• C4b2a
  • Moreover, T. cruzi promotes secretion of plasma membrane-derived vesicles from host cells, which prevent the activity of C3 convertase C4b2a and thereby may hinder complement. (frontiersin.org)
  • Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb. (genetex.com)
  • C4b2a is the widely used short‐hand nomenclature for the C4b-C2a complex in the complement field, and similar nomenclature is used for the remaining complexes in the following). (embopress.org)
  • inhibition
  • Although the exact involvement of complement needs to be carefully investigated for each disease, therapeutic modulation of complement activity emerges as an attractive target for upstream inhibition of inflammatory processes. (jimmunol.org)
  • CR2-targeted complement inhibition has been proved to be a potential therapeutic strategy for many diseases, such as influenza virus-induced lung tissue injury, postischemic cerebral injury and spinal cord injury. (biomedcentral.com)
  • CR2-Crry is expressed in CHO cells, and its biological activity is determined by complement inhibition assays. (biomedcentral.com)
  • CR2-Crry-mediated targeting complement inhibition will alleviate the local inflammation and provide an effective treatment for the severe neurological diseases associated with EV71 infection. (biomedcentral.com)
  • pathogen
  • When the carbohydrate-recognising heads of MBL bind to specifically arranged mannose residues on the surface of a pathogen, MASP-2 is activated to cleave complement components C4 and C2 into C4a, C4b, C2a, and C2b. (wikipedia.org)
  • serum
  • More than 20 types of complements are present in serum found circulating normally in human body in inactive forms (called as zymogens or proenzymes) . (microbeonline.com)
  • inhibitor
  • The mice are then divided into two groups, in one of which the mice are treated with CR2-Crry targeted complement inhibitor, and in the other with phosphate-buffered saline. (biomedcentral.com)
  • The potential bioavailability and efficacy of the targeted complement inhibitor are evaluated by histology, immunofluorescence staining and radiolabeling. (biomedcentral.com)
  • Serpin peptidase inhibitor clade G member 1 ( C1 inhibitor ) inhibits activated C1r and C1s and thus regulates complement activation . (pathwaymaps.com)
  • antibodies
  • In the early 20th century, this controversy was resolved when it became understood that complement can act in combination with specific antibodies, or on its own in a non-specific way. (wikipedia.org)
  • Pathogens
  • Yet it has become evident that complement not only acts as a sensor of pathogens but also recognizes diseased and damaged host cells, and it closely collaborates with other immune and defense systems to eliminate potential danger ( 1 , 2 ). (jimmunol.org)
  • The past decade revealed a new perception of complement that reaches beyond the elimination of pathogens and includes key functions in immune surveillance, homeostasis, and mediation of inflammatory responses ( 1 , 2 ). (jimmunol.org)
  • infection
  • This infers resistance to complement-mediated cell lysis, allowing parasite survival and infection. (genecards.org)
  • In this context, the complement, as one of the first line of host defense against infection was shown to play an important role in recognizing T. cruzi metacyclic trypomastigotes and in controlling parasite invasion. (frontiersin.org)
  • An important step during T. cruzi infection is when intracellular trypomastigotes are release to bloodstream where they may be target by complement. (frontiersin.org)