• Distal
  • Sometimes, minor abnormalities of other bone structures, often caused by disease or injury, such as a fracture of the distal end of the radius with upward displacement of the distal fragment. (wikipedia.org)
  • Madelung deformity of the wrist is caused by a growth disturbance in the inferior volar part of the epiphysial growth plate in the distal radius resulting in a volar placed slope of the lunate facet and scaphoid facet. (wikipedia.org)
  • Syndrome
  • In humans, evidence of a frameshift mutation in the bHLH domain of HAND1 has been correlated with hypoplastic left heart syndrome (a serious form of congenital heart disease where the left side of the heart is severely underdeveloped), aiding in the implication that HAND1 expression is a factor to patients suffering from the disease. (wikipedia.org)
  • She was born with constriction ring syndrome, a congenital abnormality causing the loss of several of her fingers and toes before birth. (wikipedia.org)
  • cleft
  • A median cleft was present in the affected hand with absence of the 3rd and 4th digits, giving rise to a characteristic lobster-claw appearance. (hindawi.com)
  • On local examination, a median cleft was present on the affected hand. (hindawi.com)
  • flexor
  • The following tendon deviations can induce congenital clasped thumb: The flexor tendons are too short (the thumb is drawn into the palm) The abductor tendons are hypoplastic or absent The extensor tendons are hypoplastic or absent Furthermore, a tight thumb web space (the area between thumb and index finger) can contribute to congenital clasped thumb. (wikipedia.org)
  • lobster-claw
  • The left hand showed aplasia of the 3rd and 4th digits, giving a characteristic lobster-claw appearance (Figure 1 ). (hindawi.com)
  • anomaly
  • There are many types of hand or arm deficiency, the anomaly is so varied that obtaining support can be difficult. (blogspot.com)
  • Congenital clasped thumb describes an anomaly which is characterized by a fixed thumb into the palm at the metacarpophalangeal joint in one or both hands. (wikipedia.org)
  • The anomaly is in most cases bilateral (present in both hands). (wikipedia.org)
  • differentiation
  • A member of the HAND subclass of basic Helix-loop-helix (bHLH) transcription factors, the Heart and neural crest-derived transcript-1 (HAND1) gene is vital for the development and differentiation of three distinct embryological lineages including the cardiac muscle cells of the heart, trophoblast of the placenta, and yolk sac vasculogenesis. (wikipedia.org)
  • symptoms
  • Pain and deformity are the main symptoms patients present with. (wikipedia.org)
  • Additional symptoms included muscle atrophy in the legs and hands, deafness, cataracts, and a tissue mass covering the roof of his mouth. (wikipedia.org)
  • joints
  • The cardinal clinical feature is persistent swelling of the affected joint(s), which commonly include the knee, ankle, wrist, and small joints of the hands and feet. (wikipedia.org)
  • present
  • The skin graft itself usually has a slightly different color and further hyperpigments (2, 3, 4, 5) when placed on the hand and can have hair growth that would not normally be present between fingers. (clinicaltrials.gov)
  • It occurs predominantly in adolescent females who present with pain, decreased range of motion, and deformity. (wikipedia.org)
  • In humans/animals this condition can present itself on one or both hands. (wikipedia.org)
  • The name of the condition indicates that it affects the bones of the spine (spondylo-) and the ends of bones (epiphyses), and that it is present from birth (congenital). (wikipedia.org)
  • birth
  • A 4-year-old child presented to the pediatric department with a deformed left hand since birth. (hindawi.com)
  • thumb
  • Hand function can be improved if the functions of thumb pinch or finger grasp is compromised. (emoryhealthcare.org)
  • showed that boys are twice as often affected with congenital clasped thumb compared to girls. (wikipedia.org)
  • Weak or absent extensors and/or abductors (the extensor pollicis brevis tendon, the extensor pollicis longus tendon or, rarely, the abductor pollicis longus tendon), can cause a disbalance, leading to an abnormal position of the thumb: congenital clasped thumb. (wikipedia.org)
  • Diagnosing the congenital clasped thumb is difficult in the first three to four months of life, as it is normal when the thumb is clutched into the palm in these first months. (wikipedia.org)
  • Treatment of congenital clasped thumb includes two types of therapy: conservative and surgical. (wikipedia.org)
  • The extra digit is most common on the ulnar (little finger) side of the hand, less common on the radial (thumb) side, and very rarely within the middle three digits. (wikipedia.org)
  • citation needed] This is a less common situation, in which the affectation is on the side of the hand towards the thumb. (wikipedia.org)
  • common
  • This is the most common situation, in which the extra digit is on the ulnar side of the hand, thus the side of the little finger. (wikipedia.org)
  • disease
  • Digital abnormalities occurred in 5,171 children of mothers who smoked during their pregnancies but who did not suffer from health problems like heart disease, diabetes, or high blood pressure. (newsinferno.com)
  • This aids in the implication that HAND1 expression is a factor to patients suffering from congenital heart disease. (wikipedia.org)
  • Mutation of HAND1 has been shown to hinder the effect of GATA4, another vital cardiac transcription factor, and is associated with congenital heart disease. (wikipedia.org)
  • HAND factors function in the formation of the right ventricle, left ventricle, aortic arch arteries, epicardium, and endocardium implicating them as mediators of congenital heart disease. (wikipedia.org)
  • This is thought to be either congenital, a result of childhood disease and trauma or due to an amputation later in his life. (wikipedia.org)
  • Injury
  • The arm had healed but the injury may have caused some paralysis down his right side, leading to deformities in his lower legs and foot and would have resulted in him walking with a pronounced, painful limp. (wikipedia.org)
  • feet
  • The TWIST gene in mice, functions in the development of the muscle and skeleton of the face, head, hands, and feet. (wikipedia.org)
  • Their hands and feet, however, are usually average-sized. (wikipedia.org)
  • often
  • Madelung's deformity is usually characterized by malformed wrists and wrist bones and is often associated with Léri-Weill dyschondrosteosis. (wikipedia.org)
  • children with hand abnormalities were often brought to Diamond by their parents, not only for treatment but to illustrate how she had overcome her handicap. (wikipedia.org)
  • children
  • Formed in 1978, the organization's mission has evolved from a single issue advocacy group to a more comprehensive support network for families of children with hand and arm deficiency. (blogspot.com)
  • The data revealed that children of pregnant women who smoked one to 10 cigarettes per day were 29% more likely to have a child with a toe or finger deformity. (newsinferno.com)
  • trauma
  • He was one of four reasonably complete skeletons from the cave which displayed trauma-related abnormalities, which in his case would have been debilitating to the point of making day-to-day life painful. (wikipedia.org)
  • radial
  • The deformity varies in degree from a slight protrusion of the lower end of the ulna, to complete dislocation of the inferior radio-ulnar joint with marked radial deviation of the hand. (wikipedia.org)
  • bones
  • Other skeletal signs include flattened vertebrae (platyspondyly), a hip joint deformity in which the upper leg bones turn inward (coxa vara), and an inward- and downward-turning foot (called clubfoot). (wikipedia.org)
  • thumbs
  • To summarize, the causes of congenital clasped thumbs may vary between patients and can sometimes be a combination of the preceding components. (wikipedia.org)
  • The most global format is the classification of McCarrol, which divides the congenital clasped thumbs into two groups. (wikipedia.org)
  • Treatment of all categories of congenital clasped thumbs should start with either serial plaster casting or wearing a static or dynamic splint for a period of six months, while massaging the hand. (wikipedia.org)