Acid kinase kinase kinase found activates phosphates adenylate kinase. Medical search. Frequent questions

The alpha subunit specifically activates the next enzyme in the cascade, adenylate cyclase. (wikipedia.org)
Adenylate cyclase manufactures cyclic adenosine monophosphate (cyclic AMP or cAMP), which activates protein kinase A (cAMP-dependent protein kinase). (wikipedia.org)
Within certain cells the enzyme adenylate cyclase makes cAMP from ATP, and typically this reaction is regulated by hormones such as adrenaline or glucagon. (drrestivo.com)
The G proteins will then activate adenylate cyclase and upregulate their conversion of ATP to cAMP. (imingo.net)
Both cannabinoid receptors (CBRs) are, in fact, part of the heptahelical G protein-coupled receptor (GPCR) family and can inhibit adenyl cyclase activity or even stimulate mitogen-activated protein kinases (MAPKs), being, therefore, classified as Gi/0 receptors [ 3 - 5 ]. (irjournal.org)
Cytokines bind to their receptors, activating signal transduction pathways such as adenylate cyclase/cAMP, phospholipase C/inositol trisphosphate, and Ca 2+ and tyrosine kinases. (biomedcentral.com)
Cannabinoids act at the CB1 receptor to inhibit adenylate cyclase activity via a pertussis toxin-sensitive G-protein. (jneurosci.org)
In this study we have examined the interactions of CB1 and D2 receptors on adenylate cyclase. (jneurosci.org)
Both D1 and D2 dopamine receptors also couple to adenylate cyclase via G-proteins. (jneurosci.org)
whereas dopamine D2 receptors inhibit adenylate cyclase via G i -proteins ( Sibley and Monsma, 1992 ). (jneurosci.org)
The FSH receptor activates G(s) proteins which leads to the activation of adenylyl cyclase and produces the secondary messenger cAMP. (smpdb.ca)
Depending on which family the G protein is, it goes on to activate (G αs protein subunit) or inhibit (G αi protein subunit) the membrane-bound cyclase. (pancreapedia.org)
Two aspartic acid residues in the active site of the cyclase (AC or GC) promotes the binding of ATP. (pancreapedia.org)

The conformation change in the receptor activates G proteins, a heterotrimeric protein with α, β, and γ subunits. (wikipedia.org)
Western blot was carried out to detect the expression levels of autophagic-related proteins (Unc-51 like autophagy activating kinase 1, beclin 1, autophagy related 5, microtubule-associated protein 1A/1B-light chain 3, ubiquitin-binding protein p62), glycolysis-related proteins (hexokinase 2, phosphofructokinase, pyruvate kinase M2) and activated protein kinase signalling pathway proteins. (ijpsonline.com)
We also demonstrated that altering the intermediate amino acid did not alter the specificity of the regulatory proteins for their protein substrates. (scirp.org)
These proteins were L-lactate dehydrogenase B(LDHB), glyceraldehyde-3-phosphate dehydrogenase, glucose-6-phosphate isomerase (GPI), phosphoglycerate mutase 2 (PGAM2), gelsolin and isoform 8 of titin. (biomedcentral.com)
Protein to protein interaction network analysis showed glycolytic enzymes, such as isoform alpha-enolase of alpha-enolase, isoform 1 of triosephosphate isomerase and glyceraldehyde-3-phosphate dehydrogenase, had more connections than other proteins in myocardial metabolism during ischemia. (biomedcentral.com)
K + currents and bioluminescence resonance energy transfer between labelled G proteins and GIRK show that M2Rs catalyze Gβγ subunit release at higher rates than β2ARs, generating higher Gβγ concentrations that activate GIRK and regulate other targets of Gβγ. (elifesciences.org)

Immunoblot analyses with anti-active mitogen-activated protein kinases (MAP-Ks) revealed that D1 receptors, D2 receptors, group I mGluRs, and group II mGluRs all contribute to MAP-K activation in prefrontal cortex, and that combined activation of dopamine receptors and mGluRs synergistically or additively activate MAP-Ks. (jneurosci.org)

Phosphorylase a is the enzyme responsible for the release of glucose-1-phosphate from glycogen polymers. (wikipedia.org)

The combined results indicate that glycolysis is regulated by the compartmental expression of hexokinase 2, pyruvate kinase M1, and pyruvate kinase M2 in photoreceptors, whereas the inner retinal neurons exhibit a lower capacity for glycolysis and aerobic glycolysis. (molvis.org)
Pyruvate kinase [Interproscan]. (ntu.edu.sg)

The 3' replication has freely activated by RNase Z surface, a mature binding in receptors( reviewed in Maraia and Lamichhane 2011). (evakoch.com)
Stimulated muscarinic acetylcholine receptors (M2Rs) release Gβγ subunits, which slow heart rate by activating a G protein-gated K + channel (GIRK). (elifesciences.org)
Stimulated β2 adrenergic receptors (β2ARs) also release Gβγ subunits, but GIRK is not activated. (elifesciences.org)
These two branches control heart rate by stimulating different G protein-coupled receptors (GPCRs), which in turn activate ion channels that modify the electrical properties of cardiac pacemaker cells ( DiFrancesco, 1993 ). (elifesciences.org)

Expression of nucleoside diphosphate kinase, mitochondria-associated adenylate kinase, and several mitochondria-associated creatine kinase isozymes was highest in the outer retina, whereas expression of cytosolic adenylate kinase and brain creatine kinase was higher in the cones, horizontal cells, and amacrine cells indicating the diversity of ATP-buffering strategies among retinal neurons. (molvis.org)
Reasonably specific markers for blood tests including creatine kinase muscle/brain isoform (CK-MB), cardiac troponin T (cTnT) and cardiac troponin I (cTnI) are released after the onset of significant necrosis instead of early ischemia, and they all require a level of myocardial necrosis to prompt their release from myocytes before they can be detected. (biomedcentral.com)

Lipolysis is the metabolic process through which triacylglycerols (TAGs) break down via hydrolysis into their constituent molecules: glycerol and free fatty acids (FFAs). (imingo.net)
MIM:614857), a then 11-deoxycortisol focal Defect of Cbl secretion expressed by activated Tregs of the molecules gut( AdoCbl) and methylcobalamin( MeCbl). (evakoch.com)
They are fatty acid-derived molecules, synthesized by membrane phospholipids [ 9 , 10 ]. (irjournal.org)
The inhibition of mitochondrial complex activity by metformin might be a mechanism of metformin-induced AMPK activation9, as intracellular ATP levels are decreased by the inhibition of mitochondrial complex activity and AMP levels are increased by the action of adenylate kinase converting two molecules of adenosine diphosphate (ADP) to ATP and AMP (Figure 1). (cyberleninka.org)
AMP molecules can then bind to the y subunit of AMPK and activate AMPK activity directly or by inhibiting dephosphorylation of AMPK phosphorylated by liver kinase B1 (LKB1) or calcium/calmodulin-dependent protein kinase kinase-ß (CAMKKß)10. (cyberleninka.org)
The coenzyme is therefore found in two forms in cells: NAD + is an oxidizing agent - it accepts electrons from other molecules and becomes reduced , this reaction forms NADH, which can then be used as a reducing agent to donate electrons. (wikidoc.org)

AMP may be produced by the hydrolysis of one high energy phosphate bond of ADP. (drrestivo.com)
Cellular ATP is buffered by specialized equilibrium-driven high-energy phosphate (~P) transferring kinases. (molvis.org)

Nucleic Acids Res. (smpdb.ca)

Cyclic nucleotides, like other nucleotides, are composed of three functional groups: a ribose sugar, a nitrogenous base, and a single phosphate group. (pancreapedia.org)

by TLR-activated mouse PDC, and reduces check details their capacity to stimulate CD4+ T cells. (c-kitinhibitors.com)

The activated receptor catalyzes removal of GDP from the G protein alpha subunit (Gα i ), which allows intracellular GTP to bind. (elifesciences.org)

Provided by Elsevier N.V. All rights earmarked.Caffeic acid phenethyl ester (Cpe) is a bioactive portion based on honeybee hive propolis. (inhibitorlibrary.com)
Cyclic nucleotides form when the phosphate group of the molecule of nucleotide triphosphate (ATP or GTP) is attacked by the 3' hydroxyl group of the ribose, forming a cyclic 3',5'-phosphate ester with release of pyrophosphate. (pancreapedia.org)

Glucose is the major substrate for ATP synthesis through glycolysis and oxidative phosphorylation (OXPHOS), whereas intermediary metabolism through the tricarboxylic acid (TCA) cycle utilizes non-glucose-derived monocarboxylates, amino acids, and alpha ketoacids to support mitochondrial ATP and GTP synthesis. (molvis.org)
The mechanism may be related to the improvement of glycolysis dysfunction and alleviation of autophagy over activation of activated protein kinase. (ijpsonline.com)

A cyclic nucleotide, unlike other nucleotides, has a cyclic bond arrangement between the ribose sugar and the phosphate group. (pancreapedia.org)

also, the 5' download volatility trading of the cytoplasm is involved actually by cationic end-product by the RNase proximity water cell, which has a direct RNA( RNA H1 in pathways) and at least 10 Fructose-6-phosphate nucleus( activated in Jarrous 2002, Xiao et al. (evakoch.com)
however, recent investigations have shown that adenosine monophosphate-activated protein kinase-independent pathways can explain some of metformin's beneficial metabolic effects as well as undesirable side-effects. (cyberleninka.org)
These regulatory inputs involve not only the conserved Rim101/PacC pathway, but also the calcium-activated phosphatase calcineurin, the Wsc1-Pkc1-Slt2 MAP kinase, the Snf1 and PKA kinases and oxidative stress-response pathways. (microbialcell.com)

This enzyme, in turn, activates phosphorylase kinase, which then phosphorylates glycogen phosphorylase b, converting it into the active form called phosphorylase a. (wikipedia.org)
The enzyme protein kinase A that was stimulated by the cascade initiated by glucagon will also phosphorylate a single serine residue of the bifunctional polypeptide chain containing both the enzymes fructose-2,6-bisphosphatase and phosphofructokinase-2. (wikipedia.org)
Most of the ATP in cells is produced by the enzyme ATP synthase , which converts ADP and phosphate to ATP . (drrestivo.com)
The role of the C8-H of ATP in the binding and/or phosphoryl transfer on the enzyme activity of a number of kinase and synthetase enzymes has been elucidated. (biomedcentral.com)
The intrinsic catalysis rate mediated by each kinase enzyme is complex, yielding apparent K M values ranging from less than 0.4 μM to more than 1 mM for ATP in the various kinases. (biomedcentral.com)
We have demonstrated the mechanism by which the enzyme activities of Group 2 kinases, shikimate kinase (SK) and adenylate kinase 1 (AK1), are controlled by the C8-H of ATP. (biomedcentral.com)
The lability of the C8-H mediated by active site residues co-ordinated to the purine ring of ATP therefore plays a significant role in explaining the broad K M range associated with kinase steady state enzyme activities. (biomedcentral.com)

These mechanisms were developed using structurally conserved amino acid residues within hydrogen-bonding distance of a nucleotide in the active sites of crystallised kinases of a particular mechanistic class. (biomedcentral.com)
On the basis of these conserved mechanisms, the role of the nucleotide C8-H in initiating the formation of a pentavalent phosphorus intermediate from the γ-phosphate of ATP and the substrate nucleophile was defined. (biomedcentral.com)
2) this Ca 2+ influx took place through voltage-activated Ca 2+ ion channels (inhibition by d-cis-diltiazem,verapamil) and (3) cyclic nucleotide-gated ion channels were not involved in this process (no effect of Mg 2+ ). (biologists.com)
The compound is a dinucleotide, since it consists of two nucleotides joined through their phosphate groups: with one nucleotide containing an adenosine ring, and the other containing nicotinamide . (wikidoc.org)
After a ligand binds to the GPCR, it activates a heterotrimeric G-protein, which is composed of three subunits: a guanine nucleotide binding α-subunit, and a βγ-heterodimer (98). (pancreapedia.org)

cAMP then activates protein kinase A (PKA) which phosphorylates downstream effectors that lead to a specific cellular response. (smpdb.ca)

As a cellular energy sensor, AMP - activated protein kinase ( AMPK ) is activated in response to a variety of conditions that deplete cellular energy levels, such as nutrient starvation (especially glucose), hypoxia and exposure to toxins that inhibit the mitochondrial respiratory chain complex. (drrestivo.com)

Crude nucleic acid extraction is sufficient for your application like PCR (typically not for NGS or other sensitive downstream applications). (biosearchtech.com)
Highly purified nucleic acids are required for a variety of downstream applications like PCR or NGS. (biosearchtech.com)
Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)

In organisms, NAD + can be synthesized from scratch ( de novo ) from the amino acids tryptophan or aspartic acid . (wikidoc.org)

Adenosine Monophosphate (AMP) - research has found that increased levels of AMP can induce an increase in the activity of AMPK which works to switch cells from ATP consumption to ATP production. (drrestivo.com)
Decreased adenosine triphosphate (ATP) and increased adenosine monophosphate (AMP) content by metformin as a result of decreased mitochondrial complex activity contributes to adenosine monophosphate-activated protein kinase (AMPK) activation. (cyberleninka.org)

AMP -activated protein kinase (AMPK) has emerged as a key regulator of skeletal muscle fat metabolism . (drrestivo.com)
The activated AMPK might provide protective benefits in HIRI via prevention of energy decline, inhibition of inflammatory response, suppression of hepatocyte apoptosis and attenuation of oxidative stress. (drrestivo.com)
AMPK is a highly conserved serine/threonine protein kinase composed of a catalytic a subunit and two regulatory p and y subunits, and is activated by an increased AMP : adenosine triphosphate (ATP) ratio in metabolic stress conditions, such as hypoxia or glucose depriva-tion5. (cyberleninka.org)

Recent studies have focused on asymmetric synthesis of structurally complex amino acids, using what has proved to be a very versatile radical-based methodology and also the use of structurally unusual heterocycles for masking the reactivity of synthetically valuable functional groups. (exeter.ac.uk)
The use of radical-based methodology in the synthesis of highly substituted amines and amino acids. (exeter.ac.uk)

To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. (imingo.net)
The PPS1 protein was expressed in Escherichia coli, and the protein was shown to catalyze the hydrolysis of p-nitrophenyl phosphate, dephosphorylate phosphotyrosyl, and phosphothreonyl residues in synthetic diphosphorylated peptides and to inactivate the human ERK1 protein. (embl.de)

Degradation of high-energy phosphates [ 36 ] and decreased mitochondrial respiratory control [ 21 ] were demonstrated in exercised muscle, indicating the energetic impairment. (scielo.org.ar)
Role of Free Fatty Acids in Physiological Conditions and Mitochondrial Dysfunction. (imingo.net)
Moreover, RNF213 was demonstrated to regulate non-mitochondrial oxygen consumption ( 13 ), consequently playing a role in tumor resistance to hypoxia, and to be capable of activating the NF-κB signaling pathway ( 11 , 13 , 14 ), hinting at involvement in the immune response. (biorxiv.org)

IL-33 activates group 2 innate lymphoid cells (ILC2) to produce the type 2 cytokines IL-5 and IL-13 that initiate innate immunity-driven allergic responses. (justia.com)

Finally the PPP can also be used to produce glyceraldehyde-3-phosphate which can then be fed into the TCA and ETC cycles allowing for the harvest of energy. (imingo.net)
In the sixth step of the glycolytic pathway, the first step of the second phase, the payoff phase, glyceraldehyde 3-phosphate dehydrogenase (EC 1.2.1.12) catalyses the oxidation of glyceraldehyde 3-phosphate to 1,3-bisphosphoglycerate (1,3-BPG), with the concomitant reduction of NAD + to NADH. (imingo.net)
Glyceraldehyde 3-phosphate dehydrogenase [Interproscan]. (ntu.edu.sg)

They remove the phosphate group from both phospho-tyrosine and phospho-serine/threonine residues. (embl.de)
The deduced amino acid sequence of PPS1p shows similarity with protein-tyrosine phosphatases (PTPases) and is most closely related to a subfamily of PTPases that are capable of dephosphorylating phosphoseryl and phosphothreonyl residues as well as phosphotyrosyl residues. (embl.de)
Using a combination of ATP deuterated at the C8 position (C8D-ATP) as a molecular probe with site directed mutagenesis (SDM) of conserved amino acid residues in shikimate kinase and adenylate kinase active sites, we have elucidated a mechanism by which the ATP C8-H is induced to be labile in the broader kinase family. (biomedcentral.com)
The SDM clearly identified the amino acid residues involved in both the catalysis and regulation of phosphoryl transfer in SK and AK1 as mediated by C8H-ATP. (biomedcentral.com)

An essential pathologic finding is the accumulation of normally structured glycogen in most tissues. (medscape.com)

GSD type Ic is deficiency of translocase T2 that carries inorganic phosphates from microsomes into the cytosol and pyrophosphates from the cytosol into microsomes. (medscape.com)

References: [6] Fatty acid metabolism. (imingo.net)
In the cell, RNF213 was shown to be involved in fatty acid metabolism ( 11 ), and to associate with intracellular lipid droplets in a manner dependent on its E3 ligase and ATPase activities ( 12 ). (biorxiv.org)

The activated GPCR then triggers the exchange of GDP to GTP on the Gα subunit. (elifesciences.org)

In vitro analysis revealed that a putative switch-protein kinase regulator, RsbW, is capable of interacting directly with σ 66 , as well as phosphorylating its own antagonist, RsbV1, rendering it inactive. (plos.org)

Upon stimulation, acetylcholine (ACh) released from the vagus nerve binds to and activates M2Rs in sinoatrial node (SAN) pacemaker cells, promoting the engagement of the GDP-bound G protein trimer (Gα i (GDP)βγ). (elifesciences.org)
Dissociated Gβγ directly binds to and activates GIRK channels. (elifesciences.org)

The breakdown of fats is termed beta-oxidation, or "fatty acid" oxidation because the triglycerides are being oxidized into their most basic functional parts. (imingo.net)
SCIRP: Food and Nutrition Sciences, Vol. In this process, both in vivoand in cultur… This binding will likewise lead to the cAMP/PKA-led phosphorylation of hormone sensitive lipase, that will ultimately drive the release of free fatty acids and glycerol. (imingo.net)
Lipolysis /lɪˈpɒlɪsɪs/ is the metabolic pathway through which lipid triglycerides are hydrolyzed into a glycerol and three fatty acids. (imingo.net)
after reuptake, AEA is hydrolyzed by fatty acid amide hydrolase (FAAH), and 2-AG by monoacylglycerol lipase (MAGL). (irjournal.org)

The complexed calcium has been found to be increased twofold in patients with uremia. (abdominalkey.com)

The amino acid located between the regulatory threonine and the catalytic histidine is highly conserved being serine in PPDK and cysteine in PEPS. (scirp.org)
A comparison of known PPDK and PEPS sequences revealed a high level of conservation of the amino acid sequence surrounding the catalytic histidine located within a central domain of the enzymes that was composed of GGXTS/CHAAI/VI/VA/SR with the regulatory threonine and catalytic histidine (shown in bold) conserved in all species. (scirp.org)

This suggests that MGCs utilize TCA cycle anaplerosis and cataplerosis to generate GTP and ~P transferring kinases to produce ATP that supports MGC energy requirements. (molvis.org)
Analysis of the predicted amino acid sequence suggests that the protein consists of an active phosphatase domain, an inactive phosphatase-like domain, and an NH2-terminal extension. (embl.de)
As its name suggests, the receptor is activated by follicle-stimulating hormone (FSH) and plays an important role in the regulation of reproduction. (smpdb.ca)

Why, then, do cosubstrates so often possess nucleotides as their binding tags, rather than for example amino acids or peptides? (heresy.is)

ATP is able to power cellular processes by transferring a phosphate group to another molecule and this process is called phosphorylation. (drrestivo.com)

Additionally in comparison with trials with out temperature remedy, effects of compression proportion healing had been lowered simply by 80%.Calcium/calmodulin (Ca2+/CaM)-dependent necessary protein kinase II (CaMKII) partners raises throughout mobile Ca2+ to simple reactions in excitable cellular material. (inhibitorlibrary.com)
The calcium complexes are formed with bicarbonate, phosphate, and acetate. (abdominalkey.com)

GM-CSF down-regulates inhibited by factors( T-lymphocytes, mouse heterotrimers, necessary phosphatidylinositol, p46 acids) estimated at acids of intrinsic tissues. (evakoch.com)

This study provides evidence that a switch-protein kinase regulatory network controls availability of σ 66 , the main sigma subunit for transcription in Chlamydia . (plos.org)
Both are regulated by a phosphorylation-dephosphorylation mechanism involving a bifunctional serine/ threonine kinase and a pyrophosphorylase (PPDK regulatory protein, PDRP, and PEPS regulatory protein, PSRP, respectively). (scirp.org)
In plants the regulatory mechanism involves phosphorylation of a threonine residue that is separated by a single amino acid from the histidine residue that forms a phosphorylated intermediate during catalysis. (scirp.org)
Rapamycin was found to block the interaction of TLR with myeloid differentiation primary response gene 88 (MyD88), resulting in reduced interferon regulatory factor-7 (IRF-7) phosphorylation [16]. (c-kitinhibitors.com)

It is activated by rising AMP and falling ATP by a complex mechanism that results in an ultrasensitive response. (drrestivo.com)
All the kinase mechanistic classes were clustered into two proposed mechanisms depending on how the C8-H is induced to be labile, namely by either the co-ordination of a backbone carbonyl to C6-NH 2 of the adenyl moiety (a "push" mechanism), or based on the protonation of N7 of the adenyl moiety (a "pull" mechanism). (biomedcentral.com)

The functionality required for the catalysis and regulation of phosphoryl transfer was found to be conserved within the families or fold-groups. (biomedcentral.com)
This step is necessary for the nucleophilic catalysis on the 5' α-phosphate by the newly formed oxyanion. (pancreapedia.org)

The Affymetrix data revealed varied gene expression patterns of the ATP synthesizing and regulating enzymes found in the muscle, liver, and brain. (molvis.org)

Tilly JL, Aihara T, Nishimori K, Jia XC, Billig H, Kowalski KI, Perlas EA, Hsueh AJ: Expression of recombinant human follicle-stimulating hormone receptor: species-specific ligand binding, signal transduction, and identification of multiple ovarian messenger ribonucleic acid transcripts. (smpdb.ca)

This domain can be found in dual specificity phosphatases. (embl.de)
other specificity is tiny gene activity and distribution browser through the kinase of the R-RasGAP complex ileal to suitable or through the functionality of RhoA. (evakoch.com)

transiting of such constituent c receptor type VIa regions in kinase during activation. (evakoch.com)

It has been demonstrated that the adenyl moiety of ATP plays a direct role in the regulation of ATP binding and/or phosphoryl transfer within a range of kinase and synthetase enzymes. (biomedcentral.com)
As a result, a number of conserved mechanisms were proposed, wherein the C8-H of the adenyl moiety was found to play a direct role in the control of phosphoryl transfer [ 2 ]. (biomedcentral.com)

Our suite of DNA and RNA extraction and purification reagents yield high-quality nucleic acids, without burdening your team with lengthy protocols and complex workflows. (biosearchtech.com)

Nicotinamide adenine dinucleotide is a dinucleotide since it consists of two nucleotides joined by a pair of bridging phosphate groups. (wikidoc.org)
These nucleotides are joined together by a bridge of two phosphate groups through the 5' carbons. (wikidoc.org)

I'll be wildly optimistic and assume that you remember a thing or two about nucleic acids, so we will mostly skip this topic. (heresy.is)

This stimulation of cAMP was not Ca 2+ -sensitive and was unaffected by a range of protein kinase inhibitors. (jneurosci.org)

typically, reticulum of deaminase by kinase extends the download of primary transporters by docking the brain of RhoA. (evakoch.com)

[ 2 ] In 1978, Narisawa et al proposed that a transport defect of glucose-6-phosphate (G6P) into the microsomal compartment may be present in some patients with GSD type I. (medscape.com)
[ 3 ] proposed that a transport defect of glucose-6-phosphate (G6P) into the microsomal compartment may be present in some patients with GSD type I. Thus, GSD type I is divided into GSD type Ia caused by G6Pase deficiency and GSD type Ib resulting from deficiency of a specific translocase T1. (medscape.com)

Anatomy16

Organisms9

Chemicals and Drugs174

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Phenomena and Processes39

Information Science3

Cyclase13

Proteins6

Mitogen-activat1

Glucose-1-phospha1

Pyruvate2

Receptors4

Creatine kinase2

Molecules6

High energy ph2

Nucleic Aci1

Single phosphate group1

Stimulate1

Alpha subunit1

Ester2

Glycolysis2

Ribose1

Pathways3

Enzyme7

Nucleotide5

Phosphorylates1

Inhibit1

Downstream3

Aspartic acid1

Adenosine Monophosphate2

AMPK3

Synthesis2

Hydrolysis2

Mitochondrial3

Cytokines1

Glyceraldehyde3

Residues4

Glycogen1

Inorganic1

Metabolism2

GPCR1

Regulator1

Binds2

Fatty4

Twofold1

Catalytic2

Suggests3

Peptides1

Molecule1

Calcium2

Intrinsic1

Regulatory4

Mechanism2

Catalysis2

Liver1

Signal transduction1

Specificity2

Constituent1

Adenyl2

Complex1

Nucleotides2

Skip1

CAMP1

Typically1

Defect2