Activity adenoviruses human. Medical search. Frequent questions

The coxsackievirus and adenovirus receptor acts as the receptor for the 4 most common viruses that cause human myocarditis: type C (type 2 and type 5) adenovirus and coxsackievirus B3 and B4. (medscape.com)
Tunicamycin has also been used to study the functional effects of coxsackievirus and adenovirus receptor (CAR) glycosylation in COS-7 cells. (sigmaaldrich.com)
Adv infects the host cells through binding to different cellular receptors such as coxsackievirus and adenovirus receptor (CAR) [ 12 ]. (hindawi.com)

During viral replication, adenovirus early region 1A (E1A) is a gene that is expressed. (wikipedia.org)
Adenovirus protein regulation of viral genes has been studied in adenovirus type-5, or Ad5. (wikipedia.org)
While adenovirus likely blocks cellular translation in this way, it does not affect the translation of its own viral mRNAs. (wikipedia.org)
Adenovirus ocular infections (epidemic keratoconjunctivitis [EKC], follicular conjunctivitis, and pharyngeal conjunctival fever) are the most common ocular viral infections worldwide. (arvojournals.org)
As a result, we used biophysical tools to study West Nile and Adenovirus viral RNAs. (biophysics.org)
Therefore, our labora-tory mainly focuses on deciphering the communication events between human proteins and viral nucleic acids. (biophysics.org)
To overcome this obstacle, conditional oncolytic viruses (such as conditional replication adenovirus (CRAD)) are developed to specifically target prostate without (or with minimal) systemic toxicity due to viral self-replication. (hindawi.com)
The adenovirus early region 1 (E1) gene, which comprises E1a and E1b, encodes the viral early proteins that are necessary for adenoviral replication and the consequent oncolysis of permissive host cells. (hindawi.com)
E1-deleted (including E1a-deleted) adenoviruses are replication defective and are commonly used as viral vectors to carry therapeutic genes for gene therapy. (hindawi.com)
A ≥ 5 log 10 (99.999%) decrease of bacteria and ≥ 4 log 10 (99.99%) reduction in viral titre represented effective bactericidal and virucidal activity, respectively, per European standards. (springer.com)
Chastain-Moore AM, Roberts T, Trott DA, Newbold RF, Ornelles DA , An activity associated with human chromosome 21 permits nuclear colocalization of the adenovirus E1B-55K and E4orf6 proteins and promotes viral late gene expression. (coriell.org)
It is essential that each individual in a health crisis be treated with equal gravity and value, a principle we have upheld by pursuing further clinical study of brincidofovir that will inform its use in adenovirus and other serious DNA viral infections. (nlvpartners.com)
It also exhaustively introduces the concrete mechanism of invading GC cells and the viral genome composition of adenovirus and herpes simplex virus type 1 (HSV-1). (frontiersin.org)
These findings reveal the existence, sensor, a specific downstream target, and viral antagonists of a STING-independent DNA sensing pathway (SIDSP) in human cells. (woofahs.com)
Demonstration of p7 ion channel activity in cellular membranes and its inhibition by amantadine affirm the protein as a target for future anti-viral chemotherapy. (microbiologyresearch.org)
The most common organisms are viral, particularly those from the group known as adenoviruses. (msdmanuals.com)
The most common viral pathogens recovered from hospitalized patients admitted with CAP include human rhinovirus and influenza . (medscape.com)

Our results indicate a common and pivotal role for distinct vitamin K- dependent coagulation factors in mediating hepatocyte transduction by adenoviruses in vitro and in vivo. (gla.ac.uk)
To determine whether N -chlorotaurine (NCT) demonstrates antiviral activity against adenovirus (Ad) in vitro and in the Ad5/NZW rabbit ocular model. (arvojournals.org)
The in vitro activity of NCT was evaluated by incubating different Ad serotypes with several concentrations of NCT for 1 hour and determining the reduction in Ad titers. (arvojournals.org)
NCT demonstrated antiviral activity against adenovirus in vitro and in vivo. (arvojournals.org)
This study determined the antiviral activity of filociclovir (FCV) against ocular HAdV isolates in vitro and in the Ad5/NZW rabbit ocular model. (researchgate.net)
2003). A previous in-vitro study on the role of GDF-5 in periodontal ligament cells has shown that exogenous GDF-5 promotes cell proliferation while suppressing the activity of alkaline phosphatase (ALP), which is closely related to tissue calcification and which is secreted during the formation of tissue calcifications. (ispub.com)
In this study, we have analyzed and compared three prostate-specific promoters (PSA, probasin, and MMTV LTR) for their specificity and activity both in vitro and in vivo . (hindawi.com)
PVP-I 7% gargle/mouthwash showed rapid bactericidal activity and virucidal efficacy in vitro at a concentration of 0.23% PVP-I and may provide a protective oropharyngeal hygiene measure for individuals at high risk of exposure to oral and respiratory pathogens. (springer.com)
Tunicamycin plays an important role in the antitumor activity of trastuzumab on breast cancer in vitro and in vivo . (sigmaaldrich.com)
We previously identified the function of the hepatitis C virus (HCV) p7 protein as an ion channel in artificial lipid bilayers and demonstrated that this in vitro activity is inhibited by amantadine. (microbiologyresearch.org)
In Vitro Testing of Antimicrobial Activity of Bone Cement. (biophysica.com)
Previous data from transient expression studies and in vitro experiments suggest that these growth-promoting activities correlate with E1B-55K-mediated transcriptional repression of p53-targeted genes. (bvsalud.org)

Upon local delivery, adenovirus (Ad) serotype 5 viruses use the coxsackie and Ad receptor (CAR) for cell binding and αv integrins for internalization. (gla.ac.uk)
When administered systemically, however, their role in liver tropism is limited because CARpermissive and mutated viruses show similar biodistribution, a finding recently attributed to blood coagulation factor (F) IX or complement protein C4BP binding to the adenovirus fiber and "bridging" to either low-density lipoprotein receptorrelated protein or heparan sulfate proteoglycans. (gla.ac.uk)
Human FX substantially enhanced hepatocyte transduction by CAR-permissive and mutated viruses in an ex vivo liver perfusion model. (gla.ac.uk)
Adenovirus and Ebstein-Barr virus have been considered the most common viruses that cause myocarditis. (medscape.com)
Adenoviruses, which have been used safely in clinical trials involving thousands of participants, have several class advantages over other viruses with oncolytic potential. (nature.com)
In addition to seasonal endemic viruses, emerging and re-emerging virus outbreaks such as severe acute respiratory syndrome and Middle East respiratory syndrome coronaviruses (SARS-CoV and MERS-CoV) require close contact for human-to-human transmission and can spread nosocomially [ 5 , 6 ]. (springer.com)
Human Advs are nonenveloped double-stranded DNA viruses and belong to the Adenoviridae family [ 7 , 8 ]. (hindawi.com)
Currently circulating in humans are subtype A(H1N1) and A(H3N2) influenza viruses. (who.int)
However, during periods of low influenza activity and outside of epidemics situations, the infection of other respiratory viruses e.g. rhinovirus, respiratory syncytial virus, parainfluenza and adenovirus can also present as Influenza-like Illness (ILI) which makes the clinical differentiation of influenza from other pathogens difficult. (who.int)
Brincidofovir is an oral nucleotide analog that has shown broad-spectrum antiviral activity against all five families of DNA viruses that affect humans, including cytomegalovirus (CMV), adenovirus (AdV), BK virus and herpes simplex viruses. (nlvpartners.com)
Brincidofovir has shown broad-spectrum activity against all five families of DNA viruses that affect humans, including CMV, AdV, BKV and herpes simplex viruses. (nlvpartners.com)
In his latest research, he and a team of collaborators have shed new light on a type of molecular motor used to package the DNA of a number of viruses, including such human pathogens as herpes and the adenoviruses. (lbl.gov)
From left) Craig Hetherington, Carlos Bustamante and Shixin Liu have shed new light on a type of molecular motor used to package the DNA of a number of viruses, including herpes and the adenoviruses. (lbl.gov)
Adenoviruses are naked viruses with an icosahedral nucleocapsid containing a 36 kb linear double-stranded DNA genome that encodes 30-40 proteins. (bvsalud.org)
2-7 Although SARS has not re-appeared, sporadic cases of human infection with avian influenza viruses continue to occur. (who.int)
Respiratory viruses, particularly RSV, adenovirus and influenza, were commonly associated with hospitalization for SARI. (who.int)

The idea behind this study is to place the Ad5 E1 region in cis complementation (i.e., use E1 as a transgene) back into an E1-deleted, replication-defective adenovirus under the control of a prostate-specific promoter (PSP). (hindawi.com)
We tested the possibility of altering the course of retinal degeneration in the rd mouse through subretinal injection of a recombinant replication-defective adenovirus that contains the murine cDNA for wild-type (beta PDE, Ad.CMV beta PDE. (nih.gov)
constructed arrays of replication-defective adenoviruses containing cDNA library clones - that they named 'PhenoSelect' libraries - and demonstrated the power of this approach by screening for genes that affect osteoblast differentiation. (the-scientist.com)

Cyclin A may also form a complex with the adenovirus oncoprotein E1A which has DNA binding activity. (bdbiosciences.com)
We show that the E1A oncoprotein of human adenovirus 5 and the ICP0 protein of Fenretinide herpes simplex virus 1 block this response. (woofahs.com)
The multifunctional adenovirus E1B-55K oncoprotein can induce cell transformation in conjunction with adenovirus E1A gene products. (bvsalud.org)

The best PSP was selected to construct a prostate-specific oncolytic adenovirus (CRAD) by controlling the adenoviral E1 region. (hindawi.com)
TILT was founded on the unique discovery from clinical observations that oncolytic adenoviruses potently engage T cell responses in cancer patients. (nature.com)
Successfully translating this discovery, the company's therapeutic approach revolves around the use of armed oncolytic adenoviruses that replicate only in cancer cells and, when they do so, modify the tumor microenvironment, restoring the ability of the immune system to eliminate aberrant cells. (nature.com)
Oncolytic adenoviruses (OAds) demonstrated great potential for the treatment of cancer in many pre-clinical studies. (bmj.com)

Human adenovirus (HAdV) serotype 14 is rarely identified. (cdc.gov)
The exact cause is not yet known, but there is circumstantial evidence suggesting that human adenovirus F41 (HAdV-F41) might be p. (researchgate.net)
Presently, there is no FDA- or EMA-approved antiviral for the treatment of human adenovirus (HAdV) ocular infections. (researchgate.net)
Human adenovirus (HAdV) infection is common in the general population and can cause a range of clinical manifestations, among which pneumonia and keratoconjunctivitis are the most common. (researchgate.net)
Human adenovirus (HAdV) infections remain a significant cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). (biomedcentral.com)
Human adenovirus (HAdV) infection constitutes a major cause of morbidity and mortality in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). (biomedcentral.com)

BACKGROUND: External quality assessments (EQAs) for the molecular detection of human respiratory syncytial virus (RSV) are necessary to ensure the standardisation of reliable results. (cdc.gov)

However, studies have found that, using polymerase chain reaction (PCR) assay for the diagnosis, parvovirus B19 and human herpesvirus 6 are the most frequent pathogens in patients with acute myocarditis. (medscape.com)

nevertheless, recent developments in the treatment of CMV infections have resulted in improved human health and perhaps will encourage the development of new therapeuti. (researchgate.net)
Human cytomegalovirus (HCMV) infections are widespread among the human population. (researchgate.net)
DURHAM, N.C., March 11, 2014 (GLOBE NEWSWIRE) - Chimerix, Inc. (Nasdaq:CMRX) today announced that it has reached agreement with the U.S. Food and Drug Administration (FDA) for the immediate initiation of a pilot trial of open-label brincidofovir for the treatment of adenovirus infections in immunocompromised patients. (nlvpartners.com)
In Viet Nam, human infections with avian influenza A(H5N1) virus have occurred since 2003 1 and cases of severe acute respiratory syndrome (SARS) occurred in 2004. (who.int)

abstract = "Human serum butyrylcholinesterase (Hu BChE) is a promising therapeutic against the toxicity of chemical warfare nerve agents, pesticide intoxication, and cocaine overdose. (nebraska.edu)

Adenovirus vectors are widely used in gene therapy and vaccine development due to their ability to efficiently deliver genes and antigens to target cells. (inventiv.org)
There are 11 human SCGB genes and five pseudogenes. (biovendor.com)
Our results demonstrate that E1B-55K oncoproteins function as promiscuous transcriptional repressors of both p53-dependent and -independent genes and further support the model that manipulation of cellular transcription is central to adenovirus-induced cell transformation and oncogenesis. (bvsalud.org)

Recombinant adenovirus type 5 (rAd) has been used as a vaccine platform against many infectious diseases and has been shown to be an effective vaccine vector. (mdpi.com)
A logistical error temporarily interrupted vaccine production, and newly arriving trainees received no adenovirus vaccines from the summer of 1994 through late March 1995. (usuhs.edu)
The sole manufacturer has permanently stopped adenovirus vaccine production. (usuhs.edu)
For instance, Vaxart Inc. is developing an oral adenovirus vector-based vaccine for COVID-19 that can provide long-lasting immunity against the virus. (inventiv.org)
Another company, GenVec Inc., is developing an adenovirus vector-based vaccine for the prevention of Ebola virus disease. (inventiv.org)
For instance, the Coalition for Epidemic Preparedness Innovations (CEPI) has invested $8.4 million in the development of an adenovirus vector-based vaccine for COVID-19. (inventiv.org)
Another study showed that an adenovirus vector vaccine containing an HIV-1 envelope gene was incapable in reimmunizing primed immune responses using non-adjuvanted genetic DNA. (inventiv.org)
Late last month Merck announced that it has begun human trials of a new experimental HIV vaccine that has generated quite a bit of excitement within the scientific community. (treatmentactiongroup.org)
A common component to many gene therapy and vaccine research programs, the adenovirus is a virus capable of causing the common cold. (treatmentactiongroup.org)

A recombinant adenovirus vector (AdCL) was used to transfer human catalase cDNA into EC of whole thickness rabbit corneas ex vivo. (bmj.com)

These protein products play a role in regulating the gene itself and in growth activities of the virus. (wikipedia.org)
With regards to cellular translation of the host cell, it has been concluded that adenovirus selectively inhibits cellular translation via displacement of MAP kinase-interacting serine/threonine-protein kinase 1 (Mnk1), an eukaryotic translation initiation factor. (wikipedia.org)
The adenovirus early region 1A (E1A) 289R protein is composed of 289 amino acids, with four conserved regions: CR1 (42-80), CR2 (115-137), CR3 (145-191), CR4 (240-289). (wikipedia.org)
A number of PSPs have been defined over the years that include, but not limited to, promoters of prostate-specific antigen (PSA), probasin (PB), mouse mammary tumor virus (MMTV LTR), prostate-specific membrane antigen (PSMA), human glandular kallikrein 2 (hK2), and prostatic steroid-binding protein C3. (hindawi.com)
Faha B, Ewen ME, Tsai LH, Livingston DM, Harlow E. Interaction between human cyclin A and adenovirus E1A-associated p107 protein. (bdbiosciences.com)
However, its widespread application is hampered by difficulties in large-scale production of the native protein from human plasma and/or availability as a recombinant protein suitable for use in vivo. (nebraska.edu)
The human SCGB3A2 gene encodes a protein of molecular weight 10.2 kDa consisting of 93 amino acids, of which the N-terminal 21 amino acid residues exhibit a characteristic signal sequence that may function to target the protein to a secretory pathway. (biovendor.com)
The expression of SCGB3A2 was reported in human carcinomas, suggesting the use of this protein as a tumour marker. (biovendor.com)
Mitochondrial alterations induced by the p13II protein of human T-cell leukemia virus type 1. (microbiologyresearch.org)
It is a galactose-binding protein without known catalytic activity and is expressed mainly by activated microglial cells in the central nervous system (CNS). (lu.se)
However, the biochemical basis for the combined enzyme deficiency is a loss of a protective protein that interacts with both enzymes to produce catalytic activity. (medscape.com)

With the development of more effective and safe adenovirus vector-based vaccines, the market is expected to witness further growth in the coming years. (inventiv.org)
Preexisting or inducible immunity to vaccines against adenovirus (Ad), limits the use of First Generation vector vaccines. (inventiv.org)
While a handful of companies are testing or have tested potential HIV vaccines in human volunteers, none of these trials have generated nearly as much excitement as the latest announcement from officials at Merck. (treatmentactiongroup.org)

This is an pre-made gene silencing adenovirus that expresses a shRNA to knockdown human IER3 gene. (vectorbiolabs.com)
This is an Adenovirus expressing shRNA for silencing of Human CAV1. (vectorbiolabs.com)

The antiviral agent cidofovir, a nucleoside analogue that inhibits adenovirus DNA polymerase, 2 was successfully tested through phase II clinical trials for this indication. (arvojournals.org)
No antiviral drug has been approved for treating adenoviruses. (researchgate.net)
Tunicamycin was first isolated from Streptomyces lysosuperificus based on its antiviral activity. (sigmaaldrich.com)
Fenretinide DNA-PK as the sensor of this pathway and demonstrate that DNA-PK kinase activity drives a robust and broad antiviral response. (woofahs.com)
Third, IRF3 and IRF7 are essential for both DNA-activated antiviral responses in human cells. (woofahs.com)
During this COCA Call, clinicians learned about 2016 -2017 influenza activity to date, and heard an overview of CDC's recommendations for healthcare providers including influenza vaccination and the use of antiviral medications for the treatment of influenza. (cdc.gov)

PVP-I gargle/mouthwash diluted 1:30 (equivalent to a concentration of 0.23% PVP-I) showed effective bactericidal activity against Klebsiella pneumoniae and Streptococcus pneumoniae and rapidly inactivated SARS-CoV, MERS-CoV, influenza virus A (H1N1) and rotavirus after 15 s of exposure. (springer.com)

Adenovirus likely displaces Mnk1 from eIF4G and inhibits eIF4E phosphorylation, both of which are important components of the eIF4a translation initiation complex in cells. (wikipedia.org)

Methods to generate immune responses using the adenovirus Vectors are provided that allow multiple vaccinations with one adenovirus virus vector, and vaccinations of individuals with preexisting immunity. (inventiv.org)
Preexisting immunity can interfere with the effectiveness of adenovirus vector vaccinations. (inventiv.org)
This study investigated whether SCFAs have protective effect for immunity during fowl adenovirus-4 (FAdV-4) infection. (bvsalud.org)

Prior to starting vaccinations against adenovirus types 4 and 7 in 1971, these serotypes were the major causes of ARD in basic trainees. (usuhs.edu)
The market for methods, compositions, and methods for creating an adenovirus virus vector for multiple vaccinations is rapidly growing. (inventiv.org)
The use of adenovirus vectors for multiple vaccinations is particularly attractive because they can be engineered to express multiple antigens, which can provide protection against multiple diseases. (inventiv.org)
Several companies are actively engaged in the development of adenovirus vectors for multiple vaccinations. (inventiv.org)
The market for adenovirus vectors for multiple vaccinations is also witnessing significant investments from governments and private organizations. (inventiv.org)
In conclusion, the market for methods, compositions, and methods for creating an adenovirus virus vector for multiple vaccinations is witnessing significant growth due to the increasing prevalence of infectious diseases, the growing demand for gene therapy, and the rising investments in research and development activities. (inventiv.org)

however, this phenomenon was fully rescued by acute infusion of human FX. (gla.ac.uk)

The key, it appears, turns out to be the addition of an adenovirus "vector" to the mix. (treatmentactiongroup.org)
Nonhuman primates and humans are probably the main reservoirs of the virus, and anthroponotic transmission (man-vector-man) occurs during outbreaks. (bvsalud.org)

The adenovirus genetic information is encoded by a double stranded linear DNA molecule. (wikipedia.org)

however, some mice showed ongoing, worsening inflammation similar to that seen in humans. (medscape.com)
By using the model epitope SIINFEKL, we studied the efficacy of the peptide-coated conditionally replicating adenoviruses (PeptiCRAds) in immunocompetent mice bearing B16-OVA melanomas. (bmj.com)
Mutations in the beta subunit of the cGMP phosphodiesterase gene (beta PDE) can cause a recessively inherited retinal degeneration in several species, including mice, dogs and humans. (nih.gov)
In this study, recombinant (r) adenoviruses (Ads) encoding full-length and truncated rHu BChEs were tested for in vivo expression in mice. (nebraska.edu)
Model mice for allergic airway inflammation were intranasally administered recombinant adenovirus that express SCGB3A2, and the effect of overexpressed SCGB3A2 on antigen-induced airway inflammation was investigated. (biovendor.com)
In the studies conducted in humans, it was not possible to determine whether G-CSF was successfully expressed in the brains of the patients, which could explain the discrepancy in results in humans versus mice. (neurosciencenews.com)
The dramatic reduction in brain atrophy in mice, if verified in humans, could lead to highly effective emergency treatments for stroke and other diseases that often cause brain damage such as heart attack. (neurosciencenews.com)
For control mice, which did not receive G-CSF in eye drops, the MRI technique identified brain areas with reduced metabolic activity and eventual cerebral atrophy as the result of ischemia. (neurosciencenews.com)
Mice treated with the G-CSF gene therapy retained normal levels of metabolic activity and did not reveal any areas of cerebral atrophy. (neurosciencenews.com)
To further investigate these observations in vivo, we take advantage of WT and Gal3KO mice subjected to intranigral injection of adenovirus overexpressing human αSyn as a PD model. (lu.se)

As a postdoctoral fellow, I began my career studying human extra-cellular matrix proteins using X-ray crystallography and light scattering. (biophysics.org)
The adenovirus system offers broad tropism, allowing the efficient delivery of cDNAs to different cell-types for systematic screening based on cellular phenotypes. (the-scientist.com)
By revving up the activity of the body's killer T-cells, the boosted cellular immune response is then capable of attacking the virus by destroying the cells it has already infected. (treatmentactiongroup.org)

Coxsackievirus B serotypes 1-6 have been associated with human myocarditis, but the most serious cases have been attributed to types 3 and 4. (medscape.com)
Human Advs are divided into seven subgroups including 53 serotypes based on immunologic and biological characteristics. (hindawi.com)

Adenovirus early region 1A (E1A) is a gene expressed during adenovirus replication to produce a variety of E1A proteins. (wikipedia.org)
These proteins are functionally important for growth of adenoviruses. (wikipedia.org)
The adenovirus early region 1A gene is translated to produce E1A proteins by using the host cell's molecular machinery. (wikipedia.org)
The E1A gene refers to the gene that encodes E1A proteins specifically involved in adenovirus replication. (wikipedia.org)
citation needed] In the adenovirus, the final translation products, or E1A proteins, are proline-rich and have been found to localize in the nucleus. (wikipedia.org)
I got excited about his research activities, especially working with RNA (as I already had experience working with polysac-charides and proteins) and started communications with him. (biophysics.org)

Chemiosmotic Mechanism of Antimicrobial Activity of Ag+ in Vibrio cholerae. (biophysica.com)

Since 2002 we have successfully developed Natural BioMedical PolyPeptide GlycoProteins & Herbs MediFormula that is all-round solution to human disease and healthcare. (hum-molgen.org)

This outbreak demonstrates continued susceptibility of military recruits to adenovirus type 4 and warns of future outbreaks. (usuhs.edu)

It can strongly activate Cell Actin Cytoskeleton, T-LAK (T-Lymphokine-Activated Killer) and PMN (Polymorphonuclear) Leukocytes involved in tumor rejection, suppress tumor cell proliferation, mediate antitumor and oncocytic activity, and to activate bacteriolysis, bacteriophagy and rivustatic activity. (hum-molgen.org)

Virus isolation and serologic studies from a sample of patients identified the agent as adenovirus type 4. (usuhs.edu)
Although miRNAs have been examined in Adv type 3-infected human laryngeal epithelial cells and Adv type 2-infected human lung fibroblast cells [ 19 , 20 ], there is no research about small RNA profiling in whole blood of Adv-infected pneumonia children. (hindawi.com)
These activity levels are orders of magnitude higher than 1.9 U/ml of mouse BChE present in wild-type mouse serum. (nebraska.edu)
However, regulation of Angptl8 in human type 2 diabetes mellitus (T2DM) and renal dysfunction has not been determined. (phoenixpeptide.com)
Elevated circulating lipasin/betatrophin in human type 2 diabetes and obesity. (phoenixpeptide.com)

The publication of the human genome sequence has increased the need for high-throughput approaches to undertake functional annotation analysis. (the-scientist.com)

The global market for adenovirus vectors is expected to grow at a compound annual growth rate (CAGR) of 9.9% from 2020 to 2027. (inventiv.org)
The invention concerns methods of generating immune responses using Adenovirus vectors that allow multiple vaccination regimens. (inventiv.org)
The greatest problem with adenovirus-based vectors is their inability to maintain long-term transgene expression. (inventiv.org)

Human adenovirus (Adv) infection is responsible for most community-acquired pneumonia in infants and children, which results in significant morbidity and mortality in children every year. (hindawi.com)
Knowing the miRNA expression profile will help understand the role of miRNAs in modulating the host response to adenovirus infection and possibly improve the diagnosis of adenovirus-infected pneumonia. (hindawi.com)
In our study, total RNA extracted from whole blood of adenovirus-infected pneumonia children and healthy controls were analyzed by small RNA deep sequencing. (hindawi.com)
These highly upregulated microRNAs may have crucial roles in Adv pathogenesis and are potential biomarkers for adenovirus-infected pneumonia. (hindawi.com)
Human adenovirus (Adv) infection is responsible for most community-acquired pneumonia in infants and children [ 1 , 2 ]. (hindawi.com)

The majority of work on adenovirus transcription has focused on human adenovirus, specifically Ad2 and Ad5. (wikipedia.org)

This phenomenon was not dependent on proteolytic activation or cell signaling activity and for FX was mediated by direct virus-factor binding. (gla.ac.uk)
Thereafter, rHu BChE levels dropped rapidly and very little or no activity was detected in the serum 10 days post-virus administration. (nebraska.edu)
The Phi29 virus that was the subject of this study is a bacteriophage of Bacillus subtilis , a bacterium found in soils and the human gut. (lbl.gov)
Here we show that the ion channel activity of HCV p7 expressed in mammalian cells can substitute for that of influenza virus M2 in a cell-based assay. (microbiologyresearch.org)
De wetenschappelijke gemeenschap vecht tegen de tijd voor de productie van een vaccin, maar het is moeilijk om een veilig en effectief product op de markt te brengen zo snel als het virus zich verspreidt. (kanker-actueel.nl)
The Zika virus is transmitted to humans through the bite of an infected mosquito of the genus Aedes , mainly Aedes aegypti . (bvsalud.org)
Les cas d'hospitalisation étaient généralement associés à des virus respiratoires, en particulier au VRS, à l'adénovirus et à la grippe. (who.int)

RESEARCH DESIGN AND METHODS- Human microvascular HMEC-1 endothelial cells were incubated in low and high glucose concentrations (5 and 30 mmol/l, respectively), and activation of nrf2 was assessed by nuclear translocation. (diabetesjournals.org)
Supporting activities include the development of epidemiological, experimental laboratory, and risk-assessment methods that could produce internationally comparable results, and the development of manpower in the field of toxicology. (inchem.org)

A MAGE-A1-targeting PeptiCRAd, encoding for granulocyte-macrophage colony stimulating factor, was able to eradicate human melanomas and increased the percentage of human MAGE-A1-CD8 T cells compared to the naked OAd. (bmj.com)
They transduced primary human mesenchymal cells, screened for the induction of alkaline phosphatase activity and isolated known (BMPs and FosB) and novel inducers of osteoblast differentiation. (the-scientist.com)
Tunicamycin has been used to study the effect of N-linked glycosylation of human proton-coupled folate transporter (HsPCFT) in HeLa cells. (sigmaaldrich.com)
In addition, the WSPE inhibited proliferation of HT29 human colon cancer cells. (mdlinx.com)
Generation of inhibitory peptides against bacteria and HT29 human colon cancer cells improved with [pineapple peel powder] supplementation of yogurt. (mdlinx.com)
Adv replicates efficiently in human cells and triggers an innate immune response such as inflammatory response in the host cells. (hindawi.com)
The knockdown of this human gene was validated by qPCR in A549 cells. (vectorbiolabs.com)
Second, unlike mouse cells, human cells possess a robust STING-independent DNA sensing pathway that is delayed relative to the cGAS-STING pathway. (woofahs.com)
Thus, human cells C but not mouse cells C have a robust STING-independent DNA sensing pathway (SIDSP). (woofahs.com)
Open in a separate window Figure 2: A STING-independent DNA sensing pathway (SIDSP) in human cells(A) Primary mouse embryonic fibroblasts were treated with Lipofectamine alone (Lipo) or the indicated ligands for four hours before harvest and quantitative RT-PCR (RT-qPCR) analysis of mRNA expression. (woofahs.com)
B) PMA-differentiated human U937 monocytes or two clonal lines of STING KO U937 cells were treated with the indicated ligands for 16 hours before harvest and RT-qPCR analysis of mRNA expression. (woofahs.com)
The aim of this study was to assess whether activation of nrf2 by sulforaphane in human microvascular endothelial cells prevents metabolic dysfunction in hyperglycemia. (diabetesjournals.org)
The G-CSF was delivered by inserting the G-CSF gene into an adenovirus that is safe in humans and known to infect brain cells efficiently. (neurosciencenews.com)

To thoroughly test the efficacy of any gene therapies in humans, it is critical to establish that the gene is expressed in the test participants. (neurosciencenews.com)

Screening for sequence variations in the exons and the 5´ promoter region of the SCGB3A2 gene among patients with asthma and healthy control individuals revealed the presence of a point mutation, in the promoter region, that appears to be responsible for reduced transcriptional activity of the gene and is associated with an increased risk of asthma. (biovendor.com)

In the mouse model, recombinant human SCGB3A2 exhibited anti-fibrotic and growth factor activities comparable to those of recombinant mouse SCGB3A2. (biovendor.com)

Taken together, the incorporation of [pineapple peel powder] and probiotics in yogurts offers new opportunities in the development of novel functional foods, and this approach could lead to the development of novel bioactive peptides having antibacterial and anticancer activity," concluded the authors of one study investigating the antibacterial effects of yogurt. (mdlinx.com)
Human (Major Histocompatibility Complex) MHC Molecules were first discovered in 1900 when scientists tried to propagate tumors, to named by Dr. George Snell who won the Nobel Prize in 1980, and to Dr. Peter C. Doherty and Dr. Rolf M. Zinkernagel (Nobel Prize 1996 in Physiology & Medicine) study to demonstrate Immune Defense related to MHC. (hum-molgen.org)
Given the significant breadth of the areas under study, and the limited human and financial resources of the Organization to carry out the full studies, the Secretariat sought external support. (who.int)

GDF-5 also increased the gene expression and enzyme activity of alkaline phosphatase. (ispub.com)

Broad-Spectrum Bactericidal Activity of Ag2O-Doped Bioactive Glass. (biophysica.com)

Our armed adenovirus is uniquely designed to make silent tumors visible to the immune system, enabling T cell therapies and checkpoint inhibitors to work," said Akseli Hemminki. (nature.com)
More specifically, data from our CAN-2409 clinical trial demonstrated robust evidence of local and systemic anti-tumor activity in patients with non-small cell lung cancer who had an inadequate response to immune checkpoint inhibitors. (tmcnet.com)
The data demonstrated evidence of local and systemic anti-tumor activity in patients with inadequate response to previous immune checkpoint inhibitor (ICI) treatment and showed a disease control rate of 77 percent (20/26) in patients entering the trial with disease progression despite ICI treatment. (tmcnet.com)

This new, rapid, non-invasive administration and evaluation of gene therapy has the potential to be successfully translated to humans," says Richard Conroy, Ph.D., Director of the NIBIB Division of Applied Science and Technology. (neurosciencenews.com)
The overall aim is to successfully demonstrate a system in animals that can be translated to humans. (neurosciencenews.com)

The increasing prevalence of infectious diseases, the growing demand for gene therapy, and the rising investments in research and development activities are some of the key factors driving the growth of the market. (inventiv.org)

Subretinal injection of Ad.CMV beta PDE results in beta PDE transcripts and increased PDE activity and delays photoreceptor cell death by six weeks. (nih.gov)

and interleukin-2 (IL-2), which is important for retaining high T cell activity at the tumor. (nature.com)
In human cell lines, tunicamycin enhances cytotoxicity stimulated by cisplatin. (sigmaaldrich.com)

Anatomy25

Organisms33

Diseases17

Chemicals and Drugs62

Analytical, Diagnostic and Therapeutic Techniques and Equipment41

Phenomena and Processes56

Disciplines and Occupations3

Information Science4

Named Groups1

Health Care3

Coxsackievirus and adenovirus receptor3

Viral17

Vitro12

Viruses16

Replication-defective3

Oncoprotein3

Oncolytic4

HAdV6

Respiratory syncy1

Pathogens1

Infections4

Abstract1

Genes3

Vaccine9

CDNA1

Protein11

Vaccines3

ShRNA2

Antiviral6

Rotavirus1

Inhibits1

Immunity3

Vaccinations6

Acute1

Vector2

Genetic1

Mice10

Cellular3

Serotypes2

Proteins6

Antimicrobial1

20021

Demonstrates1

Antitumor1

Type5

Genome1

Vectors3

Pneumonia5

Transcription1

Virus7

Methods2

Cells13

Efficacy1

Promoter1

Recombinant human1

Study3

Alkaline phosphatase1

Bactericidal activity1

Immune3

Successfully2

Gene therapy1

Injection1

Cell2