• Beta-crystallin A4 (CRYBA4) is a member of the beta/gamma-crystallin family which are the dominant structural components of the vertebrate eye lens. (prospecbio.com)
  • The CRYBA4 gene being a beta acidic group member is part of a gene cluster with beta-B1, beta-B2, and beta-B3. (prospecbio.com)
  • All six exons of crystallin, beta A4 gene ( CRYBA4 ) were amplified by PCR methods and direct sequencing. (molvis.org)
  • Beta-crystallins construct aggregates of various sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. (prospecbio.com)
  • Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. (wikipedia.org)
  • Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). (oftalmic.ru)
  • Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. (wikipedia.org)
  • Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. (wikipedia.org)
  • This gene, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B2. (oftalmic.ru)
  • Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. (wikipedia.org)
  • 1991). "Human gamma-crystallin genes. (wikipedia.org)
  • The transcription of the beta-globin genes in mouse erythroleukemia cells has been examined by hybridizing labeled RNA obtained from isolated nuclei after chain elongation in the presence of [alpha-32P]UTP. (shengsci.com)
  • Gamma-crystallin D is a protein that in humans is encoded by the CRYGD gene. (wikipedia.org)
  • Micrograph of a section of the cerebral cortex from a person with Alzheimer's disease , immunostained with an antibody to amyloid beta (brown), a protein fragment that accumulates in amyloid plaques and cerebral amyloid angiopathy . (wikipedia.org)
  • [9] However, some proteinaceous lesions lack birefringence and contain few or no classical amyloid fibrils, such as the diffuse deposits of amyloid beta (Aβ) protein in the brains of people with Alzheimer's. (wikipedia.org)
  • Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinemia, renal failure, or kidney transplants. (lookformedical.com)
  • Gamma-crystallin D is a protein that in humans is encoded by the CRYGD gene. (wikipedia.org)
  • Entrez Gene: CRYGD crystallin, gamma D". Graw J (1998). (wikipedia.org)
  • Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. (wikipedia.org)
  • Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. (nih.gov)
  • 19. Facile cloning and sequence analysis of goose delta-crystallin gene based on polymerase chain reaction. (nih.gov)
  • Multiple binding sites overlap with those of the protective mini αA-crystallin chaperone MAC peptide. (bvsalud.org)
  • 2. Characterization of gamma S-crystallin isoforms from lip shark (Chiloscyllium colax): evolutionary comparison between gamma S and beta/gamma crystallins. (nih.gov)
  • 4. Characterization of gammaS-crystallin isoforms from a catfish: evolutionary comparison of various gamma-, gammaS-, and beta-crystallins. (nih.gov)
  • 9. Sequence analysis of one major basic beta-crystallin (beta Bp) of amphibian lenses: evolutionary comparison and phylogenetic relatedness between beta- and gamma-crystallins. (nih.gov)
  • 15. Octopus S-crystallins with endogenous glutathione S-transferase (GST) activity: sequence comparison and evolutionary relationships with authentic GST enzymes. (nih.gov)
  • 6. Characterization of gamma-crystallins from a hybrid teleostean fish: multiplicity of isoforms as revealed by cDNA sequence analysis. (nih.gov)
  • 10. Sequence analysis of frog alpha-crystallin cDNA and its deduced primary structure: comparison of alpha A subunit chains among different vertebrate species. (nih.gov)
  • 12. Sequence analysis of frog rho-crystallin by cDNA cloning and sequencing: a member of the aldo-keto reductase family. (nih.gov)
  • 3. Characterization of gamma-crystallin from a catfish: structural characterization of one major isoform with high methionine by cDNA sequencing. (nih.gov)
  • 18. The amino-terminal sequences of four major carp gamma-crystallin polypeptides and their homology with frog and calf gamma-crystallins. (nih.gov)
  • Unique secondary and tertiary structure of shark gamma-crystallin. (nih.gov)
  • Las beta-cristalinas poseen una estructura similar a las GAMMA CRISTALINAS al presentar ambas motivos de clave griega. (bvsalud.org)
  • Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. (wikipedia.org)
  • Mechanistic studies using bis-8-anilino-1-naphthalene sulfonic acid as a proxy drug showed that it bound to MAC sites, improved Tm of both H2O2 oxidized and native human gamma D, and suppressed turbidity of oxidized HγD, most likely by trapping exposed hydrophobic sites. (bvsalud.org)
  • Induced transcription of the mouse beta-globin transcription unit in erythroleukemia cells. (shengsci.com)