumar, "Antioxidant Activity in in Vivo and in Vivo Cultures of Onion Varieties (Bellary and CO 3)," Food and Nutrition Sciences , Vol. 4 No. 9, 2013, pp. 918-923. (scirp.org)
Carboxyfullerene directly inhibits in vitro growth of Streptococcus pyogenes and enhances bactericidal activity of neutrophils in mice in vivo [ 5874 ], suggesting that the fullerene derivative "can be considered an antimicrobial agent for group A streptococcus infection. (nanomedicine.com)
Preliminary In Vitro and In Vivo Evaluation of Antidiabetic Activity of Ducrosia anethifolia Boiss. (hindawi.com)

Cumene hydroperoxide (CuOOH) was used as free radical promoter. (researchgate.net)
These cumene hydroperoxide-dependent activities of microsomes were significantly inhibited by micromolar concentrations of metyrapone and also by known substrates of cytochrome P-450, thus demonstrating the essential role of this hemeprotein in these reactions. (aspetjournals.org)

To evaluate the radiomodulatory influence of a leaf extract of Mentha piperita (Linn) on hepatic antioxidant status and lipid peroxidation in Swiss albino mice. (unboundmedicine.com)

Rats consuming a liquid diet containing 7% ethanol for 4, 7, 14, or 21 days exhibited a significantly decreased ambulation activity, accompanied by a reduced frequency and duration of explorative rearing in an open-field task 4, 7, and 14 days after chronic ethanol ingestion, whereas presumed adaptation to the neurologic effects of ethanol was observed on day 21. (nih.gov)
Bee bread ethanol extract demonstrated significantly higher antioxidant properties compared to bee bread aqueous extract with the highest total phenolic and flavonoid contents in sample from Perak and the highest free radical scavenging activity in sample from Selangor. (ijpsonline.com)
Results: Plasma analysis showed significantly decreased SOD and CAT activities, and UA level in RAS patients compared to control group. (bvsalud.org)
Plasma GSHPx activity was significantly higher in RAS patients. (bvsalud.org)
In saliva, SOD and CAT activities, and UA levels were significantly higher in RAS patients, while GSHPx activity was lower compared to control. (bvsalud.org)

preventing lipid peroxidation through the thiobarbituric reactive species method, for reducing ferric ions to ferrous ions and chelating activity. (2siglas.pt)

These compounds have varying degrees of activity as free radical scavengers. (wikipedia.org)
OH), non-free-radical compounds (H 2 O 2 ) and singlet oxygen ( 1 O 2 ), which can be formed by different mechanisms in living organisms. (intechopen.com)
2006). These beneficial compounds alter metabolic pathways and hormonal actions that are associated with the development of cancer, stimulate the immune system and have antioxidant activity (Craig, 1999). (scialert.net)
The compounds showed inhibitory activity in a concentration dependant manner. (hindawi.com)

There was dense lenticular opaciﬁcation in all of Group II, minimal opaciﬁcation in 33.3% of Group III, no opaciﬁcation in 66.7% of Group III, and no opaciﬁcation in Group I. Signiﬁcantly lower mean activities of lenticular antioxidant enzymes were noted in Group II, compared to Group I and III. (molvis.org)
Rutin prevents experimental selenite-induced cataractogenesis in rat pups, possibly by preventing depletion of antioxidant enzymes and of GSH, and by inhibiting lipid peroxidation. (molvis.org)

To investigate the possible free radical-scavenging activity of an extract of Cineraria maritima on selenite-induced cataractous lenses in Wistar rat pups. (molvis.org)
Pepper exerts a free-radical scavenging activity. (doctorshealthpress.com)

Six diatom species displayed specific anti-inflammatory, anticancer (blocking human melanoma cell proliferation), and anti-biofilm (against the bacteria Staphylococcus epidermidis ) activities whereas, none of the other microalgae were bioactive against the conditions tested for. (frontiersin.org)

The radical scavenging activity of 1,1-diphenyl-2-picrylhydrazyl was highest in fruit juice followed by methanol extract of leaf and stem. (ijpsonline.com)
and radical scavenging activity. (innovareacademics.in)

It is also added with zinc and Vitamin E to combat lipid peroxidation, which may beneficial for health. (gvado.com)

The G. lancifolia fruit juice exhibited high antibacterial activity against Pseudomonas aeruginosa, Escherichia coli, Micrococcus luteus, Streptococcus mutans, Bacillus mycoides and Bacillus subtilis. (ijpsonline.com)
Other studies [ 5877 ] have also found antibacterial activity of fullerene derivatives, and even of carbon nanotubes [U. Sagman, personal communication, December 2002]. (nanomedicine.com)
The objective of this study was to identify fractions with the highest antibacterial activity against Bacillus subtilis and to determine antioxidant activities and establish the chromatographic fractions as candidate antibacterial and antioxidant agents. (innovareacademics.in)
The strongest antibacterial activity against B. subtilis (ATCC 6633) was observed with fractions B and C obtained in this research, with a minimum inhibitory concentration value of 312.5 Î¼g/mL. (innovareacademics.in)
leaves possess antibacterial and antioxidant activities. (innovareacademics.in)

Plants are rich sources of phytochemicals such as saponin, tannin, flavanoids, phenolic and alkaloids, which possess a variety of biological activities including antioxidant potential. (intechopen.com)
Moreover, the total phenolic content of R. mucronata (720.79 mg/gm of dry leaves) was very high and a strong positive correlation was observed between its phenolic content and its antioxidant activity. (unboundmedicine.com)

If lipid peroxidation contributes to the pathogenesis of retinopathy of prematurity and chronic lung disease, these results suggest an explanatory mechanism. (bmj.com)

The therapeutic properties of honey, once considered a form of folk or preventive medicine, are acquiring importance for the treatment of acute and chronic free radical-mediated diseases (atherosclerosis, diabetes and cancer). (researchgate.net)
The effects of chronic ethanol intoxication on the open-field behavior, on antioxidant enzyme activities, and the degree of lipid peroxidation were investigated. (nih.gov)
Chronic ethanol ingestion elicited a significant increase in GSH-Px activity (by a maximum of approximately 32% on day 14), whereas opposite alterations in GSH-R and catalase activities were recorded (49% of the control value on day 4 and 17% on day 21, respectively). (nih.gov)
2011). Larger quantities of free radicals (reactive disease, diabetes, chronic respiratory diseases, and oxygen species [ROS]) present in the cigarette cancer (WHO, 2012). (bvsalud.org)

Although S. baicalensis inhibited the lipid peroxidation in rat liver microsomes and red blood cells, the extract showed inhibitory actions on aminopyrine N-demethylase and xanthine oxidase activities as well as an pro-oxidant effect observed in the Fe3+-EDTA-H2O2 system. (nih.gov)

To the best of our knowledge, this is the first study considering oxidative activity of both serum and tissue specimens in human basal cell carcinoma (BCC), which is the most common tumor in the world. (scirp.org)

Our study revealed that the possible mechanism of the biological activities in onion could be due to the free radical scavenging and antioxidant activities. (scirp.org)
The differences in compositions and antioxidant activities among the samples might be related to the floral sources and geographical locations. (ijpsonline.com)

2003). From a large number of Zingiberaceae species that have been used for culinary and/or medicinal purposes, only few members have studied for their potential anticancer activity. (scialert.net)
Ducrosia species were investigated mainly for their oil analysis and their biological activities [ 6 ]. (hindawi.com)

Some herbs from South Africa and India were studied for their biological activity and protective effects using various cell lines or animal modells. (europa.eu)

The anticancer model's overal antioxidant activity (34.72 µg/mL) was slightly lower than quercetin (30.44 µg/mL) but higher than ascorbic acid (41.68 µg/mL). (who.int)

The hypothesis for this study was that lipid peroxidation, as evidenced by urinary MDA concentration, increases following blood transfusion. (bmj.com)
In 1993, MSAD-C 60 was found effective against HIV-1 and HIV-2 with 50% effective concentration (EC50) averaging 6 x 10 -6 M in acutely or chronically infected human lymphocytes, and with selective activity against HIV-1 protease [ 732 ]. (nanomedicine.com)

The results of the present investigation suggest the antioxidant and free radical scavenging activities of leaf extract of M. piperita are the likely mechanism of radiation protection. (unboundmedicine.com)

Spices, which have good antioxidant activity, were cooked with sweet potato leaves to appreciate their impact on nutrients losses prevention. (ishs.org)

SOD eliminates superoxide free radicals that cause cell damage and destroy melanocytes. (tratamientodelvitiligo.es)
Vitamin E . An antioxidant that protects body tissue from the damage caused by free radicals. (tratamientodelvitiligo.es)

Anatomy20

Organisms12

Diseases12

Chemicals and Drugs166

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes25

Technology, Industry, Agriculture6

Information Science1

Health Care3

Oxidative stress10

Inhibition6

Reactive oxygen3

Antioxidants8

Glutathione peroxidase3

DPPH7

Extracts13

Membranes4

Scavenge2

Assays2

Protein5

Malondialdehyde3

Cellular3

Thiobarbituric acid2

Metabolism1

Enzymatic1

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Oxidation2

Anti-inflammatory activity1

Vivo3

Cumene2

Hepatic1

Significantly5

Ferrous1

Compounds4

Enzymes2

Free radical-scavengi2

Proliferation1

Scavenging Activity2

Zinc1

Antibacterial5

Phenolic2

Pathogenesis1

Chronic4

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Protective1

Ascorbic acid1

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