Activates interferon gamma. Medical search. Frequent questions

STAT1 is activated to regulate gene expression in response to extracellular signaling polypeptides including cytokines, interferons, and growth factors. (thermofisher.com)
Poly ICLC may stimulate the release of cytotoxic cytokines and by inducing interferon-gamma production, may increase the tumoricidal activities of various immunohematopoietic cells. (globaldata.com)
The interferon-α/β receptor (IFNAR) is a virtually ubiquitous membrane receptor which binds endogenous type I interferon (IFN) cytokines. (wikidoc.org)
The release of proinflammatory cytokines (eg, interferon-gamma) by activated T cells could determine the damage to the enterocyte, increased proliferation in the intestinal crypts, and, finally, severe damage to the intestinal mucosa architecture. (helpforibs.com)
At infection sites, activated T cells secrete cytokines (eg, interferon-gamma [IFN-gamma]) that induce production of macrophage migration inhibitory factor, preventing macrophages from leaving. (msdmanuals.com)
M1, "classically activated," pro-inflammatory macrophages are stimulated by cytokines such as IFN-gamma and by various microbial components (eg, lipopolysaccharide). (msdmanuals.com)
M2 "alternatively activated" anti-inflammatory macrophages are stimulated predominantly by cytokines such as IL-4 and IL-13. (msdmanuals.com)

When intravenously injected into mice with metastatic melanoma , it was able to deliver signaling molecules, called cyclic dinucleotides, across the cell membranes of their liver macrophages, where they stimulated the production of immune-related proteins called type 1 interferons via a stimulator of an interferon gene (STING) pathway. (news-medical.net)
[7] [8] Upon binding of type I interferons, IFNAR activates the JAK-STAT signalling pathway , along with MAPK , PI3K , and Akt signaling pathways. (wikidoc.org)
SCAP stimulated with TNFα and interferon gamma (IFNγ) activated kynurenine pathway. (nottingham.ac.uk)
In addition, we studied another death-inducing pathway via interferon gamma signaling and detected high-level upregulations of human leukocyte antigen A (HLA-A) and beta 2-microglobulin (B2M) with only moderate killing efficacy. (uni-bielefeld.de)

Secreted autoantibodies specific to receptors or receptor ligands can activate or inhibit receptor functions. (hindawi.com)
Chemokines bind and activate the CXCR3 receptor on Th1 cells, further enhancing IFN-γ and ILs secretion. (endotext.org)
NMR structure of the interferon-binding ectodomain of the human interferon receptor. (wikidoc.org)
KLRF1, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release (Kuttruff et al. (nih.gov)

It activates the oligoadenylate synthetase (OAS) and the p68 protein kinase. (globaldata.com)
This is because the type 1 interferons and interferon-gamma triggered the expression of a protein called PD-L1 on the cancer cells. (news-medical.net)
Regulators of small G-proteins like guanine nucleotide releasing factor GNRP (Ras-GRF) (which contains 2 PH domains), guanine nucleotide exchange proteins like vav, dbl, SoS and Saccharomyces cerevisiae CDC24, GTPase activating proteins like rasGAP and BEM2/IPL2, and the human break point cluster protein bcr. (embl.de)
Mechanistically, METTL3 mediates sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) mRNA m6A to promote its translation, leading to the activation of cholesterol biosynthesis. (bvsalud.org)

Moreover they induce the upregulation of activating FcR on effector cells. (hindawi.com)
[9] For example, type I IFNs induce interferon-stimulated gene ( ISG ) expression, classically resulting in a robust anti-viral immune response. (wikidoc.org)

Effects of ozone upon macrophage-interferon interactions. (cdc.gov)
The effects of ozone (10028156) upon macrophage/interferon interactions were examined. (cdc.gov)
This suggests that in- vivo ozone exposure would probably alter the ability of macrophage like cells to interact with, and be activated by INFg, which would consequently impact upon other macrophage dependent system cells during times of host antigen or bacterial challenge. (cdc.gov)

All function as regulators of cellular activty by interacting with cell-surface receptors and activating various signalling pathways. (embl.de)
Human dNK cell function is differentially regulated by extrinsic cellular engagement and intrinsic activating receptors in first and second trimester pregnancy. (nih.gov)
Transcriptome analysis revealed a significant imbalance of ligands for activating and inhibitory NK-cell receptors in iPS-fibro. (biomedcentral.com)

Compared to parental fibroblasts, iPSC-derivatives had a reduced expression of HLA-I simultaneously with an increased gene expression of major activating ligands, such as MICA , NECTIN2 , and PVR . (biomedcentral.com)

IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. (joplink.net)
It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (joplink.net)
Interferons produce antiviral and antiproliferative responses in cells. (embl.de)
Interferons [ ( PUBMED:3022999 ) ] are proteins which produce antiviral and antiproliferative responses in cells. (embl.de)

Proteins in this entry are different from the interferon gamma family. (embl.de)

Dendritic cells in the skin act as sentinel APCs, taking up antigen, then traveling to local lymph nodes where they can activate T cells. (msdmanuals.com)

Deposited immune complexes can activate complement and effector cells. (hindawi.com)
By analyzing mutation levels, it was possible to distinguish sequences from cells that were recently activated from naïve B cells from those that were activated by memory recall. (nature.com)
These were released into the blood, activating another type of immune cell called natural killer cells in the spleen and lung, which produced interferon-gamma inside the lung metastases. (news-medical.net)
Natural killer cells can't specialize in recognition of a particular pathogen, but we found that once they've been activated, they can respond more easily and effectively to the next call for activation. (disabled-world.com)
To overcome this, lead author Megan A. Cooper, M.D., Ph.D., a postdoctoral fellow in pediatric Rheumatology, activated mouse natural killer cells in culture, stained them with a fluorescent green dye and injected them back into the mice. (disabled-world.com)
Improved responses included increased cell replication and production of interferon gamma, a compound that has anti-pathogen activities and helps spread the immune response by activating additional immune cells. (disabled-world.com)
To elucidate the importance of Th1 cells in the pathogenesis of AA we investigated the functional role of interferon (IFN)-gamma in the experimental induction of AA. (unboundmedicine.com)
IFNgamma(-/-) mice fail to activate Th1 cells in response to the transplanted (auto)antigens, which suggests an essential requirement for IFN-gamma-mediated Th1 activation in the induction of AA. (unboundmedicine.com)
2] Ultimately, the interaction between gliadin peptides and HLA molecules activates intestinal T cells. (helpforibs.com)
While immunotherapy uses drugs and genetic manipulation techniques to activate the immune system and make it more effective at finding and fighting cancer cells, the Belgian researchers took a different approach. (mesothelioma.net)
Though the study found that the virus had no direct impact on the mesothelioma cells themselves, it did activate production of Gamma-interferon, a type of natural killer cell that controlled the mesothelioma cells. (mesothelioma.net)
Within the CNS the immune system activates an inflammation process that damages the myelin (i.e. the fatty substance that surrounds and insulates the nerve fibers), the nerve fibers themselves and the cells specialized in myelin production (i.e. (biomedcentral.com)
Soluble HLA-G is an immunosuppressive molecule inducing apoptosis of activated CD8(+) T cells and down-modulating CD4(+) T cell proliferation. (biovendor.com)

The main conserved structural feature of interferons is a disulphide bond that, except in mouse beta interferon, occurs in all alpha, beta and omega sequences. (embl.de)

Type I interferons (alpha, beta) belong to the larger helical cytokine superfamily, which includes growth hormones, interleukins, several colony-stimulating factors and several other regulatory molecules. (embl.de)

Single-cell RNA sequencing revealed that METTL3 suppressed antitumor immune response by reducing granzyme B (GZMB+) and interferon gamma-positive (IFN-Î³+) CD8+ T cell infiltration, thereby facilitating immune escape. (bvsalud.org)

QuantiFERON®-TB de mesure de la production d'interféron gamma a été comparé au test tuberculinique cutané chez 59 jeunes âgés de moins de 20 ans en contact rapproché avec des cas immunocompétents de tuberculose pulmonaire confirmés. (who.int)
Nous suggérons d'ajouter la mesure de la production d'interféron gamma au test tuberculinique cutané pour prendre ou non la décision de réaliser une radiographie des poumons ou d'entamer une chimioprophylaxie, au moins chez les sujets jeunes (âgés de moins de 20 ans). (who.int)

On the basis of their sequence interferons are classified into five groups: alpha, alpha-II (or omega), beta, delta (or trophoblast) and gamma. (embl.de)
This entry also includes also interferon omega and tau. (embl.de)

Interferon alpha, beta and delta. (embl.de)

[ 63 ] In addition, studies in patients with a first attack of neurologic symptoms suggestive of MS have demonstrated decreased disability and lower secondary relapse rates with interferon treatment. (medscape.com)

The enzyme gamma-interferon-inducible lysosomal thiol reductase (GILT) plays an important role in promoting the processing and presentation of major histocompatibility complex (MHC) class II-restricted antigens. (bvsalud.org)

Produced by lymphocytes activated by specific antigens or mitogens. (joplink.net)
Mammalian phosphatidylinositol-specific phospholipase C (PI-PLC) (see IPR000909 ) isoforms gamma and delta. (embl.de)

PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. (embl.de)

25. Macrophage activation to kill Leishmania major: activation of macrophages for intracellular destruction of amastigotes can be induced by both recombinant interferon-gamma and non-interferon lymphokines. (nih.gov)
39. Activation of mouse peritoneal macrophages in vitro and in vivo by interferon-gamma. (nih.gov)
9] "The phagosomal proteome in interferon-gamma-activated macrophages. (tcdb.org)
IFN-gamma is also a potent activator of macrophages. (nih.gov)
Exposure to IFN-gamma greatly enhances the microbicidal (and, to a lesser degree, citotoxic) activity of macrophages and induces them to secrete nitric oxide and monokines such as IL-1, IL-6, IL-8, and TFNalpha. (nih.gov)
CD64 is expressed on monocytes, macrophages, dendritic cells, granulocytes activated with interferon-gamma and early myeloid lineage cells. (bdbiosciences.com)
B7-1 is expressed on activated B cells, activated T cells, and macrophages. (rndsystems.com)
The ability of the host to control infection and resolve disease requires the generation of cell-mediated immune responses capable of activating host macrophages to eliminate intracellular parasites. (hindawi.com)
IL-18 induces Interferon gamma (IFNγ) production and is important for the activation of T cells, macrophages and other cell types [13]. (immunochemistry.com)
The macrophages are usually activated by interferon-gamma, macrophages presenting fragmented peptides to the helper T cells that produce antibodies. (microbenotes.com)

This activates and redirects CTLs to DLL3-expressing tumor cells, which results in the CTL-mediated cell death of DLL3-expressing tumor cells. (nih.gov)
It is known that natural killer (NK) cells take part in innate immunity to remove pathogens and cancer cells, and secrete interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), macrophage inflammatory protein-1β (MIP-1β) and other molecules to mediate the adaptive immunity. (justia.com)

[ 24 ] and interleukin 5 (IL-5) with interferon gamma. (medscape.com)
We hypothesize pFUS up-regulates renal interferon-γ (IFNγ) and stimulates MSC to produce interleukin-10 (IL-10) after migrating to kidneys. (nih.gov)
22. Macrophage activation by interferon-gamma from host-protective T cells is inhibited by interleukin (IL)3 and IL4 produced by disease-promoting T cells in leishmaniasis. (nih.gov)
Although interferon gamma (IFN-gamma) secretion is essential for control of most intracellular pathogens, host survival often also depends on the expression of interleukin 10 (IL-10), a cytokine known to counteract IFN-gamma effector functions. (indexindex.com)

35. Establishment of murine macrophage hybridoma clones capable of acquiring tumoricidal activity upon activation with recombinant interferon-gamma and lipopolysaccharide. (nih.gov)
3) in "vivo" effects of combination treatment with recombinant interferon-gamma and alpha in chronic HCV-infection. (nih.gov)

24. Phenotypic characterization of human T lymphocyte populations producing macrophage-activating factor (MAF) lymphokines. (nih.gov)

Dendritic cells in the skin act as sentinel APCs, taking up antigen, then traveling to local lymph nodes where they can activate T cells. (msdmanuals.com)

We found that the protein kinase C activator, 12-O-tetradecanoyl-phorbol 13-acetate (TPA), but not interferon-gamma (IFN-gamma), prolonged the survival of adherent vasculature lung neutrophils from endotoxemic rats, a response that was correlated with reduced apoptosis. (nih.gov)
Endotoxin administration also induced expression of total p38 and p44/42 mitogen activated protein kinases (MAPK) in neutrophils, as well as phosphatidyl inositol 3 kinase (PI3K) and its downstream target protein kinase B (PKB). (nih.gov)
It also activates neutrophils, NK cells, and vascular endothelial cells. (nih.gov)
Occurrence of neutrophils and activated Th1 cells in UVB-induced erythema. (qxmd.com)

Additionally, B7-2 is expressed at low levels on monocytes and can be up‑regulated through Interferon gamma. (rndsystems.com)
Christopher B. Cole, MD, PhD , of the National Cancer Institute, discusses findings from a phase I study of intraperitoneal monocytes activated by interferons alpha and gamma in patients with ovarian cancer. (ascopost.com)

Because caspase-1 is a principle effector protease within the pyroptotic cell death pathway, it stands to reason that the intracellular detection of activated caspase-1 be a key indicator of a pyroptosis activity. (immunochemistry.com)

We found that the expression of CYP19 via promoters PII, I.3, and I.7 in Hs578t cells was, in part, dependent on the activation of two VEGF signaling pathways: mitogen-activated protein kinase (MAPK) 1/3 and phospholipase C (PLC). (nih.gov)
In contrast to its inhibitory role in the IL-17 pathway, the STAT1 protein helps promote other immune processes called the interferon-alpha/beta (IFNA/B) and interferon-gamma (IFNG) signaling pathways. (medlineplus.gov)
The effects of the increase in activated STAT1 protein on other signaling pathways are thought to underlie the variety of features that can occur in immunodeficiency 31C, but the specific mechanisms are not well understood. (medlineplus.gov)
Their findings were further supported by the identification of heightened inflammatory response in those restrained rats where part of the activated inflammatory pathways demonstrated the upregulated expression of key mediators like c-Jun kinase (JNK) and Xbox Binding Protein-1 (XBP-1). (nature.com)
Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by blocking the formation of phosphorylated STAT1 and promoting ubiquitin-mediated proteasome-dependent degradation of STAT1 (PubMed:23799612) (By similarity). (proteopedia.org)

Differential actions of pituitary adenylyl cyclase-activating polypeptide and interferon gamma on Th2- and Th1-associated chemokine expression in cultured murine microglia. (uchicago.edu)

which activates the cells that destroy pathogens. (asianage.com)
Edible vaccines are required to activate the mucosal immune response system(MIS), where human pathogens initiate infection. (microbenotes.com)

27. Production of macrophage-activating factor by T lymphocyte clones and correlation with other lymphokine activities. (nih.gov)
Although IFN-gamma tends to promote the differentiation of B cells and CD8 T cells into immunologically active effectors, it does not promote lymphocyte proliferation. (nih.gov)
Non-infected mice immunized with rv2190c DNA or ag85a DNA showed higher levels of interferon-gamma (IFN-γ) in stimulated spleen lymphocyte culture supernatants, and had more Th1 cells and an elevatory ratio of Th1/Th2 immune cells in whole blood, indicating that Th1-type immune response was predominant. (biomedcentral.com)

31. Studies on macrophage-activating factor (MAF) in antitumor immune responses. (nih.gov)
40. Studies on macrophage-activating factor (MAF) in antitumor immune responses. (nih.gov)
[10] [11] Imiquimod activates the innate and adaptive immune responses via binding to Toll-like receptor 7 and activation of nuclear factor kappa-B with the resultant cytokine release and recruitment of plasmacytoid predendritic cells to the site of medication application with subsequent release of Interferon-alpha and a Th1 response. (statpearls.com)

Interferon-γ is a potent multifunctional cytokine which is secreted primarily by activated NK cells and T cells. (biolegend.com)

Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NF-kappa-B activation, and activates AP-1 (By similarity). (proteopedia.org)

1] "Activated T cells express a novel gene on chromosome 8 that is closely related to the murine ecotropic retroviral receptor. (tcdb.org)

The activated B cells migrate to the mesenteric lymph nodes, where they mature plasma cells, finally migrating to the mucosal membrane to secrete immunoglobulin A (IgA). (microbenotes.com)

STAT3 can also be activated by Interferon-alpha, Interferon-gamma, EGF, PDGF and IL6. (thermofisher.com)
STAT3 has been shown to be activated by IFN-alpha but not IFN-beta. (thermofisher.com)
Activates STAT3 leading to cellular transformation (By similarity). (proteopedia.org)

T cells in peripheral bloodstream mononuclear cells depleted of Compact disc4+ T cells neglect to proliferate when activated with malarial antigens in vitro. (bioskinrevive.com)
Although at any given time point only a fraction of the cells appeared to simultaneously produce IL-10 and IFN-gamma, IL-10 production could be stimulated in IL-10(-)IFN-gamma(+) cells by further activation in vitro. (indexindex.com)

It points to a mechanism involving the TLR7 receptor (Toll-like Receptor 7), usually activated in innate immune system cells by pathogen recognition. (asianage.com)

Chromatin immunoprecipitation and electrophoretic mobility shift assay were used to determine the IFNγ-activated pSTAT1 and NF-κB association with the chromatin DNA of the nos2 promoter. (biomedcentral.com)

Further analysis revealed that the same IL-10(+)IFN-gamma(gamma) population displayed potent effector function against the parasite while, paradoxically, also inducing profound suppression of IL-12 production by antigen-presenting cells. (indexindex.com)

Study results demonstrated an increase in cell lysis by IL-2-activated NK and LAK cells, and a reduction in endothelial cell injury by taurine. (ndnr.com)

In regards to the possibility of taurine reducing the antitumor efficacy of IL-2, it was found that taurine did not alter activated NK-cell-mediated antitumor function, yet it significantly enhanced LAK cell activity (Finnegan et al. (ndnr.com)

Molecular mechanisms of the combination of retinoid and interferon-gamma for inducing differentiation and increasing apoptosis in human glioblastoma T98G and U87MG cells. (musc.edu)
Differentiation decreased telomerase activity in rat glioblastoma C6 cells and increased sensitivity to IFN-gamma and taxol for apoptosis. (musc.edu)

Induction of apoptosis and immune response by all-trans retinoic acid plus interferon-gamma in human malignant glioblastoma T98G and U87MG cells. (musc.edu)

CD4+CD8+ cells exhibited phenotypic characteristics of activated memory T lymphocytes. (pasteur.fr)

The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. (rush.edu)

There was no difference in cell killing activity between the control and previously activated cells. (nih.gov)
RESULTS: We demonstrate CD8+ tissue resident memory T (TRM) cells are the dominant activated T cell subset in ICI-colitis. (ox.ac.uk)
Single-cell RNA sequencing analysis confirms activated CD8+ TRM cells express high levels of transcripts for checkpoint inhibitors and interferon-gamma in ICI-colitis. (ox.ac.uk)
In addition, experiments with T. gondii-specific IL-10(+)IFN-gamma(+) CD4 clones revealed that although IFN-gamma expression is imprinted and triggered with similar kinetics regardless of the state of Th1 cell activation, IL-10 secretion is induced more rapidly from recently activated than from resting cells. (indexindex.com)

NK cells also produce interferon gamma to signal other immune cells. (nih.gov)
The previously activated NK cells didn't spontaneously produce more interferon gamma than control NK cells. (nih.gov)

However, when isolated cells were activated in the lab, the previously activated NK cells produced significantly more interferon gamma than the control cells. (nih.gov)

It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. (rush.edu)

Mammalian phosphatidylinositol-specific phospholipase C (PI-PLC) (see IPR000909 ) isoforms gamma and delta. (embl.de)

In the case of chronic inflammation, the cellular residues present after tissue destruction activate TLR7 in Th1 cells. (asianage.com)

Estrogen partially down-regulates PTEN to prevent apoptosis in VSC4.1 motoneurons following exposure to IFN-gamma. (musc.edu)

Following a series of reactions, the destroyed tissue activates previously unknown signals in Th1 cells, causing them to die. (asianage.com)
Interferon-Gamma-Producing CD8+ Tissue Resident Memory T Cells Are a Targetable Hallmark of Immune Checkpoint Inhibitor-Colitis. (ox.ac.uk)

Relapsing neurologic Whipple's disease (marked by bouts of worsening of symptoms) is sometimes treated with a combination of antibiotics and weekly injections of interferon gamma, a substance made by the body that activates the immune system. (nih.gov)

We reviewed the most important recent studios on relationship between IFN-gamma and chronic course of hepatitis C. (nih.gov)

Unexpectedly, IFN-gamma-secreting T-bet(+)Foxp3(-) T helper type 1 (Th1) cells were found to be the major producers of IL-10 in these animals. (indexindex.com)
The antigenic epitopes are present on the surface of APC with the assistance of the helper of T cells, which then activate B cells. (microbenotes.com)

PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. (embl.de)

Anatomy35

Organisms24

Diseases14

Chemicals and Drugs111

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes49

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Health Care2

Cytokines7

Pathway4

Receptor4

Protein4

Induce2

Macrophage3

Receptors3

Ligands1

Antiviral4

Proteins1

Lymph nodes1

Cells13

Sequences1

Molecules1

Immune response1

Production2

Omega2

Alpha1

Treatment1

Role1

Specific2

Domains1

Macrophages10

Tumor2

Interleukin4

Recombinant inter2

Lymphokines1

Dendritic cells1

Neutrophils4

Monocytes2

Intracellular1

Pathways5

Cultured murine1

Pathogens2

Lymphocyte3

Immune responses3

Cytokine1

Inflammatory1

Gene1

Secrete1

STAT33

Vitro2

Usually activated1

Assay1

Potent1

Endothelial1

Antitumor1

Differentiation2

Malignant1

Phenotypic1

Lymphocytes1

Cell4

Produce2

Significantly1

Activity1

Phospholipase1

Cellular1

Exposure1

Tissue2

Combination1

Chronic1

Helper2

Found1