• liver
  • Markedly inhibited 7-dehydrocholesterol-delta 7-reductase activity in liver microsomes from Smith-Lemli-Opitz homozygotes. (jci.org)
  • The introduction of the double bond in lathosterol at C-5 to form 7-dehydrocholesterol that is catalyzed by lathosterol-5-dehydrogenase was equally rapid in controls and homozygotes liver microsomes (120 +/- 8 vs 100 +/- 7 pmol/mg protein per min, P = NS). (jci.org)
  • Thus, lathosterol 5-dehydrogenase is equally active which indicates that homozygotes liver microsomes are viable. (jci.org)
  • Other acquired causes of decreased activity include kidney and liver disease, malignancy (cancer), malnutrition, and burns. (wikipedia.org)
  • Assay of butyrylcholinesterase activity in plasma can be used as a liver function test as both hypercholinesterasemia and hypocholinesterasemia indicate pathological processes. (wikipedia.org)
  • As discovered by site-directed mutagenesis, glutamate-268 is a key component of liver acetaldehyde dehydrogenase and is also critical to catalytic activity. (wikipedia.org)
  • Individuals with deficient acetaldehyde dehydrogenase activity are far less likely to become alcoholics, but seem to be at a greater risk of liver damage, alcohol-induced asthma, and contracting cancers of the oro-pharynx and esophagus due to acetaldehyde overexposure. (wikipedia.org)
  • genetic
  • Oddly, in Africa A11 is at very low frequencies, and homozygotes are rare, suggesting that other genetic susceptibilities may exist that steer the virus toward Burkitt's lymphoma. (wikipedia.org)
  • hepatic
  • In Smith-Lemli-Opitz homozygotes, the transformation of 7-dehydrocholesterol to cholesterol by hepatic microsomes was blocked although 7-dehydrocholesterol was produced abundantly from lathosterol. (jci.org)
  • ADP is a rare autosomal recessive acute hepatic porphyria secondary to the deficiency of ALA dehydratase activity. (psychiatryadvisor.com)
  • protein
  • However, in progression, reduced ras Ha -associated ERK protein and activity, increased Δ5PTEN-associated cyclin E2 expression, and unique K1/K13 profiles following TPA treatment suggest that PTEN loss, rather than ras Ha activation, gives rise to a population of cells with greater malignant potential. (aacrjournals.org)
  • Alternate mechanisms of PTEN-mediated tumorigenesis, possibly independent of AKT ( 12 , 13 ), show that PTEN directly associates with p53 increasing stability, protein levels, and transcriptional activity ( 14 ). (aacrjournals.org)
  • neurons
  • Here, we emphasize the two-way communication that goes on between these cells, beginning with how neurons can modulate microglial state and activity, for example, by specific chemokine, classic neurotransmitters, and purinergic signaling. (hindawi.com)
  • This leads to sustained depolarizations in GABAergic neurons and reduced inhibitory activity in the central nervous system. (pubmedcentralcanada.ca)
  • subjects
  • Fibroblast cell strains developed from healthy subjects and from AT homozygotes, ATHs, and atherosclerosis patients were compared for (1) survival, by the colony-forming assay and (2) DNA synthesis inhibition after irradiation, determined by [ 3 H]thymidine incorporation, cell cycle distribution, and the expression of p 53 and p 21 proteins, analyzed by flow cytometry. (ahajournals.org)
  • However
  • However, A3 and A11 can process and load antigens even when proteosome activity is diminished suggesting an alternative mechanism for loading which may benefit in recovery from some disease but impair recovery of others. (wikipedia.org)
  • disease
  • Glucocerebrosidase activity, the diagnostic marker for Gaucher's disease, is the most commonly measured in leukocytes and fibroblasts using 4-methylumbelliferyl-β-D-glucopyranoside as synthetic β-glucoside. (springer.com)
  • human
  • Environmental factors that cause transgressive segregation can be influenced by human activity and climate change. (wikipedia.org)
  • Both human activity and climate change have the capability to force species of a specific genome to interact with other species with different genomes. (wikipedia.org)
  • values
  • The lysosomal β-glucosidase activities determined in the microsystem were in good correlation with the values determined during macro-scale measurements. (springer.com)
  • cells
  • Afterwards, determined β-glucocerebrosidase activity was recalculated with regard to 10 5 cells present in samples used for the tests. (springer.com)