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Acid PhosphatasePhosphoprotein PhosphatasesTartratesProtein Tyrosine PhosphatasesProtein Phosphatase 2Protein Phosphatase 1Phosphoric Monoester HydrolasesGlucose-6-PhosphataseLysosomesIsoenzymesPhosphatidate PhosphataseHistocytochemistryProstateOsteoclastsPhosphorylationMolecular Sequence DataDual-Specificity PhosphatasesProtein Tyrosine Phosphatase, Non-Receptor Type 11cdc25 PhosphatasesProtein Tyrosine Phosphatase, Non-Receptor Type 1Amino Acid SequencePhosphatesProtein Tyrosine Phosphatase, Non-Receptor Type 6Okadaic AcidMyosin-Light-Chain PhosphataseSubstrate SpecificityKineticsAlkaline PhosphataseProtein Tyrosine Phosphatases, Non-ReceptorPhosphorylase PhosphataseBone ResorptionGlucuronidaseHydrogen-Ion ConcentrationReceptor-Like Protein Tyrosine Phosphatases, Class 2Ethers, CyclicDual Specificity Phosphatase 1RANK LigandMicroscopy, Electron4-NitrophenylphosphataseThymolphthaleinElectrophoresis, Polyacrylamide GelBase SequenceNitrophenolsBone and BonesEsterasesVanadatesHydrolasesHexosaminidasesReceptor-Like Protein Tyrosine Phosphatases, Class 3Enzyme RepressionMolecular WeightOrganophosphorus CompoundsSemenSignal TransductionArylsulfatasesLiverCells, CulturedReceptor-Like Protein Tyrosine Phosphatases, Class 4Sequence Homology, Amino AcidMitogen-Activated Protein Kinase PhosphatasesCell LineEnzyme ActivationNucleotidasesOrganophosphatesCloning, MolecularMutationSaccharomyces cerevisiaeThiamine PyrophosphataseEnzyme InhibitorsOrganoidsDual Specificity Phosphatase 6Protein Tyrosine Phosphatase, Non-Receptor Type 2OxazolesProstatic NeoplasmsMetalloproteinsSH2 Domain-Containing Protein Tyrosine PhosphatasesLeucyl AminopeptidaseCalcineurin6-PhytaseMacrophagesCell MembraneAcetylglucosaminidaseSubcellular FractionsCathepsinsEscherichiaProtein BindingCathepsin KClinical Enzyme TestsRecombinant ProteinsPTEN PhosphohydrolaseCell DifferentiationTime FactorsGlycogen-Synthase-D PhosphataseGene Expression Regulation, EnzymologicGolgi ApparatusReceptor Activator of Nuclear Factor-kappa BBinding SitesMicrocystinsChromatography, GelRabbits
Alkaline PhosphataseProstatic acid phosphPurple acid phosphataseProtein phosphatasesSerumTRAPEnzymesTartrateAssayCalciumInhibitionGlucoseAmino acidsOrganic acidsEnzyme activitiesDehydrogenaseTargets proteinProteinsPhytase activityInhibitorEnzymatic ActivitiesVitroBoneStepwiseContrastPredominantlyInhibitorySoilDensityCatalytic activitySynthesisFindingsMitochondrialPP2APathwaysTypeRenalMetabolismExertCatalaseCellsTherapeuticMarkersMolecularAnalysesEncodesAccumulationLysosomalHigherComplexCompoundsReactionMRNA
Alkaline Phosphatase5
  • The treatment response of serum TRACP5b activity, bone alkaline phosphatase (BAP) activity, and concentrations of NH2-terminal telopeptide of type 1 collagen (NTX) in 68 breast cancer patients with bone metastasis were determined. (tmu.edu.tw)
  • A ratiometric fluorescent assay for evaluation of alkaline phosphatase activity based on ionic liquid-functionalized carbon dots. (nih.gov)
  • 3. The plasma membrane enzyme, alkaline phosphatase, increased in activity after bile-duct ligation. (portlandpress.com)
  • In comparison with corresponding baseline values, only dried plum significantly decreased serum levels of bone turnover markers including bone-specific alkaline phosphatase and tartrate-resistant acid phosphatase-5b. (nih.gov)
  • The purpose of this study was to investigate the activities of the total acid phosphatase (TAP), tartrate-resistant acid phosphatase (TRAP), low molecular weight protein tyrosine phosphatase (LMW-PTP) and alkaline phosphatase (ALP) enzymes, as well as the possible correlation in the serum and in unstimulated whole saliva of children. (bvsalud.org)
Prostatic acid phosph2
  • They monitored the prostate size and therapeutic efficacy by measuring serum prostatic acid phosphatase levels and concluded that androgenic activity in the body influences prostate cancer, at least with respect to serum phosphatase. (wikipedia.org)
  • In contrast, the RIP1-deficient cells were defined by increased expression of tartrate-sensitive prostatic acid phosphatase as a broadly acting ectonucleotidase. (aspetjournals.org)
Purple acid phosphatase1
  • Mature grain phytase activity (MGPA) in the Triticea tribe cereals has evolved through gene duplications and neo-functionalization of the purple acid phosphatase phytase gene ( PAPhy ) in a common ancestor. (frontiersin.org)
Protein phosphatases2
  • It is a potent inhibitor of specific protein phosphatases and is known to have a variety of negative effects on cells. (chemspider.com)
  • They are potent inhibitors of protein phosphatases 1 and 2A (PP1 and PP2A) and cause a variety of adverse symptoms in humans and animals if ingested. (cdc.gov)
Serum12
  • Serum tartrate-resistant acid phosphatase 5b (TRACP5b) activity is a novel bone resorption marker. (tmu.edu.tw)
  • Serum TRACP5b activity, BAP activity, and NTX level of breast cancer patients with bone metastasis were significantly higher than those of normal controls. (tmu.edu.tw)
  • 7. Serum activities of mitochondrial, plasma membrane, microsomal, lysosomal and cytosol marker enzymes tended to increase post-ligation, particularly at 8 days. (portlandpress.com)
  • 8. Monoamine oxidase, a predominantly mitochondrial enzyme, was greatly elevated in the serum after 1 day but had returned to normal activities by 8 days. (portlandpress.com)
  • I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. (wikipedia.org)
  • Observing the changes of activity of some lysosomal enzymes in blood serum of female rabbits subjected to injection of 10 microg of ghrelin/kg of body weight. (nel.edu)
  • In the blood serum the activity of cathepsins D and L, alanine aminopeptidase, acid phosphatase, lysosomal lipase and lysosomal esterase was determined. (nel.edu)
  • As a result of ghrelin injection the activity of all the enzymes examined in blood serum increased markedly. (nel.edu)
  • Changes of lysosomal enzymes activities in the blood serum caused by the effects of ghrelin should be regarded as the response of the lysosomal system. (nel.edu)
  • Enzymatic activities were measured in pairs of concurrently obtained serum and salivary samples from 32 children in good oral and systemic health (16 of each sex) with a median age of 6.4 ± 3.3 years (range 1.08 - 12.92 years). (bvsalud.org)
  • The enzymatic activities of all the studied enzymes were higher in serum than in saliva. (bvsalud.org)
  • We concluded that the salivary TRAP has a potential to be use as biomarkers of pathologies and states that modify its activity in the serum. (bvsalud.org)
TRAP7
  • Tartrate-resistant acid phosphatase (TRAP or TRAPase), also called acid phosphatase 5, tartrate resistant (ACP5), is a glycosylated monomeric metalloprotein enzyme expressed in mammals. (wikipedia.org)
  • In knockout studies, TRAP−/− mice exhibit mild osteopetrosis, associated with reduced osteoclast activity. (wikipedia.org)
  • In TRAP overexpressing transgenic mice, mild osteoporosis occurs along with increased osteoblast activity and bone synthesis. (wikipedia.org)
  • Tartrate-resistant acid phosphatase (TRAP) is a basic iron-binding protein with high activity towards phosphoproteins, ATP and 4-nitrophenyl phosphatase. (thermofisher.com)
  • This gene provides instructions for making an enzyme called tartrate-resistant acid phosphatase type 5 (TRAP). (medlineplus.gov)
  • The TRAP enzyme primarily regulates the activity of a protein called osteopontin, which is produced in bone cells called osteoclasts and in immune cells. (medlineplus.gov)
  • However, tartrate-resistant acid phosphatase (TRAP) activity and the number of osteoclast cells (TRAP-positive multinucleated cells) were not changed by nSP treatment in the presence of receptor activator of nuclear factor κB ligand (RANKL) at doses that did not induce cytotoxicity by silica particles. (springer.com)
Enzymes3
  • 2005). Carbohydrate metabolizing enzymes (e.g., α-amylase), lipid degrading enzymes (e.g., lipase) and phosphatases (acid and alkaline phosphatases) were recorded among target enzymes which should be disturbed and may provide more accurate information on the molluscicide-induced stress on molluscs. (scialert.net)
  • Rhizosphere soil was sampled and analyzed on the activity of enzymes involved in the cycling of C, N, S and P. (copernicus.org)
  • Markers of bone resorption include collagen degradation products, non-collagenous proteins, osteoclastic enzymes, and osteocyte activity markers. (saveourbones.com)
Tartrate5
Assay3
  • Biochemical assay for enzyme activity is the method of definitive diagnosis. (medscape.com)
  • Here, we describe a method to detect microcystins in human plasma by using immunocapture followed by a protein phosphatase inhibition assay. (cdc.gov)
  • This assay quantitates the summed inhibitory activity of nearly all MCs and NOD on PP2A relative to a common MC congener, microcystin-LR (MC-LR). (cdc.gov)
Calcium1
  • Bromelain extracts are actually composed of a variety of substances, including peroxidase, acid phosphatase, calcium, and protease inhibitors. (wakeup-world.com)
Inhibition2
  • The inhibitory effect of IL-10 on MMP activity, was not enought to inhibit cell differentiation, since a-IL-10 NA was not able to revert the inhibition by EP7 of RM-induced TRAP+. (conicet.gov.ar)
  • In the absence of ECSIT, the stimulatory actions of RANKL on complex I activity and all other markers of oxidative phosphorylation, as well as their inhibition by E2, were prevented. (bvsalud.org)
Glucose4
  • In the present study, glucose, acid and alkaline phosphatases (ACP and ALP), α-amylase and lipase were measured for the first time in tissue homogenates of Biomphalaria arabica snails, molluscan intermediate host for Schistosoma mansoni in Saudi Arabia. (scialert.net)
  • Glucose 6-phosphatase activity and ribonucleic acid, which are localized predominantly in the rough endoplasmic reticulum, were increased. (portlandpress.com)
  • One form, Von Gierke disease ( GSD type Ia , glucose-6-phosphatase deficiency ), causes clinically significant end-organ disease with significant morbidity. (medscape.com)
  • Acid maltase catalyzes the hydrogenation reaction of maltose to glucose. (medscape.com)
Amino acids2
  • Using EBNA3C amino acids 365-545 in a yeast two hybrid screen, we found an interaction with the Growth Arrest and DNA-damage protein, Gadd34. (scienceopen.com)
  • Amino acids 483-610 of Gadd34, including the two PP1a interaction, and the HSV-1 ICPγ34.5 homology domains, are required for the interaction. (scienceopen.com)
Organic acids1
  • Plants have evolved numerous adaptive developmental and metabolic responses to cope with growth under phosphate-limited conditions, and these responses include modifying the root system architecture (RSA), increasing acid phosphatase activity (APA), and the release of low-molecular-weight organic acids [ 20 ]. (biomedcentral.com)
Enzyme activities3
  • Ancient Amazon soils are characterised by low concentrations of soil phosphorus (P). Therefore, it is hypothesised that plants may invest a substantial proportion of their resources belowground to adjust their P-uptake strategies, including root morphological, physiological (phosphatase enzyme activities) and biotic (arbuscular mycorrhizal (AM) associations) adaptations. (springer.com)
  • 4. No changes in mitochondrial enzyme activities were noted after 1 day but there was a 50% reduction 8 days after ligation. (portlandpress.com)
  • Lysosomal enzyme activities did not change in the liver tissue. (portlandpress.com)
Dehydrogenase2
  • 6. Lactate dehydrogenase, a cytosol enzyme, showed a decrease in activity after 1 day but an increase in tissue activities 8 days after ligation. (portlandpress.com)
  • Enzyme assays were conducted to measure dehydrogenase and acid phosphatase activities, and similar assays were performed for fluorescein diacetate (FDA) activity to assess potential degradation of complex organics. (usda.gov)
Targets protein3
  • Salicylic acid targets protein phosph. (ugent.be)
  • Salicylic acid targets protein phosphatase 2A to attenuate growth in plants," CURRENT BIOLOGY , vol. 30, pp. 381-395, 2020. (ugent.be)
  • Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. (scienceopen.com)
Proteins1
  • When consumed with food, its activity will mostly be expended on helping the body to break down dietary proteins, easing the body's digestive burden. (wakeup-world.com)
Phytase activity2
  • A high phytase activity in food and feedstuffs is desirable to ensure high bioavailability of phytate bound phosphate and counter the antinutritional effects of non-digested phytate. (frontiersin.org)
  • However, overexpression of MtPHY1 resulted to higher phytase activity than the other gene. (isaaa.org)
Inhibitor1
  • The eIF-2alpha-P phosphatase activities are sensitive to inhibitor 2. (scienceopen.com)
Enzymatic Activities1
  • however, enzymatic activities indicated no statistically significant differences among landforms and horizons. (usda.gov)
Vitro3
  • Preliminary In Vitro and In Vivo Evaluation of Antidiabetic Activity of Ducrosia anethifolia Boiss. (hindawi.com)
  • Preliminary in vitro evaluation of the antidiabetic activity of crude extract and its furanocoumarins was carried out ( α -amylase, α -glucosidase, and β -galactosidase). (hindawi.com)
  • and (iii) the alpha subunit in purified eIF-2 phosphorylated in vitro is specifically dephosphorylated by S10 fractions of wild-type infected cells at a rate 3000 times that of mock-infected cells, whereas the eIF-2alpha-P phosphatase activity of gamma(1)34.5- virus infected cells is lower than that of mock-infected cells. (scienceopen.com)
Bone3
  • Nature of mononuclear cells positive for acid phosphatase activity in bone marrow of patients with renal osteodystrophy. (bmj.com)
  • Our data support the use of either TRACP5b activity or NTX level to follow up breast cancer patients with bone metastasis after treatment instead of the prevailing BAP activity. (tmu.edu.tw)
  • By testing for these bone turnover markers, we can get a snapshot of bone turnover activity. (saveourbones.com)
Stepwise2
  • By means of multiple logistic regression with stepwise selection, we determined that TRACP5b activity has a higher probability than NTX level to indicate treatment response as a function of percent change after treatment (18 times versus 12 times). (tmu.edu.tw)
  • Phytases (myo-inositol hexakisphosphate 3-,6- and 5-phosphohydrolase, EC 3.1.3.8, EC 3.1.3.26, and EC 3.1.3.72) are phosphatases that can initiate the stepwise hydrolysis of phytate, the main storage form of phosphate in seeds and the major antinutritional factor for bio-availability of micronutrient in food and feed ( Lott, 1984 ). (frontiersin.org)
Contrast1
  • In contrast to eIF-2alpha-P phosphatase activity, extracts of mock-infected cells exhibit a 2-fold higher phosphatase activity on [32P]phosphorylase than extracts of infected cells. (scienceopen.com)
Predominantly1
  • Benz[α]pyrene hydroxylase activity, predominantly found in the smooth endoplasmic reticulum, was decreased. (portlandpress.com)
Inhibitory1
  • The compounds showed inhibitory activity in a concentration dependant manner. (hindawi.com)
Soil2
  • Specifically, we expected that plants which invest in finer roots, and therefore have greater ability to explore large soil volumes, would have a high investment in physiological adaptations such as enhanced phosphatase production. (springer.com)
  • Agriculture, mining, urbanization and other human activities result in temporary land-use and once complete, used and degraded land should be rehabilitated and restored to minimize loss of soil carbon. (mdpi.com)
Density1
  • We measured fine root diameter, specific root length (SRL), specific root area (SRA), root tissue density (RTD), root phosphatase activity (APase) and arbuscular mycorrhizal (AM) fungi colonisation. (springer.com)
Catalytic activity2
  • In combination with additional mutagenesis and enzyme activity studies, our structural data provide important insights into substrate recognition and the mechanism for catalytic activity of ACP6. (rcsb.org)
  • GO and KEGG analyses indicated that numerous DE lncRNAs might be involved in diverse biological processes related to phosphate, such as lipid metabolic processes, catalytic activity, cell membrane formation, signal transduction, and nitrogen fixation. (biomedcentral.com)
Synthesis3
  • Preclinical research indicates that pineapple leaves may modulate cholesterol synthesis and activity in a manner similar to statins, but likely without the over 300 known adverse health effects of the statin drug chemical class . (wakeup-world.com)
  • The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase. (scienceopen.com)
  • These results indicate that in infected cells, gamma(1)34.5 interacts with and redirects phosphatase to dephosphorylate eIF-2alpha to enable continued protein synthesis despite the presence of activated PKR. (scienceopen.com)
Findings2
  • The results were compared with findings in Pappenheim and acid phosphatase stained slides. (thieme-connect.com)
  • To better understand the mechanisms behind these findings, enzyme activity and DNA analyses were conducted on selected samples from a shoulder slope landform in the earlier Ozark study. (usda.gov)
Mitochondrial1
  • Loss of ECSIT decreased complex I activity, oxygen consumption, NAD+/NADH redox ratio, and ATP production and increased mitochondrial ROS. (bvsalud.org)
PP2A2
  • SA directly binds to A subunits of protein phosphatase 2A (PP2A), inhibiting activity of this complex. (ugent.be)
  • Among PP2A targets, the PIN2 auxin transporter is hyperphosphorylated in response to SA, leading to changed activity of this important growth regulator. (ugent.be)
Pathways1
  • Lysophosphatidic acid (LPA) is an important bioactive phospholipid involved in cell signaling through Gprotein-coupled receptors pathways. (rcsb.org)
Type2
  • Lysophosphatidic acid phosphatase type 6 (ACP6) is an LPA-specific acid phosphatase that hydrolyzes LPA to monoacylglycerol (MAG) and phosphate. (rcsb.org)
  • Although at least 14 unique GSDs are discussed in the literature, the 4 that cause clinically significant muscle weakness are Pompe disease (GSD type II, acid maltase deficiency ), Cori disease ( GSD type III , debranching enzyme deficiency), McArdle disease ( GSD type V , myophosphorylase deficiency), and Tarui disease ( GSD type VII , phosphofructokinase deficiency). (medscape.com)
Renal1
  • Fifty two of 63 patients with renal osteodystrophy had one or more mononuclear cells positive for acid phosphatase in the marrow. (bmj.com)
Metabolism1
  • For example, inherent differences in nitrogen metabolism of plant- and insect-associated microbiomes may dictate whether neonicotinoid-based insecticides ultimately exert antimicrobial activities or not. (researchgate.net)
Exert1
  • The regulatory genes primarily the transcription factors that exert their activity by binding to certain cis DNA elements and consequently either up regulated or down regulate to target expression. (scielo.br)
Catalase1
  • 5. Liver catalase and d-amino acid oxidase activities showed a slight increase at 1 day post-ligation but a significant fall by 8 days. (portlandpress.com)
Cells2
  • In immune system cells, osteopontin helps fight infection by promoting inflammation, regulating immune cell activity, and turning on various immune system cells that are necessary to fight off foreign invaders. (medlineplus.gov)
  • β -methylene-ADP-inhibitable ecto-AMPase activity were elevated in the FADD-deficient cells. (aspetjournals.org)
Therapeutic1
  • Keep in mind that bromelain's potential therapeutic activity, depends entirely on how you take it. (wakeup-world.com)
Markers2
  • Osteocyte activity markers can also be observed to measure resorption levels. (saveourbones.com)
  • The in vivo activity was investigated by measuring some oxidative stress markers. (hindawi.com)
Molecular2
  • It has a molecular weight of approximately 35kDa, a basic isoelectric point (7.6-9.5), and optimal activity in acidic conditions. (wikipedia.org)
  • Hydrotropism allows roots to forage for water, a process known to depend on abscisic acid (ABA) but whose molecular and cellular basis remains unclear. (nature.com)
Analyses1
  • Based on the root enzyme activity analyses, overexpression of any of the two genes could lead to increase in acid phosphatase activities. (isaaa.org)
Encodes1
  • In the rat, the ORF is 981 bp in length and encodes for a 327-amino acid protein. (wikipedia.org)
Accumulation2
  • LncRNAs are involved in a wide range of regulatory mechanisms that impact gene expression, including chromatin remodeling, modulation of alternative splicing, fine-tuning of miRNA activity, and the control of mRNA translation or accumulation [ 5 ]. (biomedcentral.com)
  • Acid maltase deficiency is a unique glycogenosis in that the glycogen accumulation is lysosomal rather than in the cytoplasm. (medscape.com)
Lysosomal1
Higher1
  • Root morphological traits were related to APase activity, with higher APase activity in roots with higher SRL and SRA but lower RTD. (springer.com)
Complex2
Compounds1
  • At least 279 microcystins have been identified, and most of these compounds share a common amino acid, the Adda side chain. (cdc.gov)
Reaction1
MRNA1
  • Transcribed from this gene is a 1.5kb mRNA with an open reading frame (ORF) of 969-975 bp encoding a 323-325 amino acid protein. (wikipedia.org)