In contrast to METH, which induced pronounced deficits in dopaminergic neuronal markers, repeated doses of MDA or MDMA did not alter striatal tyrosine hydroxylase (TH) activities or reduce striatal dopamine concentrations. (erowid.org)
Tph2 mutants were capable of thermoregulation and keeping physiologic body temperature when the environmental temperature was reduced and exhibited significantly more activities at both the room and elevated temperatures. (aspetjournals.org)
Dopamine1
concentrations of dopamine (DA) and 5-hydroxytryptamine (5HT) and their respective metabolites were decreased in parallel with the decline in activity of the enzymes. (erowid.org)
Concentrations2
Like METH, single or multiple doses of either drug caused marked reductions in both tryptophan hydroxylase (TPH) activity and concentrations of 5-hydroxytryptamine (5HT) and 5-hydroxyindoleacetic acid (5HIAA) in several brain regions. (erowid.org)
Our findings warrant SJW's therapeutic efficacy to alleviate nicotine withdrawal associated depression by virtue of its ability to improve serotonergic activity by increasing brain TRP, 5-HT concentrations and decreased turnover. (setpublisher.com)
Physiological2
Combined effects of edible tryptophan and ascorbic acid on some physiological, biological and behavioral parameters on workers of the Iranian honey bee, Apis mellifera meda L. (ac.ir)
This study was considered the effect of bees feeding with mixture of tryptophan and ascorbic acid on some of physiological , behavioral, and productive parameters in Iranian honey bee. (ac.ir)
Metabolites1
Many factors participate in molecular complexes that affect DNA methylation or demethylation, participate in methylation-dependent focusing on of additional molecular factors to genome areas, or regulate binding and/or activities of DNMTs, TETs, and additional epigenetic factors, either directly or via intermediate metabolites. (edrc2013.org)
Although diet, surgery, and exercise are the primary treatments for obesity, these activities are often supplemented using appetite suppressants. (researchgate.net)
The treatments included tryptophan(12 mg/gr) , ascorbic acid (2 mg/gr) combined in 1:1 syrup ( sugar 1 kg per 1 liter of water), and for control treatment only used syrup. (ac.ir)
The minimum levels was recorded respectively in ascorbic acid (17.59± 0.35 pg/ml), (74±3.06 pg/ml) and tryptophan(15.2±0.31 pg/ml) treatments. (ac.ir)
Serotonergic1
Present study aims to investigate the acute effects of St John's Wort (SJW) on nicotine withdrawal syndrome and serotonergic hypo activity in mice. (setpublisher.com)
Mice2
Nicotine withdrawn (NW) mice were evaluated for locomotor activity and abstinence signs at 72 h. (setpublisher.com)
Behavioral analysis in SJW administered NW mice showed attenuation in nicotine abstinence signs (shaking, scratching, chewing and facial tremors) and locomotor activity when compared with respective controls. (setpublisher.com)
Depression1
The reduction in 5HT content corresponded to the depression of TPH activity in all regions examined. (erowid.org)
Drug1
Additionally, use of the drug takes priority over other activities and commitments, there is a gradual increase in tolerance, and somatic withdrawal sometimes occurs when use of the substance stops. (encyclopedia.pub)
Effect1
2,3,7,8-Tetrachlorodibenzo- p -dioxin as an antiestrogen: Effect on rat uterine peroxidase activity. (cdc.gov)
Cell3
This indolamine advances apoptosis, which arrests the cell cycle and regulates metabolic activity. (explorationpub.com)
Many laboratories have focused on the functions of the clock genes and proteins that are involved in cellular activities, including cell survival, cell cycle regulation, proliferation, apoptosis, DNA damage repair, and tumor promotion or suppression [ 5 , 6 ]. (explorationpub.com)
Melatonin has oncostatic properties that are mediated by induction of apoptosis, arresting the cell cycle, regulation of metabolic activity, and the inhibition of hypoxia-inducible factor 1α (HIF-1α) activity [ 9 ]. (explorationpub.com)
Studies1
Early studies used p -chlorophenylalanine (pCPA), an inhibitor of tryptophan hydroxylase to deplete 5-HT from cats, rats, monkeys, and humans (reviewed in Jouvet, 1969 , 1972 ). (aspetjournals.org)
Total1
F) Assay for TDO enzyme activity, determined in total liver lysates from 10-week-old animals of each genotype. (biomedcentral.com)
Phenylalanine-Hydroxylase2
DmTPH) kodiert, wurde als neues, drittes Gen in der Familie der aromatischen Aminosäure-Hydroxylasen (AAAH) in Drosophila melanogaster neben Tyrosin-Hydroxylase (TH) und Phenylalanine-Hydroxylase (PAH oder Henna) kloniert. (fu-berlin.de)
Dihydropteridine reductase deficiency presents as atypical phenylketonuria due to insufficient production of biopterin, a cofactor for phenylalanine hydroxylase. (nih.gov)
Tryptophan (TRP) is an essential dietary amino acid that, unless otherwise committed to protein synthesis, undergoes metabolism via the Tryptophan-Kynurenine (TRP-KYN) pathway in vertebrate organisms. (mdpi.com)
Neurons2
Differentiated hiPSCs synthesize 5-HT, express specific markers, such as tryptophan hydroxylase 2 and 5-HT transporter, and exhibit an electrophysiological signature characteristic of serotonergic neurons, with spontaneous rhythmic activities, broad action potentials and large afterhyperpolarization potentials. (uni-wuerzburg.de)
We showed the enzyme activity of DmTPH to hydroxylate Trp to 5OHTrp is higher than Henna and Trp is a more suitable substrate for DmTPH than for Henna. (fu-berlin.de)
Transporter1
We have reached this state for several genes - the CB1 cannabis receptor, the 5-HT transporter, Tryptophan hydroxylase 2, 5-HT1A and 5HT1B receptors and brain-derived neurotrophic factor (BDNF). (europa.eu)
Decreases1
Positron emission tomography (PET) brain imaging studies of people who have stopped using MDMA have shown decreases in brain activity at rest in prefrontal, parietal, and mediotemporal cortices as well as in the amygdala, cingulate, and hippocampus. (nih.gov)
6 In general, the septum and hippocampus have inhibitory actions on HPA activity, whereas the effect of the amygdala is largely permissive. (jpn.ca)
Another regulatory force on HPA system activity is provided by inhibitory feedback actions of adrenal steroids exerted through corticosteroid receptors located in different brain areas. (jpn.ca)
Selective1
Citalopram enhances serotonin activity as a result of selective reuptake inhibition at the presynaptic neuronal membrane. (medscape.com)
The present study examines whether harman and norharman may influence the phagocytic activity of insect hemocytes by regulating serotonin levels. (biomedcentral.com)
Significantly greater serotonin levels and hemocyte phagocytic activity were observed after 24 h of exposure to food contaminated with harman and norharman. (biomedcentral.com)
They confirm for the first time that harman and norharman (metabolites of the entomopathogenic fungus C. coronatus ) elevate serotonin levels in G. mellonella hemocytes, thus potentially stimulating their phagocytic activity. (biomedcentral.com)
Brain4
How emotional stressors can lead to an inflamed brain that directly affects physiology and activity is yet to be fully understood. (nature.com)
However, the N-ethylated derivative of MDA, N-ethyl-3,4-methylenedioxyamphetamine (MDE), was much less potent in its ability to lower brain hydroxyindoles, and in most regions examined did not significantly affect TPH activity. (erowid.org)
MDMA affects the brain by increasing the activity of at least three neurotransmitters (the chemical messengers of brain cells): serotonin, 89,90 dopamine, and norepinephrine. (nih.gov)
105 More studies are needed to determine whether the observed changes in brain activity in people who use MDMA are caused by MDMA, other drug use, or other common risk factors that predispose people to use MDMA. (nih.gov)
Hippocampus1
13 ] have also shown similar UPR-related activity in hippocampus and have suggested that the hippocampus exhibits significant apoptotic activation under restraint stress paradigm. (nature.com)
Essential1
The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases. (nih.gov)