In vivo , OBEX reduces weight gain by decreasing adiposity gain and increasing energy expenditure in high fat diet-fed mice through the activation of thermogenesis in brown adipose tissue (BAT) independent of eating behaviors. (nature.com)
In mice, adipocyte MHCII increased within 2 weeks on HFD, paralleling increases in proinflammatory ART markers and decreases in anti-inflammatory ART markers, and preceding adipose tissue macrophage (ATM) accumulation and proinflammatory M1 polarization. (nih.gov)
It is a complex and multifactorial condition characterized by excessive accumulation of adipose tissue, which can lead to various health complications such as cardiovascular disease, type-2 diabetes, and certain cancers. (alliedacademies.org)
A study that looked at the relationship between visceral adipose tissue and bone mineral density found a negative effect of adiposity on bone health. (medscape.com)
Lipid10
Lipid accumulation product (LAP) is an alternative continuous index of lipid accumulation, which is computed from waist circumference (WC, cm) and triglycerides (TGs, mmol/l): (WC-65) ×TG (men) and (WC-58) ×TG (women). (biomedcentral.com)
Lipid accumulation should be defined and measured specifically in those contexts where accumulation may represent a physiologic danger [ 6 , 7 ]. (biomedcentral.com)
These contexts might be described as lipid over accumulation [ 8 ]. (biomedcentral.com)
Kahn described a simple index for estimating lipid over accumulation among adults - designated the "lipid accumulation product" (LAP) - based on a combination of two measurements that are safe and inexpensive to obtain. (biomedcentral.com)
If LAP is better correlated than BMI with cardiovascular risk factors, this finding would support the notion that the over accumulation of lipid carries worse cardiovascular consequences than the less specific over accumulation of weight [ 9 ]. (biomedcentral.com)
Conclusions: TH9507 reduced truncal fat, improved the lipid profile and did not increase glucose levels in HIV-infected patients with central fat accumulation. (natap.org)
In addition, high-fat diet induced comparable levels of lipid accumulation in livers of Ffar1 +/+ and Ffar1 −/− mice. (diabetesjournals.org)
Consistent with in vivo findings, oleuropein dose-dependently suppressed lipid accumulation in 3T3-L1 cells during preadipocyte differentiation. (elsevierpure.com)
Additionally, exposure of the 3T3-L1 preadipocytes to oleuropein resulted in a marked attenuation of the secreted frizzled-related protein 2 (WNT inhibitor) or galnon (galanin receptor agonist) induced cellular lipid accumulation. (elsevierpure.com)
tion with lipid profile, analysis should be adjusted for overall adiposity. (who.int)
Regional adiposity3
We first explored the associations between physical behaviors and total and regional adiposity. (humankinetics.com)
Total body fat mass and regional adiposity were measured using dual-energy X-ray absorptiometry. (humankinetics.com)
Total (postprandial) and parasympathetic-dependent IS correlated negatively with whole-body fat (R-2 0.81 and 0.87) and regional adiposity (R-2 0.85 and 0.79). (ibict.br)
While genetics, diet, and physical activity have traditionally been considered the main drivers of obesity, emerging research suggests that epigenetics plays a pivotal role in regulating adiposity. (alliedacademies.org)
Obesity - Adiposity or the fat accumulation offers poor support to the veins. (drvikram.com)
Fatty replacement occurs when pancreatic cells that secrete enzymes (acinar cells) are replaced by adipocytes, while fatty infiltration refers to the accumulation of adipocytes due to obesity. (fitnesshacks.org)
Visceral fat accumulation1
Recent studies also suggest that growth hormone levels are reduced in HIV-infected patients, and correlate inversely with excess visceral fat accumulation [8,9]. (natap.org)
Obese5
Conclusions Serum leptin could be used as a surrogate convenient marker of adiposity in overweight/obese adolescent boys with T1D, equivalent to BMI Z-score or BMI%95. (bmj.com)
Whether serum adipokines could be used as convenient, surrogate markers of adiposity in obese/overweight adolescents with T1D is not known. (bmj.com)
The exact actions of PPARbeta/delta are still being researched, though in obese animals it appears to decrease adiposity. (bodybuilding.com)
PCOS may contribute to the pattern of fat accumulation in this reported non-obese population. (imsociety.org)
Applying these adiposity, were more predictive of cardio- criteria, 728 overweight and obese women vascular disease risk factors than BMI, a were eligible to participate in the study. (who.int)
Genome-wide association studies have identified common genetic variants robustly associated with anthropometric indicators of adiposity. (nature.com)
Mice5
However, Ffar1 +/+ and Ffar1 −/− mice had similar weight, adiposity, and hyperinsulinemia on high-fat diets, and Ffar1 −/− mice showed no improvement in glucose or insulin tolerance tests. (diabetesjournals.org)
Loss of stearoyl-CoA desaturase-1 function in mice , on the other hand, confers protection against adiposity, according to another study. (naturalnews.com)
Scope: The aim of the present study was to investigate the antiobesity effect of oleuropein on high-fat diet (HFD) induced body weight gain and visceral adiposity in mice, and to explore the underlying mechanisms involved. (elsevierpure.com)
The protective effect of oleuropein against HFD-induced adiposity in mice appeared to be mediated through the upregulation of genes involved in WNT10b-mediated signaling and downregulation of genes involved in galanin-mediated signaling cascades. (elsevierpure.com)
Indices1
In non-HIV-infected patients [6] and among HIV-infected patients with changes in fat distribution [7], increased waist-to-hip ratio (WHR) and central fat accumulation is related to increased metabolic risk indices. (natap.org)
Circumference2
Waist circumference measures the accumulation of fat around the abdominal area (central adiposity). (medicscientist.com)
Nonetheless, relative or absolute central adiposity may confer excess cardiovascular risk. (natap.org)
Excess central adiposity (called apple shape), particularly when it results in a high waist-to-hip ratio (reflecting a relatively low muscle-to-fat mass ratio), increases risk. (msdmanuals.com)
Objective: To investigate the effects of TH9507, a novel growth hormone releasing factor, on abdominal fat accumulation, metabolic and safety parameters in HIV-infected patients with central fat accumulation. (natap.org)
A new study examines the role of cortisol and testosterone in the accumulation of abdominal fat among normal weight women with PCOS. (medscape.com)
Metabolic1
But abdominal adiposity has been shown to be more closely linked with adverse metabolic consequences and has been suggested to precede insulin resistance [ 9 ]. (biomedcentral.com)
Waist1
An important related aspect is that, during the menopausal transition, women develop increased adiposity mainly at the waist. (imsociety.org)
Overweight2
If you notice any large accumulations of fat on your horse in the areas outlined in the diagram, chances are your horse is overweight and in danger of serious health consequences. (theplaidhorse.com)
The objective of this study was to assess the association among sexual maturation (SM), overweight and central adiposity in children and adolescents. (bvsalud.org)
Predictive1
Despite BMI being an indicator of adiposity, and thus a marker of CVR, its predictive value for CVR or CVD is limited (3). (imsociety.org)
Infiltration3
However, the fatty components in the pancreas are in the shape of adiposity cell infiltration ( 4 ). (fitnesshacks.org)
Multiple terms have been used to describe this fat accumulation such as the non-alcoholic fatty pancreas (NAFP), fatty infiltration (FI) of the pancreas, pancreatic steatosis, pancreatic lipomatosis, fatty replacement, and lipomatous pseudohypertrophy of the pancreas. (fitnesshacks.org)
During female aging, a muscle mass decrease occurs as well as greater accumulation and infiltration of fat, resulting from the endocrine changes that occur during the climacteric [1,2]. (bvsalud.org)
Central2
Healthy lifestyle behaviours appeared to attenuate the genetic influence on changes across age in BMI and central adiposity during mid-adulthood. (nature.com)
HIV-infected patients treated with highly active antiretroviral therapy (HAART) commonly experience changes in fat distribution that include increased visceral and central fat accumulation [1], as well as loss of subcutaneous fat in association with insulin resistance and dyslipidemia [2,3]. (natap.org)
Conclusion2
The conclusion of these studies was that reduced OxPhos led to reduced adiposity and increased insulin sensitivity--a contradiction of the theory that reduced OxPhos was the cause of T2DM. (bruker.com)
Studies using higher dose, pharmacologic growth hormone (GH) administration have resulted in reduced visceral adiposity in this population, but are associated with increased insulin resistance and side effects [10-13]. (natap.org)
HFD-associated postprandial insulin resistance is largely mediated by impairment of parasympathetic-dependent insulin action, which correlates with adiposity. (ibict.br)
Fatty2
Although clinically relevant lesions become evident in middle-aged adults, it has been demonstrated that fat accumulation (known as fatty streaks) begins in early childhood [ 5 ]. (hindawi.com)
The enzyme deficiencies lead to the accumulation of mucopolysaccharides in the lysosomes of the cells in the connective tissue and to an increase in their excretion in the urine. (medscape.com)
16q24.3 (Morquio syndrome): The deficiency of enzymes in Morquio syndrome type A or type B leads to the accumulation of keratan sulfate and chondroitin-6-sulfate in the connective tissue, the skeletal system, and the teeth. (medscape.com)
Weight2
Persistent gut microbiota due to gastric bypass reduce host weight and adiposity. (radeps.com)
The fat mass gain in peri- and young postmenopausal women may determine either of two phenotypes: the "apple" shape due to fat accumulation in the abdomen or the "pear" shape due to accumulation in the buttocks. (imsociety.org)
Healthy1
The pertinent public health question is whether or not an individual can attenuate the influence of their genetic risk for adiposity by healthy lifestyle behaviours? (nature.com)
Results1
The beauty center professional can propose a cellulite and/or adiposity detection, show the results, recommend an appropriate treatment, and monitor the results. (ips-aesthetics.com)
Physical1
The aim of this study was to examine modification of genetic influences on changes across age in adiposity during mid-adulthood by physical activity and smoking. (nature.com)
Type1
With contact thermography method, our liquid crystal plates allow to detect and classify the stages of cellulite and the type of adiposity . (ips-aesthetics.com)
Suggests1
That suggests that deletion of AIF does not cause accumulation of ROS or induce inflammation-important for the next stage of their experiments. (bruker.com)
Study2
In this study, we assessed the effect of TH9507, a novel growth hormone releasing factor (GRF) analog, over 12 weeks in HIV-infected men and women with evidence of fat redistribution and increased truncal adiposity. (natap.org)
Accelerated accumulation of multimorbidity after bilateral oophorectomy: A population-based cohort study. (radeps.com)
Large1
I ly region 4 gene was transferred to a retrovirus and inserted nfection with human adenovirus 36 (Adv 36) has been into preadipocytes in vitro, the gene was capable of induc- reported to cause a large accumulation of fat in 4 animals ing the enzymes and enhancing fat accumulation ( 13 ). (cdc.gov)
Measures1
Less is known concerning the performance of LAP as compared to the measures of abdominal adiposity. (biomedcentral.com)
Studies1
The difference from previous studies may be due to absence of accumulation of ROS in this particular model of OxPhos deficiency. (bruker.com)
Analysis1
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