AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsHealth Care
AdenomaPituitary NeoplasmsPituitary GlandGrowth Hormone-Secreting Pituitary AdenomaProlactinomaACTH-Secreting Pituitary AdenomaAdenoma, ChromophobePituitary Gland, AnteriorPituitary ApoplexyPituitary HormonesSphenoid BoneAcromegalyPituitary DiseasesSella TurcicaPituitary ACTH HypersecretionAdenoma, AcidophilProlactinAdrenocorticotropic HormoneHuman Growth HormoneSphenoid SinusGrowth HormoneCushing SyndromeHypopituitarismAdenoma, PleomorphicPituitary Hormones, AnteriorAdenoma, VillousACTH Syndrome, EctopicOctreotideCraniopharyngiomaThyrotropinAdenoma, BasophilNelson SyndromeReceptors, SomatostatinBromocriptineSomatotrophsEmpty Sella SyndromePituitary Function TestsHydrocortisoneAdrenocortical AdenomaPituitary Adenylate Cyclase-Activating PolypeptideImmunohistochemistryCavernous SinusSomatostatinMagnetic Resonance ImagingHypophysectomyThyrotropin-Releasing HormonePituitary Gland, PosteriorAdenoma, Liver CellMultiple Endocrine Neoplasia Type 1Growth Hormone-Releasing HormoneEndocrine Gland NeoplasmsCorticotrophsLuteinizing HormoneCorticotropin-Releasing HormoneHMGA2 ProteinNeurosurgical ProceduresSecurinFollicle Stimulating HormoneMultiple Endocrine NeoplasiaGlycoprotein Hormones, alpha SubunitHyperprolactinemiaThyrotrophsPro-OpiomelanocortinGanglioneuromaGonadotropins, PituitaryGigantismHypothalamo-Hypophyseal SystemNeoplasms, Multiple PrimaryGonadotropinsRadiosurgeryRNA, MessengerCentral Nervous System CystsAdrenal GlandsColorectal NeoplasmsPneumoencephalographyPituitary-Adrenal SystemTranscription Factor Pit-1Gonadotropin-Releasing HormoneColonic PolypsHormonesAdrenal InsufficiencyKi-67 AntigenReceptors, Pituitary HormoneCerebrospinal Fluid RhinorrheaAdrenal Cortex NeoplasmsNeuroendoscopyChoristomaChromograninsDopamine AgonistsReceptors, Pituitary Hormone-Regulating HormoneHyperplasiaAdrenal CortexColonoscopyAdenomatous PolypsMeningiomaReverse Transcriptase Polymerase Chain ReactionEndocrine Surgical ProceduresDiabetes InsipidusErgolinesPituitary Hormone-Releasing Hormones
AdrenocorticotropicSecretionTumorGlandHypersecretionCarcinomaBenignCushingNeoplasmsHypothalamusMicroadenomasHormonesFamilial isolated pituitary adenomaStalkCarcinomasNeuroendocrineBilateralThyroid-stimulaEctopic ACTH secretHormoneLesionsProlactinomasEndocrineMacroadenomaPatientsHypercortisolismPlasma ACTH levelsResectionDiagnosis of pituitaryCorticotropinCushing's DiseaseFollicular AdenomaSuppressing ACTH productionApoplexySellaPathogenesisBronchial carcinoidsClinicallySyndromeCorticotroph cellsLevels of cortisolHypothalamicOccult
Adrenocorticotropic14
Secretion12
  • Endogenous Cushing's syndrome can be defined as a condition resulting from prolonged and inappropriate exposure to excessive amounts of cortisol, partial loss of the normal counter-regulation of the hypothalamic-pituitary-adrenal axis and loss of circadian rhythm in cortisol secretion ( 1 1. (scielo.br)
  • Other less common etiologies of endogenous Cushing's syndrome include ectopic ACTH secretion (EAS ~10%), adrenal adenomas and carcinomas and, more rarely, adrenal primary macronodular adrenal hyperplasia (PMAH) or primary pigmented nodular adrenal disease (PPNAD) ( Table 1 ). (scielo.br)
  • In some individuals, the cause of Cushing syndrome is surplus cortisol secretion that does not depend on stimulation from ACTH and is associated with disorders of the adrenal glands. (apollohospitals.com)
  • BMP-4 treatment of AtT-20 mouse corticotrophinoma cells has an inhibitory effect on ACTH secretion and cell proliferation. (unisr.it)
  • Decreases CRH, ACTH, and cortisol secretion. (dailymeded.com)
  • 5,6 In functional adenoma, the presentations depend on the hormone over secretion. (researchsquare.com)
  • Prolactin secretion in the BCX 1470 normal pituitary is tonically inhibited by hypothalamic dopamine through dopamine D2 receptors (Drd2) expressed on lactotroph cell membranes (Ben Jonathan & Hnasko 2001). (cell-metabolism.com)
  • Normally, cortisol and ACTH both act in a negative feedback loop to inhibit excessive secretion of CRH. (pediagenosis.com)
  • Hyperpigmentation of the skin is seen only in patients with an abnormally elevated ACTH secretion. (pediagenosis.com)
  • The most common cause of hypopituitary or hyperpituitary secretion is a pituitary or hypothalamic tumor. (msdmanuals.com)
  • ACTH maintains the adrenal gland size, structure, and function and induces adrenal steroid production and secretion. (medscape.com)
  • ACTH secretion is regulated by the hypothalamus through CRH and vasopressin, by some paracrine factor, and by negative feedback of the glucocorticoids. (medscape.com)
Tumor29
  • Pituitary tumorigenesis is driven by germline and somatic mutations as well as genetic and epigenetic mechanisms, interacting in complex ways still not entirely understood and influencing tumor formation, growth, and invasion. (medscape.com)
  • Pituicytoma, granular cell tumor of the neurohypophysis, and spindle cell oncocytoma are nonneuroendocrine tumors arising in the posterior pituitary and occur much less frequently than pituitary adenomas. (medscape.com)
  • Although there is no formal consensus on what defines NS, corticotroph tumor growth and/or gradually increasing ACTH levels are important diagnostic elements. (nih.gov)
  • Patients found with pituitary incidentalomas can be susceptible to several types of adverse outcomes: hormonal hypersecretion, hypopituitarism, neurologic morbidity due to tumor size, and malignancy in rare cases. (the-hospitalist.org)
  • What is a pituitary tumor? (mayfieldclinic.com)
  • A tumor that grows from the pituitary gland is called an adenoma. (mayfieldclinic.com)
  • The most common pituitary tumor, a prolactinoma, causes an overproduction of the hormone that helps control sexual function. (mayfieldclinic.com)
  • Silent corticotroph adenoma with multiple cysts: Pars intermedia tumor? (elsevierpure.com)
  • Dive into the research topics of 'Silent corticotroph adenoma with multiple cysts: Pars intermedia tumor? (elsevierpure.com)
  • Unexpectedly, the definite postoperative histopathological diagnosis of the removed tumor was pituicytoma and not pituitary adenoma. (eurospe.org)
  • The tumor cells were not stained for prolactin, growth hormone and ACTH. (medassocthai.org)
  • A pituitary adenoma is generally a benign, slow growing tumor that occurs in the pituitary gland. (doctorlawyergroup.com)
  • Based on whether the pituitary adenoma is a hormone-producing or hormone-inactive tumor, the patient will present with different symptoms. (doctorlawyergroup.com)
  • The pituitary adenoma can bleed internally causing a sudden increase in size or the tumor can outgrow its blood supply and the dead tissue will swell. (doctorlawyergroup.com)
  • Optometrists and ophthalmologists should seriously consider the possibility of a pituitary tumor when the patient presents with an unexplained loss of visual field (especially peripheral vision), double vision, or blurred vision as the growth of a pituitary tumor can cause compression on the visual pathway (retina, optic nerve, etc). (doctorlawyergroup.com)
  • Treatment for pituitary adenomas depends on the presence of hormone production, size of the tumor, invasion of the tumor into surrounding structures, and the age and health of the patient. (doctorlawyergroup.com)
  • For example, bromocriptine and cabergoline are used to treat tumors secreting prolactin because these medications decrease prolactin levels and tumor size. (doctorlawyergroup.com)
  • Pituitary adenomas that require surgery are usually minimally invasive techniques, where the tumor is removed through the nose. (doctorlawyergroup.com)
  • Cushing's disease refers to a pituitary-dependent cause of Cushing's syndrome: a tumor (adenoma) in the pituitary gland produces large amounts of ACTH, causing the adrenal glands to produce elevated levels of cortisol. (dailymeded.com)
  • 9 Horsley performed first operation for PAs using transcranial approach, 10 and by 1907, Schloffer was the first to resect pituitary tumor with nasal transsphenoidal approach. (researchsquare.com)
  • Despite their benign features pituitary tumors can cause considerably morbidity due to both hypersecretion of pituitary trophic hormones and excessive tumor growth that can affect surrounding tissue. (cell-metabolism.com)
  • Prolactinoma treatment The major goals of treatment in patients with prolactinomas are to normalize serum PRL levels to restore gonadal function to reduce tumor size and to preserve or improve residual pituitary function. (cell-metabolism.com)
  • Excessive ACTH may also be produced from ectopic ACTH-producing tumors, most frequently broncho- genic small cell tumor. (pediagenosis.com)
  • The tumor was removed via transsphenoidal endoscopy - a minimally invasive surgery that removes tumors in the pituitary region through the nose. (cushingsdiseasenews.com)
  • Based on the patient's medical history, clinical and laboratory symptoms, and the characteristics of the tumor cells, she was diagnosed with ectopic ACTH-producing pituitary adenoma (EAPA). (cushingsdiseasenews.com)
  • Here, we report the case of a fatal pituitary carcinoma evolving within two years from an adrenocorticotrophic hormone (ACTH)-secreting macroadenoma and review the global literature regarding this rare neuroendocrine tumor. (biomedcentral.com)
  • These results are presented with a review of the relevant literature on the differential characteristics of FRT versus SRS in the treatment of functional and non-functional pituitary adenomas and validate postoperative irradiation as a potentially safe and effective means for tumor control. (elsevierpure.com)
  • Familial isolated pituitary adenoma (FIPA) is an inherited condition characterized by development of a noncancerous tumor in the pituitary gland (called a pituitary adenoma). (medlineplus.gov)
  • These changes likely impair the ability of the AIP protein to control the growth and division of cells, allowing pituitary cells to grow and divide unchecked and form a tumor. (medlineplus.gov)
Gland37
Hypersecretion1
  • Introduction: Cushing s syndrome results from increased or aberrant expression of ACTH, CHR, or neuroendocrine receptors that leads to uncontrolled hypersecretion of cortisol. (endocrine-abstracts.org)
Carcinoma6
  • Case report: ACTH-secreting pituitary carcinoma metastatic to the liver in a patient with a history of atypical pituitary adenoma and Cushing's disease. (uams.edu)
  • In this report, we present the case of effective TMZ treatment in a 42-year-old man with ACTH-secreting carcinoma. (eur.nl)
  • In younger children, CS may be caused by ACTH-independent cortisol producing adrenocortical lesions including adrenal adenoma, adrenal carcinoma or adrenal hyperplasia (diffuse or multinodular). (austinpublishinggroup.com)
  • Cortisol excess may also be seen in primary adrenal disease caused by benign bilateral adrenal hyperplasia, a cortisol-secreting adenoma, or, less likely, a carcinoma. (pediagenosis.com)
  • The latency period between initial presentation of a pituitary adenoma and the development of distal metastases marking carcinoma is extremely variable, and some patients may live well over 10 years with pituitary carcinoma. (biomedcentral.com)
  • We describe a patient with an ACTH-producing carcinoma of the pituitary with refractory Cushing's disease and hepatic metastases. (biomedcentral.com)
Benign1
Cushing10
  • A pituitary adenoma which secretes ADRENOCORTICOTROPIN, leading to CUSHING DISEASE. (uams.edu)
  • Introduction: This study evaluates the diagnostic accuracy of clinical features and first line routine screening tests to differentiate ACTH-ectopic syndrome from Cushing s disease (CD).Materials and methods: The retrospective clinical and biochemical presentations of 180 patients with histologically proven ACTH-dependent Cushing s syndrome (CS) (159 CD, 21 ACTH-ectopic syndrome) were compared according to the cause of hypercortisolism. (endocrine-abstracts.org)
  • There are rare reports of patients with a meningioma secreting CRH presenting paraneoplasic Cushing s syndrome. (endocrine-abstracts.org)
  • Medication is also required when the patient has Cushing syndrome due to ectopic corticotropin (ACTH) and the primary source cannot be found or when surgery has not cured the hypercortisolism. (medscape.com)
  • Seldom, when a tumour develops in an organ that generally does not produce ACTH, the tumour will begin to secrete this hormone in excess, resulting in Cushing syndrome. (apollohospitals.com)
  • Coincidence of pituicytoma and pituitary-dependent Cushing s disease was only reported in an adult man. (eurospe.org)
  • On the other hand, the term "Cushing Disease (CD)" describes hypercortisolism due to an ACTH-secreting pituitary adenoma and is the most common cause of endogenous CS. (austinpublishinggroup.com)
  • Hypercortisolism due to ACTH excessive production causes Cushing syndrome, manifested by weight gain, redistribution of fat resulting in centripetal obesity, diabetes mellitus, hypertension, and mood disorders. (researchsquare.com)
  • Pituitary-dependent disease should be considered in the differential diagnosis of Cushing syndrome in CNC patients. (kl.ac.at)
  • He discovered the connection between the pituitary and adrenal glands, leading to the understanding of the eponymous Cushing syndrome and Cushing disease. (medscape.com)
Neoplasms1
  • Pituitary carcinomas are extremely rare neoplasms, representing only 0.1% to 0.2% of all pituitary tumors. (biomedcentral.com)
Hypothalamus4
  • Additionally, up to 41% of patients with macroadenomas were found to have varying degrees of hypopituitarism due to compression of the hypothalamus, the hypothalamic-pituitary stalk, or the pituitary itself. (the-hospitalist.org)
  • The hypothalamus then regulates pituitary hormone levels, depending on the needs of the body. (mayfieldclinic.com)
  • Ovarian insufficiency is considered primary if the ovary fails to function normally in response to appropriate gonadotropin stimulation provided by the hypothalamus and pituitary. (medscape.com)
  • Ovarian insufficiency is considered secondary if the hypothalamus and pituitary fail to provide appropriate gonadotropin stimulation. (medscape.com)
Microadenomas5
  • See also Pituitary Tumors , Pituitary Macroadenomas , Pituitary Microadenomas , Pituitary Apoplexy , and Pituitary Disease and Pregnancy . (medscape.com)
  • Autopsy studies have revealed a prevalence ranging from 1.5% to 26.7% for adenomas less than 10 mm, considered to be microadenomas. (the-hospitalist.org)
  • Based on size, pituitary tumors may be classified as microadenomas (less than 10mm) or macroadenomas (larger than 10mm). (mayfieldclinic.com)
  • It can affect individuals at any age, but it is most prevalent in the second and third decades of life and is mostly (~80-90%) caused by pituitary tumors with a diameter less than 10 mm (microadenomas) ( 5 5. (scielo.br)
  • Based on their size pituitary adenomas are classified as microadenomas ( 10mm) or giant adenomas (>40mm). (cell-metabolism.com)
Hormones5
  • This paper deals with the problem of CD prognostic factors after neurosurgery.Design: ACTH and cortisol blood levels, free cortisol in daily urine, MRI, histology (hemotaxiline eosine staining) and immunohistochemistry (with antibodies to the pituitary tropic hormones, Ki-67, CD31 and VEGF) of th. (endocrine-abstracts.org)
  • Functioning pituitary tumors secrete high levels of hormones and interfere with other body organs. (mayfieldclinic.com)
  • Nonfunctioning pituitary tumors do not secrete hormones. (mayfieldclinic.com)
  • The adrenal glands are an integral part of the endocrine system, secreting hormones that act throughout the body to regulate functions and promote homeostasis. (ashp.org)
  • The inner medulla is responsible for secreting the hormones epinephrine and norepinephrine (also known as adrenaline and noradrenaline, respectively). (ashp.org)
Familial isolated pituitary adenoma1
Stalk2
  • Craniopharyngiomas typically grow from the pituitary stalk upward into the third ventricle and cause symptoms similar to pituitary adenomas. (mayfieldclinic.com)
  • Other possible presentations relating to compression of brain structures include visual loss, headache, the "stalk effect", and pituitary apoplexy. (doctorlawyergroup.com)
Carcinomas5
  • In this section the general characteristics of pituitary adenomas are discussed, followed by separate sections on subtypes of pituitary adenomas, pituitary neuroendocrine tumors grading, and pituitary carcinomas. (medscape.com)
  • Temozolomide (TMZ) is an alkylating chemotherapeutic agent that has recently been used in some cases as a new therapeutic tool for pituitary carcinomas and aggressive pituitary adenomas. (eur.nl)
  • Pituitary carcinomas are rare neuroendocrine tumors affecting the adenohypophysis. (biomedcentral.com)
  • Like adenomas, the vast majority of reported pituitary carcinomas are endocrinologically active (88%), with most secreting adrenocorticotrophic hormone (ACTH) or prolactin (PRL)[ 3 ]. (biomedcentral.com)
  • Less commonly, pituitary carcinomas may metastasize hematogenously - a prominent feature of ACTH-producing carcinomas - resulting in metastatic invasion of the liver, bone, ovaries, heart, and lung. (biomedcentral.com)
Neuroendocrine2
  • Pituitary adenomas are neuroendocrine tumors derived from intrinsic cells of the adenohypophysis. (medscape.com)
  • This chapter summarizes the most recent data on the use of the somatostatin analogues (SSAs), octreotide (OCT) and lanreotide for the treatment of patients with pituitary and neuroendocrine tumors (NETs). (aianmodena.org)
Bilateral2
Thyroid-stimula2
  • We present a 49 year old male patient with thyroid stimulating hormone (TSH) producing pituitary macroadenoma. (medassocthai.org)
  • Thus somatotropinomas secrete growth hormone (GH) prolactinomas secrete prolactin (PRL) thyrotropinomas secrete thyroid-stimulating hormone (TSH) and corticotropinomas secrete adrenocorticotropin hormone (ACTH). (cell-metabolism.com)
Ectopic ACTH secret1
  • Alternatively, the glucocorticoid excess may be due to adrenal neoplasia or to ectopic ACTH secreting tumors. (endocrine-abstracts.org)
Hormone7
  • Assessment of NFPA proliferative index and adrenocorticotrophic hormone staining to identify silent corticotroph adenomas are recommended for providing guidance on the risk of adenoma progression and the benefit of earlier adjuvant radiation. (guidelinecentral.com)
  • Magnetic resonance imaging (MRI) of the pituitary, the corticotropin-releasing hormone (CRH) test and the high-dose dexamethasone suppression test are the main tests for the differential diagnosis of ACTH-dependent Cushing's syndrome. (scielo.br)
  • The three most common hormone-producing adenomas are Prolactinomas, Growth hormone-secreting pituitary adenoma, and ACTH-secreting pituitary adenoma. (doctorlawyergroup.com)
  • Corticotropin-releasing hormone (CRH) is the main hypothalamic regulator of pituitary ACTH production. (pediagenosis.com)
  • POMC is modified by various enzymes to produce ACTH, β -lipotropin, and melanocyte-stimulating hormone (MSH). (pediagenosis.com)
  • These patients, who have a disease form called Cushing's disease , have tumors that produce the ACTH hormone in excess, which then stimulates the adrenal glands, sitting atop the kidneys, to produce and release cortisol into the bloodstream. (cushingsdiseasenews.com)
  • For GKSRS, the median dosage was 16 Gy for non-functional adenomas and 23 Gy for hormone-secreting tumors. (elsevierpure.com)
Lesions3
  • 1 Three commonly discovered lesions by hospitalists are pituitary, thyroid, and adrenal incidentalomas. (the-hospitalist.org)
  • Broad categories of etiologies should be considered: pituitary adenoma, nonpituitary tumors, vascular lesions, infiltrative disorders, and others (see Table 2). (the-hospitalist.org)
  • preschool children mostly present with adrenocortical lesions, whereas the cause of hypercortisolism in older children is usually a corticotropin (ACTH) secreting pituitary adenoma. (austinpublishinggroup.com)
Prolactinomas3
  • Prolactinomas are the most frequently observed pituitary adenomas and most of them respond well to conventional treatment with dopamine agonists. (cell-metabolism.com)
  • Prolactinomas Among functioning pituitary tumors prolactinomas are the most frequently observed in the clinic (40%) (Ciccarelli 2005). (cell-metabolism.com)
  • Eight of 25 (32%) prolactinomas and 3 of 11 (27%) GH-adenomas had an H-score greater than 20, while no differences were seen for the other types. (bvsalud.org)
Endocrine5
  • Recently, the Endocrine Society released consensus recommendations to guide the evaluation and treatment of pituitary incidentalomas, which are included in the approach outlined below. (the-hospitalist.org)
  • It is characterized by tumors envolving the parathyroid glands, the endocrine pancreas and the pituitary. (endocrine-abstracts.org)
  • Pituitary adenomas can be diagnosed based on endocrine function testing, imaging, and visual field testing. (doctorlawyergroup.com)
  • Генералізований гіпопітуїтаризм Generalized hypopituitarism refers to endocrine deficiency syndromes due to partial or complete loss of anterior lobe pituitary function. (msdmanuals.com)
  • These novel data highlight the expression of an immune checkpoint such as CTLA4 on pituitary endocrine cells, a finding that could be exploited for therapeutical applications. (bvsalud.org)
Macroadenoma1
Patients12
  • [ 2 ] Incidental adenomas can be found in nearly 10% of autopsied patients. (medscape.com)
  • Before the operation all patients have high F, ACTH, negative LDDST and posi. (endocrine-abstracts.org)
  • ISTURISA (osilodrostat) is a cortisol synthesis inhibitor indicated for the treatment of adult patients with Cushing's disease for whom pituitary surgery is not an option or has not been curative. (businesswire.com)
  • In this study, we report that bone morphogenetic protein-4 (BMP-4) is expressed in the corticotrophs of human normal adenohypophysis and its expression is reduced in corticotrophinomas obtained from Cushing's patients compared with the normal pituitary. (unisr.it)
  • Regardless of the adenoma's location, most patients will require steroid replacement postoperatively at least in the interim as long-term suppression of pituitary ACTH and normal adrenal tissue does not recover immediately. (dailymeded.com)
  • Patients with pituitary tumors who received transsphenoidal surgery during 2019 - 2021 were included. (researchsquare.com)
  • CONCLUSION: PRKAR1A loss-of-function mutations can rarely lead to ACTH-secreting pituitary adenomas in CNC patients. (kl.ac.at)
  • Loss-of-heterozygosity analysis of the pituitary tumour revealed loss of the wild-type copy of PRKAR1A, suggesting a role of this gene in the pituitary adenoma development.CONCLUSION: PRKAR1A loss-of-function mutations can rarely lead to ACTH-secreting pituitary adenomas in CNC patients. (kl.ac.at)
  • The program will review the importance of comorbidities and symptoms management in patients with hypercortisolemia due to an ACTH-secreting pituitary adenoma. (endocrine.org)
  • This analogue will be available to treat patients with ACTH-secreting adenomas in a short time. (aianmodena.org)
  • Pituitary function in patients with empty sella syndrome is frequently normal. (msdmanuals.com)
  • We report a single center experience with 33 patients with non-functional (16 patients), ACTH- (five patients), GH- (four patients), or prolactin-secreting (eight patients) tumors treated with FRT or SRS. (elsevierpure.com)
Hypercortisolism1
  • Less than 1% phaeochromocytoma accompanied by symptoms of ACTH-dependent hypercortisolism. (endocrine-abstracts.org)
Plasma ACTH levels2
  • In these cases, plasma ACTH levels are reduced to near zero, due to the effect of the negative feedback loop on the HPA axis. (pediagenosis.com)
  • Physiologic variations of plasma ACTH levels occur in response to physical stress (eg, hypoglycemia), diurnal variation (eg, highest in morning and lowest in late evening), and feedback inhibition from cortisol (see below). (medscape.com)
Resection3
  • Following pituitary adenoma resection or unilateral adrenalectomy, mineralocorticoid replacement is not usually required. (medscape.com)
  • Transsphenoidal surgery with an operative microscope was a standard procedure for pituitary adenomas resection in our institution. (researchsquare.com)
  • Fractionated radiotherapy (FRT) and gamma knife stereotactic radiosurgery (GKSRS) are used as adjuvant therapies to surgical resection for functional and non-functional pituitary adenomas, although their optimum role in the treatment algorithm, as well as long-term safety and efficacy, still awaits further study. (elsevierpure.com)
Diagnosis of pituitary1
Corticotropin1
  • The most common cause of CS is exogenous administration of glucocorticoids or corticotropin (ACTH). (austinpublishinggroup.com)
Cushing's Disease6
  • In this product theater, Dr. Kevin Yuen from the Barrow Neurological Institute and Pituitary Center will review the pathogenesis and treatment of Cushing's Disease within the context of a patient case. (businesswire.com)
  • Cushing's disease (CD) is a rare clinical condition that is due to ACTH-producing pituitary adenoma, and it is the most common etiology of endogenous Cushing's syndrome after 6 yrs of age (~70%) ( 2 2. (scielo.br)
  • Outcomes of therapy for Cushing's disease due to adrenocorticotropin-secreting pituitary macroadenomas. (scielo.br)
  • This series of live educational events is designed for regional experts in pituitary care to present live, in-person using interactive case-based discussion which will benefit clinicians to better manage and monitor response to treatment of Cushing's Disease. (endocrine.org)
  • Cushing's disease should be used in cases of anterior pituitary ACTH-secreting tumors. (pediagenosis.com)
  • This form of Cushing's syndrome can be very difficult to differentiate from Cushing's disease in the early stages of each, and the clinician needs to be aware of the various pathophysiological mechanisms involved in excessive ACTH production. (pediagenosis.com)
Follicular Adenoma1
  • METHODS: In our study, immunohistochemical staining was used to explore the expression of Cyclin D1 and P21 in PTC, paracancerous tissue, follicular adenoma (FA) and papillary thyroid hyperplasia. (bvsalud.org)
Suppressing ACTH production1
  • Dexamethasone is a medication that normally lowers cortisol levels by suppressing ACTH production. (cushingsdiseasenews.com)
Apoplexy1
Sella2
Pathogenesis1
  • The molecular mechanisms governing the pathogenesis of ACTH-secreting pituitary adenomas are still obscure. (unisr.it)
Bronchial carcinoids1
  • It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. (utsouthwestern.edu)
Clinically2
  • [ 3 ] Pituitary adenomas are uncommon in the pediatric population, but most tumors of childhood are clinically functioning adenomas and are thought to be more aggressive. (medscape.com)
  • 2009 Fernandez 2010) and studies of autopsy specimens identified up to a 20% prevalence of clinically occult pituitary adenomas (Ezzat 2004). (cell-metabolism.com)
Syndrome2
  • Phaeochromocytomas are responsible for the development ACTH-ectopic syndrome in 5% cases. (endocrine-abstracts.org)
  • Now, a team of researchers in China described the case of a woman who developed a very rare case of Cushing's syndrome associated with an ectopic ACTH-secreting pituitary adenoma located in the clivus region, a bone at the base of the skull, close to the spine. (cushingsdiseasenews.com)
Corticotroph cells1
  • CRH acts on the corticotroph cells of the anterior pituitary, causing them to secrete pro-opiomelanocortin (POMC), which is posttranslationally modified into ACTH. (pediagenosis.com)
Levels of cortisol1
  • Cancerous and non-cancerous tumors, especially lung tumors, can secrete ACTH, triggering high levels of cortisol. (fibromyalgia-symptoms.org)
Hypothalamic3
  • In either case, choose a medication with a short half-life to maximize the chance of recovery of the hypothalamic-pituitary-adrenal (HPA) axis. (medscape.com)
  • PHENOTYPE: Homozygous null mice for one allele display dysregulation of the hypothalamic-pituitary-adrenal axis activity under stress and resting conditions. (utsouthwestern.edu)
  • Normally, ACTH is produced and regulated by the hypothalamic-pituitary-adrenal (HPA) axis. (pediagenosis.com)
Occult1
  • In some occasions, this removes negative feedback from a previously occult pituitary adenoma, which starts growing rapidly and produces extreme levels of ACTH, leading to hyperpigmentation. (dailymeded.com)