• protein
  • Higher amounts of the actin filament-severing protein cofilin associated with TrkA isolated from neurons treated with NGF compared with that from neurons treated with NT3. (sciencemag.org)
  • Each tropomyosin molecule is held in this blocking position by troponin, a smaller, globular protein that is bound to both tropomyosin and actin. (blogspot.com)
  • The diaphanous proteins are members of the ubiquitous formin protein family that can physically link the actin filament system with the Rho GTPases. (biologists.org)
  • sites
  • The results illustrate the necessity of considering additional or alternative sites to F-actin to account for the observed binding of aldolase to the thin filaments of skeletal muscle. (biochemj.org)
  • One molecule of troponin binds to each molecule of tropomyosin and regulates the access to myosin-binding sites on the seven actin molecules in contact with tropomyosin. (blogspot.com)
  • Thus, cytosolic calcium-ion concentration determines the number of troponin sites occupied by calcium, which in turn determines the number of actin sites available for cross-bridge binding. (blogspot.com)
  • cells
  • Recently, we characterized several profilin isoforms from maize pollen for their ability to alter cytoarchitecture when microinjected into living plant cells and for their association with poly-L-proline and monomeric actin from maize pollen. (mysciencework.com)
  • When ZmPRO4 was microinjected into plant cells, the effect on actin-dependent nuclear position was significantly more rapid than that of another pollen profilin isoform, ZmPRO1. (mysciencework.com)
  • In this study, we demonstrate that profilin isoforms expressed in a single cell can have different effects on actin in living cells and that the poly-L-proline binding function of profilin may have important consequences for the regulation of actin cytoskeletal dynamics in plant cells. (mysciencework.com)
  • effect
  • Retrograde transport of TrkA endosomes was impaired in NGF-treated neurons expressing an shRNA directed against cofilin, an effect that was largely rescued by application of the actin-depolymerizing agent latrunculin A. More of the GTPase Rac1, which can enhance activation of cofilin, was activated and associated with TrkA endosomes in neurons treated with NGF compared with those treated with NT3. (sciencemag.org)