Loading...
  • enzymatic
  • The resulting enzyme is thermolabile and in homozygotes, enzymatic activity is depressed to 35% of its usual level. (wikipedia.org)
  • The oxidation of acetaldehyde to acetate can be summarized as follows: Acetaldehyde + NAD+ + Coenzyme A ↔ Acetyl-CoA + NADH + H+ In humans, there are three known genes which encode this enzymatic activity, ALDH1A1, ALDH2, and the more recently discovered ALDH1B1 (also known as ALDH5). (wikipedia.org)
  • Evidence in support of this idea from animal work has also suggested that this cognitive deficit is due to functional and biochemical factors such as changes in enzymatic activity, chemical messengers, or gene expression in cortical circuits. (wikipedia.org)
  • liver
  • Markedly inhibited 7-dehydrocholesterol-delta 7-reductase activity in liver microsomes from Smith-Lemli-Opitz homozygotes. (jci.org)
  • The introduction of the double bond in lathosterol at C-5 to form 7-dehydrocholesterol that is catalyzed by lathosterol-5-dehydrogenase was equally rapid in controls and homozygotes liver microsomes (120 +/- 8 vs 100 +/- 7 pmol/mg protein per min, P = NS). (jci.org)
  • Thus, lathosterol 5-dehydrogenase is equally active which indicates that homozygotes liver microsomes are viable. (jci.org)
  • Other acquired causes of decreased activity include kidney and liver disease, malignancy (cancer), malnutrition, and burns. (wikipedia.org)
  • Assay of butyrylcholinesterase activity in plasma can be used as a liver function test as both hypercholinesterasemia and hypocholinesterasemia indicate pathological processes. (wikipedia.org)
  • As discovered by site-directed mutagenesis, glutamate-268 is a key component of liver acetaldehyde dehydrogenase and is also critical to catalytic activity. (wikipedia.org)
  • Individuals with deficient acetaldehyde dehydrogenase activity are far less likely to become alcoholics, but seem to be at a greater risk of liver damage, alcohol-induced asthma, and contracting cancers of the oro-pharynx and esophagus due to acetaldehyde overexposure. (wikipedia.org)
  • wild-type
  • The ALDH2-deficient subunit is dominant in hybridization with a wild type subunit, resulting in inactivation of the isozyme by interfering with catalytic activity and increasing turnover. (wikipedia.org)
  • genetic
  • Oddly, in Africa A11 is at very low frequencies, and homozygotes are rare, suggesting that other genetic susceptibilities may exist that steer the virus toward Burkitt's lymphoma. (wikipedia.org)
  • protein levels
  • Alternate mechanisms of PTEN-mediated tumorigenesis, possibly independent of AKT ( 12 , 13 ), show that PTEN directly associates with p53 increasing stability, protein levels, and transcriptional activity ( 14 ). (aacrjournals.org)
  • Enzymes
  • In other studies, D.P. Agarwal and colleagues associated race-based variations in the activity alcohol-metabolizing enzymes with the occurrence of alcohol flush reactions to alcohol and alcoholic beverages in certain Asian populations. (wikipedia.org)
  • genes
  • The aim of the present study was to examine the ability of stress-induced brain activity and serotonin-related genes to predict the response to sustained placebo treatment in patients with social anxiety disorder (SAD). (jneurosci.org)
  • They demonstrated reduced locomotor activity, altered myelin-related genes and neuron-specific deficiencies in circuit formation. (wikipedia.org)
  • extracellular
  • PTEN inactivation in K14.cre/PTEN flx/flx keratinocytes resulted in epidermal hyperplasia/hyperkeratosis and novel 12- O -tetradecanoylphorbol-13-acetate (TPA)-promoted papillomas, whereas HK1.ras/K14.cre/PTEN flx/flx cohorts displayed a rapid onset of papillomatogenesis due to a synergism of increased AKT activity and extracellular signal-regulated kinase (ERK) elevation. (aacrjournals.org)
  • thus
  • Thus, during early papillomatogenesis, PTEN loss promotes ras Ha initiation via elevation of AKT activity and synergistic failures in cyclin regulation. (aacrjournals.org)
  • Spermine is a powerful regulator of erythrocyte cation channel cytosolic Ca2+ activity and, thus, cell survival. (deepdyve.com)
  • However
  • However, in progression, reduced ras Ha -associated ERK protein and activity, increased Δ5PTEN-associated cyclin E2 expression, and unique K1/K13 profiles following TPA treatment suggest that PTEN loss, rather than ras Ha activation, gives rise to a population of cells with greater malignant potential. (aacrjournals.org)
  • However, A3 and A11 can process and load antigens even when proteosome activity is diminished suggesting an alternative mechanism for loading which may benefit in recovery from some disease but impair recovery of others. (wikipedia.org)
  • erythrocytes
  • Cytosolic Ca2+ was estimated from Fluo-3 fluorescence, cell volume from forward scatter, cell membrane scrambling from annexin V binding and cation channel activity with whole-cell patch-clamp in human erythrocytes. (deepdyve.com)
  • cells
  • Afterwards, determined β-glucocerebrosidase activity was recalculated with regard to 10 5 cells present in samples used for the tests. (springer.com)
  • disease
  • Glucocerebrosidase activity, the diagnostic marker for Gaucher's disease, is the most commonly measured in leukocytes and fibroblasts using 4-methylumbelliferyl-β-D-glucopyranoside as synthetic β-glucoside. (springer.com)
  • human activity
  • Mercury is a ubiquitous environmental toxicant that derives both from natural sources and human activity. (springer.com)
  • Environmental factors that cause transgressive segregation can be influenced by human activity and climate change. (wikipedia.org)
  • Both human activity and climate change have the capability to force species of a specific genome to interact with other species with different genomes. (wikipedia.org)
  • values
  • The lysosomal β-glucosidase activities determined in the microsystem were in good correlation with the values determined during macro-scale measurements. (springer.com)
  • assays
  • Cell-based promoter reporter assays demonstrated that CYP2B6 luciferase activity was synergistically enhanced in the presence of both −82T→C mutation and rifampicin (RIF)-activated PXR. (aspetjournals.org)
  • proteins
  • gal activity in RO4987655 your skin aswell as oxidized proteins deposition in the muscle tissue of maturing zebrafish [10 15 RO4987655 29 equivalent to that confirmed in human beings with age group . (healthweblognews.info)
  • members
  • The combination of homozygote lethality and dosage compensation in heterozygotes may explain why POU4F1 mutations have not been identified in any human disease, whereas diseases are associated with several other members of the POU domain transcription factor class. (wikipedia.org)
  • Incest is sexual activity between family members or close relatives. (wikipedia.org)
  • This typically includes sexual activity between people in a consanguineous relationship (blood relations), and sometimes those related by affinity, stepfamily, those related by adoption or marriage, or members of the same clan or lineage. (wikipedia.org)
  • expression
  • These findings suggest that the remarkable variability in CYP2B6 expression and activity may be a major determinant of the efficacy and toxicity of these widely used drugs that are characterized by narrow therapeutic indices. (aspetjournals.org)
  • growth
  • In contrast with the well-known effects of neuropeptide signaling on neuronal activity and the strength of synaptic transmission, regulation of synaptic growth and development by neuropeptides has not previously been clearly established. (rupress.org)