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  • cyclin
  • The decision to commit to a new round of cell division occurs when the cell activates cyclin-CDK-dependent transcription which promotes entry into S phase. (wikipedia.org)
  • inhibitor
  • Additionally, the UNG promoter was not immunoprecipitated by E2F transcription factors in extrtacts from H460 cells treated with the DHFR inhibitor, methotrexate (12.5uM), but was immunoprecipitated with E2F-1 and E2F-4 in H460 extracts from cells treated with the crosslinking agent, cisplatin (12.5uM). (aacrjournals.org)
  • gene transcription
  • In order to decipher the mode of Rage function on gene transcription levels during inflammation, we applied global gene expression profiling on time-resolved samples of mouse back skin, which had been treated with the phorbol ester TPA, a potent inducer of skin inflammation. (beds.ac.uk)
  • human
  • A synthetic peptide corresponding to a sequence in the middle region of human E2F4(228-243aa LPKPALAQSQEASRPN), different from the related mouse and rat sequences by four amino acids. (bosterbio.com)
  • chromatin
  • The MH2 domain is also a binding platform for cytoplasmic anchors, DNA-binding cofactors, histone modifiers, chromatin readers, and nucleosome- positioning factors. (wikipedia.org)
  • recognition
  • The recognition of ADAbs would depend on factors like the timing from the test taken in accordance with dosing, duration of treatment and, significantly, the assay utilized (Desk 1). (bus2226w16.com)
  • regulatory
  • Despite this, HCC is a relatively understudied cancer that lacks biomarkers for prognosis and the regulatory factors involved in carcinogenesis remain uncharacterized [ 1 ]. (hindawi.com)
  • cells
  • The transforming growth factor-beta (TGF β ) was discovered more than two decades ago and was isolated as a secreted factor from sarcoma virus-infected cells [ 1 - 3 ]. (hindawi.com)
  • However
  • However, E2F4 migrates as an heterogeneous set of bands between 57-64 kDa which are associated with extensive phosphorylations (Beijersbergen et al. (atlasgeneticsoncology.org)
  • cancer
  • The available analytes include cytokines, chemokines, growth factors, cancer markers and other common markers. (bosterbio.com)
  • E2f1
  • In the classic paradigm of mammalian cell cycle control, Rb functions to restrict cells from entering S phase by sequestering E2F activators ( E2f1 , E2f2 and E2f3 ), which are invariably portrayed as the ultimate effectors of a transcriptional program that commit cells to enter and progress through S phase 1 , 2 . (pubmedcentralcanada.ca)
  • Although it is a maxim of mammalian cell cycle regulation that the E2F1-3 activator subclass is required for cell proliferation, the evidence for this is based almost exclusively on in vitro studies using cells derived from murine and human tissues or on the in vivo analysis of Rb mutant mice 1 , 2 . (pubmedcentralcanada.ca)
  • To explore the functions of the E2F activator subclass, we derived E2f1 −/− ;E2f2 −/− ;E2f3 LoxP /− ES cells ( Supplementary Fig. 1a, 1b ) and compared the consequences of inactivating the conditional E2f3 LoxP allele in these cells versus in E2f1 −/− ;E2f2 −/− ;E2f3 LoxP / LoxP MEFs. (pubmedcentralcanada.ca)
  • In another negative feedback loop, E2F1-3 promote the transcription of E2F6-8, which in turn repress G1-S transition. (wikipedia.org)
  • Three of them are activators: E2F1, 2 and E2F3a. (wikipedia.org)
  • In REF52 cells, overexpression of activator E2F1 is able to push quiescent cells into S phase. (wikipedia.org)
  • chromatin
  • The Rb-E2F/DP complex also attracts a histone deacetylase (HDAC) protein to the chromatin, reducing transcription of S phase promoting factors, further suppressing DNA synthesis. (wikipedia.org)
  • The MH2 domain is also a binding platform for cytoplasmic anchors, DNA-binding cofactors, histone modifiers, chromatin readers, and nucleosome- positioning factors. (wikipedia.org)
  • complex
  • p130Cas and HEF1 are a structurally related pair of such docking molecules that localize to the focal adhesion complex, assembling members of adhesion and growth factor-related signaling cascades ( 10 , 11 ). (jimmunol.org)
  • Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element. (genecards.org)
  • cells
  • DOI: http://dx.doi.org/10.7554/eLife.10473.001 GSK1120212 (JTP-74057, Trametinib) performed a report in dendritic cells where they studied a -panel of transcription factors by ChIP-Seq following LPS excitement. (health-media.net)
  • AND-34, a novel GDP exchange factor, is expressed constitutively at significant levels in murine splenic B cells, but not in murine splenic T cells or thymocytes. (jimmunol.org)
  • release
  • Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. (genecards.org)