AnatomyDiseasesAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
BronchiectasisBronchographySputumCiliary Motility DisordersAspergillosis, Allergic BronchopulmonaryHemoptysisMucociliary ClearanceKartagener SyndromeCystic FibrosisTomography, X-Ray ComputedRespiratory Function TestsForced Expiratory VolumeCoughBronchitisVital CapacityMucusCommon Variable ImmunodeficiencySuppurationPseudomonas InfectionsLung DiseasesRespiratory Tract Infections
Adults with bronchiectasisPrevalence of bronchiectasisExacerbationsCysticMethodsRisk of developing broDiagnosisInfectionLung diseaseBronchialTherapy for bronchiectasis2021Treatment of bronchiectasisDevelopment of bronchiectasisGuidelines for bronchiectasisSevere bronchiectasisEuropean BronchiectasisCylindrical bronchiectasisEtiologyIdiopathicAirwayComputed tomographyStablePneumoniaEMBARCClinicallyRecurrentOutcomesRegistrySeverity IndexDemographicObjectiveCommon chronicCorrelationCharacteristicsExerciseDiseaseRadiologicalHospitalizationChronic inflammatoryAbnormalCohortTherapiesClinical trialsHeterogeneityEtiologicalAdult patientsCochraneNeutrophilic inflammation
Adults with bronchiectasis1
Prevalence of bronchiectasis4
Exacerbations11
  • Bronchiectasis is a long-term respiratory condition characterised by persistent airway infection and recurrent exacerbations in the presence of structurally abnormal bronchi. (ersjournals.com)
  • To determine the effect of anticholinergic therapy in acute exacerbations and stable bronchiectasis. (cochrane.org)
  • The per episode healthcare cost burden of hospitalizations for paediatric bronchiectasis exacerbations is substantial. (asthmafoundation.org.nz)
  • Interventions that prevent hospitalized exacerbations and reduce severity of childhood bronchiectasis with even moderate effectiveness are likely to result in substantial hospital costs savings. (asthmafoundation.org.nz)
  • We know that the level of lung inflammation is important for long term health in bronchiectasis, so we wanted to know whether the sputum colour, when assessed when the patient is healthy with no chest infection, had any relationship to long-term outcomes such as lung function and frequency and severity of exacerbations. (thesynapse.net)
  • Although amoxicillin-clavulanate is the recommended first-line empirical oral antibiotic treatment for non-severe exacerbations in children with bronchiectasis, azithromycin is also often prescribed for its convenient once-daily dosing. (edu.au)
  • No randomised controlled trials involving acute exacerbations in children with bronchiectasis have been published to our knowledge. (edu.au)
  • We hypothesised that azithromycin is non-inferior to amoxicillin-clavulanate for resolving exacerbations in children with bronchiectasis. (edu.au)
  • By 21 days of treatment, azithromycin is non-inferior to amoxicillin-clavulanate for resolving exacerbations in children with non-severe bronchiectasis. (edu.au)
  • Individuals with bronchiectasis experienced a median of two exacerbations (IQR 1-4) per year and 4483 (26·4%) patients had a hospitalisation for exacerbation in the previous year. (hunimed.eu)
  • Compared with other regions, patients in central and eastern Europe had more severe bronchiectasis measured by the Bronchiectasis Severity Index (51·3% vs 35·1% in the overall cohort) and more exacerbations leading to hospitalisations (57·9% vs 26·4% in the overall cohort). (hunimed.eu)
Cystic13
  • Lung transplantation has become an excellent treatment option for patients with cystic fibrosis (CF) and bronchiectasis with very advanced lung disease. (nih.gov)
  • There is a paucity of data on incidence, prevalence and mortality associated with non-cystic fibrosis bronchiectasis. (ersjournals.com)
  • Using primary care data (Clinical Practice Research Datalink (CPRD)), we aimed to establish the incidence and prevalence of non-cystic fibrosis bronchiectasis in UK adults from 2004 to 2013. (ersjournals.com)
  • In contrast, there have been many randomised trials in chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF) over the past 20 years, leading to a tendency for bronchiectasis researchers to use end-points and therapies previously developed in these two diseases. (ersjournals.com)
  • Saad AB, Migaou A, Fahem N, Mhamed SC, Rouatbi N, Joobeur S. Severity assessment of non-cystic fibrosis bronchiectasis by the FACED score. (patsjournal.org)
  • This study aimed to determine the relation of the FACED score (a multidimensional score contributing to stratify patients into risk categories) with the severity of non-cystic fibrosis bronchiectasis (NCFB) among our population. (patsjournal.org)
  • We enrolled children aged 1-19 years with radiographically proven bronchiectasis unrelated to cystic fibrosis. (edu.au)
  • Cystic type on HRCT is found to be common in bronchiectasis patients in our region. (jclmm.com)
  • We aimed to assess the effect of MBL deficiency on disease severity in non-cystic fibrosis bronchiectasis. (ed.ac.uk)
  • METHODS: We recruited patients with non-cystic fibrosis bronchiectasis and age-matched and sex-matched controls at a specialist bronchiectasis clinic in Edinburgh, UK. (ed.ac.uk)
  • A report of B cepacia bronchiectasis is presented where a previously healthy mother of two cystic fibrosis children colonised with B cepacia became infected by the same epidemic strain. (bmj.com)
  • We present a case of chronic B cepacia bronchiectasis in the mother of two children with cystic fibrosis already colonised with B cepacia . (bmj.com)
  • however, its presence, frequency, and clinical significance in non-cystic fibrosis bronchiectasis remain unclear. (a-star.edu.sg)
Methods5
  • To evaluate the use of end-points in bronchiectasis trials, we conducted a systematic review of published bronchiectasis trials from 2008 to 2018 and extracted end-points used, definitions, methods of analysis and responsiveness. (ersjournals.com)
  • Methods: Semi-structured interviews with ten patients with bronchiectasis were conducted to explore perceptions of exercise, potential barriers and facilitators of exercise. (edgehill.ac.uk)
  • Methods: EMBARC is an international clinical research network for bronchiectasis. (hunimed.eu)
  • Materials and Methods: In this study 150 bronchiectasis patients coming to Dhiraj Hospital, Pipariya, Vadodara within a span of 18 months were included. (jclmm.com)
  • Methods: Patients with bronchiectasis were recruited in Asia (Singapore and Malaysia) and the United Kingdom (Scotland) (n = 238), forming the Cohort of Asian and Matched European Bronchiectasis, which matched recruited patients on age, sex, and bronchiectasis severity. (a-star.edu.sg)
Risk of developing bro2
  • Certain purebred dogs and older dogs may have an increased risk of developing bronchiectasis. (avma.org)
  • HIV-1 infected children with a history of recurrent pneumonia, profound immuno-suppression (CDC immunologic category 3), and LIP appear to have a higher risk of developing bronchiectasis. (johnshopkins.edu)
Diagnosis12
  • The accuracy of International Classification of Diseases (ICD) diagnosis codes for NTM infection has been evaluated only in limited fashion ( 6 ) and is unknown in the context of bronchiectasis, which most patients with pulmonary NTM infection have ( 7 , 8 ). (cdc.gov)
  • We investigated the accuracy of ICD diagnosis codes for NTM infection among Medicare beneficiaries in the United States by using the Bronchiectasis and NTM Research Registry (BRR) as the reference standard. (cdc.gov)
  • We identified persons with a diagnosis of bronchiectasis (ICD Ninth Revision, Clinical Modification [ICD-9-CM], codes 494.0 or 494.1) from 2006-2014 Medicare data. (cdc.gov)
  • Median duration of clinical signs prior to diagnosis of bronchiectasis was 9 months (range, 1 day to 10 years). (avma.org)
  • In 2008, the Spanish Society of Pulmonology (SEPAR) published the first guidelines in the world on the diagnosis and treatment of bronchiectasis. (archbronconeumol.org)
  • Almost 10 years later, considerable scientific advances have been made in both the treatment and the evaluation and diagnosis of this disease, and the original guidelines have been updated to include the latest therapies available for bronchiectasis. (archbronconeumol.org)
  • The usefulness of imaging signs for the diagnosis of PH and of coronary lesions by using chest HRCT examination was demonstrated, underlying the role of modern diagnostic and treatment strategies in certain bronchiectasis patient sub-populations. (cnaa.md)
  • Conclusion: It is essential to evaluate the cardiac status of bronchiectasis patients at the time of diagnosis as cardiac manifestations are one of the dreadful complications. (ijmpr.in)
  • Emphasizing the role of multi-detector computed tomography chest in the etiological diagnosis of pulmonary bronchiectasis. (jclmm.com)
  • Criteria and definitions for the radiological and clinical diagnosis of bronchiectasis in adults for use in clinical trials: international consensus recommendations. (jclmm.com)
  • Bronchiectasis diagnosis was associated with a higher prevalence of chronic rhinosinusitis with nasal polyps (54.6% vs. 38%, p = 0.001) and higher serum IgE levels (673.4 vs. 412.1 kUI/L, p = 0.013). (unisa.it)
  • Bronchiectasis were found in 42% of patients at the time of diagnosis. (bvsalud.org)
Infection9
  • BRR is a database of persons with bronchiectasis, NTM infection, or both at 13 US medical institutions ( 8 ). (cdc.gov)
  • Nevertheless, patients with preexisting bronchiectasis are susceptible to NTM but the prevalence of NTM pulmonary infection in different species and geographical areas is still not fully understood. (nih.gov)
  • Our findings suggested that the prevalence NTM infection is high in patients with bronchiectasis. (nih.gov)
  • Pseudomonas aeruginosa is responsible for chronic infection in many bronchiectasis patients but it is not known whether it is associated with worse clinical outcomes independent of the underlying severity of disease. (ersjournals.com)
  • Pseudomonas aeruginosa is one of the most important organisms causing chronic infection in bronchiectasis, because of its capacity to maintain virulence despite antibiotic therapies by forming biofilms and easily developing antimicrobial resistance [ 4 - 6 ]. (ersjournals.com)
  • Although worldwide the commonest cause of bronchiectasis is previous acute lung infection, there is a large range of other causes and bronchiectasis could remain a relatively common condition even in high-income countries. (ersjournals.com)
  • Bronchiectasis can coexist and/or be associated with other long-term respiratory conditions, such as chronic obstructive pulmonary disease (COPD) and asthma, as well as many nonrespiratory diseases, including rheumatoid arthritis and HIV infection. (ersjournals.com)
  • Antimicrobial Treatment in Bronchial Infection in Patients with Bronchiectasis. (archbronconeumol.org)
  • Chronic neutrophilic inflammation, in both the presenceand absence of infection, is a feature of bronchiectasis in adults andchildren. (edu.au)
Lung disease7
  • Bronchiectasis is a chronic suppurative lung disease often characterised by airflow obstruction and hyperinflation, and leading to decreased exercise tolerance and reduced health status. (bmj.com)
  • Bronchiectasis is a chronic (often suppurative) lung disease not traditionally included in the definition of COPD, but also characterised by airflow obstruction and symptoms including cough, sputum production, wheeze, dyspnoea, and decreased exercise tolerance. (bmj.com)
  • The colour of the phlegm from patients with the lung disease bronchiectasis can indicate the degree of inflammation in their lungs and predict their future outcomes, according to new research presented at the European Respiratory Society International Congress in Milan, Italy. (thesynapse.net)
  • Bronchiectasis is a common chronic lung disease characterized by recurrent infections due to defective mucus clearance from the airways and can progress to chronic respiratory failure and death. (biomedcentral.com)
  • Weincluded this study of 25 adults with chronic lung disease (only 32% of peopleincluded in the trial had bronchiectasis), as the other conditions were linkedto development of bronchiectasis, and all were characterised by chronic sputumproduction. (edu.au)
  • One small trial reported a reduction in sputum production andimproved dyspnoea among adults with chronic lung disease who were treated withinhaled indomethacin, indicating that additional studies on the efficacy ofNSAIDs for treatment of patients with bronchiectasis are warranted. (edu.au)
  • Chronic suppurative lung disease and bronchiectasis in children and adults in Australia and New Zealand. (medscape.com)
Bronchial1
  • The aim of our study was to evaluate the effectiveness of PD, percussion, CT, and huffing in subjects with bronchiectasis and assess the quantity and quality of bronchial mucus produced (measurement of wet and dry weight and determination of viscoelastic properties). (rcjournal.com)
Therapy for bronchiectasis1
  • Cochrane Abstracts , Evidence Central , evidence.unboundmedicine.com/evidence/view/Cochrane/431498/all/Anticholinergic_therapy_for_bronchiectasis. (unboundmedicine.com)
20211
  • The first cohort of patients recruited to the EARCO (European Alpha1 Research Collaboration) International Registry data base by the end of 2021 was analysed for radiological evidence of both emphysema and bronchiectasis as well as baseline demographic features. (gencat.cat)
Treatment of bronchiectasis2
  • We looked for randomised studies addressing this question but we could not identify any evidence for or against the use of anticholinergic drugs in the treatment of bronchiectasis. (cochrane.org)
  • Treatment of bronchiectasis was highly heterogeneous between regions. (hunimed.eu)
Development of bronchiectasis1
Guidelines for bronchiectasis2
  • The 2017 European Respiratory Society (ERS) guidelines for bronchiectasis were unable to recommend any pharmacotherapy with strong evidence because of a lack of trials demonstrating statistically significant benefits [ 3 ]. (ersjournals.com)
  • The European Respiratory Society (ERS) published guidelines for bronchiectasis management in 2017 which recommends a minimum bundle of investigations that includes complete blood count (CBC), Immunoglobulin A (IgA), Immunoglobulin M (IgM) and immunoglobulin G (IgG) in all bronchiectasis patients [ 1 ] with further investigations to be done on the clinical suspicion and on the treating physician's discretion. (biomedcentral.com)
Severe bronchiectasis2
European Bronchiectasis1
  • Dr Critchton and her colleagues recorded the sputum colour in 13,484 out of 19,324 patients who regularly coughed up sputum and who were enrolled in the pan-European bronchiectasis registry, EMBARC. (thesynapse.net)
Cylindrical bronchiectasis2
  • On thoracic radiographs, cylindrical bronchiectasis, generalized disease, and right cranial lung lobe involvement were most common. (avma.org)
  • High resolution chest CT scans showed heterogeneous air trapping, cylindrical bronchiectasis, and patchy ground-glass opacities. (cdc.gov)
Etiology1
  • The etiology of bronchiectasis varies geographically, but there is a lack of published data examining its etiology specifically within the Middle Eastern population. (biomedcentral.com)
Idiopathic2
  • Thirty two patients with idiopathic bronchiectasis were randomly allocated to one of three groups: PR plus sham IMT (PR-SHAM), PR plus targeted IMT (PR-IMT), or control. (bmj.com)
  • In our study, post-infectious, idiopathic, and PCD were identified as the most common etiologies of bronchiectasis. (biomedcentral.com)
Airway4
  • The long-term monitoring of the bronchiectasis patients from a multidimensional perspective highlighted some correlations according to the etiological, imaging, ventilatory patterns and chronic airway infections in the bronchiectasis patients. (cnaa.md)
  • Introduction Bronchiectasis is an increasingly common chronic inflammatory airway disease. (elsevierpure.com)
  • Bronchiectasis is a widely prevalent airway disease characterized by airway dilatation and recurrent infections, that can lead to respiratory failure in severe cases. (biomedcentral.com)
  • Objectives: To determine the frequency and geographic variability that exists in a sensitization pattern to common and specific allergens, including house dust mite and fungi, and to correlate such patterns to airway immune-inflammatory status and clinical outcomes in bronchiectasis. (a-star.edu.sg)
Computed tomography1
Stable3
  • No formal recommendations can be made about the use of anticholinergic therapy in acute or stable bronchiectasis based on the literature currently available. (cochrane.org)
  • The aim of our study was to characterise the lipids obtained from serum and airways in bronchiectasis patients in the stable state. (ed.ac.uk)
  • Sundrarajaperumal A, Nedunchezhian R, Ranganathan D, Sundar V. Radiological and pulmonary function test assessment in clinically stable bronchiectasis patients. (jclmm.com)
Pneumonia4
EMBARC1
Clinically2
  • Data obtained by the enrolled patients were analyzed, focusing the attention on those patients with concomitant clinically relevant bronchiectasis.ResultsAbout 15.5% patients have bronchiectasis. (unisa.it)
  • Improving endophenotyping of sensitized bronchiectasis, a clinically significant state, and a "treatable trait" permits therapeutic intervention in appropriate patients, and may allow improved stratification in future bronchiectasis research and clinical trials. (a-star.edu.sg)
Recurrent2
  • Bronchiectasis is a chronic respiratory disease that causes persistent cough, sputum production and recurrent chest infections. (ersjournals.com)
  • Bronchiectasis is characterized by abnormal, permanent dilation of the bronchi, 1 which results in chronic cough, mucus production in the airways, and recurrent pulmonary infections. (rcjournal.com)
Outcomes3
  • Although those CF and bronchiectasis patients with severe respiratory disease are often infected with organisms that display in vitro resistance to the commonly used antibiotics, they usually have successful outcomes with transplantation, which are reported to be the same as in those patients with less resistant bacteria. (nih.gov)
  • We evaluated secondary safety outcomes in a comparative effectiveness study of chronic inhaled corticosteroids (ICS) and macrolide monotherapy in bronchiectasis patients. (elsevierpure.com)
  • Interpretation: Bronchiectasis shows important geographical variation in causes, microbiology, severity, and outcomes across Europe. (hunimed.eu)
Registry2
  • We conducted a retrospective analysis of our bronchiectasis patient registry, extracting clinical and demographic characteristics from electronic medical records. (biomedcentral.com)
  • We evaluated the frequency of bronchiectasis on severe asthma in a real-life setting, through the 'Severe Asthma Network Italy' (SANI) registry.MethodsSANI registry encompasses demographic, clinical, functional and inflammatory data of Italian severe asthmatics. (unisa.it)
Severity Index1
  • At the time of review, 11 patients had died (median age, FEV %predicted, and bronchiectasis severity index (BSI) 59 years, 38% and 15.5 respectively), all due to respiratory failure, and as expected, all were classed severe on BSI. (biomedcentral.com)
Demographic1
  • Objective -To determine demographic, clinical, and radiographic features of bronchiectasis in dogs. (avma.org)
Objective4
  • The objective of this study was to evaluate the risk of lower respiratory tract infectious events among patients followed for bronchiectasis and receiving non biologic DMARDs and/or biologic treatments for rheumatic diseases, and to assess factors associated with infections, and in particular disease-modifying treatments. (biomedcentral.com)
  • Objective: To explore the views and experiences of adult patients with bronchiectasis towards exercise. (edgehill.ac.uk)
  • Objective: To investigate prevalence and spatial distribution of air cysts and bronchiectasis associated with mechanical ventilation in patients with severe acute respiratory distress syndrome. (elsevierpure.com)
  • The main objective of this study was to compare physical activity (PA) levels subjectively and objectively between patients with bronchiectasis and healthy individuals using an accelerometer and a questionnaire. (ogu.edu.tr)
Common chronic1
  • Introduction: Bronchiectasis is one of the common chronic respiratory diseases and associated with respiratory morbidity and mortality. (jclmm.com)
Correlation2
  • Aim of the study: The study aimed to find out the Prevalence of Pulmonary Artery Hypertension and its Correlation with the Severity of Bronchiectasis in a Tertiary Care Hospital. (ijmpr.in)
  • HRCT score in bronchiectasis: correlation with pulmonary function tests and pulmonary artery pressure. (jclmm.com)
Characteristics4
  • Dr Megan Crichton, a postdoctoral researcher at the University of Dundee, UK, who presented the research, said: "One of the main characteristics of bronchiectasis is a productive cough, with almost three quarters of bronchiectasis patients producing sputum daily. (thesynapse.net)
  • This aim of this study was to describe the clinical characteristics of bronchiectasis and compare between different European countries. (hunimed.eu)
  • Clinical, Radiological, and Lung Function Characteristics of Post-tuberculosis Bronchiectasis: An Experience From a Tertiary Care Center in India. (jclmm.com)
  • Background Although bronchiectasis has been recognised as a feature of some patients with Alpha1-Antitrypsin deficiency the prevalence and characteristics are not widely known. (gencat.cat)
Exercise3
Disease10
  • Bronchiectasis is a chronic and progressive respiratory disease characterised by permanent dilation of bronchi, impairment of mucus clearance, chronic cough and sputum production, and an increased frequency of respiratory infections [ 1 ]. (ersjournals.com)
  • 8 Theoretically, one would therefore expect pulmonary rehabilitation to be as effective in bronchiectasis as it is in COPD, but to date only one study has been performed which included only seven patients with the disease. (bmj.com)
  • Bronchiectasis is a chronic respiratory disease. (cochrane.org)
  • Bronchiectasis is an orphan disease with few randomised controlled trials (RCTs) having been conducted and a limited understanding of its pathophysiology. (ersjournals.com)
  • The study demonstrated the prognostic value of imaging scores and multidimensional indices in assessing the severity of the disease and the impact on the quality of life of patients with bronchiectasis. (cnaa.md)
  • Monocenter, retrospective systematic study of all patients with a chronic inflammatory rheumatic disease and concomitant bronchiectasis, seen between 2000 and 2009. (biomedcentral.com)
  • Lower respiratory tract infectious events are frequent among patients receiving biologics for chronic inflammatory rheumatic disease associated with bronchiectasis. (biomedcentral.com)
  • Background: Bronchiectasis is a heterogeneous, neglected disease with few multicentre studies exploring the causes, severity, microbiology, and treatment of the disease across Europe. (hunimed.eu)
  • is a cause of brain abscesses in patients with underlying pulmonary structural disease like bronchiectasis. (archivosdeneurociencias.org)
  • INTERPRETATION: MBL might be an important modifier of disease severity in non-CF bronchiectasis. (ed.ac.uk)
Radiological1
  • Several bronchiectasis phenotypes were revealed based on the analysis of clinical, radiological, microbiological and ventilatory patterns and their role in the personalized approach for patients with bronchiectasis in the Republic of Moldova was shown. (cnaa.md)
Hospitalization1
Chronic inflammatory1
Abnormal1
  • Air cysts, bronchiectasis, and the percentage of normal and abnormal tissue were quantified for each segment and correlated to the duration and variables of mechanical ventilation. (elsevierpure.com)
Cohort1
  • Measurements and Main Results: A high frequency of sensitization to multiple allergens was detected in bronchiectasis, exceeding that in a comparator cohort with allergic rhinitis (n = 149). (a-star.edu.sg)
Therapies2
  • The failure of some therapies to show benefit in bronchiectasis, notably recombinant DNAse in the late 1990s, has led many to suggest this approach is flawed and that specific trial end-points and approaches are needed for bronchiectasis [ 4 ]. (ersjournals.com)
  • Further characterisation of these lipids and understanding the interplay of anti and pro-inflammatory lipid mediators could lead to the development of novel anti-inflammatory therapies for bronchiectasis. (ed.ac.uk)
Clinical trials2
  • Bronchiectasis is an increasing clinical problem, but multiple recent clinical trials have failed to reach their primary end-point. (ersjournals.com)
  • In this study, we conducted a systematic review of the end-points used in bronchiectasis clinical trials with the goal of identifying the most widely used end-points, their definitions and responsiveness, and of identifying research priorities for optimising pharmacotherapy trials. (ersjournals.com)
Heterogeneity1
  • The theoretical significance consists in the proposal of a new complex conceptual framework for scientific and practical evaluation of the bronchiectasis heterogeneity. (cnaa.md)
Etiological2
  • To determine the etiological and phenotypical peculiarities, correlated with the clinical, imaging, functional and microbiological patterns in bronchiectasis for the proposal of the management strategy in adult patients. (cnaa.md)
  • Based on the study, the etiological diversity of bronchiectasis in adults was demonstrated, including the rare etiological forms, with the presentation of imaging features and the needed paraclinical tests for their confirmation. (cnaa.md)
Adult patients1
Cochrane1
  • The relevant data of the prevalence of NTM in patients with bronchiectasis were retrieved by searching the main databases such as PubMed, MEDLINE, Cochrane Library, and EMBASE. (nih.gov)
Neutrophilic inflammation1
  • Bronchiectasis is characterised by excessive neutrophilic inflammation. (ed.ac.uk)