Acid gene anion exchange protein 1 erythrocyte. Medical search. Frequent questions

Specific point mutations in human anion exchanger 1 (AE1) convert this electroneutral anion exchanger into a monovalent cation conductance. (tcdb.org)
The protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. (antibodypedia.com)
The encoded protein associates with the red cell membrane protein glycophorin A and this association promotes the correct folding and translocation of the exchanger. (antibodypedia.com)
To test the pathophysiology, we produced mice that lack the erythroid anion exchanger (AE1), the principal Ank1 ligand. (dana-farber.org)
Anion exchanger 1 (AE1), also known as band 3 or SLC4A1, plays a key role in the removal of carbon dioxide from tissues by facilitating the exchange of chloride and bicarbonate across the plasma membrane of erythrocytes. (rcsb.org)
Here we report the crystal structure of the band 3 anion exchanger domain (AE1(CTD)) at 3.5 angstroms. (rcsb.org)
Human being anion exchanger 2 (AE2) is definitely a plasma membrane protein that regulates intracellular pH and cell volume. (techuniq.com)
Keywords: anion exchanger 2 tumor suppressor P16 ERK gastrin Launch Colon cancer is normally a significant global public medical condition with rapidly increasing incidence. (techuniq.com)

The animal AE proteins consist of homodimeric complexes of integral membrane proteins that vary in size from about 900 amino acyl residues to about 1250 residues. (tcdb.org)
Consumption of tea has been linked to a sense of relaxation commonly associated with the content of the non-proteinogenic amino acid theanine, which is found within the tea leaves. (mdpi.com)
2. Describe how monosaccharides and amino acids are absorbed from gut. (medical-junction.com)
7, 9, 15, 20, 21, 23, 24) Insulin normally acts as a shuttle to drive amino acids, glucose, fatty acids, glucosamine and other precursors into the cell so that the cell may synthesize required structures for tissue repair. (life-enthusiast.com)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)
The order of amino acids as they occur in a polypeptide chain. (lookformedical.com)
Twenty alpha-amino acids are the subunits which are polymerized to form proteins. (lookformedical.com)
All recognized mutations for AD are associated with increased deposition of amyloid-beta (Abeta), a peptide fragment comprising 39-43 amino acids that derive from the catabolism of the amyloid precursor protein (APP) molecule. (medscape.com)

16 this range (primarily cytochrome P-450 mediated oxidation to fatty acids and alcohols) is slow, while the aromatics are metabolized faster (oxidation of alkyl site and/or ring, sometimes with formation of reactive intermediates, and conjugation with glutathione, glucuronic acid, or glycine) (ATSDR 1999). (cdc.gov)
State the physiological role of lysophospholipids & fatty acids produced by the breakdown of lecithin. (medical-junction.com)
2. Classify the fatty acids in details & indicate their physical properties. (medical-junction.com)
Whereas the trisaccharidic head group of Gb 3 defines the specificity of Shiga toxin binding, the lipophilic part composed of sphingosine and different fatty acids is suggested to determine its localization within membranes impacting membrane organisation and protein binding eventually leading to protein internalisation. (springer.com)
The results clearly highlight the influence of the different fatty acids of the Gb 3 sphingolipids on the phase behaviour and the binding properties of Shiga toxin B subunits, even though the membranes were only doped with 5 mol% of the receptor lipid. (springer.com)
Among the short chain fatty acids (SCFA), butyrate is a natural nutrient found in food (i.e. butter and milk product) and is also produced physiologically (from 40 to 100 mmol) from intestinal fermentation of fiber [ 1 ]. (biomedcentral.com)
Fatty acids (FA) are both substrates and effectors of the hepatic oxidative pathways. (biomedcentral.com)
They are β-oxidized in mitochondria and some of them (namely long chain fatty acids) are known to have a decoupling-like effect on mitochondrial oxidative phosphorylation [ 6 , 7 ]. (biomedcentral.com)

Members of both the SLC4 and SLC26 mammalian gene families encode Na + -independent Cl - -HCO3 - exchangers. (tcdb.org)
A comparable volume-pH(i) link may also be important in other cell types expressing anion exchangers. (ox.ac.uk)

Acanthocytes can result from abnormalities in membrane lipids and proteins. (medscape.com)
However, some rare conditions have normal lipids and abnormal membrane proteins. (medscape.com)
MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
Extraction procedures are optimized to precipitate and remove proteins and nucleic acids while maximizing solubilization of GSLs along with other lipids. (springer.com)

[ 4 ] To preserve the red blood cell's shape and regulate the cell's deformability and mechanical stability, the plasma membrane is tethered to a filamentous network of proteins known as the membrane skeleton. (medscape.com)
1. Discuss how the fluidity of plasma membrane largely depends on its lipid composition. (medical-junction.com)
1. Discuss the role of phospholipid, cholesterol and carbohydrates in the structural and functional aspect of plasma membrane. (medical-junction.com)
Mitogen-activated proteins kinases (MAPK) transmit cell-proliferation indicators from plasma membrane to nucleus. (techuniq.com)

Our goal is to elucidate the functional networks that coordinate protein synthesis and quality control in the early secretory pathway. (stanford.edu)
The proteostasis network (PN) is an assembly of distinct dynamic molecular pathways that control the functionality of the proteome (proteome homeodynamics) during protein synthesis, folding, trafficking, and degradation. (hindawi.com)
a key enzyme for the synthesis of DHA and sapienic acid. (ocl-journal.org)
The extracellular transport of molecules 1, 4A and 103( synthesis) for regulation cell membranes and upstream DCs triggers reduced through modfiying to the functional midwifery CCR6 and not another extracellular different melanin( Yang et al. (erik-mill.de)
A net linear flux of glycogen synthesis (~11.10 ± 0.60 μmol glucosyl units.h -1 .g -1 liver wet weight) occurred until the 6th hr post-feeding in both groups, whereas butyrate delayed it until the 8th hr. (biomedcentral.com)
Net glycogenolysis always appeared after the 8th hr, whereas flux of mitochondrial ATP synthesis returned to near basal level (0.91 ± 0.19 μmol.min -1 .g -1 liver ww). (biomedcentral.com)

During the process of acid secretion, the cellular pH increases, triggering the release of the "trigger" loop from the cytoplasmic domain. (wikipedia.org)
2007). These proteins are important for the regulation of intracellular pH (pH i ) and play crucial roles in the epithelial absorption of HCO 3 - (e.g., in the renal proximal tubule) and secretion of HCO 3 - (e.g., in the pancreatic duct). (tcdb.org)
Many mutations in this gene are known in man, and these mutations can lead to two types of disease: destabilization of red cell membrane leading to hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis. (antibodypedia.com)

These regulators include canonical genes that control lipid metabolism as well as genes involved in ubiquitination, transcription, and mitochondrial function. (stanford.edu)
Mitochondrial genes and proteins were induced upon pan-CD44 kd, as were oxidative phosphorylation genes. (bvsalud.org)
Mitochondrial ATP turnover, calculated after specific inhibition of glycolysis, was stable (~0.70 ± 0.25 μmol.min -1 .g -1 liver ww) during the first two hr whatever the force-feeding, and increased transiently about two-fold at the 3rd hr in glucose. (biomedcentral.com)

They contain one or more sialic acid (N-ACETYLNEURAMINIC ACID) residues. (lookformedical.com)
Up-regulation of sialic acid-containing glycans, termed hypersialylation, is a common feature of cancer-associated glycosylation, driving disease progression and immune escape through the engagement of Siglec receptors on tumor-infiltrating immune cells. (bvsalud.org)
After separation by TLC, 10 -12 -10 -9 mol quantities of GSL can be chemically detected with orcinol, a reagent for hexoses and with resorcinol-HCl, a reagent for sialic acid. (springer.com)

This highly complex 'protein biogenesis' process is assisted by a diverse network of folding catalysts and protein-modifying enzymes and is scrutinized by molecular chaperones and other 'quality control' factors which ensure that only correctly folded and assembled proteins exit the ER and proceed to distal compartments of the secretory pathway. (stanford.edu)
Can someone guide me on the references of spectrophotometer methods used to measure enzymes or proteins newly discovered in the blood serum? (researchgate.net)
What are the main references (book or research) for one or more, that specify methods for measuring newly discovered enzymes or proteins, in which simple manual methods are used. (researchgate.net)
1, 3) Antioxidants, such as Coenzyme Q10, alpha lipoic acid and NADH (nicotinamide adenine dinucleotide) and anti-catabolic enzymes, such as glutathione peroxidase, superoxide dismutase and catalase minimize the damage due to ROS. (life-enthusiast.com)
Moreover, the analysis of the transcriptional system relating to the up-cited enzymes revealed a decreased gene expression subsequent to the enrichment of germination medium with the effectors. (springer.com)
The mitochondria have their own chaperones and proteolytic enzymes that remove damaged or unfolded proteins [ 18 - 20 ]. (hindawi.com)
In complexes, the other enzymes affect cleaved CBF1( or RBPJkappa), while in channels they are required Lag-1, immediately that the m ' CSL ' demonstrates separated been to this produced feature experience breast. (evakoch.com)
RNA enzymes may observe from also translocated proteins, they may phosphorylate suggested in proteins with delayed strategies, or they may outline known in membranes of factor factors. (evakoch.com)

Ankyrins link integral membrane proteins to the spectrin-based membrane skeleton. (dana-farber.org)
This indicates that AE1 and probably other integral membrane proteins have a 'lipid-anchoring' function. (dana-farber.org)

Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)
Oxidative stress has been implicated in the pathogenesis and progression of chronic obstructive pulmonary disease (COPD) 1 - 5 . (ersjournals.com)
Several reviews have summarised the available data on the presence (table 1 ⇓ ) and consequences (table 2 ⇓ ) of oxidative stress in the lungs of "healthy" smokers and smokers with COPD 1 - 5 , 9 . (ersjournals.com)

Anion exchange protein 2 (AE2) is a membrane transport protein that in humans is encoded by the SLC4A2 gene. (wikipedia.org)

The cryo electron microsopic studies revealed that human AE2 protein forms a homodimer and stays in resting state of inward-facing conformation at physiological pH. (wikipedia.org)
Further conformational changes then turn the AE2 protein into an outward-facing conformation, releasing HCO3- into the extracellular environment and capturing Cl- into the binding pocket. (wikipedia.org)
Finally, the AE2 protein returns to its inward-facing conformation and releases Cl- into the cytosol. (wikipedia.org)
Comparing this structure with a substrate-bound structure of the uracil transporter UraA in an inward-facing conformation allowed us to identify the anion-binding position in the AE1(CTD), and to propose a possible transport mechanism that could explain why selected mutations lead to disease. (rcsb.org)
It is of fundamental importance in determining PROTEIN CONFORMATION. (lookformedical.com)
Jens simultaneously was for Statoil as a conformation Exploration Geologist, and he found act erythrocyte survival with Professor Virginia Toy at the University of Otago in New Zealand as expression of a Fulbright Fellowship. (erik-mill.de)

Although mammalian SLC4/AE polypeptides mediate only electroneutral Cl - -anion exchange, trout erythroid AE1 also promotes osmolyte transport and increased anion conductance. (tcdb.org)

Hereditary defects in membrane skeleton proteins. (dana-farber.org)
These hereditary adjustments disrupt or alter multiple signaling pathways such as for example Wnt/β-catenin Notch Hedgehog epidermal development aspect receptor (EGFR) Ras and PI3K/Akt [1]. (techuniq.com)

Search proteins in UniProtKB for this molecule. (rhea-db.org)

BACKGROUND: Acid retention associated with reduced GFR exacerbates nephropathy progression in partial nephrectomy models of CKD and might be reflected in CKD patients with reduced eGFR by increased anion gap (AG). (cdc.gov)

1. Glucose and fructose form similar osazone crystals. (medical-junction.com)
However, the amount of energy that can be stored in this way is limited: for their hydroxyl groups, glucose units are very hydrophilic: 1 g of glycogen binds 2.7 g of water. (helmberg.at)

release species with building protein of the translocation, with more inactive events clubbing with larger enzyme untranslated components in cleavage process( Bohling et al. (erik-mill.de)

receptors of Kv 1-4 dysplasia both residues and stones, not, molecules of Kv 5-12 3-kinase morphological effects. (erik-mill.de)

Local attraction of substrates and co-substrates enhances weak acid and base transmembrane transport, and principles in the attraction and facilitation of weak acid and base transport substrates, including monocarboxylates, ammonium, bicarbonate, and arsenite, plus protons as a co-substrate have been elucidated ( Epalle and Beitz 2022 ). (tcdb.org)
CONCLUSIONS: The data suggest that high AG, even after adjusting for serum bicarbonate, is a contributing acid-base mechanism to CKD progression in moderate CKD. (cdc.gov)

33, inorganic extractions re- placed ion exchange at the beginning of jutawan trader forex nuclear fuel cycle for separating uranium from other leach liquors. (qrforex.com)
Inorganic compounds derived from hydrochloric acid that contain the Cl- ion. (lookformedical.com)
Several important physiological and physio-pathological functions are played by many CA isozymes, which are strongly inhibited by aromatic and heterocyclic sulfonamides as well as inorganic, metal complexing anions. (rhea-db.org)

Upon CD44 kd, tumor angiogenesis was increased in the paranecrotic areas, accompanied by reduced HIF-1α and CEACAM5 but increased E-cadherin expression. (bvsalud.org)

This working cycle of the AE2 protein replaces a weak acid anion with a strong acid anion, thereby lowering the cellular pH and re-balancing pH homeostasis. (wikipedia.org)

Urine chloride was 95 mmol/L, pH 7.0, and urine protein-creatinine ratio 400 mg/g. (abdominalkey.com)
Relevant of mutagenicity and clastogenici- angiosarcomas of the liver, which carcinogens discussed in this chap- ty, including the induction of sister are rare tumours, were identified in ter do not include pharmaceutical chromatid exchange (SCE), chro- humans, rats, and mice exposed to drugs classified in Group 1, which mosomal aberrations (CA), and mi- vinyl chloride. (who.int)

Although the C-terminal domain comprises a small percentage of the total protein, this domain in some cases (i) has PSD-95/Discs Large/ZO-1-binding motifs that may be important for protein-protein interactions (e.g. (tcdb.org)
Van Veen, H. W. (2016) Bacterial ABC multidrug exporters: from shared proteins motifs and features to diversity in molecular mechanisms. (cam.ac.uk)

Common among these 10 interactions of organic compounds, their power to detect excess cancer agents is the electrophilic nature of or their metabolites, with DNA and R 1 risk at particular sites. (who.int)

The red blood cell membrane is composed of a lipid bilayer and proteins assembled in a complex manner that protects the red blood cell's integrity and allows a bidirectional flux of electrolytes, energy, and information between the cell and its environment. (medscape.com)
The lipid bilayer contains nearly equal quantities (molar ratio of 0.9-1) of unesterified cholesterol and phospholipids asymmetrically distributed between the outer and inner leaflets. (medscape.com)
Membrane proteins must be threaded co-translocationally into the lipid bilayer to become membrane-integrated, often with complex topologies and typically form hetero- or homo- oligomers. (stanford.edu)

1. Classify phospholipids with examples. (medical-junction.com)
One can classify them into the ganglio (GalNAc-β-1-4-Gal), globo (Gal-α-1-4-Gal), lacto (Gal-β-1-3-GlcNAc-β-1-3-Gal), and neolacto (Gal-β1-4-GlcNAcβ-1-3-Gal) series. (springer.com)
METHODS: A validated administrative claims algorithm was used to classify individual's ages 18-89 years at index date (first claim with a diagnosis of motor neuron disease or ALS between 1 January 2007 and 31 December 2011) with Medicare Advantage prescription drug coverage into mutually exclusive categories: ALS, no ALS, and possible ALS. (cdc.gov)

Acute displacement of pH(i) (superfusion of weak acids/bases) triggered rapid pH(i) recovery. (ox.ac.uk)
Acute exposure causes marked depletion of antioxidants in plasma 13 , 14 , intracellular GSH in erythrocytes 15 and GSH in ELF 10 , 12 . (ersjournals.com)

Bone marrow & Lymphoid tissues Brain Breast and female reproductive system Connective & Soft tissue Endocrine tissues Eye Gastrointestinal tract Kidney & Urinary bladder Liver & Gallbladder Lymphoid Male reproductive system Muscle tissues Myeloid Pancreas Proximal digestive tract Respiratory system Skin * nTPM: Normalized TPM levels represent consensus gene expression calculated using two data sets. (antibodypedia.com)
This implies two consecutive capillary exchange systems: one in the intestinal wall, the second, with low remaining blood pressure, in the liver. (helmberg.at)
Butyrate delayed the transient increase (1.80 ± 0.33 μmol.min -1 .g -1 liver ww) to the 6th hr post-feeding. (biomedcentral.com)
such read mit selbsttests gezielt mathematik failure content Liver: long figures for atrial acids. (augenta.net)
or each of these agents, carcinogenicity in rats and/or mice, els, differences in exposure con- there was sufficient evidence of car- for example for the liver (aflatoxins, ditions between studies in animals cinogenicity from studies in rats and/ trichloroethylene [TCE], and vinyl and in humans, or limitations in Part 1 · Chapter 1. (who.int)

1, 7) Membrane and extra-cellular matrix damage leads to decreased ideal first-intention healing involving parenchyma. (life-enthusiast.com)
Cells express a pool of thousands of different proteins that need to be tightly controlled for proper cellular structure, organization, and function. (hindawi.com)
Damage-centric theories focusing on loss of genetic and cellular function have been proposed, as well as programmatic theories focusing on unwanted gene and cellular function. (preprints.org)

14) strand proteins in gene-internal of FGFR3 and capable sunshine amyloid or proteotoxic cell increasing( Otsuki, 1999). (evakoch.com)

AE1 and NBCe1), and (iii) may provide sites for regulation of transporter function via protein kinase A phosphorylation (e.g. (tcdb.org)

A decrease occurs in polyunsaturated versus saturated and monounsaturated fatty acid content in red blood cells of patients with cirrhosis. (medscape.com)
Spur cells, or acanthocytes, are large erythrocytes covered with spikelike projections that vary in width, length, and distribution (see image below). (medscape.com)
Expression of phosphorylation-defective PLIN5 S155A in Plin5 null cells resulted in decreased rates of lipolysis and triglyceride-derived fatty acid oxidation. (uci.edu)
DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)
1-4) ROS react with cells initiating chain reactions that result in tissue damage causing inflammation, spasm, pain and disease. (life-enthusiast.com)
All Cbl cells bind a psychomotor CourseExplore that fails sterile entry buildings on linked proteins. (erik-mill.de)
The exchange of huge amounts of molecules between hepatocytes and blood is facilitated by fenestration of the endothelial cells lining wide sinusoids, allowing plasma to enter the perisinusoidal space, also known as space of Disse. (helmberg.at)
Other cell types derived from hematopoietic stem cells include platelets and erythrocytes. (justia.com)

Australopithecus benefited both from the inactivation of the GULO and uricase genes and from bipedalism causing the cognitive capital of the Homo genus to develop advantageously. (ocl-journal.org)
The polymorphism of this gene appears to have been essential in allowing the Homo genus to adapt to its food, and for its evolution. (ocl-journal.org)
With the advent of cooking and new mutations producing even more FADS2 , the brain reached its maximum size in Homo neanderthalensis , in a food ecosystem that provided favorable quantities of α-Linolenic acid and DHA. (ocl-journal.org)
Homo sapiens , benefiting from new variants of the FADS2 gene, were able to adapt to this harsh environment, whereas Neanderthal man was unable to do so and became extinct. (ocl-journal.org)
Homo est devenu un consommateur régulier de produits carnés en complément des végétaux et d'insectes. (ocl-journal.org)
Avec l'apport de la cuisson et de nouvelles mutations plus productives de FADS2, le volume cérébral a trouvé son apogée chez Homo neanderthalensis dans un écosystème alimentaire favorable en acide α-linolénique et DHA. (ocl-journal.org)

Neurobiol Dis 5:417431 Burley SK, Petsko GA (1985) Aromatic-aromatic interaction: a mechanism of protein struc- ture stabilization. (qrforex.com)

FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)
Being typically a minor component of the cell membrane, they are of utmost importance for biological functions that rely on lipid-lipid and lipid-protein interactions (Schnaar and Kinoshita 2015 ). (springer.com)
Title: Protein interactions with nanosized hydrotalcites of different composition. (aablocks.com)

Here, we present a systematic study of hard PC formation on the surface of upconversion nanoparticles (UCNPs) coated with positively-charged polyethyleneimine (PEI) and negatively-charged poly (acrylic acid) (PAA) polymers in serum-supplemented cell culture medium. (bvsalud.org)
Based on the ganglio GSL series, gangliosides are synthesized, where sialic acids are linked to the glycan structure to produce negatively charged GSLs. (springer.com)

Acanthocytosis has also been associated with the rare hypobetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP) syndrome, a disease of childhood akin to Hallervorden-Spatz disease and a defect in the gene for pantothenate kinase. (medscape.com)

The pH (HYDROGEN-ION CONCENTRATION) of the arterial BLOOD provides an index for the total body acid-base balance. (lookformedical.com)
It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (lookformedical.com)

The present work shows that carboxy-SNARF-1, a pH fluorophore, when used with confocal imaging or flow cytometry, reliably reports pH(i) in individual, human RBCs, provided intracellular fluorescence is calibrated using a 'null-point' procedure. (ox.ac.uk)
These molecules enabled us to address the question, where the Gb 3 sphingolipids are localized prior protein binding by means of fluorescence microscopy on giant unilamellar vesicles. (springer.com)

Here we describe the 3.2 Å cryo-EM structure of human DEC-205, thereby illuminating the structure of the mannose receptor protein family. (uci.edu)
The dysplasia receptor connect formed left into 12 processes, 1-12 with orange proteins from each ssDNA. (erik-mill.de)

It has been determined that VPS13A encodes for a protein called chorein. (medscape.com)

The balance between acids and bases in the BODY FLUIDS. (lookformedical.com)

Genes affected upon CD44 kd in xenografts specifically overlapped concordantly with genes correlating with CD44 isoform 4 (but not isoform 3) in patients, validating the clinical relevance of the used model and highlighting the metastasis-promoting role of CD44 isoform 4. (bvsalud.org)

AE2 is functionally similar to the Band 3 Cl−/HCO3− exchange protein. (wikipedia.org)
The protein comprises two domains that are structurally and functionally distinct. (antibodypedia.com)

Title: Compelling advantages of negative ion mode detection in high-mass MALDI-MS for homomeric protein complexes. (aablocks.com)

Title: Determination of hydroxy acids in cosmetics by chemometric experimental design and cyclodextrin-modified capillary electrophoresis. (aablocks.com)

The glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments and carries out the stilbene disulphonate-sensitive exchange transport of anions. (antibodypedia.com)
In this slow-flow compartment, blood plasma comes into direct contact with the hepatocytes' microvilli, which are packed with transport proteins. (helmberg.at)

In humans, the AE family (also called the SLC4 family) is composed of 10 paralogous members, among which are the proteins that perform Na + -independent Cl-HCO 3 - exchange (e.g. (tcdb.org)
In this chapter, electrophilic agents nogenicity from studies of exposed (benzene, 1,3-butadiene, and eth- include direct-acting electrophilic humans. (who.int)
All of the chemicals discussed of this chemical was raised to carci- lung and the nasal cavity were iden- here are IARC Group 1 agents and nogenic to humans (Group 1) based tified as target organs in humans as such can be characterized as on strong mechanistic evidence and rats, respectively. (who.int)

Southeast Asian ovalocytosis (SAO, Melanesian ovalocytosis) results from the heterozygous presence of a deletion in the encoded protein and is common in areas where Plasmodium falciparum malaria is endemic. (antibodypedia.com)
In 2001, a deletion mutation in the gene (now known as VPS13A) localized to chromosome band 9q21 was identified as the site for the defect generating the autosomal recessive form of NA. (medscape.com)
BRAF1 For example mutation or deletion of APC KRAS and MCC genes. (techuniq.com)

Anatomy6

Organisms4

Diseases1

Chemicals and Drugs69

Analytical, Diagnostic and Therapeutic Techniques and Equipment18

Phenomena and Processes37

Technology, Industry, Agriculture2

Information Science4

Health Care1

Exchanger8

Amino8

Fatty acids8

Exchangers2

Lipids4

Plasma membrane4

Synthesis6

Secretion3

Mitochondrial3

Sialic Acid3

Enzymes8

Integral membrane2

Oxidative3

SLC4A21

Conformation6

Erythroid1

Hereditary2

Molecule1

EGFR1

Glucose2

Enzyme1

Residues1

Bicarbonate2

Inorganic3

Tumor1

Weak acid1

Chloride2

Motifs2

Metabolites1

Lipid bilayer3

Classify3

Acute2

Liver5

Cellular3

Amyloid1

Transporter1

Cells8

Homo6

Mechanism1

Interactions3

Negatively-charged2

Kinase1

Hydrogen-Ion Concentra2

Fluorescence2

Receptor2

Encodes1

Bases1

Isoform1

Functionally2

Complexes1

Determination1

Transport2

Humans3

Deletion3