Activity inhibitory concentration 50. Medical search. Frequent questions

Aqueous and ethanol extracts of propolis were analysed phytochemically and examined for their antiviral activity in vitro. (nih.gov)
Severe acute respiratory syndrome (SARS) is an from in vitro testing indicate that ribavirin concentrations infectious disease caused by a newly identified human that inhibit other viruses sensitive to ribavirin do not inhibit coronavirus (SARS-CoV). (cdc.gov)
Prevention concluded that further in vitro testing of antiviral drugs exhibit in vitro anti-SARS-CoV activity. (cdc.gov)
The recent epidemic has shown that knowledge is lack- allow rapid screening of commercially available antiviral ing regarding the clinical management and treatment of agents, enabling those with in vitro evidence of activity to infected patients. (cdc.gov)
All the extracts and fractions were evaluated for cytotoxicity and anti-HIV-1 activity using different in vitro assays. (nih.gov)
Recently, we and others have demonstrated in vitro activity and clinical efficacy of the Bcl-2 inhibitor venetoclax as a single agent in relapsed/refractory T-PLL (r/r-TPLL). (haematologica.org)
GST activity was studied in-vitro in human erythrocytes or as the purified enzyme. (cdc.gov)
The complexes were screened in vitro against a fungal species and eight species of bacteria, revealing their antimicrobial activity. (springer.com)
In vitro antibacterial and cytotoxic activity of leaf extracts of Centella asiatica (L.) Urb, Warburgia salutaris (Bertol. (biomedcentral.com)
In vitro anti-HIV-1 activity of delavirdine was assessed by infecting cell lines of lymphoblastic and monocytic origin and peripheral blood lymphocytes with laboratory and clinical isolates of HIV-1. (drugs.com)
We discovered that a conjugated metabolite derived from quercetin possesses considerable anti-oxidant activity in several in vitro experiments. (rsc.org)
Psilostachyin C exerted in vitro trypanocidal activity against Trypanosoma cruzi epimastigotes, trypomastigotes and amastigotes, with 50% inhibitory concentration (IC50) valuesof 0.6, 3.5 and 0.9g/mL, respectively, and displayed less cytotoxicity against mammalian cells, with a 50% cytotoxic concentration (CC50) of 87.5g/mL. (conicet.gov.ar)
Radiopeptides retained a high affinity for the CCK-2/gastrin-R in vitro (50% inhibitory concentration values of ∼1 nmol/L) and internalized rapidly in CCK-2/gastrin-R-positive cells. (snmjournals.org)
The synthesized compounds were evaluated for their biological activity in vitro: tuberculostatic, antibacterial, cytotoxic, and anticancer. (springer.com)
in the present study, they examined the in vitro antioxidant properties and cholinesterase inhibitory activity of fractions and extracts of Salvia leriifolia Benth (Lamiaceae). (naturalproductsinsider.com)
In vitro antibacterial and non-stick activity of extracts from leaves of Psidium guineense Sw. (bvsalud.org)
LA activity is identified by in vitro prolongation of clotting time in coagulation assays. (medscape.com)

The aqueous and 50% ethanolic extracts of A. catechu showed IC50 values of 1.8 ± 0.18 μg/ml and 3.6 ± 0.31 μg/ml, respectively in cell-free virus based assay using TZM-bl cells and HIV-1NL4.3 (X-4 tropic). (nih.gov)
In the above assay, n-butanol fraction exhibited anti-HIV-1 activity with an IC50 of 1.7 ± 0.12 μg/ml. (nih.gov)
The n-butanol fraction demonstrates a potent inhibitory activity against the viral protease (IC50 = 12.9 μg/ml), but not reverse transcriptase or integrase. (nih.gov)
Data processing: Data is processed by using Excel analysis and half-inhibitory concentration (IC50) is calculated by using GraphPad Prism 6.0.2. (bindingdb.org)
FRC markedly suppressed the TBARS production in a concentration-dependent manner, leading to 50% (IC50) and 100% (IC100) inhibitory concentrations of 20 and 95 microg/mL, respectively, which was similar to the effect of butylated hydroxyanisole. (koreamed.org)
FRC inhibited lens AR by 50% (IC50) and 90% (IC90) at approximately 2 and 31.6 microg/mL, respectively, comparable to the effect of quercetin. (koreamed.org)
In the first test, the team used the modified colorimetric Ellmans method against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and found the n-hexane extract had inhibitory concentration 50 percent (IC50) values of 0.59 and 0.21 mg/mL for AChE and BChE, respectively. (naturalproductsinsider.com)
Interestingly, the half maximal inhibitory concentration (IC50) of BLMs in different cancer cell lines varies from nM to μM ranges. (lookformedical.com)
HUVEC when comparing the IC50 (half maximal inhibitory concentration) values. (lookformedical.com)
The half-maximal inhibitory concentration (IC50) of Cd and the safe doses of SFN were determined using a methyl thiazolyl tetrazolium (MTT) assay. (lookformedical.com)
In this investigation, the cytotoxicity of 20 α-methylene-γ-lactones towards normal breast epithelial MCF-10A cells as well as breast cancer JIMT-1 cells is compared, by determining the inhibitory concentration 50 (IC50) from dose response curves. (lu.se)

In recent studies, this linker modified analog of goniothalamin was shown to be cytotoxic against PC-3 (prostate cancer) and MCF-7 (human breast cancer) cell lines with half maximal inhibitory concentration values of 0.13 Î¼M and 2.6 Î¼M, respectively. (lookformedical.com)
Moreover, threohydrobupropion has been reported to weakly inhibit the reuptake of norepinephrine, dopamine, and serotonin with rat IC50Tooltip half-maximal inhibitory concentration or Ki values of 16 μM, 47 μM, and 67 μM, respectively. (wikipedia.org)

Despite the antimicrobial activity of macrophages, Mtb has been able to establish a series of strategies to handle the host immune machinery, interfere with, and arrest the phagosome maturation, counteract mycobactericidal molecules and ultimately survive in a hostile intracellular environment ( 8 - 10 ). (frontiersin.org)
Compounds having both anticancer and antimicrobial activity have promising therapeutic potential due to their selective cytotoxicity and their potential to reduce the occurrence of bacterial and fungal infections in immune-compromised cancer patients. (biomedcentral.com)
The molecular approach of using Geneious Prime software and protein prediction data base for characterization of bacteriocin is novel and predicts " KSSAYSLQMGATAIKQVKKLFKKWGW " as peptide responsible for antimicrobial activity. (researchsquare.com)
Corallina officinalis had higher antimicrobial activity, with values of minimum inhibitory concentrations ranging from 0.156 to 5 mg mL-1. (bvsalud.org)
The antimicrobial activity of medicinal plants has shown better pharmacological action when such plants are loaded into a drug delivery system than when they are not loaded. (who.int)

Herein, we also demonstrate that compounds developed to target mutant IDH1 can be repurposed as wild-type IDH1 inhibitors, because these drugs surprisingly become potent inhibitors of wtIDH1 in cancer cells under conditions present in tumors: specifically, we found that wtIDH1 is critical for PDAC cell survival under low-glucose conditions, and allosteric IDH inhibitors effectively block wtIDH1 activity under low magnesium. (nature.com)
In our quest to find new antimicrobial agents with potent anticancer activity, the biological potential of leaves from the three medicinal plants Centella asiatica , Warburgia salutaris and Curtisia dentata as used by Zulu traditional healers for the treatment of cancer is investigated. (biomedcentral.com)
In addition, we have demonstrated that chlorimuron ethyl (CE), a member of the sulfonylurea herbicide family, has potent antifungal activity against five different Candida species and Cryptococcus neoformans (with minimum inhibitory concentration, 50% values as low as 7 nM). (rcsb.org)
Of these compounds, luteolin showed the most potent inhibitory activity (IC(50)=1.5μg/mL). (greenmedinfo.com)
In any case, it is about 20% as pharmacologically potent as bupropion and in the range of 20 to 50% as potent as bupropion in mouse models of depression. (wikipedia.org)

Complete inhibition of cytopathic anti-SARS-CoV activity. (cdc.gov)
The results presented here show a potential anti-HIV-1 activity of A. catechu mediated by the inhibition of the functions of the viral protein and Tat. (nih.gov)
The optimal IC 50 values for tyrosinase inhibition and 2,2-diphenyl-1-picrylhydrazyl (DPPH) removal by the A. niger- fermented extracts were 30 and 12 μ g/mL, respectively. (hindawi.com)
The possible use of the degree of inhibition of glutathione-S- transferase (GST) activity as a biological marker for determining exposure to chemicals such as acrolein (107028), styrene -oxide (96093), propylene-oxide (75569), ethylene-dibromide (106934), and ethylene-dichloride (107062) was explored. (cdc.gov)
Results used to determine the conditions for the definitive study: The range-finding test revealed inhibition rates of 20.1%, 74.2% and 100% for test substances concentrations of 10, 10 and 100 mg/L, respectively. (europa.eu)
Thus, this study demonstrated for the first time that the glycolic extracts of C. pachystachya have promising chemical and biological characteristics for the development of a multifunctional cosmetic with antioxidant and tyrosinase-inhibition activities. (bvsalud.org)

Among the analysed compounds, only galangin and chrysin displayed some antiviral activity. (nih.gov)
These results could be attributed to an increase in the concentration of original active compounds and the biosynthesis of new compounds during fermentation. (hindawi.com)
While GST activity was inhibited by all these compounds, acrolein was the most inhibitory. (cdc.gov)
Pharmaceutical and scientific communities have recently received the attention of the medicinal plants and various publications have documented the therapeutic worth of natural compounds to validate the claims of their biological activity. (academicjournals.org)
All the compounds were screened for their tuberculostatic, antibacterial, and anticancer activities. (springer.com)
Preliminary results indicated that target compounds exhibited weak tuberculostatic and antibacterial activities. (springer.com)
Seven compounds inhibited the growth of some cancer cell lines, whereas one of the 2-quinoline derivatives displayed favorable activity against all tested cancer cells with GI 50 values of 0.92-13 μM. (springer.com)
Sulfonamides are compounds with diverse pharmacological activity. (springer.com)
The amidine functional group is an important structural element of compounds with established pharmacological activity. (springer.com)
The results presented in this study suggest these compounds warrant further development with a view to assessing their clinical activity. (hud.ac.uk)

Inflammatory activity, represented by standardized uptake values (SUVmax) of FDG at pre-determined locations of esophagus, stomach and duodenum, were compared. (who.int)
The acetone extracts from Waburgia salutaris revealed noteworthy anti-proliferative effect yielding IC 50 value of 34.15 μg/ml against MCF-7 cell line, while acetone extract from Curtisia dentata significantly ( P ≤ 0.05) revealed promising IC 50 values of 41.55, 45.13, 57.35 and 43.24 μg/ml against A549, HeLa, CaCo-2 and MCF-7 cell lines. (biomedcentral.com)
IC 50 and IC 90 values (50% and 90% inhibitory concentrations) for laboratory isolates (n = 5) ranged from 0.005 to 0.030 microM and 0.04 to 0.10 microM, respectively. (drugs.com)
SP-4 (residues 192-203), SP-8 (residues 483-494), and SP-10 (residues 668-679) significantly blocked the interaction between S protein and ACE2 by biotinylated enzyme-linked immunosorbent assay, with IC 50 values of 4.30 ± 2.18, 6.99 ± 0.71, and 1.88 ± 0.52 nmol, respectively. (scienceopen.com)
EC50 values: Determined by probit analysis of the respiration rates at different test substance concentrations. (europa.eu)
The values of LD50 (lethal dose 50%) calculated from experiments are different for each cell line . (lookformedical.com)

The 50% inhibitory concentration (IC(50)) of aqueous and ethanol propolis extracts for HSV-1 plaque formation was determined at 0.0004% and 0.000035%, respectively. (nih.gov)
Both propolis extracts exhibited high anti-HSV-1 activity when the viruses were pretreated with these drugs prior to infection. (nih.gov)
Acacia catechu (Mimosa family) stem bark extracts have been used traditionally as a dietary supplement as well as a folk medicine given its reported anti-inflammatory, immunomodulatory, hepatoprotective, antioxidant, anti-microbial and anti-tumor activities. (nih.gov)
The present study was undertaken to evaluate the anti-HIV-1 activity of the extracts from stem bark of A. catechu. (nih.gov)
The aqueous and 50% ethanolic extracts of A. catechu stem bark were prepared and 50% ethanolic extract was further fractioned by successively partitioning with petroleum ether, chloroform and n-butanol. (nih.gov)
The physiological characteristics of the fermented extracts, namely, tyrosinase inhibitory activity, antioxidant activity, antibacterial activity, and anti-skin-aging activity, were evaluated and compared with those of unfermented extracts. (hindawi.com)
Compared with the unfermented extracts, the fermented extracts also contained greater antibacterial activity against tested stains including MRSA . (hindawi.com)
Extracts were assayed for antibacterial activity using the agar well diffusion and micro plate dilution assay. (biomedcentral.com)
The extracts further revealed a broad-spectrum antibacterial activity against bacterial strains used in the study. (biomedcentral.com)
Overall, the extracts had good antibacterial activity and anti-proliferative effects against selected cancerous cell lines. (biomedcentral.com)
Given the good antibacterial activity of the extracts the plants may act as an immune booster and prevent infection in immunosuppressed cancer patients. (biomedcentral.com)
A 40.8μg/mL concentration of the ethyl acetate fraction of the ethanolic extracts of adlay bran (ABE-EtOAc) effectively inhibited mast cell degranulation. (greenmedinfo.com)
Here, we explored the seasonal metabolomic changes in Jania rubens and found notable changes between extracts of different seasons in the metabolomic profile and in their anticancer activity. (bvsalud.org)
As for depigmenting activity, both extracts were able to inhibit tyrosinase. (bvsalud.org)
Cell viability assay also revealed that the extracts could safely be used in concentrations of 125 µg/mL. (bvsalud.org)
This study determined the Minimum Inhibitory Concentration and the Minimum Inhibitory Concentration of Adherence of hydroalcoholic extracts of the leaves of strawberry guava (Psidium guineense Sw. (bvsalud.org)
L. egeregia was regarded as the prototype of the anticancer species due to its profound flavonoid concentration (85.40 µg/mL) and cytotoxicity (9.46 µg/mL) compared to other extracts. (who.int)

50 against SARS CoV, however, may take years. (cdc.gov)

3) Measurement results are shown in Table 1, which indicate that most of the synthesized benzofuran amidated derivatives have significantly xanthine oxidase inhibitory activity. (bindingdb.org)

In addition, minimum bactericidal concentrations (MBC), lactate dehydrogenase (LDH) release assay and rhodamine 6G intake assay were used to ascertain the antibacterial activity. (biomedcentral.com)
Additionally, molecular dynamics simulations were performed to estimate stability and flexibility of best complexes, while collagenase activity colorimetric assay was carried out to study the effects of (1), (2) and (3) on collagenase. (ijpsonline.com)

When injected into humans as an intravascular antibiotic at concentrations at or above the LD50 of 40-60 μM, surfactin has hemolytic effects. (wikipedia.org)

In vivo antitumor activity and toxicity were evaluated in Hep G2 cell xenograft model. (dovepress.com)
ACNVs were found to possess specific antitumor cell proliferation activity associated with an apoptosis-inducing pathway. (dovepress.com)
Intensive studies on the antitumor activity of sulfonamides were also carried out [ 5 ]. (springer.com)

6 In addition, independent annexin V/Hoechst assays of primary T-PLL cells on NK-Tert stromal support demonstrated modest single-agent activity of ibrutinib ( Figure 1D , Online Supplementary Figure S2A ). (haematologica.org)
In addition, the team screened the antioxidant activity in three different assays, finding the ethyl acetate extract of S. leriifolia had the highest activity. (naturalproductsinsider.com)

The fermented methanol extract exhibited the highest antityrosinase activity, total phenolic content, and antioxidant activity. (hindawi.com)
The Fall extract was fractionated and tested for cytotoxic activity toward an array of cancer cell lines. (bvsalud.org)
The Minimum Inhibitory Concentration obtained for strawberry guava extract ranged from 275 to 1100 mg.ml-1. (bvsalud.org)
The aim of this study was to evaluate the antifungal activity of Syngonanthus nitens (S. nitens) extract that was not loaded (E) or loaded (SE) into a liquid crystal precursor system (S) for the treatment of vulvovaginal candidiasis (VVC) with Candida albicans. (who.int)

Clinical studies show that depressed patients had elevated antioxidant enzyme activity. (ijpsonline.com)
Antioxidant activity. (bvsalud.org)
The anticancer model's overal antioxidant activity (34.72 µg/mL) was slightly lower than quercetin (30.44 µg/mL) but higher than ascorbic acid (41.68 µg/mL). (who.int)

73 of 74 clinical isolates had an IC 50 ≤0.18 microM. (drugs.com)
Following administration of delavirdine 400 mg 3 times daily (n = 67, HIV-1-infected patients), the mean ±SD steady-state peak plasma concentration (C max ) was 35 ± 20 microM (range: 2 to 100 microM), systemic exposure (AUC) was 180 ± 100 microM per hour (range: 5 to 515 microM per hour), and trough concentration (C min ) was 15 ± 10 microM (range: 0.1 to 45 microM). (drugs.com)
Rat corneal/retinal homogenate was treated with 50 microM FeCl3 in the presence of FRC (3.2-100 microg/mL) for 30 min at 37degrees C, and thiobarbituric acid-reactive substances (TBARS) was quantified as a lipid peroxidation parameter. (koreamed.org)

Besides the natural bioactive properties in plants, flavonoids are phytochemicals with several medically-relevant biological activities such as antiviral, antifungal, antibacterial antihepatotoxic, anti-osteoporotic, antiulcer, anti-proliferative. (rsc.org)

Microscopic observation of SE revealed an absence of filamentous cells 24 h of exposure to a concentration of 31.2 mug/mL. (who.int)

Extraction of EO-JC was performed by use of hydrodistillation using a Clevenger-type apparatus, and the EOs were analyzed by gas chromatography coupled with mass spectrometry (GC-MS). Antifungal activity of EO-JC was evaluated by the use of solid-state diffusion (disc method) and microdilution to determine the minimum inhibitory concentration (MIC), against three strains of fungus, Aspergillus niger , Aspergillus flavus, and Fusarium oxysporum . (hindawi.com)
The antifungal activity of EO-JC on solid media exhibited inhibitions in the range of 49% to 87%, and MIC was between 3.125 and 7.80 μ g EO-JC/mL. (hindawi.com)
The results showed effective antifungal activity after incorporation into S for all strains tested, with MICs ranging from 31.2 to 62.5 mug/mL. (who.int)

In polyherbal medicine, medicinal plants with lower doses are strongly recommended to prevent side effects and achieve the necessary pharmacological activity[ 4 ]. (ijpsonline.com)

Strains were seeded on blood agar plates to determine the Minimum Inhibitory Concentration by the agar-diffusion technique. (bvsalud.org)

The minimal inhibitory concentration (MIC) was determined by the microdilution technique. (who.int)

The minimum inhibitory concentration (MIC) of surfactin is between 12-50 μg/ml. (wikipedia.org)
In this study, we investigated if de novo ATP production of cells in the VBNC state is a suitable indicator for overall cell viability that can be utilized to determine the minimum ATP inhibitory concentration (MAIC) of antibiotics and other antimicrobials. (frontiersin.org)
The inclined tubes technique was used for Minimum Inhibitory Concentration of Adherence evaluation in the presence of 5% of sucrose, in Mueller-Hinton broth. (bvsalud.org)

Interestingly, this compound induced ultrastructural alterations, as seen by transmission electron microscopy, in which vacuolisation and a structural appearance resembling multivesicular bodies were observed even at a concentration as low as 0.2g/mL. (conicet.gov.ar)

Therefore, we assayed the inhibitory effects of small peptides derived from S protein on the binding of S protein to ACE2 and on the S-protein-pseudotyped retrovirus infectivity. (scienceopen.com)
Inhibitory effects of adlay bran Coix lachryma-jobi L. var. (greenmedinfo.com)
The effects of certain parameters, involving pH solution, initial dye concentration, algae dose, and contact time, were investigated on the sorption of dye. (bvsalud.org)

[ 3 ] Thus, some authors recommend using a sensitive reagent with minimal phosphatidyl serine concentrations when using aPTT in the evaluation of a patient with suspected LA activity. (medscape.com)

We probed putative mechanisms and demonstrated clinical feasibility and activity of a putative combination by treating two patients with active, r/r-T-PLL. (haematologica.org)

Chemical Composition and Evaluation of Antifungal and Insecticidal Activities of Essential Oils Extracted from Jambosa caryophyllus (Thunb. (hindawi.com)
Association between erosive esophagitis, FDG activity and anthropometric evaluation, including body mass index (BMI), waist circumference, visceral and subcutaneous adipose tissue volumes were analyzed. (who.int)
Regardless of the aPTT reagent used, interpretation of a prolonged aPTT in evaluation of LA activity must involve further tests to fulfill the aforementioned mentioned criteria to confirm the presence of LA. (medscape.com)

In drug combination studies of delavirdine with zidovudine, didanosine, zalcitabine, lamivudine, interferon-α, and protease inhibitors, additive to synergistic anti-HIV-1 activity was observed in cell culture. (drugs.com)

2) Add the substrate 0.48 mM XA 50 μL to start the reaction, read every 15 s at a wavelength of 295 nm and record the absorbance for a total of 7 min. (bindingdb.org)
Activity of AR from rat lens was assayed in the presence of FRC (1-31.6 microg/mL) at 25degrees C using glyceraldehyde as a substrate. (koreamed.org)

Surfactin is a broad-spectrum antibiotic with detergent-like activity increasing the permeability of cell membranes in all bacteria, regardless of their Gram stain classification. (wikipedia.org)

In solution, it has a characteristic "horse saddle" conformation (PDB: 2NPV) that explains its large spectrum of biological activity. (wikipedia.org)
However, although Michael acceptors are reactive, the Michael addition is reversible and it can be assumed that also other parts of the molecules will moderate the binding to and the release from any given nucleophilic site in a protein, and thereby moderate a specific biological activity. (lu.se)

Furthermore, when the environment is packed with proteins and lipids, surfactin faces a buffer effect lowering its antiviral activity. (wikipedia.org)

Studies of various medicinal plants and other natural products from nature have shown the anti-proliferative, cytostatic and cytotoxic activities of various phytochemicals against different cancer cells [ 3 ]. (biomedcentral.com)

Once inside, the anticancer activities rely on their abilities to produce DNA breaks, thus leading to cell death. (lookformedical.com)

Fermentation may increase the physiological and biochemical activities of biological substrates by modifying their naturally occurring molecules [ 3 ]. (hindawi.com)

Bupropion is a norepinephrine-dopamine reuptake inhibitor and nicotinic acetylcholine receptor negative allosteric modulator, with its metabolites contributing substantially to its activities. (wikipedia.org)
Threohydrobupropion circulates at higher concentrations than bupropion during bupropion therapy, similarly to hydroxybupropion but in contrast to erythrohydrobupropion-which circulates at similar concentrations as bupropion. (wikipedia.org)
Dry mouth during bupropion therapy has been associated with threohydrobupropion concentrations. (wikipedia.org)

especially for those subgroups who have one or more factors historically associated with lower response rates to interferon-based therapies (e.g. advanced fibrosis/cirrhosis, high baseline viral concentrations, black race, IL28B non CC genotype, prior null response to peginterferon alfa and ribavirin therapy). (medicines.org.uk)
Electroencephalography may be helpful in the initial workup of a patient with cirrhosis and altered mental status, when ruling out seizure activity may be necessary. (medscape.com)

pretreatment abolished the concentration dependence. (cdc.gov)

It is likely to act as a bioactive compound by exerting reactive oxygen species (ROS)-scavenging activity and/or binding to specific proteins such as oxidative enzymes and transcriptional factors in signal transduction pathways. (rsc.org)
98% pure [ 99m Tc]Demogastrin 1-3 species in specific activities of ∼37 GBq/μmol. (snmjournals.org)

Delavirdine is rapidly absorbed following oral administration, with peak plasma concentrations occurring at approximately 1 hour. (drugs.com)
Glucose rapidly increased DAG content and PKC enzyme activity in microsomes, but not in plasma membranes or other membranes, during a 30-min treatment of rat adipocytes. (jci.org)
The ef- find new modes of action and to develop fect of neem on the activity of insects has active agents based on natural plant prod- been neglected up to now, possibly because ucts, efforts are being made to isolate, it does not rapidly lead to mortality. (who.int)

68 Ga labeling of DOTA-conjugated adnectin (BXA-206362) was performed in NaOAc-buffer at pH 5.5 (50°C, 15 min). (snmjournals.org)

Howev- screen and develop phytochemicals pos- er, affected insects cannot survive adverse sessing pesticidal activity. (who.int)

The olized in nasal tissues in the rat and mouse and that a metabolic role of metabolism in olfactory injury is unknown (Cruzan et basis exists for the observed inspired concentration dependence al . (cdc.gov)

Several exposures including inhalation and contact were used to determine lethality, as well as the repulsion test was conducted at concentrations of 4, 8, 16, and 32 μ L EO-JC. (hindawi.com)

The WDI was defined as the duration between discontinuation of drug administration and the point at which the estimated liver PPG concentration was below the tolerance for 99% of the population. (avma.org)
The WDI was defined as the duration between discontinuation of drug administration and the point at which the estimated milk PPG concentration was below the safe level for 99% of the population. (avma.org)
Significant activity was also shown against the slower growing MAC 26 tumour for LS 4577 (the soluble pro-drug of LS 4559). (hud.ac.uk)

Concentrations inhibiting 50 percent of the activity (I50) ranged from around 10(- 3) to 10(-4) molar. (cdc.gov)
Genetic characterization indicated that the virus is only distantly related to known coronaviruses (identical in 50 to 60 percent of the nucleotide sequence). (scienceopen.com)

Anatomy5

Organisms50

Diseases9

Chemicals and Drugs145

Analytical, Diagnostic and Therapeutic Techniques and Equipment14

Phenomena and Processes29

Technology, Industry, Agriculture1

Information Science1

Health Care1

Geographicals1

Vitro17

IC5011

Half maximal inhibitory concentration2

Antimicrobial activity5

Potent5

Inhibition6

Compounds10

Values6

Extracts17

SARS-CoV1

Derivatives1

Assay2

Humans1

Antitumor3

Assays2

Extract4

Antioxidant3

MicroM3

Antibacterial1

Exposure1

Antifungal activity3

Pharmacological activity1

Strains1

Microdilution1

Minimum3

Interestingly1

Effects3

Minimal1

Clinical1

Evaluation3

Protease1

Substrate2

Bacteria1

Biological activity2

Antiviral activity1

Cytotoxic activities1

Anticancer activities1

Fermentation1

Bupropion3

Cirrhosis2

Pretreatment1

Species2

Rapidly3

Buffer1

Develop1

Metabolism1

Inhalation1

Drug3

Percent2