• structure
  • Characterization of the molecular modulators that govern the formation of the different types of F-actin structure is an area of intense research. (biologists.org)
  • Actin is a dynamic structure that can adapt two states of flexibility, with the greatest difference between the states occurring as a result of movement within sub-domain 2. (wikipedia.org)
  • dynamic
  • These dynamic F-actin structures can be found in migrating cells, spreading cells and growth cones of advancing neurons. (biologists.org)
  • complex
  • The exact mechanism mediating the final scission of the intercellular bridge connecting the dividing cells is not fully understood, but requires the local constriction of endosomal sorting complex required for transport (ESCRT)-III-dependent helices, as well as remodelling of lipids and the cytoskeleton at the site of abscission. (actindynamics.net)
  • found
  • Additionally, protein tyrosine kinases, found only in multicellular eukaryotes, provide links between extracellular signals and F-actin-dependent cellular processes. (biologists.org)
  • site
  • While the microtubules of the intercellular bridge are cut by the ESCRT-associated enzyme Spastin, the mechanism that clears F-actin at the abscission site is unknown. (actindynamics.net)
  • role
  • We will also discuss the recently reported role of MICAL1 in controlling F-actin clearance in the ESCRT-III-mediated step of cytokinetic abscission. (actindynamics.net)
  • formation
  • Thus, the diverse array of stimuli that individually stimulate chemotaxis, cell spreading and neurite extension promote the formation of similar F-actin structures. (biologists.org)
  • Skeletal actin itself, when expressed, causes expression of several other "myogenic genes", which are essential to muscle formation. (wikipedia.org)