• Physical therapy guided by a therapist who is experienced in working with patients with connective-tissue abnormalities and joint dysfunction can be very helpful in the management of long-term health. (medscape.com)
  • Individuals with Ehlers-Danlos syndrome (EDS) demonstrate connective-tissue abnormalities due to defects in the inherent strength, elasticity, integrity, and healing properties of the tissues. (medscape.com)
  • Phosphatidylserine-exposing platelets, usually located around a thrombus, provide a negatively charged membrane surface, which supports coagulation factor binding and the formation of tenase and prothrombinase complexes ( 6 , 7 ). (frontiersin.org)
  • Intracranial dysfunction of hemostatic processes triggers profound local and systemic consequences, often with lethal outcomes including thrombosis, local vascular occlusion, hypoxic tissue damage, coagulation factor neurotoxicity, ischemic stroke, hemorrhage, and edema. (rmmj.org.il)
  • Storage-stable glycoprotein blood coagulation factor that can be activated to factor Xa by both the intrinsic and extrinsic pathways. (lookformedical.com)
  • EDS is caused by various abnormalities in the synthesis and metabolism of collagen and other connective-tissue proteins in the ECM, such as elastin, proteoglycans, and macromolecular proteins. (medscape.com)
  • Biochemical studies on collagen molecules are possible with cultured skin fibroblasts to confirm vascular-type EDS (type IV), arthrochalasia-type EDS (types VIIA and VIIB), and dermatosparaxis-type EDS (type VIIC). (medscape.com)
  • The process of thrombus formation is considered to be initiated by von Willebrand factor (VWF) binding to exposed collagen or laminin in the damaged vessel wall, followed by shear-dependent platelet binding to VWF through the glycoprotein (GP)Ib-V-IX complex ( 1 , 3 , 4 ). (frontiersin.org)
  • [ 1 ] This group of connective-tissue disorders is characterized by abnormal collagen synthesis causing hyperextensibility of the skin, hypermobility of the joints, and tissue fragility, as is seen by easy bruising and delayed wound healing with atrophic scarring. (medscape.com)
  • Collagen is the most abundant protein in the body and is the most common protein found in the ECM. (medscape.com)
  • One critical mediator of DIC is the release of a transmembrane glycoprotein called tissue factor (TF). (wikipedia.org)
  • Unique to each connective protein array is the path of production, its relative proportion, and distribution in tissues or organs. (medscape.com)
  • Constituent composed of protein and phospholipid that is widely distributed in many tissues. (lookformedical.com)
  • Deficiency of factor V leads to Owren's disease. (lookformedical.com)
  • A deficiency of factor X, sometimes called Stuart-Prower factor deficiency, may lead to a systemic coagulation disorder. (lookformedical.com)
  • Intrahepatic fibrin(ogen) deposition was abolished in mice with liver-specific tissue factor deficiency, pinpointing the trigger of coagulation after PHx. (ashpublications.org)
  • Each tissue and organ system has an array of connective proteins. (medscape.com)
  • Activated form of factor X that participates in both the intrinsic and extrinsic pathways of blood coagulation. (lookformedical.com)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • This complex further activates factor IX and X to IXa and Xa, respectively, leading to the common coagulation pathway and the subsequent formation of thrombin and fibrin. (wikipedia.org)
  • The process of the interaction of BLOOD COAGULATION FACTORS that results in an insoluble FIBRIN clot. (lookformedical.com)
  • An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. (lookformedical.com)
  • Factor V accomplishes this by forming a complex with factor Xa, phospholipid, and calcium (prothrombinase complex). (lookformedical.com)
  • Ehlers-Danlos syndrome (EDS) consists of a group of inherited heterogeneous disorders that share a common decrease in the tensile strength and integrity of the skin, joints, and other connective tissues. (medscape.com)
  • Elastin allows for the tissues to stretch and return to their original state and hence is present in the ECM of blood vessels, lungs, and skin. (medscape.com)
  • 1 While the brain represents only 2% of the body mass, it receives 20% of cardiac output, resulting in the flow rate of approximately 50 mL of blood per 100 g of tissue every minute. (rmmj.org.il)
  • It is a test of the intrinsic pathway (factors VIII, IX, XI, and XII) and the common pathway (fibrinogen, prothrombin, factors V and X) of BLOOD COAGULATION. (lookformedical.com)
  • TF is also abundant in tissues of the lungs, brain, and placenta. (wikipedia.org)
  • While brain tumor cells express tissue factor (TF) and other effectors of the coagulation system (coagulome), their propensity to induce local and peripheral thrombosis is highly diverse, most dramatic in the case of glioblastoma multiforme (GBM), and less obvious in pediatric tumors. (rmmj.org.il)
  • In addition, the absence of the lymphatic circulation in the brain places demands on the vascular system in terms of the interstitial fluid circulation pattern 3 and mitigation of physical stress on tissues locked within the rigid confines of the intracranial space. (rmmj.org.il)
  • The ECM is defined as the outer cell components of tissue that provide structural support to the cells. (medscape.com)
  • Like all viruses, the EBOV largely relies on host cell factors and physiological processes for its entry, replication, and egress. (biomedcentral.com)
  • In fact, every cell needs iodine, and thyroid and hormonal tissues need it the most. (welladjusted.co)
  • [ 7 ] The specific characteristics of a particular form of EDS stem from the tissue-specific distribution of various components of the extracellular matrix (ECM). (medscape.com)
  • Recombinant factor VIIa has been used to help control surgical bleeding, but experience is limited and the usual surgical precautions for patients with EDS should be followed. (medscape.com)
  • It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. (lookformedical.com)
  • and FACTOR X. It is used for monitoring anticoagulant therapy with COUMARINS. (lookformedical.com)
  • We propose a therapeutic regimen to supplement the current supportive therapy aiming to reduce viral load, the most important factor in the determination of mortality. (biomedcentral.com)
  • Upon exposure to blood and platelets, TF binds with activated factor VIIa (normally present in trace amounts in the blood), forming the extrinsic tenase complex. (wikipedia.org)
  • With a vascular injury, TF becomes exposed to blood and binds plasma factor VIIa, and the resulting complex initiates a series of enzymatic reactions leading to clot formation and vascular sealing. (hindawi.com)
  • When mechanical or chemical damage of the vascular wall occurs, subendothelial TF is expressed/exposed to blood flow and binds plasma factor VIIa, which circulates as an enzyme at a concentration of approximately 0.1 nM (1% of plasma factor VII) [ 4 ] and escapes the inhibition by serine proteases inhibitors because of its poor enzymatic qualities [ 1 , 5 ]. (hindawi.com)
  • This complex further activates factor IX and X to IXa and Xa, respectively, leading to the common coagulation pathway and the subsequent formation of thrombin and fibrin. (wikipedia.org)
  • Thrombin accelerates its own generation via several feed-back reactions, cleaves fibrinogen, and activates factor XIII, which leads to the formation of a crosslinked insoluble fibrin clot [ 6 , 7 ] (Figure 1 ). (hindawi.com)
  • and activates factor XIII to form a cross-linked fibrin clot. (hindawi.com)
  • The factor VIIa-TF complex initiates blood coagulation by activating the zymogens factor IX and factor X to their respective serine proteases, factor IXa and factor Xa. (hindawi.com)
  • TFPI serves to attenuate the activity of the extrinsic factor Xase, the trigger of coagulation. (hindawi.com)
  • We noted up-regulation of genes related to coagulation [tissue factor ( F3 ) and coagulation factor II receptor-like 2 ( F2RL2 )] and differential regulation of genes related to F3 signaling ( FOS, JUN, and NFKBIA ). (nih.gov)
  • Trauma does not appear to be a predisposing factor. (medscape.com)
  • The biomembranes numerical during muscle glycogen under different modifications are, cell, application reduced, differentiation and architecture human professions promoter The transcription of rafts targeted in co-factor is involved starting in unpaired cells, and act: people, DSIF, NELF, P-Tefb etc. (evakoch.com)
  • Within these sensory organs, expression of the transcription factor Emx2 is restricted to only one side of the LPR in the maculae or one of the two sibling HCs in neuromasts. (nih.gov)
  • It is a component of the factor VIIa-TF complex enzyme and plays a primary role in both normal hemostasis and thrombosis. (hindawi.com)
  • TF is an integral transmembrane protein expressed by various cells, is a component of the factor VIIa-TF complex enzyme and is essential for normal hemostasis [ 1 , 2 ]. (hindawi.com)
  • Oxidative stress and hypoxia are two key biochemical factors in the development of rheumatoid arthritis (RA). (bvsalud.org)
  • As clotting factors and platelets are used up, bleeding may occur. (wikipedia.org)