• E2f3
  • The present study was designed to determine the possible impact of hepatitis C virus (HCV) infection on the expression of telomerase (TERT), retinoblastoma (RB1), E2F3, TP53, CDKN1A (p21) and fibroblast growth factor receptor- 3 (FGFR3) genes in patients with bladder cancer (BC). (biomedcentral.com)
  • regulate
  • The transforming growth factor-beta (TGF β ) superfamily encompasses widespread and evolutionarily conserved polypeptide growth factors that regulate and orchestrate growth and differentiation in all cell types and tissues. (hindawi.com)
  • It acts as a mediator of the signals initiated by the transforming growth factor beta (TGF-β) superfamily of cytokines, which regulate cell proliferation, differentiation and death. (wikipedia.org)
  • Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase CCNDBP1 NM_012142 May negatively regulate cell cycle progression CCNG1 NM_004060 May play a role in growth regulation CCNH NM_001239 Involved in cell cycle control and in RNA transcription by RNA polymerase II. (wikipedia.org)
  • human
  • A synthetic peptide corresponding to a sequence in the middle region of human E2F4(228-243aa LPKPALAQSQEASRPN), different from the related mouse and rat sequences by four amino acids. (bosterbio.com)
  • MA5-11276 targets E2F-4 Transcription Factor in GS, IF, IHC (P), and WB applications and shows reactivity with Human and Rat samples. (thermofisher.com)
  • Synthetic peptide within Human E2F4 aa 250-350. (abcam.com)
  • cyclin
  • The decision to commit to a new round of cell division occurs when the cell activates cyclin-CDK-dependent transcription which promotes entry into S phase. (wikipedia.org)
  • chromatin
  • The MH2 domain is also a binding platform for cytoplasmic anchors, DNA-binding cofactors, histone modifiers, chromatin readers, and nucleosome- positioning factors. (wikipedia.org)
  • cells
  • It is likely involved in the early responses of resting cells to growth factor stimulation. (genecards.org)
  • The transforming growth factor-beta (TGF β ) was discovered more than two decades ago and was isolated as a secreted factor from sarcoma virus-infected cells [ 1 - 3 ]. (hindawi.com)
  • Additionally, the UNG promoter was not immunoprecipitated by E2F transcription factors in extrtacts from H460 cells treated with the DHFR inhibitor, methotrexate (12.5uM), but was immunoprecipitated with E2F-1 and E2F-4 in H460 extracts from cells treated with the crosslinking agent, cisplatin (12.5uM). (aacrjournals.org)
  • the binding of these transcription factors with the UNG promoter of pemetrexed treated cells have also been evaluated in this study. (aacrjournals.org)
  • regulatory
  • Despite this, HCC is a relatively understudied cancer that lacks biomarkers for prognosis and the regulatory factors involved in carcinogenesis remain uncharacterized [ 1 ]. (hindawi.com)