• mechanism
  • While Apimostinel exhibits a similar mechanism of action GLYX-13 (another drug undergoing development by Naurex), it differs from GLYX-13 in that it is markedly more potent by weight. (mentalhealthdaily.com)
  • terms
  • Due to its favorable influence on metabolic parameters, it was concluded that lumateperone, unlike many other available antipsychotics such as risperidone, may not cause an increase in the risk of diabetes or cardiovascular disease, and hence may prove to be a significant improvement relative to many existing antipsychotic drugs in terms of long-term safety and tolerability. (wikipedia.org)
  • This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 3.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. (bmj.com)
  • activity
  • In accordance with its poor metabolic stability, acetothiolutamide is not orally bioavailable, and shows activity only via injected routes such as subcutaneous and intravenous. (wikipedia.org)
  • relative
  • It is thought that this property may improve the effectiveness and reduce the side effect profile of lumateperone relative to currently-available antipsychotics, a hypothesis which is supported by the observation of minimal catalepsy in mice treated with the drug. (wikipedia.org)
  • sold
  • It was initially developed in the late-1970s and used in scientific research before being sold as a designer drug in the mid-2000s. (wikipedia.org)
  • Buspirone, sold under the brand name Buspar, is an anxiolytic drug that is primarily used to treat generalized anxiety disorder (GAD). (wikipedia.org)