• ligands
  • The cytotoxic activity of the NK-cells is controlled by the balance between inhibitory and activating receptors, whose ligands are self-Major Histocompatibility Complex (MHC) class I molecules and molecules expressed on stressed, viral infected, and tumor cells. (hindawi.com)
  • CD44 is a receptor for hyaluronic acid and also interacts with other ligands, such as osteopontin, collagens, and matrix metalloproteinases. (prospecbio.com)
  • Splice variants of CD44 on colon cancer cells display sialofucosylated HCELL glycoforms that serve as P-, L-, and E-selectin ligands and fibrin, but not fibrinogen, receptors under hemodynamic flow conditions pertinent to the process of cancer metastasis. (wikipedia.org)
  • While this may be the case to some extent, it is now widely held that the main driver in lymphocyte homing is the interactions between T cell adhesion molecules (lymphocyte homing receptors) and ligands (addressins) on the tissue high endothelial venules (HEVs). (wikipedia.org)
  • He and his research team have shown that lymphocytes use a variety of different adhesion molecules or "homing receptors" to recognize organ (and/or inflammation)-specific vascular ligands or "addressins" that define the tissue position (address) of blood vessels in the body. (wikipedia.org)
  • Nat Immunol 2006 Zabel BA, Ohyama T, Zuniga L, Kim JY, Johnston B, Allen SJ, Guido DG, Handel TM, Butcher EC "Chemokine-like receptor 1 expression by macrophages in vivo: Regulation by TGF-beta and TLR ligands. (wikipedia.org)
  • Immunol
  • Y-H. Chin, R.A. Rasmussen, J.J. Woodruff, and T.G. Easton, A monoclonal anti-HEBF antibody with specificity for lymphocyte surface molecules mediating adhesion to Peyer's patch high endothelium of the rat, J. Immunol. (springer.com)
  • J.J. Woodruff, M. Katz, E. Lucas, and H.B. Stamber Jr, An in vitro model of lymphocyte homing.II.Membrane and cytoplasmic events involved in lymphocyte adherence to specialized high-endothelial venules of lymph nodes, J. Immunol. (springer.com)
  • D.M. Lewinsohn, R.F. Bargatze, and E.C. Butcher, Leukocyte-endothelial cell recognition: evidence of a common molecular mechanism shared by neutrophils, lymphocytes, and other leukocytes, J. Immunol. (springer.com)
  • Nat Immunol 2007 Staton TL, Habtezion A, Winslow MM, Sato T, Love PE, Butcher EC "CD8(+) recent thymic emigrants home to and efficiently repopulate the small intestine epithelium. (wikipedia.org)
  • Macagno A, Napolitani G, Lanzavecchia A, Sallusto F. Duration, combination and timing: the signal integration model of dendritic cell activation.Trends Immunol 2007, in press. (wikipedia.org)
  • dendritic
  • Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes. (nih.gov)
  • Butcher and his research team study the trafficking of white blood cells (lymphocytes, dendritic cells, monocytes, etc.), including their interactions with the endothelial lining of blood vessels at sites of leukocyte extravasation, and their chemotactic responses in tissues. (wikipedia.org)
  • In other investigations, the team has identified novel lymphocyte, dendritic cell and macrophage chemoattractants and receptors, as well as monocyte and arterial wall endothelial molecules that regulate monocyte-endothelial interactions in models of atherogenesis. (wikipedia.org)
  • His research established that dendritic cells are responsible for imprinting the tissue-specific homing of T lymphocytes. (wikipedia.org)
  • LAG3 is known to be involved in the maturation and activation of dendritic cells. (wikipedia.org)
  • This receptor has a wide cellular distribution, with expression on most immature and mature hematopoietic cell types (e.g. neutrophils, monocytes, T and B cells, dendritic cells, Langerhans cells and macrophages). (wikipedia.org)
  • Napolitani G, Rinaldi A, Bertoni F, Sallusto F, Lanzavecchia A. Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. (wikipedia.org)
  • 2002
  • 169: 529-539, 2002 Rosemblatt M., Gaugler M.H., Leroy C., Coulombel L. Coexpression of two fibronectin receptors, VLA-4 and VLA-5 on immature erythroblastic precursor cells. (wikipedia.org)
  • cellular
  • Lymphocytes migrate from the blood stream via a distinctive 'rolling interaction' mediated by interactions between cellular surface proteins. (wikipedia.org)
  • Cellular activation causes a conformational change which results in the cell flattening against the vessel wall. (wikipedia.org)
  • The protein negatively regulates cellular proliferation, activation, and homeostasis of T cells, in a similar fashion to CTLA-4 and PD-1 and has been reported to play a role in Treg suppressive function. (wikipedia.org)
  • expression
  • Impaired homing of CD18 lymphocytes to pLN is not due to an altered chemokine receptor expression or activation. (youscribe.com)
  • A) The expression of CCR4 in control (CTR) T cells and in T lymphocytes transduced with a retroviral vector encoding CCR4. (nih.gov)
  • Surface expression of CCR4 was evaluated by FACS analysis of CD3 + , CD4 + , and CD8 + T lymphocytes. (nih.gov)
  • The expression of activation markers and of chemokine receptors on T cells homing to the nervous system (NS) may help define their functional state. (prohealth.com)
  • Studies of chemokine receptors (CKR) in natural killer- (NK-) cells have already been published, but only a few gave detailed information on its differential expression on blood NK-cell subsets. (hindawi.com)
  • The team is also exploring mechanisms that imprint lymphocyte homing and chemokine receptor expression during tissue-specific immune responses, and are developing techniques to recapitulate such regulation in vitro for cell targeting and therapy. (wikipedia.org)
  • Upon activation, naive and central memory T cells increase expression of the KCa3.1 channel to approximately 500 channels per cell, while effector-memory T cells increase expression of the Kv1.3 channel. (wikipedia.org)
  • Among human B cells, naive and early memory B cells express small numbers of Kv1.3 and KCa3.1 channels when they are quiescent, and augment KCa3.1 expression after activation. (wikipedia.org)
  • Rivino L, Messi M, Jarrossay D, Lanzavecchia A, Sallusto F, Geginat J. Chemokine receptor expression identifies pre- T helper (Th)1, pre-Th2 and nonpolarized cells among human central memory T cells. (wikipedia.org)
  • immune
  • This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. (nih.gov)
  • Thus, organ-specific homing receptors are thought to play an essential role in determining the characteristics of local immune responses 2,5 . (springer.com)
  • Gut-specific homing is the mechanism by which activated T cells and antibody-secreting cells (ASCs) are targeted to both inflamed and non-inflamed regions of the gut in order to provide an effective immune response. (wikipedia.org)
  • The majority of human T cells rearrange their alpha and beta chains on the cell receptor and are termed alpha beta T cells (αβ T cells) and are part of the adaptive immune system. (wikipedia.org)
  • Specialized gamma delta T cells, (a small minority of T cells in the human body, more frequent in ruminants), have invariant T-cell receptors with limited diversity, that can effectively present antigens to other T cells and are considered to be part of the innate immune system. (wikipedia.org)
  • Chimeric antigen receptors (CARs, also known as chimeric immunoreceptors, chimeric T cell receptors, artificial T cell receptors or CAR-T) are engineered receptors which graft an arbitrary specificity onto an immune effector cell (T cell). (wikipedia.org)
  • To this end, they are studying the specialized homing mechanisms and functional properties of tissue infiltrating lymphocytes involved in local immune, autoimmune and regulatory responses in the GI tract (intestines, liver), skin, lungs, and other sites. (wikipedia.org)
  • It is an immune checkpoint receptor and as such is the target of various drug development programs by pharmaceutical companies seeking to develop new treatments for cancer and autoimmune disorders. (wikipedia.org)
  • Michigan dairy farmers exposed to PBBs had significant immune system abnormalities including reduced numbers of circulating blood lymphocytes, increases in lymphocytes with no detectable surface markers, and reduced functional response to specific test antigens. (wikipedia.org)
  • mediates
  • All-trans retinoic acid mediates enhanced Treg growth, differentiation and gut homing in the face of high levels of co-stimulation. (wikipedia.org)
  • hyaluronate
  • ab25224 can inhibit hyaluronate-dependent cell aggregation, prevent lympho-hemopoiesis in both Dexter and Whitlock-Witte Cultures, prevent the earliest intrathymic precursors from homing to the thymus, and costimulate the activation of freshly purified splenic CD4+ T cells. (abcam.com)
  • specificity
  • Typically, these receptors are used to graft the specificity of a monoclonal antibody onto a T cell, with transfer of their coding sequence facilitated by retroviral vectors. (wikipedia.org)
  • Their studies have shown that these adhesion receptors act coordinately with G protein-linked serpentine chemoattractant receptors in a multi-step process that controls the specificity and provides combinatorial diversity in leukocyte trafficking. (wikipedia.org)
  • retinoic
  • The 5' region of the NEDD9 promoter is regulated by all-trans retinoic acid (ATRA), and contains a retinoic acid response element (RARE) that is specifically bound by a retinoid X receptor (RXR)/retinoic acid receptor (RAR) heterodimer. (wikipedia.org)