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  • method of monitoring platel
  • The invention provides a method of monitoring platelet function in a mammal by passing blood removed from the body of the mammal through a passageway to contact an obstruction or irregularity in the passageway to generate a platelet mass in the passageway, and monitoring the flow or composition of the. (google.com)
  • hemorrhage
  • Unfortunately, these routine tests do not necessarily correlate with excessive biopsy-induced bleeding, which makes predicting and preventing hemorrhage during liver biopsy difficult. (akcchf.org)
  • to the research team will use two methods to evaluate platelet function in canine patients with chronic liver disease undergoing ultrasound guided liver biopsies to determine if there is a relationship between platelet function and hemorrhage after biopsy. (akcchf.org)
  • thrombosis
  • Congenital and idiopathic TTP are generally associated with deficiencies in ADAMTS13, a zinc metalloprotease responsible for cleaving Very Large vWF Multimers in order to prevent inappropriate platelet aggregation and thrombosis in the microvasculature. (wikipedia.org)
  • He focused his research on the role of platelets in thrombosis and haemostasis under the mentorship of Professor Tony Mitchell, DPhil, FRCP, who was the foundation professor of Medicine at the University of Nottingham. (wikipedia.org)
  • Professor Heptinstall was head of the Thrombosis and Haemostasis Research Group based in the Queen's Medical Centre, Nottingham for many years, where he engaged in extensive basic and clinical research aimed at understanding the function of platelets and other blood cells in physiological and pathological disease processes. (wikipedia.org)
  • heparin
  • The manufacturer recommends the use of hirudin as anticoagulant for samples to be tested, but studies have shown that heparin is a good alternative. (wikipedia.org)
  • receptor
  • Drugs that inhibit the GPIIb/IIIa receptor, e.g. eptifibatide, can also reduce or eliminate the ADP-induced platelet response. (wikipedia.org)
  • Inhibition of COX1, as with acetylsalicylic acid, and inhibition or absence of GPIIb/IIIa receptor, as seen in Glanzmann's thrombasthenia, will reduce platelet aggregation in response to arachidonic acid. (wikipedia.org)
  • Thrombin receptor activating peptide-6 (TRAP-6) activates platelets through the thrombin receptor protease activated receptor-1 (PAR-1). (wikipedia.org)
  • This inhibition appeared to reflect the ability of these metabolites to a) inhibit the activities of COX-1 and COX-2 thereby blocking the production of TXA2 and b) interfere with the activation of the TXA2 receptor (Thromboxane receptor) by TXA2. (wikipedia.org)
  • However while it was found to have good selectivity over the related CB1 and CB2 cannabinoid receptors as well as a number of other targets, CID-16020046 has not yet been tested against another related receptor GPR18, so its selectivity for GPR55 over this target has not been established. (wikipedia.org)
  • CID-85469571 O-1918 PSB-SB-487 Kargl J, Brown AJ, Andersen L, Dorn G, Schicho R, Waldhoer M, Heinemann A. A selective antagonist reveals a potential role of G protein-coupled receptor 55 in platelet and endothelial cell function. (wikipedia.org)
  • Glanzmann's
  • For severe bleeding, platelet transfusions can be given, however in some conditions such as Glanzmann's thrombasthenia, platelet transfusions should be given only under the supervision of a pediatric hematologist. (clinicaladvisor.com)
  • inhibit
  • Elapid snakes cause prey to die from asphyxiation because the dominating neurotoxins inhibit cholinesterase activity, thereby leading to paralysis of all muscles, including the diaphragm. (wikipedia.org)
  • These recently classified metabolites are distinguished from the many other dihydroxy-PUFA with three conjugated double bonds that do not have this critical E,Z,E configuration: they inhibit the function of platelets and therefore may be involved in controlling and prove useful for inhibiting human diseases which involve the pathological activation of these blood-borne elements. (wikipedia.org)
  • anticoagulants
  • Some anticoagulants are used in medical equipment, such as test tubes, serum-separating tubes, blood transfusion bags, and dialysis equipment. (wikipedia.org)
  • Anticoagulants: Warfarin Overdose: Used as a treatment for prevention of blood clots, however, like most drugs, side effects have been shown to increase risk of excessive bleeding by functioning in the disruption of hepatic synthesis of coagulation factors II, VII, IX, and X. Vitamin K is an antagonist to warfarin drug, reversing its activity, causing it to be less effective in the process of blood clotting. (wikipedia.org)
  • Use of defibrotide for people who are already taking anticoagulants is dangerous and use of other drugs that affect platelet aggregation, like NSAIDs, should be done with care. (wikipedia.org)
  • Blood
  • 3 . The method of claim 2 wherein the counting of the platelets in the first sample is conducted in the presence of EDTA as a blood preservative. (google.com)
  • 8 . The method of claim 5 wherein the second tube contains a blood preservative which does not interfere with platelet function to any significant degree. (google.com)
  • Some of the factors that differentiate these tests are sample volume requirements, the use of whole blood, the presence of shear, point-of-care status, need for a technician, and expense. (umassmed.edu)
  • A complete medical history, neurological and opthamological examination will be performed, including measurements of vital signs (heart rate and blood pressure), as well as magnetic resonance imaging (MRI), EDSS, and Visual Evoked Response test (VER's) to document status of disease. (clinicaltrials.gov)
  • Other safety evaluations (previously mentioned blood and urine tests) will be conducted according to the date of treatment. (clinicaltrials.gov)
  • The template below (Myeloid blood tests) is being considered for merging. (wikipedia.org)
  • Thromboelastography (TEG) is a method of testing the efficiency of blood coagulation. (wikipedia.org)
  • The decision to begin therapeutic anticoagulation often involves the use of multiple bleeding risk predictable outcome tools as non-invasive pre-test stratifications due to the potential for bleeds while on blood thinning agents. (wikipedia.org)
  • Reference ranges for blood tests are sets of values used by a health professional to interpret a set of medical test results from blood samples. (wikipedia.org)
  • Reference ranges for blood tests are studied within the field of clinical chemistry (also known as "clinical biochemistry", "chemical pathology" or "pure blood chemistry"), the area of pathology that is generally concerned with analysis of bodily fluids. (wikipedia.org)
  • Blood test results should always be interpreted using the reference range provided by the laboratory that performed the test. (wikipedia.org)
  • If not otherwise specified, a reference range for a blood test is generally the venous range, as the standard process of obtaining a sample is by venipuncture. (wikipedia.org)
  • The blood bank also provides blood components such as packed cells, platelets and fresh frozen plasma. (wikipedia.org)
  • The Blood Bank has also started the service of providing mega unit of platelets to patients of Civil Hospital Karachi, free of cost. (wikipedia.org)
  • In 1971 Stan Heptinstall sought a change in his academic direction and secured a two-year postdoctoral fellowship to study blood platelets in the newly established Faculty of Medicine in the University of Nottingham. (wikipedia.org)
  • drugs
  • A new test called the erythromycin breath test will be administered to you three times during the study to measure how your liver will metabolize these drugs. (clinicaltrials.gov)
  • VerifyNow
  • Clinical follow-up (office visit) and post-PCI VerifyNow maintenance testing will occur at 2 weeks, 3 months, and 6 months for patients in the guided therapy group. (clinicaltrials.gov)
  • VerifyNow testing, adverse event occurrence and drug compliance will be performed as part of follow-up. (clinicaltrials.gov)
  • Patients in guided and control study arms will return at 6 months for clinical follow-up and VerifyNow testing. (clinicaltrials.gov)
  • laboratory
  • Subjects will be randomized to either guided antiplatelet therapy arm (n=750) or standard therapy arm (n=750) and undergo laboratory testing, antiplatelet adjustment, and clinical follow-up for 1 year. (clinicaltrials.gov)
  • Clinical suspicion should lead to laboratory testing as described above which will likely unmask the specific disorder. (clinicaladvisor.com)
  • Uncontrolled bleeding should lead to admission to the hospital and consultation with a pediatric hematologist to help determine which laboratory tests and treatments to order. (clinicaladvisor.com)
  • These tests include a laboratory test (methotrexate level) two days following treatment, as well as routine lab tests 2 weeks following the methotrexate treatment. (clinicaltrials.gov)
  • It is determined by collecting data from vast numbers of laboratory tests. (wikipedia.org)
  • Laboratories
  • Normal levels do not exclude all forms of vWD, particularly type 2, which may only be revealed by investigating platelet interaction with subendothelium under flow, a highly specialized coagulation study not routinely performed in most medical laboratories. (wikipedia.org)
  • detect
  • Although some studies showed a link between HPR and major adverse vascular events [ 19 , 20 ], the use of platelet function analysis to detect and manage HPR continues to be debated. (biomedcentral.com)
  • Cells
  • Although the precise function of PrP is not yet known, it is possibly involved in the transport of ionic copper to cells from the surrounding environment. (wikipedia.org)
  • Assessment
  • Percentages and time-dependent units (mol/s) are used for calculated derived parameters, e.g. for beta cell function in homeostasis model assessment or thyroid's secretory capacity. (wikipedia.org)