• FGFR3
  • The biology of FGFR3 and the molecular and cellular consequences of the achondroplasia mutation are still being explained in detail to provide a more complete understanding of the disorder. (naturalpedia.com)
  • Possible future treatments for achondroplasia include chemical inhibition of receptor signaling, antibody blockade of receptor activation, and alteration of pathways that modulate the downstream propagation of FGFR3 signals. (naturalpedia.com)
  • Mutations in achondroplasia can be interpreted as a gain-of-function mutation that activates the fundamentally negative growth factor exerted by the FGFR3 pathway. (wikibooks.org)
  • infants
  • Most infants diagnosed with achondroplasia will develop thoracolumbar kyphosis, which will need to be treated delicately so they can develop good posture with much care. (wikipedia.org)