Point MutationMutation, MissenseMutationFrameshift MutationGerm-Line MutationPedigreeBase SequenceMolecular Sequence DataMutation RateExonsHeterozygoteAmino Acid SubstitutionAmino Acid SequencePolymerase Chain ReactionDNA Mutational AnalysisAllelesMutagenesis, Site-DirectedCell LinePolymorphism, Single-Stranded ConformationalMutagenesisGenotypeSequence Analysis, DNAHomozygoteCodon, NonsensePhenotypeRNA, MessengerDNA PrimersEscherichia coliProtein Structure, TertiaryGenes, RecessiveSequence DeletionDNA-Binding ProteinsCells, CulturedGenes, DominantTranscription FactorsKineticsGene DeletionSequence Homology, Amino AcidSuppression, GeneticProtein BindingMembrane ProteinsGenetic TestingBinding SitesCloning, MolecularModels, MolecularChromosome MappingTranscription, GeneticSaccharomyces cerevisiaeSignal TransductionGenetic Complementation TestTransfectionDNACodonCarrier ProteinsNuclear ProteinsBacterial ProteinsSequence AlignmentPlasmidsGenes, p53Mutant ProteinsTime FactorsMice, Inbred C57BLModels, GeneticFounder EffectSyndromeRecombinant ProteinsPromoter Regions, GeneticGene Expression RegulationGenetic LinkageGenetic Predisposition to DiseaseGene ExpressionCell NucleusMice, TransgenicMutagenesis, InsertionalModels, BiologicalBiological TransportDNA, MitochondrialBlotting, WesternReverse Transcriptase Polymerase Chain ReactionConsanguinityRecombinant Fusion ProteinsGenes, LethalDisease Models, AnimalTemperaturePhosphorylationMice, KnockoutImmunohistochemistrySaccharomyces cerevisiae ProteinsTumor Suppressor Protein p53Protein TransportProteinsGenes, BacterialCOS CellsFibroblastsPolymorphism, GeneticIntronsCell Line, TumorDNA, NeoplasmGenetic VariationStructure-Activity Relationship