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  • 1994
  • One of the most successful examples of therapeutic intervention based on this strategy is the use of benzodiazepines to enhance the response of GABA A receptors and augment inhibitory activity in the central nervous system ( Macdonald and Olsen, 1994 ). (aspetjournals.org)
  • agonists
  • By altering the response of a receptor to endogenous agonists, the modulator can change the level of signaling without necessarily changing the temporal or spatial pattern of the signaling. (aspetjournals.org)
  • ligands
  • Fluorescent receptor ligands provide a sensitive means of identifying and localizing various cellular receptors, ion channels and ion carriers. (thermofisher.com)
  • Additional fluorescently labeled receptor ligands (including low-density lipoproteins, epidermal growth factors, transferrin and fibrinogen conjugates and chemotactic peptides) are described in Probes for Following Receptor Binding and Phagocytosis-Section 16.1 , along with other probes for studying receptor-mediated endocytosis. (thermofisher.com)
  • The two cysteine residues form a disulfide linkage which results in the "cys-loop" receptor that is capable of binding acetylcholine and other ligands. (wikipedia.org)
  • membrane
  • NMDA receptor (NMDAR) activation requires concurrent membrane depolarization, and glutamatergic synapses lacking AMPA receptors (AMPARs) are often considered "silent" in the absence of another source of membrane depolarization. (jneurosci.org)
  • mAChRs
  • In contrast, the mAChRs are not ion channels, but belong instead to the superfamily of G-protein-coupled receptors that activate other ionic channels via a second messenger cascade. (wikipedia.org)
  • endogenous
  • The results raise the possibility that endogenous compounds use the site to modulate receptor function in vivo, and suggest that the receptors may represent useful targets for therapeutic intervention in cases where they have been implicated in neuropathologies such as Alzheimer's disease. (aspetjournals.org)
  • venom
  • α-Bungarotoxin (α-BTX) is one of the bungarotoxins, components of the venom of the elapid snake the Taiwanese banded krait (Bungarus multicinctus). (wikipedia.org)
  • historically also called toxin F) is a protein neurotoxin of the bungarotoxin family that is found in the venom of the many-banded krait, a snake found in Taiwan. (wikipedia.org)
  • depolarization
  • The diffusion of Na+ and K+ across the receptor causes depolarization, the end-plate potential, that opens voltage-gated sodium channels, which allows for firing of the action potential and potentially muscular contraction. (wikipedia.org)