• Phase
  • The Complaint alleges that throughout the Class Period, the Defendants made materially false and/or misleading statements and failed to disclose that Phase 2a of the AVA-101 study was not designed to show any statistical significance between the active and control groups in the secondary endpoints. (marketwired.com)
  • After the market closed on June 15, 2015, the Company issued a press release entitled, "Avalanche Biotechnologies, Inc. Announces Positive Top-Line Phase 2a Results for AVA-101 in Wet Age-Related Macular Degeneration. (marketwired.com)
  • Avalanche said that the company's treatment for wet age-related macular degeneration met its primary endpoint, however, in a conference call to discuss Phase 2 clinical trial results, the company indicated that the study wasn't designed to show statistically significant differences between active and control groups. (marketwired.com)
  • diseases
  • Nonetheless, inhibitors are used to effectively treat cancer, macular degeneration in the eye, and other diseases that involve a proliferation of blood vessels. (wikipedia.org)
  • He was the first to describe many macular diseases. (wikipedia.org)
  • 1987 - establishment of the Gass Medal in his honor by the Macula Society 1999 - Mildred Weisenfeld Award for Excellence in Ophthalmology of the American Association for Research and Vision in Ophthalmology 2001 - Helen Keller Prize for Vision Research of the Helen Keller Foundation 2004 - Laureate Recognition Award of the American Academy of Ophthalmology with Anita Agarwal: Gass' Atlas of Macular Diseases, 5th edition. (wikipedia.org)
  • Treat
  • The Intraocular Lens for Visually Impaired Patients (IOLVIP or IOL-VIP) is an intraocular lens system aiming to treat patients with poor central vision due to age related macular degeneration. (wikipedia.org)
  • It is used clinically to treat a wide range of medical conditions, including wet age-related macular degeneration, psoriasis, atherosclerosis and has shown some efficacy in anti-viral treatments, including herpes. (wikipedia.org)
  • known
  • In 1967, Dr. Gass helped to describe the most common cause of vision impairment that may follow cataract surgery, a type of macular swelling now known as Irvine-Gass syndrome. (wikipedia.org)
  • results
  • Variations in several genes, particularly in the complement system, increase the risk of developing GA. This is an active area of research but the current hypothesis is that with aging, damage caused by these stressors accumulates, which coupled with a genetic predisposition, results in the appearance of drusen and lipofuscin deposits (early and intermediate AMD). (wikipedia.org)