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Chromosome AberrationsRibsChromosomesAneuploidyChromosome MappingChromosome BandingKaryotypingX ChromosomeChromosomes, HumanChromosomes, Human, Pair 1In Situ Hybridization, FluorescenceSister Chromatid ExchangeChromosome DisordersSex ChromosomesChromosomes, Human, Pair 11Sex Chromosome AberrationsChromosomes, Human, Pair 7Chromosome PaintingChromosome DeletionMicronucleus TestsChromosome SegregationChromosomes, Human, Pair 17Chromosomes, BacterialChromosomes, Human, Pair 13Mutagenicity TestsChromosomes, Human, Pair 6Chromosomes, Human, Pair 9Chromosomes, Human, Pair 4Translocation, GeneticChromosomes, Human, Pair 21Chromosome BreakageCytogeneticsMutagensChromosomes, PlantChromosomes, Human, 6-12 and XChromosomes, FungalCytogenetic AnalysisNuclear WarfareChromosomes, Human, Pair 16Corneal Wavefront AberrationChromosomes, Human, Pair 2Chromosomes, Human, Pair 18Chromosomes, Human, Pair 22Chromosomes, Human, Pair 8Chromosome PairingChromosomes, MammalianLymphocytesChromosomes, Human, Pair 10AmericiumMetaphaseChromosomes, Human, Pair 19Chromosomes, Human, YChromosomes, Human, Pair 12Chromosomes, Artificial, BacterialChromosomes, Human, Pair 5Chromosomes, Human, XChromosomes, Human, 1-3Radiation GeneticsChromosomes, Human, Pair 14Chromosomes, Human, Pair 15Chromosomes, Human, Pair 20TriethylenemelamineMicronuclei, Chromosome-DefectiveChromosomes, Human, 16-18Linear Energy TransferChromosomes, Artificial, YeastGenetic MarkersChromosomes, Human, 13-15TrisomyGenetic LinkageMutationChromosomal InstabilityMitosisChromosomes, Human, 21-22 and YChromosome InversionChromatidsRing ChromosomesDNA DamageMosaicismAzure StainsChromosomes, Human, 4-5Dose-Response Relationship, RadiationChromosome PositioningBackground RadiationMolecular Sequence DataNucleic Acid HybridizationRadioactive Hazard ReleaseBase SequenceMitotic IndexStyrenesRecombination, GeneticAlpha ParticlesGamma RaysAberrometryHempaCentromereX Chromosome InactivationIsochromosomesInterphaseKazakhstan
Chromatid and chromosome breaksChromosomal aberrationCytogeneticAbnormalitiesMicronucleusDeletionDeletionsGenesTumorDisordersDiploid cellPairsNumericalVitroLymphocytesStructuralBreaksBiopsyInversionHaploidBreakageSegregationNucleusProbesPeripheralInterphaseGenetic materialAdditionallyCellsTerminalTumorsMutationsPloidyCellGene AmplificationComparativeHumanStabilityDifficultiesAdjacentRegionFindingsSignificantlyOncogenesMechanismTypesStudyCasesDistributionFrequently
Chromatid and chromosome breaks2
  • In this research, four types of chromosome aberrations were observed as chromatid and chromosome breaks, fragment and dicentric chromosomes. (comu.edu.tr)
  • Much of this DNA hypomethylation is in 1qh, 9qh, and 16qh, regions that are the site of whole-arm deletions, chromatid and chromosome breaks, stretching (decondensation), and multiradial chromosome junctions in mitogen-stimulated lymphocytes. (biomedcentral.com)
Chromosomal aberration4
  • In an organism, any visible abnormality in chromosome number or structure from the diploid set is known as chromosomal aberration . (schleiden-eifel.de)
  • B. This chromosomal aberration tends to manifest in males in the form of absent or delayed puberty, sterility, development of breast, etc. (schleiden-eifel.de)
  • Since nuclear swelling (NS hereafter) has been frequently observed in chromosomal aberration (CA hereafter) tests (in vitro), the relationship between NS and CAs was investigated in this study. (biomedcentral.com)
  • A type of chromosomal aberration involving DNA BREAKS. (lookformedical.com)
Cytogenetic3
Abnormalities6
  • Changes in the structure or quantity of chromosomes , which are strands of condensed genetic material, are known as chromosomal aberrations or abnormalities. (schleiden-eifel.de)
  • However, within populations there can be found abnormalities involving the structure or number of chromosomes . (schleiden-eifel.de)
  • Materials and Methods: To investigate both the presence of numerical abnormalities of chromosome 9 and p16 gene alterations in ovarian cancer, we studied 28 cases by the fluorescence in situ hybridization (FISH) technique using a DNA p16 probe and an a-satellite probe specific for chromosome 9. (iiarjournals.org)
  • Results: Numerical abnormalities of chromosome 9 were found in all studied cases. (iiarjournals.org)
  • The genetic controversy about LSD started in 1967 when Cohen, Marinello and Back (22) published a paper suggesting that LSD should be added to the list of substances capable of causing abnormalities in the chromosomes. (druglibrary.net)
  • This copy-number variation is one of the most frequent and most penetrant genetic abnormalities in autism 20 and is associated with motor problems 21 , 22 . (nature.com)
Micronucleus2
  • In this study, possible genotoxic effects of zinc oxide (ZnO) nanoparticles were investigated in cultured human peripheral lymphocytes by using chromosome aberrations and micronucleus assays (MN). (comu.edu.tr)
  • Most carcinogens that cause NS are genotoxins, which cause DNA damage, chromosomal aberrations (CAs), and micronucleus formation. (biomedcentral.com)
Deletion4
  • examples include aneuploidy (atypical chromosome number), deletion (loss of part of a chromosome), duplications (extra copies of a region of a chromosome), inversion (when part of a chromosome breaks off and reattaches in reverse. (schleiden-eifel.de)
  • Conclusion: Numerical aberrations of chromosome 9 and p16 gene deletion are common findings in ovarian cancer. (iiarjournals.org)
  • 1p36 deletion syndrome is caused by a deletion of genetic material from a specific region in the short (p) arm of chromosome 1. (medlineplus.gov)
  • CGH array revealed a deletion around 1.25 Mb at 9p24.3 loci [arr 9p24.3(204,193-1,457,665)× 1] and three duplications around 13 Mb [9p24.3p22.3(1,477,660-14,506,754)× 3] near the breakage point that formed the ring chromosome 9. (biomedcentral.com)
Deletions2
  • Chromosome counts can identify numerical changes, such as chromosome deletions or duplications. (vin.com)
  • Chromosome 9 aberrations involving the terminal end of p arm, such as terminal p deletions or ring chromosomes have been reported to cause 46,XY DSD. (biomedcentral.com)
Genes7
  • A comparison of human and chimpanzee genes in the region of this inversion indicates that two genes-ROCK1 and USP14-that are adjacent on chimpanzee chromosome 17 (which corresponds to human chromosome 18) are more distantly positioned on human chromosome 18. (schleiden-eifel.de)
  • Because even small segments of chromosomes can span many genes, chromosomal disorders are characteristically dramatic and often fatal. (schleiden-eifel.de)
  • Identifying genes on each chromosome is an active area of genetic research. (medlineplus.gov)
  • Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. (medlineplus.gov)
  • Chromosome 1 likely contains 2,000 to 2,100 genes that provide instructions for making proteins. (medlineplus.gov)
  • Researchers have identified several possible tumor suppressor genes in the deleted region of chromosome 1, and more research is needed to understand what role these genes play in neuroblastoma development. (medlineplus.gov)
  • This terminal region of chromosome 9p (9p24.3 region) contains 3 types of DMRT genes ( DMRT1 - 3 ). (biomedcentral.com)
Tumor3
  • Chromosomal aberrations from tumor biopsy samples have been studied, and certain repetitive anomalies were shown to correlate with prognosis. (vin.com)
  • The aim of the present study was to determine the significance of this tumor suppressor gene for ovarian tumorigenesis, investigating both numerical aberrations of chromosome 9 and p16 gene alterations in 28 cases of ovarian tumors, by the fluorescence in situ hybridization (FISH) technique. (iiarjournals.org)
  • This may be due to late diagnosis of these tumors in our patients as most cases diagnosed at advanced stage and the sections were taken from deep tumor tissue to increase the number of tumor cells in our samples. (researchgate.net)
Disorders4
  • The result of these mistakes is the creation of cellular aberration which have disorders in the number of their chromosomes. (ac.ir)
  • Therefore we need to come to a better understanding of the elements which are effective in causing chromosome disorders in order to develop appropriate strategies to identify or fight against diseases such as cancer. (ac.ir)
  • Chromosome 9pter aberrations, such as ring chromosome have been reported to cause 46,XY disorders of sex development (DSD), due to involvement of DMRT1 gene located at the 9p24.3 region. (biomedcentral.com)
  • Chromosome aberrations may result in CHROMOSOME DISORDERS. (lookformedical.com)
Diploid cell2
  • If a normal diploid cell is 2n, the chromosome content of a double tetrasomic cell is designated. (schleiden-eifel.de)
  • In a normally diploid cell (DIPLOIDY) the loss of a chromosome pair is termed nullisomy (symbol: 2N-2), the loss of a single chromosome is MONOSOMY (symbol: 2N-1), the addition of a chromosome pair is tetrasomy (symbol: 2N+2), the addition of a single chromosome is TRISOMY (symbol: 2N+1). (lookformedical.com)
Pairs6
Numerical1
  • We have identified numerical aberrations in 5 lymphoma patients, with 2 of the patients having multiple time points. (vin.com)
Vitro4
  • Repair of mitomycin-C-induced chromosomal aberrations was impaired in RAD51B/Rad51b-c.92delT human and mouse somatic cells in vitro and in explanted mouse bone marrow cells. (nature.com)
  • The first group includes papers describing structural changes of the chromosomes produced by LSD in vitro , ** in these experiments various concentrations of LSD are added to cultures of cells from human, animal, or plant tissues in a test-tube. (druglibrary.net)
  • According to Bloch (1983) who reviewed the literature for the World Health Organisation: 'in vivo and in vitro exposure to purified cannabinoids or cannabis resin failed to increase the frequency of chromosomal damage or mutagenesis' (p412). (druglibrary.org)
  • More recently, Zimmerman and Zimmerman (1990/1991) concluded that 'cannabis mutagenicity remains unclear', but argued that there was evidence that 'cannabinoids induce chromosome aberrations in both in vivo and in vitro studies' (p19). (druglibrary.org)
Lymphocytes1
  • ICF (OMIM #24242860) is a rare autosomal recessive disease that involves agammaglobulinemia or hypoglobulinemia with B cells as well as DNA rearrangements targeted to the centromere-adjacent heterochromatic region (qh) of chromosomes 1 and/or 16 (and sometimes 9) in mitogen-stimulated lymphocytes. (biomedcentral.com)
Structural5
  • Furthermore, these chromosomes commonly have structural aberrations that are rare in normal cells. (ac.ir)
  • These results strongly suggest that NS is mainly caused by structural aberrations in the nucleus during interphase of the cell cycle. (biomedcentral.com)
  • A number of scientific papers have been published indicating that LSD might cause structural changes in the chromosomes, genetic mutations, disturbances of embryonic development, and malignant degeneration of cells. (druglibrary.net)
  • 22) * After my arrival in the United States, I participated in a major study concentrating on structural changes of the chromosomes in the white blood cells following LSD administration. (druglibrary.net)
  • The possibility of inducing structural changes in the chromosomes by exogenous agents such as radiation, viruses, and a variety of chemicals, has been a subject of great scientific interest for a long time. (druglibrary.net)
Breaks1
  • There is, at most, mixed evidence that THC and other cannabinoids are mutagenic in standard microbial assays, such as the Ames test, and there is contradictory evidence on whether the cannabinoids are clastogenic, i.e. produce breaks in chromosomes. (druglibrary.org)
Biopsy1
  • Both single nucleotide polymorphism (SNP) array and array CGH (aCGH) have been validated as accurate methods to achieve comprehensive chromosome screening when biopsy is performed on d3 for fresh transfer on d5 [ 26 - 30 ]. (biomedcentral.com)
Inversion1
  • These are some of the most common cytogenetically visible rearrangements in humans - for example , the pericentric inversion of chromosome 9 is found in over. (schleiden-eifel.de)
Haploid1
Breakage2
Segregation2
  • Objective: During cellular divisions at times the segregation of chromosomes encounters difficulties in a way that in diploid cells in every hundred cell divisions one chromosome will makes a mistake. (ac.ir)
  • An increased tendency to acquire CHROMOSOME ABERRATIONS when various processes involved in chromosome replication, repair, or segregation are dysfunctional. (lookformedical.com)
Nucleus2
  • Each cell (except for red blood cells) contains a nucleus that houses these chromosomes. (cdc.gov)
  • A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species. (lookformedical.com)
Probes1
  • Comparison of the human with the sheep genomes by use of human chromosome-specific painting probes. (cnr.it)
Peripheral3
  • Do Peripheral Lymphocytic Chromosomal Aberrations in Dogs with Lymphoma Change During and After Treatment? (vin.com)
  • Peripheral changes in chromosomes could provide a unique window for determining what is happening to the patient. (vin.com)
  • We have determined that chromosomal aberrations can be identified in the peripheral blood of canine lymphoma patients. (vin.com)
Interphase1
Genetic material2
  • The resulting recombinase-coated ssDNA filaments can invade the homologous chromosome dsDNA, searching for a complementary sequence (chromosome pairing), which will foster genetic material exchange. (nature.com)
  • A 1q21.1 microduplication is a copied (duplicated) segment of genetic material at position q21.1 on one of the two copies of chromosome 1 in each cell. (medlineplus.gov)
Additionally2
Cells10
  • The best evidence suggests that most are due to abnormal differentiation of fetal germ cells that arise from the fetal yolk sac. (medscape.com)
  • Normal migration of these germ cells may cause gonadal tumors, whereas abnormal migration produces extragonadal tumors. (medscape.com)
  • A number of direct and indirect radiation interaction pathways can produce damage to the DNA of irradiated cells. (cdc.gov)
  • The frequency of ICF cells with chromosomal aberrations seems to increase with passage number, 3,4,40 although this is not a consistent finding. (schleiden-eifel.de)
  • ZnO induced significant increase of the ratio of chromosomal aberrations as well as percentage of abnormal cells at concentrations of 1, 5, 10 and 20 mu g/mL in 24 h treatments. (comu.edu.tr)
  • In 48 h treatments, while ZnO nanomaterials induced significant increase of the percentage of abnormal cells only at a concentration of 10 mu g/mL, and of chromosome aberration per cell in comparison to the control at concentrations of 5 and 10 mu g/mL. (comu.edu.tr)
  • More than a century ago, researchers in their investigation of cancer cells noticed that most cancers contain cells that not only posses an abnormal number of chromosomes but also differ from each other in the number of chromosomes they contain. (ac.ir)
  • FLT3 (FMS-related tyrosine kinase 3) located on chromosome 13q12.2 encodes a receptor tyrosine kinase (RTK) that activates the Ras and PI3 kinase pathway leading to the increased proliferation and inhibition of apoptosis in hemopoietic progenitor cells [ 7 ]. (hindawi.com)
  • The Immunodeficiency, Centromeric region instability, Facial anomalies syndrome (ICF) is a rare autosomal recessive disease described in about 50 patients worldwide and characterized by immunodeficiency, although B cells are present, and by characteristic rearrangements in the vicinity of the centromeres (the juxtacentromeric heterochromatin) of chromosomes 1 and 16 and sometimes 9. (biomedcentral.com)
  • To overcome the limitations brought upon by cellular fixation, membrane-permeant DNA fluorophores were designed to stain DNA stoichiometrically in live-cells (supravital staining), enabling both the quantification of DNA content and the ability to track the movement of chromosomes over time. (biomedcentral.com)
Terminal1
  • A terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability. (lookformedical.com)
Tumors1
  • We report an overall mutation frequency of 87.5%, with 76.25% of the tumors showing alterations in KIT and 11.25% in PDGFRA . (biomedcentral.com)
Mutations2
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • These assays can detect mutations in the Tk gene that result from both gene mutations and chromosome damage. (biomedcentral.com)
Ploidy1
  • Exploiting this, the present study utilized chromosome-wide SNP allelic distributions to determine the ploidy composition of over 1,000 oil palms from a commercial F1 family, including 197 derived from twin-embryo seeds. (mpob.gov.my)
Cell3
  • The chromosome number of this cell is 2n-1 = 45. (schleiden-eifel.de)
  • 1q21.1 microdeletion is a chromosomal change in which a small piece of the long (q) arm of chromosome 1 is deleted in each cell. (medlineplus.gov)
  • Abnormal DNA content has been related to aggressive behavior in Mucoepidermoid Carcinomas (MEC), Adenoid Cystic Carcinomas (AdCC), Acinic Cell Carcinomas (ACC) and oncocytomas (Onc) [8]. (researchgate.net)
Gene Amplification2
Comparative2
  • Comparative FISH mapping of bovid X chromosomes reveals homologies and divergences between the subfamilies bovinae and caprinae. (cnr.it)
  • This case study reports a rare double minute chromosome via FLT3 amplification in CMML by using array-based comparative genomic hybridization and fluorescence in situ hybridization analyses. (hindawi.com)
Human2
  • ZOO-FISH and R-banding reveal extensive conservation of human chromosome regions in euchromatic regions of river buffalo chromosomes. (cnr.it)
  • Here we report alterations in motor behaviour and cerebellar synaptic plasticity in a mouse model (patDp/+) for the human 15q11-13 duplication, one of the most frequently observed genetic aberrations in autism. (nature.com)
Stability1
  • Chromosome stability test in both cattle and river buffaloes exposed to dioxin. (cnr.it)
Difficulties1
  • There are a number of difficulties in deciding whether cannabis impairs the functioning of the immune system. (druglibrary.org)
Adjacent1
Region1
  • In other cases, individuals have a shorter or longer duplicated segment within the q21.1 region of chromosome 1. (medlineplus.gov)
Findings1
  • These findings point to deficits in synaptic plasticity and pruning as potential causes for motor problems and abnormal circuit development in autism. (nature.com)
Significantly2
  • On the other hand, this material significantly increased the micronuclei frequency (MN) at concentrations of 10 and 15 mu g/mL in comparison to the control. (comu.edu.tr)
  • The allele frequencies were not significantly different between the patients and the controls, and we did not observe any haplotype specifically associated with ET. (nel.edu)
Oncogenes1
  • In addition, polysomy 9 could lead to activation of a number of oncogenes, thus participating in the neoplastic process in the ovaries. (iiarjournals.org)
Mechanism1
  • It includes a small number of papers dealing with the detailed mechanism of the action of LSD on the deoxyribonucleic acid (DNA), the most important constituent of the chromosomes. (druglibrary.net)
Types1
  • Thousands of chromosomal aberrations have been discovered in different types of cancer. (schleiden-eifel.de)
Study3
  • Therefore, we conducted a case study of a 46,XY female to better understand the genotypic and phenotypic characteristics related to 9p24.3 aberration and DMRT1 loss. (biomedcentral.com)
  • This may be due to the few numbers of cases involved in this study. (researchgate.net)
  • This study also characterised a large number of expressed sequence tags (EST)-SSRs using an in-silico approach. (mpob.gov.my)
Cases1
  • Sex reversal due to haploinsufficiency of DMRT1 gene in ring chromosome 9 structures is exceedingly rare with only a handful of cases ever reported. (biomedcentral.com)
Distribution2
  • Results: Statistical analysis of data showed that there is only a significant difference regarding frequency distribution of cluster shape and there is no such difference for satellite shape, satellite size, and cluster size. (iranpath.org)
  • For palms with a shifted or abnormal distribution ratio, the SNP allelic frequencies were plotted along the pseudo-chromosomes. (mpob.gov.my)
Frequently1
  • A number of studies have shown that p16/CDKN2A is frequently altered in melanoma ( 9 ), pancreatic ( 10 ), urinary bladder ( 11 ) and lung cancer ( 12 ). (iiarjournals.org)