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  • turn
  • Thus, cytosolic calcium-ion concentration determines the number of troponin sites occupied by calcium, which in turn determines the number of actin sites available for cross-bridge binding. (blogspot.com)
  • length
  • Tropomyosin is a rod-shaped molecule composed of two intertwined polypeptides with a length approximately equal to that of seven actin molecules. (blogspot.com)
  • cells
  • Examination of the α-actinin localisation pattern revealed that the basal actin fibres of the main body follicle cells underwent an organised remodelling during the final stages of oogenesis. (helsinki.fi)
  • p16(INK4a ) expression in MCF7 breast cancer cells leads to increased cell size, weakened intercellular adhesion and cortical re-distribution of cytoskeletal F-actin . (antikoerper-online.de)
  • Regulation
  • Force transmission to the extracellular matrix depends on several parameters including the regulation of actin dynamics in adhesion structures, the contractility of stress fibers, and the mechanosensitive response of adhesion structures. (hindawi.com)
  • 1) The mechanism by which actin assembly is initiated in nascent adhesions, (2) the mechanosensitive maturation of FAs, (3) the molecular mechanisms underlying the formation of stress fibers, and (4) the regulation of actin assembly in focal adhesions. (hindawi.com)
  • genes
  • Skeletal actin itself, when expressed, causes expression of several other "myogenic genes", which are essential to muscle formation. (wikipedia.org)
  • To determine whether actA itself, plcB or other co-transcribed downstream regions are involved in actin assembly, mutations in the appropriate genes were generated. (wikipedia.org)
  • Biochemistry
  • Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. (innovations-report.com)
  • molecular
  • But actin is different because it absolutely requires the molecular folding help of TRiC. (innovations-report.com)
  • It seems like this molecular trade-off made the versatility of actin possible", comments Balchin. (innovations-report.com)
  • Here we highlight recent findings on the molecular mechanisms by which actin assembly is regulated in adhesion structures and the molecular basis of the mechanosensitivity of focal adhesions. (hindawi.com)
  • Dynamics
  • Hsp27 has been implicated in numerous physiological and pathological processes that involve its interaction with actin and its control of actin dynamics [ 11 - 25 ]. (hindawi.com)
  • The migratory cycle is a complex process in which actin dynamics play a central role at every step. (hindawi.com)
  • cortical
  • Cell surface (cortical) actin remodeling is a cyclic (9-step) process where each step is directly responsive to a cell signaling mechanism. (wikipedia.org)
  • Interaction
  • The fluorescence of acrylodan attached to Hsp27 increased 4-5-fold upon interaction with F-actin. (hindawi.com)
  • An early study of the Hsp25 (murine and avian isoform of Hsp27)-actin interaction concluded that Hsp25 was an actin filament barbed-end-capping protein based on limited evidence [ 26 ]. (hindawi.com)
  • In order to address some of these issues we have investigated the interaction between Hsp27 and actin, in vitro , using fluorescence probes attached to Hsp27. (hindawi.com)
  • isoforms
  • In vertebrates, three main groups of actin isoforms , alpha , beta , and gamma have been identified. (wow.com)
  • membrane protrusions
  • Actin assembly drives the extension of flat membrane protrusions called lamellipodia and finger-like protrusions called filopodia to push the membrane. (hindawi.com)
  • Actin-propelled invasive membrane protrusions promote fusogenic protein engagement during cell-cell fusion. (nih.gov)
  • Synapse
  • Additionally, actin is present at the active zone and plays a role in moving vesicles to the active zone for exocytosis into the synapse. (wikipedia.org)
  • polymers
  • The elongation phase begins when the concentration of short, F-actin polymers is significantly larger than at equilibrium. (wikipedia.org)
  • ActA
  • Actin therefore only became well known in the West in 1945, when their paper was published as a supplement to the Acta Physiologica Scandinavica. (wikipedia.org)
  • The Actin assembly-inducing protein (ActA) is a protein encoded and used by Listeria monocytogenes to propel itself through a mammalian host cell. (wikipedia.org)
  • All mutants except the actA mutants were similar to wild-type concerning association with F-actin and cell-cell spreading. (wikipedia.org)
  • structures
  • Left, scheme of a migrating cell displaying characteristic actin structures: lamellipodial and filopodial actin networks and the three classes of stress fibers (transverse arcs, dorsal stress fibers, ventral stress fibers). (hindawi.com)
  • Arp2
  • NPFs in the mammalian cell recruit and bind to the already existing actin-related-protein 2 and 3 complex (Arp2/3 complex) and induce an activating conformational change of the Arp2/3 complex. (wikipedia.org)
  • synaptic
  • F-actin can be found in the presynaptic bouton surrounding synaptic vesicle clusters and acting as scaffolding. (wikipedia.org)
  • Assembly
  • Actin filament assembly generates the force that pushes the bacterium in the mammalian host cytoplasm forward. (wikipedia.org)