alpha 1-Antitrypsin Deficiencyalpha 1-AntitrypsinPulmonary EmphysemaEmphysemaPhenotypeLiver DiseasesPulmonary Disease, Chronic ObstructiveForced Expiratory VolumeTrypsin Inhibitorsalpha 1-AntichymotrypsinLung DiseasesLungAirway ObstructionHeterozygotePancreatic ElastaseAirway RemodelingHomozygoteBronchiectasisProteostasis DeficienciesAirway ResistanceLiverMutationAllelesHepatitisLiver CirrhosisSmokingRespiratory Function TestsSpirometryGenotypeSerpinsVital CapacityBronchitis