Autoimmune glial fibrillary acidic protein astrocytopathy (A-GFAP-A) is a newly discovered autoimmune nervous system disease involving the brain, spinal cord, meninges and optic nerve. (biomedcentral.com)
Autoimmune glial fibrillary acidic protein astrocytopathy is a form of monophasic or relapsing steroid-responsive meningoencephalomyelitis often accompanied by a hallmark radial periventricular brain MRI enhancement pattern and inflammatory cerebrospinal fluid with lymphocytic pleocytosis. (medlink.com)
Neuromyelitis3
The study, " Overlap syndrome of anti-aquaporin-4 positive neuromyelitis optica spectrum disorder and systemic lupus erythematosus: A systematic review of individual patient data ," was published in the journal Lupus . (neuromyelitisnews.com)
MOG antibody-associated disorder exhibits different pathophysiological and phenotypic findings than both aquaporin-4 antibody-associated neuromyelitis optica spectrum disorder and typical MS. MOG-antibody is of particular interest in pediatric patients with clinical or radiological non-MS typical findings. (e-cep.org)
Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disorder affecting the central nervous system and associated with the presence of aquaporin-4 immunoglobulin G antibodies (AQP4-IgG) [ 1 ]. (biomedcentral.com)
Antibodies4
NMOSD patients were positive for aquaporin-4 (AQP4) antibodies, the most common type of NMOSD-causing antibody. (neuromyelitisnews.com)
reported that between 4% and 7.5% of patients with anti-NMDAR encephalitis have concurrent glial or neuronal surface antibodies (glial-Ab or NS-Ab). (antinmdafoundation.org)
Although they found that the presence of myelin oligodendrocyte glycoprotein (MOG) or aquaporin 4 antibodies was associated with demyelinating disorders and NS-Ab was associated with medial temporal or subcortical MRI findings, a positive glial fibrillary acidic protein (GFAP) antibody was nonspecific. (antinmdafoundation.org)
Progression to wheelchair dependence was faster among patients with paraneoplastic compared with nonparaneoplastic autoimmune ataxia and among those with positivity for neuronal nuclear and cytoplasmic antibodies (NNC Abs + ) only (vs positivity for plasma membrane protein Abs [PMP Abs + ] only). (jamanetwork.com)
Encephalitis3
Autoimmune encephalitis (AE) is a heterogeneous class of inflammatory diseases of the brain that can present with a wide spectrum of neuropsychiatric symptoms. (antinmdafoundation.org)
Advances in autoimmune encephalitis studies in the past 10 years have led to the identification of new syndromes and biomarkers that have transformed the diagnostic approach to the disorder. (e-cep.org)
However, current criteria for autoimmune encephalitis. (e-cep.org)
GFAP6
however, cardiac autonomic dysfunction and abnormal circadian rhythm of blood pressure, which can lead to poor prognosis and even sudden cardiac death, has never been reported in A-GFAP-A patient. (biomedcentral.com)
Abnormal heart rate variability and non-dipper circadian rhythm of blood pressure gradually developed during hospitalization, which is rare in A-GFAP-A. He had positive GFAP IgG in cerebrospinal fluid (CSF). (biomedcentral.com)
However, cardiac autonomic dysfunction and abnormal circadian rhythm of blood pressure had rarely reported in A-GFAP-A. (biomedcentral.com)
Therefore, we should pay more attention to cardiac autonomic dysfunction and abnormal CRBP in A-GFAP-A patients. (biomedcentral.com)
Autoimmune GFAP astrocytopathy manifests as a meningoencephalomyelitis (or limited form thereof) with dramatic steroid-responsiveness. (medlink.com)
Autoimmune GFAP astrocytopathy presentation is subacute (over days to a few weeks). (medlink.com)
Inflammatory1
However it can be associated with variable causes (demyelinating lesions, autoimmune disorders, infectious and inflammatory conditions). (openophthalmologyjournal.com)
Disorders3
Both autoimmune disorders, NMOSD and lupus are each characterized by the immune system wrongfully attacking the body's own tissues. (neuromyelitisnews.com)
Autoimmune Disorders An autoimmune disorder is a malfunction of the body's immune system that causes the body to attack its own tissues. (msdmanuals.com)
Autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues. (msdmanuals.com)
Diseases3
Features of NMOSD, including longitudinally extensive transverse myelitis - a type of spinal cord inflammation - and involvement of certain areas of the brain were seen at higher rates in patients with both autoimmune diseases than usually observed in NMOSD alone. (neuromyelitisnews.com)
Most patients were female (91.3%), consistent with the known female predominance in both autoimmune diseases. (neuromyelitisnews.com)
In addition, functional studies have shown that TonEBP is involved in the pathogenesis of rheumatoid arthritis, atherosclerosis, diabetic nephropathy, acute kidney injury, hyperlipidaemia and insulin resistance, autoimmune diseases (including type 1 diabetes mellitus and multiple sclerosis), salt-sensitive hypertension and hepatocellular carcinoma. (nature.com)
Autoantibodies1
Graves' disease is an autoimmune disease characterized by autoantibodies toward the thyroid stimulating hormone (TSH) receptors. (chikd.org)
Findings2
Also, in available brain MRI images from 35 patients, 27 patients had abnormal findings. (neuromyelitisnews.com)
After completing the evaluation, however, only nine (1.8%) had polyneuropathy with objective clinical signs and abnormal electrophysiological findings. (bmj.com)
Acute2
The pattern of RNFL thinning most specific to MS is temporal.3 RNFL can appear normal in the acute setting but starts to decline within 4 weeks of ON. (clevelandclinic.org)
VEPs evaluate optic nerve function by calculating P100 latency and amplitude, which are generally abnormal in the setting of acute and remote optic neuritis. (clevelandclinic.org)
Prevalence2
We aimed to validate the prevalence of anti-aquaporin 5 (AQP5) IgG in a non-Korean cohort and to optimize the method to screen the anti-AQP5 IgG. (mdpi.com)
4 ⇓ - 6 Although involvement of the peripheral nervous system is a well-documented feature of the disease, the prevalence, the type, and the underlying mechanism of CNS involvement remain unclear. (ajnr.org)
Amniotic1
The volume of amniotic fluid varies at different stages of pregnancy [ 2 , 3 ], and the average amniotic fluid volume is 400 mL at term [ 4 ]. (researchsquare.com)
Protein4
This is illustrated for bromodomain-containing protein 4 (BRD4), in which a weakly binding fragment was coupled to a 42-member poised DEL via Suzuki-Miyaura cross coupling resulting in the identification of an inhibitor with 51 nM affinity in a single step, representing an increase in potency of several orders of magnitude from an original fragment. (bvsalud.org)
A protein called aquaporin 4: This protein is present on the surface of support cells in the brain, spinal cord, and optic nerves. (msdmanuals.com)
Tonicity-responsive enhancer-binding protein (TonEBP) is a stress protein involved in the cellular response to hypertonicity, autoimmune reactions, inflammation and metabolic and genotoxic stress. (nature.com)
Increased cAMP promotes protein kinase A activity, among other effectors, and, in turn, leads to cyst growth by promoting proliferation and fluid secretion of cyst-lining cells through chloride and aquaporin channels in ADPKD kidneys. (basicmedicalkey.com)
Disease5
Sjögren syndrome is a systemic autoimmune disease that affects 0.5 to 1% of the general population. (bmj.com)
Sjögren syndrome is a chronic systemic autoimmune disease that can be classified as primary Sjögren syndrome (pSS) when presenting in isolation or secondary when related to another connective tissue disease. (ajnr.org)
4 ⇓ - 6 The current data from MRI studies support an increased frequency of high signal intensity lesions in the periventricular and/or subcortical WM on FLAIR and T2-weighted imaging, observed mainly in patients with pSS and evidence of CNS disease. (ajnr.org)
Such fatigue has also been reported in a high percentage of patients with multiple sclerosis (MS), another autoimmune disease affecting the central nervous system. (biomedcentral.com)
The high-precision, high-performance devices at this unit conduct an array of tests, such as hormone and autoimmune disease tests, tumor marker tests, and virology screening tests. (karbalahospital.org)
Diabetes mellitus1
These SNPs are associated with increased risk of type 2 diabetes mellitus, diabetic nephropathy, inflammation, high blood pressure and abnormal plasma osmolality, indicating that variation in TONEBP expression might contribute to these phenotypes. (nature.com)
Symptoms2
1, 4, 7, 8 A clinician should further narrow the diagnosis based on the timing of symptoms and associated features (Below). (clevelandclinic.org)
Objective improvements in SPS neurologic symptoms were recorded in 16 of 18 patients who received first-line immunotherapy (89%, 9/10 treated with corticosteroids, 8/10 treated with IVIg, 3/4 treated with plasma exchange, and 1 treated with rituximab). (neurology.org)
The main pathophysiology of enuresis involves nocturnal polyuria, abnormal sleep arousal, and low functional bladder capacity. (chikd.org)
Mutations1
The ELAC2 gene functions as a mitochondrial tRNA processing gene, and only 4 different pathogenic mutations have been reported in ELAC2 -associated mitochondrial dysfunction involving oxidative phosphorylation. (e-cep.org)
Patients3
4 , 5 , 7 The estimated frequency of CNS involvement ranges from 10-60% in different reports, depending on the parameters studied (eg, patient selection, diagnostic criteria, etc). 4 ⇓ - 6 Patients with pSS can present with a wide range of focal or diffuse neurologic or psychiatric manifestations, including motor/sensory deficits, transverse myelitis, and cognitive impairment. (ajnr.org)
Methods To assess GlyRα1-IgGs as biomarkers of SPS spectrum among patients and controls, specimens were tested using cell-based assays (binding [4°C] and modulating [antigen endocytosing, 37°C]). Medical records of seropositive patients were reviewed. (neurology.org)
Results GlyRα1-IgG (binding antibody) was detected in 21 of 247 patients with suspected SPS spectrum (8.5%) and in 8 of 190 healthy subject sera (4%) but not CSF. (neurology.org)
Onset1
OCT at onset of ON is also potentially confounded by edema of the optic disc, which may lead to overestimates of baseline RNFL.4 Ganglion cell layer (GCL) thickness, another OCT measure, is not confounded by disc edema but declines in a similar time frame to RNFL and therefore may be more useful as a baseline measurement. (clevelandclinic.org)
Thickness1
We analyzed optical coherence tomography (OCT) images of 244 eyes from 122 rhesus macaques (aged 4-32 years) to measure choroidal thickness (CT) and choroidal vascularity index (CVI). (qxmd.com)
Conditions1
Conditions such as cystitis, constipation, urethral obstruction, and neurogenic bladder reduce functional bladder capacity which can cause enuresis [ 3 , 4 ]. (chikd.org)
Present1
Abnormal contrast sensitivity and color vision are present in almost all adults with ON even in the absence of a measurable decrease in visual acuity. (medscape.com)
Years2
She had been dry at night after the age of 4 years, but complained of enuresis for 6 times a week from a month ago. (chikd.org)
The people has been area examined with regard to agronomic overall performance with a pair of places in Syria pertaining to 4 years along with a couple of seeding days, inside autumn and winter. (uk5099inhibitor.com)
Results1
Abnormal results are rechecked to ensure their accuracy. (karbalahospital.org)
Days1
Although the acquired immune system functions as early as 2-4 days after encountering the pathogen, some T and B cells respond specifically to the invading microorganisms, even after the immune response has ended. (biomedcentral.com)
Functions1
Fig. 4: Homeostatic or protective functions of TonEBP associated with transcription regulation. (nature.com)