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  • antipsychotic
  • Due to its favorable influence on metabolic parameters, it was concluded that lumateperone, unlike many other available antipsychotics such as risperidone, may not cause an increase in the risk of diabetes or cardiovascular disease, and hence may prove to be a significant improvement relative to many existing antipsychotic drugs in terms of long-term safety and tolerability. (wikipedia.org)
  • In such situations, alternative therapeutic approaches involving a combination of standard antipsychotic treatment with other drugs are employed. (hindawi.com)
  • activity
  • The discrepancy between the in vitro and in vivo actions of acetothiolutamide was determined to be related to rapid plasma clearance and extensive hepatic metabolism into a variety of metabolites with differing pharmacological activity, including AR partial agonism and antagonism. (wikipedia.org)
  • In accordance with its poor metabolic stability, acetothiolutamide is not orally bioavailable, and shows activity only via injected routes such as subcutaneous and intravenous. (wikipedia.org)
  • terms
  • This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 3.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. (bmj.com)
  • treatment
  • Buspirone is approved in the United States by the Food and Drug Administration (FDA) for the short- or long-term treatment of anxiety disorders or can also be used for the short-term relief of the symptoms of anxiety. (wikipedia.org)
  • The drug has also been found to be effective in the treatment of depression as a standalone drug. (wikipedia.org)
  • Apimostinel, also referred to as NRX-1074, is a drug that was originally developed by Naurex for the treatment of depression - but is now undergoing co-investigation by Naurex and Allergan (who acquired Naurex). (mentalhealthdaily.com)
  • although
  • Buspirone appears to be relatively benign in cases of single-drug overdose, although no definitive data on this subject appear to be available. (wikipedia.org)
  • Although approximately 70% of individuals who receive antidepressant medication derive substantial therapeutic benefit, the remaining 30% are partial or non-responders. (mentalhealthdaily.com)
  • development
  • Additionally, it's good to see more drugs in the development pipeline during 2018 than there were in 2015. (mentalhealthdaily.com)
  • While Apimostinel exhibits a similar mechanism of action GLYX-13 (another drug undergoing development by Naurex), it differs from GLYX-13 in that it is markedly more potent by weight. (mentalhealthdaily.com)
  • relative
  • It is thought that this property may improve the effectiveness and reduce the side effect profile of lumateperone relative to currently-available antipsychotics, a hypothesis which is supported by the observation of minimal catalepsy in mice treated with the drug. (wikipedia.org)
  • sold
  • It was initially developed in the late-1970s and used in scientific research before being sold as a designer drug in the mid-2000s. (wikipedia.org)
  • Buspirone, sold under the brand name Buspar, is an anxiolytic drug that is primarily used to treat generalized anxiety disorder (GAD). (wikipedia.org)
  • experience
  • Despite its advertisement as a recreational substance, mCPP is actually generally considered to be an unpleasant experience and is not desired by drug users. (wikipedia.org)
  • mechanisms
  • Many mechanisms of TRAIL resistance have been described (Dimberg et al , 2013 ), but their relative significance in controlling ligand and drug response in different cell types has not yet been established. (embopress.org)
  • likely
  • Additionally, alcoholic beverages and substance abuse possess been been shown to be elevated in people that have PTSD, with three main community studies confirming that ladies with PTSD are buy Ro 90-7501 3.1C4.5 times similar to more likely to abuse drugs and 1.4C3.1 times much more likely to abuse alcohol than females without PTSD (5C8). (capecodmushroom.org)
  • Unlike most current antipsychotics, such as haloperidol, risperidone, and olanzapine, lumateperone does not disrupt striatal dopamine signaling, a property which is likely due to its partial agonism of presynaptic D2 receptors. (wikipedia.org)
  • effect
  • Furthermore, the use of Dox-loaded nanobots presents an enhanced anticancer efficiency toward HeLa cells, which arises from a synergistic effect of the enhanced drug release and the ammonia produced at high concentrations of urea substrate. (ibecbarcelona.eu)
  • Gonzalvez & Ashkenazi, 2010 ), particularly with respect to incomplete (fractional) cell killing and low maximum drug effect ( E max ). (embopress.org)
  • It is thought that this property may improve the effectiveness and reduce the side effect profile of lumateperone relative to currently-available antipsychotics, a hypothesis which is supported by the observation of minimal catalepsy in mice treated with the drug. (wikipedia.org)
  • activity
  • In accordance with its poor metabolic stability, acetothiolutamide is not orally bioavailable, and shows activity only via injected routes such as subcutaneous and intravenous. (wikipedia.org)
  • relative
  • Due to its favorable influence on metabolic parameters, it was concluded that lumateperone, unlike many other available antipsychotics such as risperidone, may not cause an increase in the risk of diabetes or cardiovascular disease, and hence may prove to be a significant improvement relative to many existing antipsychotic drugs in terms of long-term safety and tolerability. (wikipedia.org)
  • sold
  • It was initially developed in the late-1970s and used in scientific research before being sold as a designer drug in the mid-2000s. (wikipedia.org)
  • interest
  • Mucosal administration of drugs and drug delivery systems has gained increasing interest. (ibecbarcelona.eu)
  • The use of enzyme catalysis to power micro- and nanomotors exploiting biocompatible fuels has opened new ventures for biomedical applications such as the active transport and delivery of specific drugs to the site of interest. (ibecbarcelona.eu)