• Currently, the etiology of drug-induced gingival overgrowth is not entirely understood but is clearly multifactorial. (medscape.com)
  • However, the complete etiology of drug-induced myopathies remains unclear. (degruyter.com)
  • We report a case of isoniazid-induced PRCA. (cdc.gov)
  • In view of previous reports of isoniazid-induced PRCA ( 3 - 5 ), we suspected this drug to be responsible in this case. (cdc.gov)
  • The exact mechanism for isoniazid-induced PRCA remains unclear, but the demonstration of antibodies reacting with nucleated red blood cells in ≈50% of cases suggests an induction of autoimmunity ( 4 , 5 ). (cdc.gov)
  • Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. (wakehealth.edu)
  • Objectives We systematically reviewed the literature to identify evidence-informed recommendations regarding the detection of drug-induced pancreatitis (DIP) and, secondarily, to describe clinical processes for the diagnosis of DIP. (bmj.com)
  • Unfortunately, the available biomarkers for SKM injury do not fully meet the needs for satisfactory detection of drug-induced damage, both in clinical and research settings, mainly due to their low sensitivity and specificity. (degruyter.com)
  • Additional implicated agents include calcium channel blockers, angiotensin-converting enzyme inhibitors, nonsteroidal anti-inflammatory drugs, antifungal agents (particularly terbinafine), chemotherapy agents, immunotherapies, proton pump inhibitors, and tumor necrosis factor (TNF) antagonists. (medscape.com)
  • The use of dopamine antagonists as antipsychotics can result in tardive dyskinesia, while drugs such as cocaine that increase striatal dopamine release can cause dependency and addiction (for review, see Hyman, 1996 ). (jneurosci.org)
  • There are several hypotheses about the mechanisms by which calcium antagonists induce gingival hyperplasia, but further investigation is still needed. (medscape.com)
  • Other focal abnormalities are quite frequent but are of such low specificity that they almost never constitute an abnormality in themselves. (medscape.com)
  • In contrast to some previously described early genes, most of the novel genes are not induced in cortex by apomorphine, indicating specificity of induction. (jneurosci.org)
  • conversely, food or one of its components may affect bioavailability and half-life, circulating plasma concentrations of drugs resulting in an increased risk of toxicity and its adverse effects, or therapeutic failure. (mdpi.com)
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury updated 11 December 2019. (medsafe.govt.nz)
  • Generalized EEG abnormalities typically signify dysfunction of the entire brain, although such dysfunction may not be symmetric in distribution. (medscape.com)
  • Abnormalities, Drug-Induced" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
  • What Drugs, Substances, or Supplements Interact with Prezcobix? (rxlist.com)
  • Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. (nih.gov)
  • Analyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebo-treated patients. (nih.gov)
  • Observational studies suggest that, similar to atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality. (nih.gov)
  • The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristic(s) of the patients is not clear. (nih.gov)
  • A very similar set of genes is induced in unlesioned animals by administration of the psychostimulant cocaine or the antipsychotic eticlopride, although in distinct striatal cell populations. (jneurosci.org)
  • Given the ongoing worldwide HIV pandemic and the increase in tuberculosis it induces, such adverse effects are more likely to be reported in the next few years. (cdc.gov)
  • A recent clinical trial identified a daily 4-month regimen that is as effective as the standard daily 6-month regimen in curing drug-susceptible tuberculosis. (cdc.gov)
  • This report provides a recommendation for using a 4-month regimen consisting of 8 weeks of daily treatment with rifapentine (RPT), isoniazid (INH), pyrazinamide, and moxifloxacin (MOX), followed by 9-weeks of daily treatment with RPT, INH, and MOX in patients with drug-susceptible tuberculosis. (cdc.gov)
  • The 4-month RPT-MOX regimen is a treatment option for patients aged ≥12 years with drug-susceptible pulmonary tuberculosis. (cdc.gov)
  • Isoniazid is an anti-bacterial drug that has been used to prevent and to treat tuberculosis since 1952. (hdkino.org)
  • Isoniazid is used to prevent active tuberculosis in persons who have an abnormal skin test for tuberculosis (latent tuberculosis) or in combination with other drugs for the treatment of active tuberculosis. (hdkino.org)
  • Symptoms usually subside within 3-4 weeks or shortly after the offending medication is withdrawn in drug-induced pulmonary eosinophilia. (medscape.com)
  • In large clinical trials, abnormalities in routine liver tests were common in patients treated with pazopanib, with serum aminotransferase elevations occurring in up to half of patients and total serum bilirubin in approximately one-third. (nih.gov)
  • The abnormality that correlates best with the presence of a structural lesion is polymorphic or arrhythmic (as opposed to monomorphic or rhythmic) delta (ie, 1-3 Hz) slowing. (medscape.com)
  • Celecoxib is among the more potent and better clinically studied, nonsteroidal anti-inflammatory drugs (NSAID) for use as a chemoprevention agent for colorectal cancer. (bvsalud.org)
  • The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment. (wakehealth.edu)
  • Pregnancy outcomes following in utero exposure to antiepileptic drugs (AEDs) are uncertain, limiting an evidenced-based approach. (emmes.com)
  • More adverse outcomes were observed in pregnancies with in utero valproate exposure vs the other antiepileptic drugs (AEDs). (emmes.com)
  • The triggers exertion, stress or exposure to cold are also associated with asthma attacks and alleviation by rest is described for exercise-induced asthma 8 . (ersjournals.com)
  • These findings indicate that the colonic mucosal injury induced by FC-exposure are associated with oxidative stress generation, inflammation response and cell apoptosis, as well as the changes in gut microbes diversity and composition. (bvsalud.org)
  • 2 Some patients may be asymptomatic and VBDS is initially identified based on laboratory abnormalities. (medsafe.govt.nz)
  • Moreover, we will discuss mechanisms of drug-induced SKM injury, traditional laboratory testing for SKM injury, and novel skeletal myocyte biomarkers under investigation. (degruyter.com)
  • At presentation, the routine laboratory test results showed no abnormalities. (biomedcentral.com)
  • On the basis of these findings, CDC recommends the 4-month regimen as a treatment option for U.S. patients aged ≥12 years with drug-susceptible pulmonary TB and provides implementation considerations for this treatment regimen. (cdc.gov)
  • This interim guidance updates 2016 guidelines by recommending and providing implementation considerations for a novel 4-month daily treatment regimen, based on high-dose daily RPT with MOX, INH, and PZA ( 1 ) as a treatment option for U.S. patients aged ≥12 years with drug-susceptible pulmonary TB. (cdc.gov)
  • CDC recommends the 4-month RPT-MOX regimen for treating patients aged ≥12 years with body weight ≥40 kg with pulmonary TB caused by organisms that are not known or suspected to be drug-resistant and who have no contraindications to this regimen. (cdc.gov)
  • however, other parasitic infections and acute hypersensitivity reactions to drugs are included as etiologies for simple pulmonary eosinophilia. (medscape.com)
  • Recent data suggest that circulating, but not local, lung IL-5 is critically required for the development of antigen-induced pulmonary eosinophilia. (medscape.com)
  • Drugs and pregnancy : human teratogenesis and related problems / edited by D. F. Hawkins. (who.int)
  • However, drug-induced myopathy is among the most frequent causes of muscle disease. (degruyter.com)
  • Liver test abnormalities are frequent during pazopanib therapy and routine monitoring is recommended at 3 to 4 week intervals. (nih.gov)
  • The grain weevil, an insect (pest) that infects grain, is a frequent contaminant of processed wheat, and its presence may contribute to respiratory abnormalities in grain workers. (cdc.gov)
  • Antibiotics are most frequently associated with VBDS, although several drug classes and medicines have been implicated. (medsafe.govt.nz)
  • Several drugs are either banned or withdrawn after introduction in the market. (medindia.net)
  • Isoniazid was withdrawn, and other antituberculous drugs were continued. (cdc.gov)
  • If SCLE is drug-induced, withdrawal of the culprit medication in conjunction with medical therapy is often necessary for disease control. (medscape.com)
  • Our Prezcobix (darunavir and cobicistat) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • However, the status of oral health prior to onset of gingival overgrowth combined with the medication are both clearly involved in the onset of drug-induced gingival hyperplasia. (medscape.com)
  • Human ATRX mutations are associated with cognitive deficits, developmental abnormalities, and cancer. (bepress.com)
  • This article discusses the relevance of this phenomenon, known as "drug-induced ego dissolution (DIED)", for cognitive neuroscience, psychology and philosophy of mind. (frontiersin.org)
  • As an immunologic condition, HIT is induced by IgG antibodies recognizing complexes of platelet factor 4 (PF4) and heparin and presents with thrombocytopenia and thrombosis [ 2 ]. (biomedcentral.com)
  • The regimen is intended for administration in settings where mycobacterial cultures, molecular and phenotypic drug susceptibility testing (DST), radiographic studies and other diagnostic tools, infrastructure for adverse event monitoring, patient-centered clinical care, and coordination with public health for case management are available. (cdc.gov)
  • Heparin-induced thrombocytopenia (HIT) is an antibody-mediated adverse drug reaction characterized by thrombocytopenia and thromboembolism. (biomedcentral.com)
  • In clinical practice, as well as during drug development and in clinical trials, the diagnosis of SKM injury can be challenging due to the variable symptomology, reliance on patient-self reporting, and lack of highly specific biomarkers, such as those available for cardiac myocyte injury (i.e., cardiac troponins) [ 3 ]. (degruyter.com)
  • For this patient, other causes for anemia (e.g., drug-induced hemolytic anemia, digestive malignancies, viral causes known to date, hematologic malignancies, and autoimmune disorders) were excluded ( 2 ). (cdc.gov)
  • The clinical picture of drug-induced myopathies may range from asymptomatic or mild myalgias, with or without muscle weakness, which are likely underreported, to chronic myopathy with severe weakness and rarely, even to massive rhabdomyolysis with acute kidney injury (AKI) [ 1 ]. (degruyter.com)
  • Varenicline has not been associated with rates of serum enzyme elevations during therapy greater than occurs with placebo therapy, but information on these abnormalities is limited and occasional instances of asymptomatic ALT elevations leading to drug discontinuation have been reported. (nih.gov)
  • The use of checkpoint inhibitors in combination therapy further complicates the safety monitoring of SKM injury due to the potential for drug-drug interactions. (degruyter.com)
  • One example is dynorphin gene expression, which is progressively induced in dorsal striatum by cocaine. (jneurosci.org)
  • These include direct myotoxicity (caused by alcohol, cocaine, glucocorticoids, and statins, amongst others), immunologically-induced inflammatory myopathy (caused by D-penicillamine, statins, and anti-cancer drugs), and indirect SKM injury (occurs as a result of a variety of different mechanisms). (degruyter.com)
  • Over the course of a typical 10-week controlled trial, the rate of death in drug-treated patients was about 4.5%, compared to a rate of about 2.6% in the placebo group. (nih.gov)
  • Serial monitoring may be useful to guide early discontinuation of DIP-associated drugs in high-risk patients, but not in lower-risk patients. (bmj.com)
  • SCLE may occur in patients with systemic lupus erythematosus (SLE), Sjögren syndrome , deficiency of the second component of complement (C2d), or it may be drug-induced. (medscape.com)
  • In perhaps as many as 30% of patients with SCLE, drugs may exacerbate or induce their disease. (medscape.com)
  • Drug-induced PRCA is a rare blood disorder in adults and has already been reported in isoniazid-treated patients ( 3 - 5 ). (cdc.gov)
  • RÉSUMÉ La présente étude prospective de suivi visait à déterminer l'incidence et les facteurs de risque des maladies iatrogènes ainsi que leur évolution chez des patients admis en unité de soins intensifs pédiatriques d'un hôpital universitaire en Libye. (who.int)
  • Heparin-induced thrombocytopenia (HIT) is a rare but important cause of morbidity and mortality in patients exposed to heparin [ 1 ]. (biomedcentral.com)
  • Patients with active infection on chest X-ray are given isoniazid combined with other antituberculous drugs . (hdkino.org)
  • Ferric citrate (FC) has been used as an iron fortifier and nutritional supplement, which is reported to induce colitis in rats, however the underlying mechanism remains to be elucidated. (bvsalud.org)
  • The exercise of describing EEG abnormalities by pathology (eg, stroke, abscess, tumor, even various types of tumors), which was common in old EEG texts, is therefore not followed here. (medscape.com)
  • Upper and lower digestive tract endoscopic examination and carcinoembryonic antigen showed no abnormalities, which lessened the likelihood of a tumor relapse. (cdc.gov)
  • Therefore, the present study proposes a strategy for drug safety monitoring using the available biomarkers of SKM injury. (degruyter.com)
  • This can be incredibly useful in both clinical practice and for de-challenge/re-challenge investigational trials where the risk of drug-induced SKM injury is present. (degruyter.com)
  • It usually occurs as part of a syndrome that involves other abnormalities and requires multidisciplinary treatment. (wikipedia.org)
  • Data from self-report questionnaires suggest that three neuropharmacological classes of drugs can induce ego dissolution: classical psychedelics, dissociative anesthetics and agonists of the kappa opioid receptor (KOR). (frontiersin.org)
  • The trial confirmed that a 4-month daily treatment regimen containing high-dose RPT and MOX, as well as INH and PZA, is as effective as (noninferior to) the standard daily 6-month regimen in curing drug-susceptible TB ( 1 ). (cdc.gov)
  • Clinical practice guidelines for treatment of drug-susceptible TB in the United States were published in 2016 ( 2 ). (cdc.gov)
  • Pazopanib is susceptible to drug-drug interactions with agents that inhibit or induce hepatic CYP 3A4 activity. (nih.gov)
  • Obtain a detailed drug history, including prescription and over-the-counter medications, nutritional supplements, and illicit drugs. (medscape.com)
  • We present a case report of a young female patient with hypercalcemia-induced acute necrotizing pancreatitis as first manifestation of a benign parathyroid adenoma.Case: A 46-year-old female presented at the emergency room with a sudden attack of severe epigastric pain and vomiting. (endocrine-abstracts.org)
  • Primary studies that may have used a drug-induced pancreatitis (DIP) diagnostic process but that were not indexed in databases using vocabulary related to DIP would not have been captured by our search. (bmj.com)
  • Focal slowing is the most common abnormality associated with focal lesions of any type, including (but not limited to) neoplastic, vascular, subdural collections, traumatic, and infectious (see images below). (medscape.com)
  • Even as the threat of war slowly fades, the common citizen in Syria is having to deal with acute drug shortages with people such as Syrian father Motaz having to decide on whether to put food on the table or pay astronomical prices to import insulin for his diabetic son. (medindia.net)
  • Serologic abnormalities are common. (medscape.com)
  • Drug-induced LQTS is the most common cause of acquired LQTS and will be the focus of this resource. (enclarapharmacia.com)
  • By contrast, the study of Drug-Induced Ego Dissolution (DIED) in healthy individuals offers a way to track down underlying mechanisms of ego dissolution, which in turn could help us gain a better understanding of the neurobiological basis of the sense of self. (frontiersin.org)
  • Drug-induced myopathies may result from various mechanisms. (degruyter.com)
  • Chemotherapy drugs perform like 'magic bullets' to destroy cancer cells in the body. (medindia.net)
  • That includes over-the-counter or prescription drugs, herbs, and supplements. (medlineplus.gov)
  • There is converging evidence that high doses of hallucinogenic drugs can produce significant alterations of self-experience, described as the dissolution of the sense of self and the loss of boundaries between self and world. (frontiersin.org)
  • When drugs enter the brain quickly, such as through injection or smoking, they are more addictive than when they enter the brain more slowly, such as when they are taken orally. (sciencedaily.com)
  • Pharmacists can assist by identifying QT-prolonging medications and other drug-related considerations to help clinicians balance prescribing decisions with other patient-specific risk factors. (enclarapharmacia.com)
  • Abbud described those who have continued to produce medicines as "heroes," adding that the ministry provides people who have health insurance with free drugs at hospitals. (medindia.net)