• Phase
  • FOCUS, a Phase I/II clinical study investigated the safety and efficacy of Lucentis in combination with verteporfin (Visudyne(R)) photodynamic therapy (PDT) compared to PDT alone in patients with predominantly classic wet AMD. (medicalnewstoday.com)
  • The Complaint alleges that throughout the Class Period, the Defendants made materially false and/or misleading statements and failed to disclose that Phase 2a of the AVA-101 study was not designed to show any statistical significance between the active and control groups in the secondary endpoints. (marketwired.com)
  • After the market closed on June 15, 2015, the Company issued a press release entitled, "Avalanche Biotechnologies, Inc. Announces Positive Top-Line Phase 2a Results for AVA-101 in Wet Age-Related Macular Degeneration. (marketwired.com)
  • Avalanche said that the company's treatment for wet age-related macular degeneration met its primary endpoint, however, in a conference call to discuss Phase 2 clinical trial results, the company indicated that the study wasn't designed to show statistically significant differences between active and control groups. (marketwired.com)
  • atrophy
  • The right side shows a PED with some subretinal hemorrhage around it on the edge of a very significant vertical macular scar with atrophy and hyperpigmentation anterior to it extending into the temporal periphery. (retinagallery.com)
  • injections
  • If this medication is proven effective in subsequent clinical studies and is approved by the FDA, patients with macular degeneration may be relieved of the nightmare of receiving monthly eye injections. (wordpress.com)
  • As elders shudder at monthly injections to the eye and its side effects, the process of bringing pazopanib eye drops for wet AMD to the clinics shall be made with incredible speed. (wordpress.com)
  • vision
  • In early 2005 Keys Moran lost vision in one eye due to wet macular degeneration. (wikipedia.org)
  • Both studies successfully reached their primary endpoints and reported unprecedented results in maintaining and/or improving vision for patients with wet age-related macular degeneration (AMD). (medicalnewstoday.com)
  • The Intraocular Lens for Visually Impaired Patients (IOLVIP or IOL-VIP) is an intraocular lens system aiming to treat patients with poor central vision due to age related macular degeneration. (wikipedia.org)
  • In 1967, Dr. Gass helped to describe the most common cause of vision impairment that may follow cataract surgery, a type of macular swelling now known as Irvine-Gass syndrome. (wikipedia.org)
  • 1987 - establishment of the Gass Medal in his honor by the Macula Society 1999 - Mildred Weisenfeld Award for Excellence in Ophthalmology of the American Association for Research and Vision in Ophthalmology 2001 - Helen Keller Prize for Vision Research of the Helen Keller Foundation 2004 - Laureate Recognition Award of the American Academy of Ophthalmology with Anita Agarwal: Gass' Atlas of Macular Diseases, 5th edition. (wikipedia.org)
  • socially
  • It is an important prerequisite for a socially fulfilling and active lifestyle. (bmj.com)
  • He feels that he can have a stronger conversation with other members of DBA and hence help keep him socially active. (dorsetblind.org.uk)
  • significantly
  • OCT SCAN: There is a significantly attenuated macular region temporally with a PED present at the border of attenuated and normal retinal pigment epithelium. (retinagallery.com)
  • substance
  • Here we looked for effects on the pulsatile ocular blood flow (POBF) originating from the choroid because with each treatment, some vaso-active substance may be released to alter normal ChBF. (arvojournals.org)
  • results
  • Variations in several genes, particularly in the complement system, increase the risk of developing GA. This is an active area of research but the current hypothesis is that with aging, damage caused by these stressors accumulates, which coupled with a genetic predisposition, results in the appearance of drusen and lipofuscin deposits (early and intermediate AMD). (wikipedia.org)